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Keywords: Hong Kong; People's Republic of China; Asia; Central Nervous System Agents; China; Drugs and Therapies; Health and Medicine; Ketones; Methadone; Methadone Therapy; Narcotic Analgesics; Pharmaceuticals EN Hong Kong People's Republic of China Asia Central Nervous System Agents China Drugs and Therapies Health and Medicine Ketones Methadone Methadone Therapy Narcotic Analgesics Pharmaceuticals 2378 2378 1 03/24/23 20230217 NES 230217 2023 FEB 17 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Drugs and Therapies - Central Nervous System Agents. Hong Kong, People's Republic of China, Asia, Central Nervous System Agents, China, Drugs and Therapies, Health and Medicine, Ketones, Methadone, Methadone Therapy, Narcotic Analgesics, Pharmaceuticals. [Extracted from the article]

Keywords: Xi'an; People's Republic of China; Asia; Antibacterials; Antibiotics; Antimicrobials; Drugs and Therapies; Electronics; Emerging Technologies; Environment; Health and Medicine; Nanotechnology; Photocatalyst; Photocatalytics; Semiconductor EN Xi'an People's Republic of China Asia Antibacterials Antibiotics Antimicrobials Drugs and Therapies Electronics Emerging Technologies Environment Health and Medicine Nanotechnology Photocatalyst Photocatalytics Semiconductor 2023 FEB 3 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Nanotechnology - Photocatalytics. Keywords for this news article include: Xi'an, People's Republic of China, Asia, Antibacterials, Antibiotics, Antimicrobials, Drugs and Therapies, Electronics, Emerging Technologies, Environment, Health and Medicine, Nanotechnology, Photocatalyst, Photocatalytics, Semiconductor, Northwest University. [Extracted from the article]

A study conducted at Shihezi University in Xinjiang, China, focused on the development of hydrogel dressings with antifreeze and rewarming properties for treating frostbite. The dressing, named PCM30B5A200, demonstrated excellent rewarming, anti-freezing, self-adhesion, and antibacterial properties. The research highlighted the importance of rapid rewarming in treating frostbite, especially in severe cold outdoor regions. The study was funded by the National Natural Science Foundation of China and the International Cooperation Project of Shihezi University, and the findings were published in Advanced Materials Interfaces. [Extracted from the article]

A recent study from China Jiliang University focused on improving drug-target interaction prediction through a new method called DTI-HAN. By constructing a drug-target heterogeneous network and introducing feature projection and fuzzy theory, the DTI-HAN method showed significant improvements in predictive performance compared to existing methods. The study's findings were validated using various databases and molecular docking, demonstrating promising results in drug development research. The research is available for further exploration and can be accessed through the provided link. [Extracted from the article]

Researchers from China University of Petroleum have developed intelligent responsive self-assembled micro-nanocapsules to delay gel gelation time in polymer gels. By using gas-phase hydrophobic SiO2 particles as capsules, the cross-linking agent is slowly released under external conditions like temperature and pH, significantly prolonging gelation time and increasing gel strength. This innovative method offers a promising approach for controlling gel properties in various applications. [Extracted from the article]

Researchers from the National University of Singapore have published a study on the challenges faced by the pharmaceutical industry in drug development, particularly in medicinal chemistry synthesis. The study highlights the potential benefits of transitioning to automated methods for drug discovery, which could improve efficiency, scalability, and safety while reducing time and costs. The research focuses on the development of an automated rotating bed reactor as part of a Cyber-Physical System-based automated drug discovery workcell, showing promising results in enhancing chemical reaction yields. This peer-reviewed study provides valuable insights into the future of pharmaceutical research and development. [Extracted from the article]

A study conducted at Guangdong Pharmaceutical University in Guangzhou, China, focused on the development of a nanodrug delivery system using dopamine-based functional molecules for efficient targeting of tumor cells. The research aimed to enhance the water solubility of chemotherapeutic drugs and improve their biodistribution through the use of drug-loaded nanoparticles that respond to pH changes in the tumor microenvironment. The nanoparticles achieved passive targeting and active targeting through folic acid on their surface, resulting in enhanced targeting efficiency on HepG2 cell lines. This work utilized three types of molecules to construct targeted nanoparticles that significantly improved the anti-tumor effect of the drug Cur through active and passive targeting mechanisms. [Extracted from the article]

Researchers at Fujian Normal University in Fuzhou, China, have developed a diaper-based wearable sensor system using a silver nano dual-structure composite hydrogel to detect biomarkers and pH in urine. This innovative sensor aims to enable personalized health management through continuous monitoring of health status. The sensor's design allows for rapid and sensitive detection of various biomarkers in urine, making it a promising tool for monitoring the health of infants, the elderly, and individuals with limited mobility. [Extracted from the article]

Researchers from Hunan University in the People's Republic of China have conducted a study on sulfate radical-based advanced oxidation processes for the simultaneous removal of antibiotic-resistant bacteria and antibiotic resistance genes. The study highlights the urgent need for efficient technologies to control antibiotic resistance, which poses a threat to human life safety and ecological stability. The research explores different activation methods of persulfate and their effectiveness in eliminating antibiotic-resistant bacteria and genes, providing valuable insights for future advancements in this field. This peer-reviewed study offers a reference for selecting sulfate radical-based advanced oxidation technology for combating antibiotic resistance in the future. [Extracted from the article]

A recent research study conducted at the University of Engineering & Technology Lahore focused on analyzing the topological descriptors of guar gum and its derivatives to predict physical properties in carbohydrates. Guar gum, a non-ionic polysaccharide, is commonly used as a thickening agent, stabilizer, or emulsifier in various products. The study found that topological descriptors can be useful in predicting physical properties such as density and molecular weight in different carbohydrates. The research was supported by King Saud University and has been peer-reviewed, providing valuable insights into the chemical structures and applications of guar gum. [Extracted from the article]

Researchers from Ulsan National Institute of Science and Technology (UNIST) in South Korea have conducted a study on MR-only radiotherapy planning using synthetic CT scans instead of real CT scans. The study explores the use of deep learning models for MR-to-CT synthesis, categorizing them into four classes: convolutional neural networks, generative adversarial networks, transformer models, and diffusion models. The research aims to improve the accuracy of treatment planning and evaluate the potential of these models for enhancing current methods in radiotherapy. This peer-reviewed study provides valuable insights into the application of deep learning in biomedical engineering for radiotherapy planning. [Extracted from the article]

Researchers from Wuyi University in Jiangmen, China, conducted a study on Rosa x damascena Herrm. essential oil (RDEO) and its anti-tyrosinase activity. The study found that RDEO exhibited effective anti-tyrosinase activity and could inhibit intracellular tyrosinase activity in B16F10 cells. The main phytochemical compositions of RDEO were citronellol, geraniol, eicosane, heneicosane, and 1-nonadecene. This research suggests that RDEO could be a potential natural tyrosinase inhibitor with applications in cosmetics and medicine. [Extracted from the article]

A study conducted in Xinjiang, China, explored the potential mechanisms of Zigongding (ZGD), a traditional Chinese medicine, in treating HPV-induced Cervical Intraepithelial Neoplasia (CIN). The research integrated network pharmacology and experimental validation to identify active ingredients, targets, and molecular mechanisms of ZGD. The study found that ZGD may modulate the estrogen receptor 1 (ESR1) to treat CIN, providing a novel insight into the therapeutic potential of ZGD in CIN treatment. This research was supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region and has been peer-reviewed. [Extracted from the article]

Researchers at Mahatma Gandhi University in Kerala, India, have published a report on the synthesis, stimuli response, and biomedical applications of polymersomes, which are hollow spherical structures made from amphiphilic block copolymers. These polymersomes have shown promise in targeted drug delivery, bioimaging, and theranostics due to their unique properties and biocompatibility. The study explores various block copolymers used to create polymersomes, different self-assembly techniques, and the potential applications of these structures as nanocarriers and nanoreactors. The research highlights the importance of efficient materials for biomedical applications and the increasing need for innovative polymersomes in the field. [Extracted from the article]

Researchers at Shanghai Jiao Tong University have developed a lidocaine-loaded iontophoresis-driven fiber-based microneedle patch for transdermal local analgesia. This innovative system allows for controllable and long-lasting pain relief through a smartphone application that enables precise dosage control. The patch combines fiber-based dissolving microneedles with iontophoresis, offering different delivery modes for various pain conditions and ensuring efficient and prolonged pain management. This research has been peer-reviewed and offers a promising system for patient-controlled local analgesia treatment. [Extracted from the article]

A study conducted by researchers at Shanghai Jiao Tong University in China explores the use of nanomaterials for repairing organ injuries. The study highlights the potential of nanorepair medicine in treating conditions such as acute kidney injury, ischemic stroke, and spinal cord injury. The researchers discuss disease characteristics associated with different types of organ injuries, provide examples of relevant nanorepair medicine, and outline strategies for organ-targeting and mitigating risk factors. The study concludes by defining and reviewing the emerging field of nanorepair medicine. [Extracted from the article]

A recent study conducted at Harbin Engineering University in China explored the use of optical fiber X-ray sensors to monitor radiation therapy. The researchers investigated an over-response phenomenon that can occur when using these sensors to measure the off-axis ratio (OAR) curve. They used simulations and experiments to analyze the energy distribution of particles and found that the over-response can be mitigated by using a high-Z metal cap. The study concluded that the OAR measured using an optical fiber X-ray sensor with a tin cap showed the closest response to that measured using an ionization chamber. This research provides valuable insights for improving precision radiotherapy. [Extracted from the article]

A recent report from the Maulana Azad National Institute of Technology in Madhya Pradesh, India, explores the integration of 3D printing (3DP) into the healthcare industry. The goal is to provide personalized solutions, improve medical procedures, and optimize healthcare delivery. The report examines the historical beginnings of additive manufacturing (AM) in medical contexts, the various categories of AM methodologies, and their manifold applications in the medical sector. The research is designed for a diverse audience, including manufacturing professionals and researchers interested in the medical dimensions of this transformative technology. [Extracted from the article]

A report from Nanning Normal University in the People's Republic of China discusses the synthesis and antiproliferative activity of 7-substituted amide estradiol derivatives. The researchers synthesized various amine derivatives of estradiol with a side chain at the 7-position and evaluated their anti-tumor activities. The compounds showed excellent activity, with shorter chains being more active than longer chains. Compound 9o was found to effectively inhibit the proliferation and migration of MCF-7 cells and induce early apoptosis in breast cancer tumors under certain concentration conditions. This research has been peer-reviewed. [Extracted from the article]

A recent study conducted at Chongqing Technology and Business University in China has explored the use of DNA-based hydrogels in disease diagnosis and treatment. DNA-based hydrogels have several advantages, including biodegradability, biocompatibility, and the ability to respond to specific triggers. The study discusses the different types of DNA hydrogels, their synthesis methods, unique properties, and applications in biosensors and drug delivery. The research also highlights the current challenges in expanding the practical application of DNA-based hydrogels. [Extracted from the article]

A recent study conducted by researchers from Banasthali Vidyapith in India has introduced a series of novel s-triazine analogues with potential medicinal properties. These analogues were synthesized and evaluated for their antimicrobial properties against Pseudomonas chlororaphis and Malassezia furfur. Two compounds, 20 and 26, demonstrated the highest activity against both microorganisms. The study also utilized Density Functional Theory (DFT) to validate the experimental findings and concluded that the synthesized compounds have pharmacokinetic properties suitable for clinical use. This research has been peer-reviewed and provides valuable insights into the potential of these analogues as antimicrobial agents. [Extracted from the article]

A recent study conducted by researchers at the Ocean University of China in Qingdao investigated the use of a carbon black-polytetrafluoroethylene (C-PTEE) cathode to degrade metronidazole (MNZ) in wastewater. The researchers optimized the performance and operating conditions of the cathode through experiments. They found that reactive oxygen species (ROS) generated by electrolytes in the NaCl and Na2SO4 systems were more effective in removing MNZ compared to the NaNO3 system. The study also proposed three possible degradation paths for MNZ and evaluated the energy consumption of the system. This research provides valuable insights for the industrial-scale application of MNZ wastewater treatment. [Extracted from the article]

A report from Xi'an Shiyou University in China discusses the synthesis of a novel compound called spirocyclic cyclopentapyridine, which plays a role in drug design and development. The researchers used commercially available 2-chloro-6-methoxypyridine as a starting material and achieved the synthesis through an eight-step reaction process, with a focus on the challenging steps of selective Negishi coupling and carbonyl reduction. The research has been peer-reviewed and provides valuable insights into the field of Obesity, Fitness, and Wellness. For more information, readers can contact the authors or access the full article through the provided DOI link. [Extracted from the article]

A study conducted by Zhejiang Normal University in Jinhua, China explores the applications and future trends of digital twins (DTs) in healthcare. DTs are virtual replicas of physical entities that use real-time data to make predictions about their physical counterparts. The study highlights the potential of DTs in personalized medicine and precision healthcare, discussing various applications such as healthcare 4.0, cardiac analysis, monitoring and management, data privacy, socio-ethical considerations, and surgical simulations. The integration of emerging technologies like big data, cloud computing, virtual reality, and the internet of things provides a foundation for implementing DTs in healthcare. The research has been peer-reviewed and is categorized under health care technologies and computational intelligence. [Extracted from the article]

Researchers from Lanzhou University of Technology in China have developed a new photocatalyst that can effectively remove antibiotics and heavy metals from aquaculture wastewater. The photocatalyst, called CQDsMIP-BNO, showed high selectivity and photocatalytic activity in removing Ceftriaxone Sodium (CTRX) and Cr (VI) within 45 minutes. The researchers also set up a photocatalytic reactor to further explore the potential of the bifunctional catalyst. This study demonstrates the feasibility of combining molecular imprinting and photocatalytic technologies for the treatment of aquaculture wastewater. [Extracted from the article]

A report from Shenyang Pharmaceutical University in China discusses research on the removal of the antibiotic ciprofloxacin from wastewater. The researchers used a combination of acidic deep eutectic solvents and zeolite imidazolate frameworks loaded onto wood to create composites that efficiently adsorbed the antibiotic. The study found that the composites had a high adsorption capacity for ciprofloxacin, and identified several mechanisms by which the adsorption occurred. The research suggests that this method has potential for removing antibiotic contaminants from wastewater. The study has been peer-reviewed and published in the Journal of Environmental Chemical Engineering. [Extracted from the article]

A study conducted at Harbin Engineering University in China has examined the application of antibacterial polyurethane in various fields such as medicine, food packaging, and water treatment. Polyurethane is a synthetic polymer widely used due to its mechanical flexibility and biodegradability. The study reviews the antibacterial modification methods of polyurethane materials and discusses the challenges faced in their application. The research has been peer-reviewed and provides valuable insights into the development and use of antibacterial polyurethane. [Extracted from the article]

A recent report from the Sardar Vallabhbhai National Institute of Technology in Gujarat, India discusses the synthesis of green fluorescent carbon dots (CDs) using cysteine and maltose as ecofriendly ligands. The CDs were found to have emission and excitation peaks at 511 and 420 nm, respectively. The researchers also discovered that the CDs could act as a sensor for venlafaxine, an antidepressant drug, through a fluorescence 'turn-off' mechanism. The sensor was successfully used to quantify venlafaxine in pharmaceutical and biological samples with good recovery rates. [Extracted from the article]

A recent study conducted at the Chinese Academy of Sciences in Shenzhen, People's Republic of China, has focused on improving the effectiveness of radiotherapy for nasopharyngeal carcinoma (NPC), a malignant tumor primarily treated with radiotherapy. The study introduces a novel segmentation network called MMCA-Net, which utilizes PET/CT images and incorporates an innovative multimodal cross attention transformer (MCA-Transformer) and a modified U-Net architecture. The method consistently outperformed other algorithms in terms of evaluation metrics, demonstrating its potential for application in other tasks. The research has been peer-reviewed and published in the IEEE Journal of Biomedical and Health Informatics. [Extracted from the article]

A study from the Harbin Institute of Technology in China explores the use of metal-organic frameworks (MOFs) in nanomedicine. MOFs have porous structures and can be used as templates for creating multifunctional structures. The study reviews recent advances in MOF derivatives, including their synthesis routes and potential applications in biosensing, bioimaging, anticancer therapy, anti-infection, and Alzheimer's disease. The research concludes that the combination of chemistry, nanotechnology, and biomedicine has the potential to greatly advance the development of MOF-based derivatives for the benefit of human health. [Extracted from the article]

A research study conducted at the University of Sargodha in Pakistan focused on optimizing the extraction conditions and characterizing the components of a newly developed garlic cultivar called NARC-G1. The study used response surface methodology to determine the optimal extraction time, solvent-to-solid ratio, and extraction temperature for various biological attributes of the garlic, including total phenolic contents, DPPH radical scavenging activity, alpha-amylase inhibition, and alpha-glucosidase inhibition. The study found that under the optimized conditions, the garlic extract exhibited high levels of these attributes. Gas chromatography-mass spectrometry analysis revealed the presence of several bioactive compounds, and in silico investigation suggested potential antihyperglycemic properties. The study concluded that these findings could contribute to the development of nutra-pharmaceutical and functional food products. [Extracted from the article]

Researchers at Beijing Technology and Business University in China have conducted a study on the use of liposomes to improve the stability and release properties of eugenol, the main component of essential oils. They successfully prepared eugenol liposomes with an average particle size of 40-70 nm and an encapsulation rate of 87.12%. By combining liposomes with electrostatic spinning technology, they also created a nanofibrous membrane that exhibited excellent antioxidant and bacteriostatic properties. This research suggests that the combination of liposomes and electrostatic spinning could have potential applications in the food and medicine industries. [Extracted from the article]

A recent study conducted by researchers at the Harbin Institute of Technology in Shenzhen, China, has focused on the potential use of metformin and paclitaxel (PTX) in cancer therapy. The researchers successfully loaded PTX into metformin oleate ionic liquid micelles, which exhibited good particle size and stability. In vitro and in vivo experiments showed that the PTX-IL/T-80 micelle had significant antitumor efficacy, with a high inhibition rate on cancer cells and a greater tumor inhibition rate in mice compared to the PTX prodrug group. The study suggests that the PTX-IL/T-80 micelle has potential for application in cancer therapy due to its synergistic antitumor effect. [Extracted from the article]

A recent study conducted by the Chinese Academy of Medical Sciences in Beijing, China, has focused on the quality control of a drug-drug cocrystal called naringenin-carbamazepine (NR-CBZ). The researchers used ATR-FTIR and Raman spectroscopies combined with chemometric techniques to quantify NR-CBZ in mixtures. They found that Raman spectra, when combined with the Savitzky-Golay filter, provided the most accurate prediction results for NR-CBZ content. The study concluded that the prediction models had a high level of accuracy, with a root mean square error of cross-validation (RMSECV) of 0.101 and a squared correlation coefficient (R2) of 0.870. This research has been peer-reviewed and provides valuable insights into the quality control of NR-CBZ. [Extracted from the article]

A study conducted at Majmaah University in Al Majmaah, Saudi Arabia, has developed a novel electrochemical sensor for monitoring tetracycline using green nanoparticles. The researchers synthesized the nanoparticles using gum Arabic polymer and silver nanoparticles. The sensor demonstrated good dispersion and homogeneity of the nanoparticles, with a wide concentration range and a low limit of detection. The study suggests that these green nanoparticles could be commercially viable for the next generation of electrochemical sensors for tetracycline detection and could also be used to detect other pharmaceutical pollutants in the environment. [Extracted from the article]

Researchers from Guangdong Pharmaceutical University in Guangzhou, China have conducted a study on the anticancer activity of cyclometalated iridium(iii) compounds. The compounds were found to have strong cytotoxicity against lung cancer cells, specifically A549 cells. The study also investigated the mechanism of antitumor activity and found that the compounds induced apoptosis of the cancer cells through a mitochondrial pathway. The results suggest that these compounds could be potential chemotherapeutic agents for photodynamic therapy of lung cancer. The research was supported by the National Natural Science Foundation of China. [Extracted from the article]

A recent report from Harbin Medical University in China highlights the role of tumor-associated macrophages in the tumor immune microenvironment and their potential as a target for therapeutic intervention. The study discusses how these macrophages can influence various factors such as tumor cell growth, invasion, metastasis, and drug resistance. The researchers summarize recent advances in understanding tumor-associated macrophages and their impact on clinical therapies, as well as the advantages and disadvantages of targeted therapy. The report provides insights for future therapeutic approaches and emphasizes the need for further research in this area. [Extracted from the article]

A report from the Hubei University of Chinese Medicine in China discusses research on personalized medicine in the context of acupuncture therapy. The study focuses on the challenge of recommending specific acupoints based on individual symptoms and the sparse nature of traditional Chinese medicine (TCM) data. The researchers propose a novel approach called the enhanced graph convolutional network with property fusion (PEGCN) to address these issues. Experimental results demonstrate the superiority of the PEGCN model in terms of evaluation metrics, suggesting that it offers an improved method for personalized treatments in TCM. The research has been peer-reviewed and more information can be obtained from the authors. [Extracted from the article]

A report from Shandong Normal University in Jinan, China, discusses the interaction between antimicrobial peptides and phospholipid membranes in Gram-negative bacterial infections. The study aims to understand the behavior of these peptides when interacting with bacterial membranes and provides insights into the mechanism of interaction at a molecular level. The research suggests that certain derived peptides are more active against Gram-negative bacteria than others. This information could be useful in designing new derivative peptides for the development of antimicrobial drugs. The study was supported by the Natural Science Foundation of Shandong Province and has been peer-reviewed. [Extracted from the article]

Researchers from the University of Science and Technology China have developed biodegradable and multifunctional microneedles (MNs) for the combined treatment of cutaneous infections. The microneedles are designed to deliver both hydrophilic and hydrophobic drugs, providing improved drug transdermal efficiency and antifungal properties. The microneedles have been shown to withstand humidity, wound exudate, and pus, and maintain their potency to effectively penetrate skin tissues. The promising outcomes of this research lay a solid foundation for clinical translation to treat deep skin-related diseases. [Extracted from the article]

A study conducted by researchers at Hanseo University in Chungnam, South Korea, explores the use of MXene-based composites as photocatalysts for the removal of pharmaceutical antibiotics-induced pollutants. MXene composites are cost-effective and easily prepared, making them desirable functional materials. The study reviews the synthesis and properties of MXene composites as photocatalysts, as well as their role in the decomposition and removal of antibiotics. The research aims to contribute to the design of future catalysts and proposes directions for further research in this field. [Extracted from the article]

A study conducted by researchers at Hunan University in Changsha, China, focuses on predicting drug-target interactions, which is a crucial step in drug discovery. The researchers propose a framework called DSG-DTI that utilizes graph machine learning to explore the complex relationships between drugs and proteins. The framework incorporates a heterogeneous graph autoencoder and an attention-based heterogeneous graph-based matrix completion to achieve accurate predictions. The study concludes that the proposed scheme outperforms other baselines in predicting drug-target interactions and can be generalized to newly registered drugs and targets. [Extracted from the article]

A study conducted by researchers at the Department of Mathematics in Karur, India, explores the use of mathematical models to predict the physical, chemical, and biological features of anticancer medications used to treat blood, breast, and skin cancer. The researchers developed distance-based topological indices (TIs) using a suggested KP-polynomial with blood cancer drugs. The results of the study suggest that this theoretical method could potentially allow chemists and healthcare professionals to anticipate the characteristics of blood cancer drugs without the need for actual experimental tests. The research also discusses the potential for drug discovery and the use of multicriteria decision-making techniques for ranking disease treatment drugs. [Extracted from the article]

Researchers at the State Key Laboratory for Manufacturing Systems Engineering in Xi'an, China have developed a new type of capacitive micromechanical ultrasonic transducer (CMUT) with annular electrodes. This design allows for significant improvements in multiple performance metrics, such as displacement and acoustic pressure, compared to conventional CMUTs. The novel CMUTs also have a simpler structure and fabrication process, making them promising for applications in air-coupled and therapeutic ultrasound. The research was funded by various organizations in China and has been peer-reviewed. [Extracted from the article]