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In the crystal structure of the title compound, 2C6H9N3 C8H6O4, terephthalic acid has a crystallographic inversion centre and the dimethylpyrimidine molecule shows approximate non-crystallographic mirror and twofold rotation symmetry. The inversion-related pyrimidine molecules form a base pair [R2 2(8) ring motif] via a pair of NH⋯N hydrogen bonds. The carboxyl groups of terephthalic acid link the base pairs via OH⋯N and NH⋯O hydrogen bonds [R2 2(8) motif] to generate a supramolecular ribbon. [ABSTRACT FROM AUTHOR]

In the crystal structure of the title compound, 2,4-diamino-5-(4-chloro­phen­yl)-6-ethyl­pyrimidin-1-ium 3-carb­oxy-4-hydroxy­benzene­sulfonate monohydrate, C12H14ClN4+·C7H5O6S−·H2O, the asymmetric unit contains two crystallographically independent protonated pyrimethamine (PMN) mol­ecules, a pair of sulfosalicylate anions and two water mol­ecules. Both the PMN molecules are protonated at one of the pyrimidine N atoms. The component species inter­act through numerous inter­molecular N—H⋯O, N—H⋯N and O—H⋯O hydrogen bonds and C—H⋯O inter­actions. [ABSTRACT FROM AUTHOR]

In the title compound, 2,4-di­amino-5-(3,4,5-tri­methoxy­benzyl)­pyrimidinium hydrogen malonate, C14H19N4O3+·C3H3O4−, the trimethoprim mol­ecule is protonated at one of the pyrimidine N atoms. The carboxyl­ate group of the hydrogen malonate ion accepts a pair of N—H⋯O hydrogen bonds from an adjacent trimethoprim mol­ecule, which is similar to the carboxyl­ate–trimethoprim cation interaction present in the complex of di­hydro­folate reductase with trimethoprim. An O atom of the carboxyl group forms an intramolecular O—H⋯O hydrogen bond with the carboxyl­ate group, leading to a folded conformation for the hydrogen malonate ion. Each hydrogen malonate ion bridges two di­amino­pyrimidine cations, via N—H⋯O and C—H⋯N hydrogen bonds, leading to a supramolecular ribbon made up of alternating cations and anions. Two such inversion-related ribbons are cross-linked by (amino)N—H⋯O(methoxy) hydrogen bonds, (pyrimidine)C—H⋯O(methoxy) hydrogen bonds and π–π stacking involving the benzene planes. [ABSTRACT FROM AUTHOR]

In the title compound, C12H14ClN4+·C6H4NO2−·H2O, the pyrimethamine molecule is protonated at one of the pyrimidine N atoms. The protonated N atom and 2-amino group of the cation interact with an adjacent nicotinate anion through a pair of N—H...O hydrogen bonds [graph set R22(8)]. The cation, anion and water molecule form a hydrogen-bonded ring motif with graph-set notation R42(8). The crystal structure is further stabilized by N—H...O and O—H...O hydrogen bonds and π–π interactions [centroid–centroid distance = 3.637 (6) Å]. [ABSTRACT FROM AUTHOR]

In the title compound [systematic name: 2,4-diamino-5-(3,4,5-trimethoxy­benz­yl)pyrimidinium tetrafluoroborate], C14H19N4O3+·BF4−, the trimethoprim (TMP) mol­ecule is protonated at one of the pyrimidine N atoms. The protonated N atom and 2-amine group of the TMP cation inter­act with the tetrafluoroborate anion through a pair of N—H⋯F hydrogen bonds [graph set R22(8)]. The inversion-related TMP cations are linked through a pair of N—H⋯N hydrogen bonds. The 2-amine group of one TMP cation and the 4-amine group of another cation are bridged by a meth­oxy O atom, via N—H⋯O hydrogen bonds. [ABSTRACT FROM AUTHOR]

In the title compound, C6H9N3·C7H6O3, the 2-amino-4,6-dimethyl­pyrimidine and 4-hydroxy­benzoic acid mol­ecules link together via N—H⋯O and O—H⋯N hydrogen bonds to form an eight-membered R22(8) ring. Further hydrogen bonds and C—H⋯O inter­actions result in the formation of a three-dimensional network. [ABSTRACT FROM AUTHOR]

In the title cocrystal, C6H9N3O2·C7H7NO2, the 2-amino-4,6-dimethoxy­pyrimidine mol­ecule inter­acts with the carboxyl group of the 4-amino­benzoic acid mol­ecule through N—H⋯O and O—H⋯N hydrogen bonds, forming a cyclic hydrogen-bonded motif [ R22(8)]. This motif further self-organizes through N—H⋯O hydrogen bonds to generate an array of six hydrogen bonds with the rings having the graph-set notation R23(6), R22(8), R42(8), R22(8) and R23(6). The 4-amino­benzoic acid mol­ecules self-assemble via N—H⋯O hydrogen bonds to form a supra­molecular chain along the c axis. [ABSTRACT FROM AUTHOR]