183 results on '"Liang, Min"'
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2. Ruthenium-Catalyzed Meta-Selective Trifluoroisopropylation of Arenes.
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Han, Shuxiong, Liang, Min, Ju, Wenjie, Wang, Junrui, Xu, Xu, Huang, Zhibin, and Zhao, Yingsheng
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- 2024
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3. Iridium-Catalyzed Ortho-Selective C–H Borylation of Aryl Ketones with Transient Imine Ligands.
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Liang, Min, Liu, Chuangchuang, Ju, Wenjie, Han, Shuxiong, Zhang, Jingyu, and Zhao, Yingsheng
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- 2024
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4. Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2.
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Chen, Liang-Min, Qian, Si-Tong, Li, Zhuo-Qing, He, Ming-Fang, and Li, Hui-Jun
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- 2024
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5. Multifunctional Drug- and AuNRs-Loaded ROS-Responsive Selenium-Containing Polyurethane Nanofibers for Smart Wound Healing
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Ahmed, Wajiha, Li, Shifen, Liang, Min, Kang, Yongyuan, Liu, Xiaoqing, and Gao, Changyou
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Elevated levels of ROS, bacterial infection, inflammation, and improper regeneration are the factors that need to be addressed simultaneously for achieving effective wound healing without scar formation. This study focuses on the fabrication of electrospun ROS-responsive selenium-containing polyurethane nanofibers incorporating deferoxamine mesylate (Def), indomethacin (Indo), and gold nanorods (AuNRs) as proangiogenesis, anti-inflammatory, and antibacterial agents for synchronized delivery to a full-thickness wound in vivo. The structure of the fabricated nanofibers was analyzed by various techniques. Toxicity was checked by CCK-8 and hemolytic assays. The efficiency of wound healing in vitrowas verified by a transwell assay and cell scratch assay. The wound healing efficiency of the nanofibers was assayed in full-thickness wounds in a rat model. The multifunctional nanofibers had a porous structure, enhanced antioxidation, antibacterial activity, and promoted wound healing. They eradicated TNF-α and IL-6, increased IL-10 expression, and revealed the angiogenic potential by increased expression of HIF-1α, VEGF, and CD31.
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- 2024
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6. Separation of fluorine and aluminum from secondary aluminum dross by calcium-cured alkali roasting−water leaching
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DONG, Liang-min, JIAO, Fen, LIU, Wei, HUANG, Ya-lin, WEI, Xin, and QIN, Wen-qing
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A combined strategy of calcium-cured alkali roasting and water leaching was devised to treat secondary aluminum dross. The effects of calcium oxide dosage, sodium hydroxide dosage, roasting temperature, and time on aluminum extraction behavior and fluorine curing behavior were studied. Under optimal experimental conditions: roasting temperature of 1000 °C, Al꞉NaOH mole ratio of 1꞉0.6, F꞉CaO mole ratio of 1꞉2.5, and roasting time of 2.0 h, fluorine and aluminum were separated, with 99.98% of the fluoride solidified and 52.97% of the aluminum extracted. The sodium aluminate products obtained by evaporation and crystallization from leaching solution met the industrial standards of China. The aqueous residue can be used as a raw material for quick-setting cement. Overall, this study provides an effective and environmentally friendly strategy for the treatment of secondary aluminum dross.
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- 2024
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7. Iridium-Catalyzed Ortho-Selective C–H Borylation of Aryl Ketones with Transient Imine Ligands
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Liang, Min, Liu, Chuangchuang, Ju, Wenjie, Han, Shuxiong, Zhang, Jingyu, and Zhao, Yingsheng
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Ortho-selective C–H borylation of aromatic ketones has not been extensively explored. Herein, we report the iridium-catalyzed ortho-selective C–H borylation of aromatic ketones using in situ-formed imine as the ligand. Good compatibility is observed for various substituted acetophenones and other aromatic ketones, and corresponding products are obtained with medium to excellent yields.
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- 2024
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8. Psoralen and Isopsoralen, TwoEstrogen-LikeNatural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2
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Chen, Liang-Min, Qian, Si-Tong, Li, Zhuo-Qing, He, Ming-Fang, and Li, Hui-Jun
- Abstract
With the increasing use of oral contraceptives and estrogen replacement therapy, the incidence of estrogen-induced cholestasis (EC) has tended to rise. Psoralen (P) and isopsoralen (IP) are the major bioactive components in Psoraleae Fructus, and their estrogen-like activities have already been recognized. Recent studies have also reported that ERK1/2 plays a critical role in EC in mice. This study aimed to investigate whether P and IP induce EC and reveal specific mechanisms. It was found that P and IP increased the expression of esr1, cyp19a1band the levels of E2 and VTG at 80 μM in zebrafish larvae. Exemestane (Exe), an aromatase antagonist, blocked estrogen-like activities of P and IP. At the same time, P and IP induced cholestatic hepatotoxicity in zebrafish larvae with increasing liver fluorescence areas and bile flow inhibition rates. Further mechanistic analysis revealed that P and IP significantly decreased the expression of bile acids (BAs) synthesis genes cyp7a1and cyp8b1, BAs transport genes abcb11band slc10a1,and BAs receptor genes nr1h4and nr0b2a. In addition, P and IP caused EC by increasing the level of phosphorylation of ERK1/2. The ERK1/2 antagonists GDC0994 and Exe both showed significant rescue effects in terms of cholestatic liver injury. In conclusion, we comprehensively studied the specific mechanisms of P- and IP-induced EC and speculated that ERK1/2 may represent an important therapeutic target for EC induced by phytoestrogens.
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- 2024
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9. Positive association between dietary manganese intake and new-onset hypertension: A nationwide cohort study in China.
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Zhang, Yuanyuan, Liu, Mengyi, Yang, Sisi, Zhang, Yanjun, Ye, Ziliang, Wu, Qimeng, Li, Rui, Zhou, Chun, He, Panpan, Liu, Chengzhang, Jiang, Jianping, Liang, Min, Wang, Guobao, Hou, Fan Fan, and Qin, Xianhui
- Abstract
To date, few studies have investigated the association between dietary manganese intake and the risk of hypertension, so the prospective relationship of dietary manganese intake and new-onset hypertension remains uncertain. We aimed to investigate the association between dietary manganese intake and the risk of new-onset hypertension in the general Chinese population. This prospective cohort study included 12,177 participants who were free of hypertension at baseline from China Health and Nutrition Survey (CHNS). Dietary intake was measured by 3 consecutive 24-h dietary recalls combined with a household food inventory. The study outcome was new-onset hypertension, defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or diagnosed by a physician or under antihypertensive treatment during the follow-up. During a median follow-up duration of 6.1 years, 4269 (44.9 per 1000 person-years) participants developed new-onset hypertension. Overall, there was a positive association between dietary manganese intake and new-onset hypertension. The adjusted HRs (95%CIs) of new-onset hypertension were 1.00 (reference), 0.97 (0.87, 1.08), 1.24 (1.10, 1.39) and 1.75 (1.52, 2.01) across the quartiles of dietary manganese intake, respectively. Accordingly, a significantly higher risk of new-onset hypertension (HR, 1.38; 95%CI: 1.27, 1.50) was found in participants in quartiles 3–4 of dietary manganese intake (≥6.0 mg/day), compared with those in quartiles 1–2 (<6.0 mg/day). In the general Chinese population, dietary manganese intake was positively associated with the risk of new hypertension, independent of sodium intake and other important covariates. • This is the first prospective study about the relationship of dietary Mn intake and hypertension. • Dietary Mn intake was positively associated with the risk of hypertension. • Maintaining an optimal Mn intake level could prevent hypertension. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Temperature-Controlled Screening of Catechol Groups in Poly(N‑Isopropylacrylamide-co-Dopamine Methacrylamide) for Cell Detachment.
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Yang, Liuxin, Ren, Pengfei, Wei, Dandan, Liang, Min, Xu, Li, Tao, Yinghua, Jiao, Guanhua, Zhang, Tianzhu, and Zhang, Qianli
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- 2024
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11. Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia
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Koeberl, Dwight, Schulze, Andreas, Sondheimer, Neal, Lipshutz, Gerald S., Geberhiwot, Tarekegn, Li, Lerong, Saini, Rajnish, Luo, Junxiang, Sikirica, Vanja, Jin, Ling, Liang, Min, Leuchars, Mary, and Grunewald, Stephanie
- Abstract
Propionic acidaemia is a rare disorder caused by defects in the propionyl-coenzyme A carboxylase α or β (PCCA or PCCB) subunits that leads to an accumulation of toxic metabolites and to recurrent, life-threatening metabolic decompensation events. Here we report interim analyses of a first-in-human, phase 1/2, open-label, dose-optimization study and an extension study evaluating the safety and efficacy of mRNA-3927, a dual mRNA therapy encoding PCCA and PCCB. As of 31 May 2023, 16 participants were enrolled across 5 dose cohorts. Twelve of the 16 participants completed the dose-optimization study and enrolled in the extension study. A total of 346 intravenous doses of mRNA-3927 were administered over a total of 15.69 person-years of treatment. No dose-limiting toxicities occurred. Treatment-emergent adverse events were reported in 15 out of the 16 (93.8%) participants. Preliminary analysis suggests an increase in the exposure to mRNA-3927 with dose escalation, and a 70% reduction in the risk of metabolic decompensation events among 8 participants who reported them in the 12-month pretreatment period.
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- 2024
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12. The low Mach number limit of non-isentropic magnetohydrodynamic equations with large temperature variations in bounded domains
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Liang, Min and Ou, Yaobin
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This paper verifies the low Mach number limit of the non-isentropic compressible magnetohydrodynamic (MHD) equations with or without the magnetic diffusion in a three-dimensional bounded domain when the temperature variation is large but finite. The uniform estimates of strong solutions are established in a short time interval independent of the Mach number, provided that the slip boundary condition for the velocity and the Neumann boundary condition for the temperature are imposed and the initial data is well-prepared.
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- 2024
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13. E-portfolios and the development of students’ reflective thinking at a Hong Kong University
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Sultana, Foujia, Lim, Cher Ping, and Liang, Min
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E-portfolios have been adopted by higher education institutions as assessment for learning tools to develop students’ reflective thinking and their ownership of learning. This paper examines how e-portfolios are integrated in an undergraduate course at a Hong Kong university to develop students’ reflective thinking. Based on the qualitative data collected and analysed from both the teacher and students in the course, this paper first discusses the different levels of reflective thinking that the students developed as they were working on their e-portfolios. It then identifies the factors that facilitate and hinder students’ development of reflective thinking, how the facilitating factors are enabled and what the hindering factors need to be addressed. These key findings highlight the pivotal role of the teacher as a learning facilitator and guide, the scaffolding role of the toolkit to support both teachers and students, and the necessity of the technical capacity building and support in the implementation of e-portfolios in higher education.
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- 2024
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14. Preparation and properties of a novel decorative base paper for formaldehyde-free adhesive impregnation
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Liang, Min, Gong, Jingya, Xu, Jianfeng, Liu, Ru, and Long, Ling
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Formaldehyde-free adhesives are gaining attention due to their compatibility with green production methods. Decorative base paper (DBP) is known for its physical strength and printability and has a high ability for absorbing aldehyde-free adhesives for impregnation. In this paper, DBP was prepared with TiO2and SiO2combined with polyvinyl alcohol (PVA), where the amount of TiO2was reduced in the pulp process. The prepared DBP was impregnated by aldehyde-free adhesive and hot-pressed on wood-based panels. The results showed that upon SiO2coating, the surface smoothness of base paper increased by 132.3 %, whereas the tensile strength increased by 33.6 %. Furthermore, the colour density of cyan, magenta, yellow and black colours increased by 75.4 %, 99.2 %, 51.9 % and 90.5 %, respectively. The surface properties like surface bonding strength and wear resistance of the covered wood-based panels were found to satisfy the standard requirements, which indicates the products can be used for furniture products.
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- 2023
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15. HFENet: Hybrid Feature Enhancement Network for Detecting Texts in Scenes and Traffic Panels
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Liang, Min, Zhu, Xiaobin, Zhou, Hongyang, Qin, Jingyan, and Yin, Xu-Cheng
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Text detection in complex scene images is a challenging task for intelligent transportation. Existing scene text detection methods often adopt multi-scale feature learning strategies to extract informative feature representations for covering objects of various sizes. However, the sampling operation inherent in multi-scale feature generation can easily impair high-frequency details (e.g., textures and boundaries), which are critical for text detection. In this work, we propose an innovative Hybrid Feature Enhancement Network (dubbed HFENet) to explicitly improve the quality of high-frequency information for detecting texts in scenes and traffic panels. To be concrete, we propose a simple yet effective self-guided feature enhancement module (SFEM) for globally lifting feature representations to highly discriminative and high-frequency abundant ones. Notably, our SFEM is pluggable and will be removed after training without introducing extra computational costs. In addition, due to the challenge and importance of accurately predicting boundaries for text detection, we propose a novel boundary enhancement module (BEM) to explicitly strengthen local feature representations in the guidance of boundary annotation for accurate localization. Extensive experiments on multiple publicly available datasets (i.e., MSRA-TD500, CTW1500, Total-Text, Traffic Guide Panel Dataset, Chinese Road Plate Dataset, and ASAYAR_TXT) verify the state-of-the-art performance of our method.
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- 2023
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16. Preparation of a Novel Formaldehyde-Free Impregnated Decorative Paper Containing MnO2 Nanoparticles for Highly Efficient Formaldehyde Removal.
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Liu, Ru, Liang, Min, Xu, Jianfeng, Sun, Yuhui, Long, Ling, Zhu, Liming, Lv, Bin, Yang, Bohan, and Ni, Yonghao
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- 2023
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17. Correlation between Polyphenol Contents and Antioxidant Activities in Different Echinacea PurpureaVarieties
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Lin, Xiao-jing, Lai, Zheng-shi-yu, Luo, Qun, Kong, Mei, Liang, Min-jian, Wu, Hong, and Bai, Mei
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Objective: Polyphenols are complex compounds containing multiple phenolic hydroxyl groups. They are widely distributed in plants and have antioxidant activities. Whether the antioxidant activities of the cultivated varieties of Echinaceaare similar to or better than those of the wild ones and the relationship between the accumulation of polyphenols and their antioxidant activities are still not clear. Methods: Folin-Ciocalteu method, high performance liquid chromatography (HPLC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric ion reducing antioxidant power (FRAP) assay, 2,2′-azino-bis(3-ethylbenzothiazoline-6)-sulfonic acid (ABTS) radical scavenging assay, and Fe
2+ chelating ability assay were used, respectively, to detect the total polyphenols and 5 kinds of caffeic acid derivatives (chicoric acid, caffeic acid, caftaric acid, chlorogenic acid, and 1,5-dicaffeoylquinic acid) in the roots, stems, leaves, and flowers, and the antioxidant activities of 3 varieties of Echinacea: E. purpureaL., cultivar E. purpurea‘Aloha’, and E. purpurea‘White Swan’. Results: E. purpureaL. had the highest contents of total polyphenols, 5 caffeic acid derivatives and antioxidant activities, followed by E. purpurea‘White Swan’ and E. purpurea‘Aloha’, respectively. E. purpurea‘White Swan’ had the strongest ability to remove the DPPH, ABTS•+ and free radicals, and to chelate Fe2+ ; E. purpureaL. had the strongest ability to reduce FRAP. The correlation analyses revealed that the contents of total polyphenols and caffeic acid derivatives of E. purpureaL. and E. purpurea‘White Swan’ were correlated with their antioxidant activities. Conclusion: E. purpureaL. was the most appropriate material for the development of medicinal plants. E. purpurea‘White Swan’ could be used as a substitute for E. purpureaL. in terms of its antioxidant activity.- Published
- 2023
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18. Mitochondria-associated ER stress evokes immunogenic cell death through the ROS-PERK-eIF2α pathway under PTT/CDT combined therapy.
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Feng, Xiaoli, Lin, Tian, Chen, Dong, Li, Zhiyang, Yang, Qiuping, Tian, Huiting, Xiao, Yao, Lin, Mingzhen, Liang, Min, Guo, Weihong, Zhao, Peng, and Guo, Zhaoze
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CELL death ,CYTOTOXIC T cells ,ENDOPLASMIC reticulum ,COPPER ,REACTIVE oxygen species ,HYDROXYL group - Abstract
Chemodynamic therapy (CDT) can effectively induce immunogenic cell death (ICD) in tumours and is thus a promising strategy for boosting the efficacy of immunotherapy. However, the mechanism by which CDT enhances ICD and lowers ICD efficiency is unknown and this restricts its clinical application. In this study, a second near-infrared (NIR-II) window irradiation-triggered hydrogen peroxide (H 2 O 2) self-supplying nanocomposite ((Cu 2 Se-CaO 2)@LA) was constructed. The modified lauric acid was melted by the heat energy of the NIR-II irradiation, to expose the CaO 2 nanoparticles, and they then reacted with water to produce H 2 O 2 and Ca
2+ . H 2 O 2 was then converted to hydroxyl radicals by the photothermal-enhanced CDT process of the Cu 2 Se nanocubes. Notably, the CDT and Ca2+ overload was found to induce sequential damage to the mitochondria and endoplasmic reticulum (ER), which upregulated the PERK-mediated eIF2α phosphorylation pathway and caused subsequent ICD. NIR-II irradiation of the (Cu 2 Se-CaO 2)@LA also increased reactive oxygen species (ROS) formation and this was sufficient to increase dendritic cell maturation, attracting cytotoxic T lymphocytes, and suppressing tumour growth in vivo. Overall, we demonstrated that an enhanced CDT strategy under NIR-II exposure and H 2 O 2 self-supply can induce extensive ICD by inducing mitochondria-associated ER stress, which represents a highly effective and promising strategy for ICD amplification and tumour immunotherapy. In this study, a second near-infrared window (NIR-II) irradiation-triggered and H 2 O 2 self-supplying nanocomposite (named (Cu 2 Se-CaO 2)@LA) was constructed and tested both in vitro and in vivo. These nanoparticles demonstrated promising antitumor activity as designed. Mechanistically, the nanoparticles could damage mitochondria and upregulate the PERK-mediated eIF2αphosphorylation pathway, further causing endoplasmic reticulum stress, and inducing immunogenic cell death through dendritic cell maturation and cytotoxic T lymphocyte recruitment augmented activity. This system represents a highly effective and promising strategy for enhancing tumor immunotherapy and provides new insights for future studies and design refinements. [Display omitted] [ABSTRACT FROM AUTHOR]- Published
- 2023
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19. Stellate Ganglion Block Improves Postoperative Sleep Quality and Analgesia in Patients with Breast Cancer: A Randomized Controlled Trial.
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Yang, Rui-zhi, Li, Yan-zhen, Liang, Min, Yu, Jian-jun, Chen, Ming-li, Qiu, Jin-jia, Lin, Shi-zhu, Wu, Xiao-dan, and Zeng, Kai
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- 2023
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20. LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway
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Lu, Jun, Fu, Liang-min, Cao, Yun, Fang, Yong, Cao, Jia-zheng, Pan, Yi-hui, Cen, Jun-jie, Liang, Yan-ping, Chen, Zhen-hua, Wei, Jin-huan, Huang, Yong, Mumin, Mukhtar Adan, Xu, Quan-hui, Wang, Ying-han, Zhu, Jiang-quan, Liang, Hui, Wang, Zhu, Deng, Qiong, Chen, Wei, Jin, Xiao-han, Liu, Zhi-ping, and Luo, Jun-hang
- Abstract
LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney cancer. However, its role in kidney tumorigenesis remains unknown. Here we hypothesized a tumor suppressive function of LZTFL1 in clear cell renal cell carcinoma (ccRCC) and its mechanism of action based on extensive bioinformatics analysis of patients’ tumor data and validated it using both gain- and loss-functional studies in kidney tumor cell lines and patient-derive xenograft (PDX) model systems. Our studies indicated that LZTFL1 inhibits kidney tumor cell proliferation by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway and inducing cell cycle arrest at G1. Clinically, we found that LZTFL1 is frequently deleted in ccRCC. Downregulation of LZTFL1 is associated with a poor ccRCC outcome and may be used as prognostic maker. Furthermore, we show that overexpression of LZTFL1 in PDX via lentiviral delivery suppressed PDX growth, suggesting that re-expression of LZTFL1 may be a therapeutic strategy against ccRCC.
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- 2023
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21. Effects of qufeng xuanfei formula in guinea pig model of airway hyperergy.
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Kun Ji, Jian-Ling Ma, Li-Qing Shi, Liang-Min Wang, Niu-Niu Li, Shang-Juan Dong, Bin Lin, Li-Yun Wang, and Shao-Hui Wen
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This work aimed to clarify the potential regulating effects of Qufeng Xuanfei formula (QFXF) on airway neurogenic inflammation and its underlying target signal pathway. Guinea pig model of airway hyperergy (AHR) was used. The relative susceptibility of major proteins to airway neurogenic inflammation was assessed using Western blot immunoassay followed by being separated by SDS-PAGE. Compared to the model group, QFXF of all concentrations effectively depressed the capsaicin enhanced cough in guinea pigs and the peak values of airway resistance significantly decreased. The results illustrated that QFXF alleviated cough symptom in guinea pigs and reduced airway neurogenic inflammation when compared to AHR model group. Airway inflammation and damage, as well as the levels of NGF, SP and c-Fos in QFXF decreased the most in the high-dose group. The mechanism of antitussive activity may be associated with reducing airway inflammation. QFXF displayed effect on chronic cough through reducing the levels of neuropeptides, attenuating airway inflammation and promoting recovery from disease to decrease the airway neuro sensitivity, suggesting that the potential mechanism may be related to Ras/ERK/c-Fos pathway. [ABSTRACT FROM AUTHOR]
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- 2023
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22. P–P Orbital Interaction Enables Single-Crystalline Semimetallic β‑MoTe2 Nanosheets as Efficient Electrocatalysts for Lithium–Sulfur Batteries.
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Lin, Guide, Liang, Min, Liu, Liying, Liu, Jun, Ao, Zhimin, Shi, Zhicong, and Ke, Xi
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- 2022
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23. Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia
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Attarwala, Husain, Lumley, Matthew, Liang, Min, Ivaturi, Vijay, and Senn, Joe
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Propionic acidemia (PA) is an ultrarare disorder caused by deficiency of the mitochondrial enzyme, propionyl-CoA carboxylase (PCC), composed of PCCA and PCCB subunits. An enzyme replacement therapy is being developed using dual messenger RNA (mRNA) therapy composed of lipid nanoparticles (LNPs) encapsulating mRNAs encoding PCCA and PCCB subunits of the PCC enzyme. We herein report on development of a translational semimechanistic pharmacokinetic (PK) and PK/pharmacodynamic (PD) model to quantify the relationship between the mRNA components of mRNA-3927 (an LNP encapsulating PCCA and PCCB mRNAs) and dose levels; PCCA/B mRNA PK and PD responses were assessed as circulating levels of primary disease markers 2-methyl citrate, 3-hydroxypropionate, and propionyl carnitine normalized to acetyl carnitine (C3/C2 ratio) to inform the first-in-human dose range and regimen selection. The translational PK/PD model was developed using preclinical data available in mice with PA, Sprague Dawley rats, and cynomolgus monkeys at dose levels ranging from 0.2 to 9 mg/kg. PCCA/B mRNA PK in mice, rats, and monkeys was adequately described using allometric scaling of volume and clearance parameters. The interspecies preclinical model was scaled allometrically to humans to predict the dose–response relationship in adult and pediatric patients with PA to guide selection of dose range and regimen for the Phase 1 clinical trial (ClinicalTrials.govIdentifier NCT04159103).
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- 2023
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24. Stellate Ganglion Block Improves Postoperative Sleep Quality and Analgesia in Patients with Breast Cancer: A Randomized Controlled Trial
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Yang, Rui-zhi, Li, Yan-zhen, Liang, Min, Yu, Jian-jun, Chen, Ming-li, Qiu, Jin-jia, Lin, Shi-zhu, Wu, Xiao-dan, and Zeng, Kai
- Abstract
Introduction: Postoperative impaired sleep quality and pain are associated with adverse outcomes. Stellate ganglion block (SGB) has shown promising results in enhancing sleep quality and alleviating neuropathic pain. This study aimed to investigate the effects of ultrasound-guided SGB on postoperative sleep quality and pain in patients undergoing breast cancer surgery. Methods: This study is a parallel-group randomized controlled clinical trial with two groups: SGB and control. Fifty female patients undergoing breast cancer surgery were randomized in a 1:1 ratio to receive preoperative ultrasound-guided single-injection SGB (SGB group) or just an ultrasound scan (control group). All participants were blinded to the group assignment. The primary outcome was postoperative sleep quality, assessed by the St. Mary’s Hospital Sleep Questionnaire and actigraphy 2 days postoperatively. The secondary outcome was postoperative pain, measured by the visual analog scale. Results: A total of 48 patients completed the study, with 23 patients in the control group and 25 in the SGB group. The postoperative St. Mary’s Hospital Sleep Questionnaire scores were significantly higher in the SGB group than in the control group on 1 day postoperative (30.88 ± 2.44 versus 27.35 ± 4.12 points, P= 0.001). The SGB also increased the total sleep time and sleep efficiency (main actigraphy indicators) during the first two postoperative nights. Compared with the control group, preoperative SGB reduced postoperative pain and the incidence of breast cancer-related lymphedema (20% versus 52.2%, P= 0.02, odds ratio 0.229, 95% confidence interval 0.064–0.821). There were no adverse events related to SGB. Conclusion: Preoperative ultrasound-guided SGB improves postoperative sleep quality and analgesia in patients undergoing breast cancer surgery. SGB may be a safe and practical treatment to enhance the postoperative quality of life in patients with breast cancer. Trial Registration: The study was registered in the Chinese Clinical Trial Registry (ChiCTR2100046620, principal investigator: Kai Zeng, date of registration: 23 May 2021).
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- 2023
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25. Superior rate performance and structural evolution of O3-type layered NaCrO2for sodium ion batteries at high temperatures
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Meng, Xiangcong, Liang, Jinji, Liang, Min, Li, Wenya, Lin, Chenhan, Ke, Xi, Shi, Zhicong, and Liu, Liying
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In order to meet the practical application of sodium ion batteries (SIBs), a low energy consumption method is recommended to synthesize the layered NaCrO2cathode materials. Enabled by the larger Na+diffusion coefficients promoted by a proper high temperature, the as-synthesized O3-type NaCrO2material shows superior rate performance even at elevated temperatures, exhibiting 47.4 mA h g−1at 100 C and 60°C. Opposite to the good cyclic capability at room temperature, however, the high-temperature cyclability of NaCrO2deteriorates due to the complex irreversible structural evolution in NaCrO2during cycling at elevated temperatures. This work boosts the industrial development of layered oxide cathode materials for SIBs with outstanding high-rate performance especially at high temperatures, and in the meantime deepens the understanding of the high-temperature capacity decay mechanism for layered oxide cathode materials.
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- 2023
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26. Temperature-Controlled Thiation of α‑Cyano-β-Alkynyl Carbonyl Derivatives for De Novo Synthesis of 2‑Aminothiophenes and Thieno[2,3‑c]isothiazoles.
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Kao, Tzu-Ting, Peng, Po-Kai, Liang, Min-Chieh, Lee, Chia-Jui, Chen, I-Chia, Shia, Kak-Shan, and Wu, Yen-Ku
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- 2022
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27. Prolonged resident nanoparticles effectively treat acute lung injury via the selective upregulation of intracellular hydrogen peroxide.
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Wang, Beiduo, Xu, Yanping, Yao, Qigu, Song, Liang, Liang, Min, Cao, Hongcui, and Gao, Changyou
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LUNGS ,HYDROGEN peroxide ,LUNG injuries ,NANOPARTICLES ,REACTIVE oxygen species ,CYTOKINE release syndrome ,EPITHELIAL cells - Abstract
Selective modulation of the types of reactive oxygen species (ROS) for the treatment of acute lung injury (ALI) has not been tackled, whereas the usually applied hydrophobic nanoparticles (NPs) are easily excreted and metabolized. Herein, a zwitterionic-segment containing polyurethane was synthesized to formulate into Pazopanib (Pazo)-loaded NPs (PUSB@Pazo NPs), which had the ability to selectively enhance the expression of H 2 O 2 but suppress other types of ROS, and achieved long retention in lung and thereby improved treatment efficacy. The zwitterionic group of PUSB effectively decreased the clearance rate of PUSB@Pazo NPs in vivo , and prolonged their resident time in lung post inhalation up to 48 h. The increase of local H 2 O 2 concentration decreased the permeability of lung epithelial cells, accompanied by the significantly reduced tissue edema and inflammatory cell recruitment. The system also reduced the expression of various inflammatory factors, revealing its effective and promising treatment for ALI. [Display omitted] • Zwitterionic ROS-responsive polyurethane (PUSB) was synthesized. • PUSB@Pazo NPs had longer residence in alveoli and selectively enhanced H 2 O 2 secretion. • Cytokine storm in ALI was suppressed with downregulated inflammatory factors. • New insights for delivery of therapeutic aerosols with significance in ALI therapy. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Cuprous oxide nanocomposites with photothermal (PTT) and chemical dynamics (CDT) effects induce cuproptosis in breast cancer using the strategy of increasing inflow and reducing outflow.
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Li, Wei, Xiao, Yao, Guo, Guohu, Peng, Jiaxin, Zhu, Nan, Chen, Zekai, Peng, Bin, Jiang, Zhaojun, Li, Ben, Yu, Guifang, Guo, Zhaoze, Liang, Min, and Guo, Weihong
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CUPROUS oxide ,BREAST ,BREAST cancer ,APOPTOSIS ,COPPER ,REACTIVE oxygen species ,CANCER cells ,CELL death - Abstract
Chemotherapy is a crucial adjuvant method of treating breast cancer, but it fails to achieve preferable prognosis as the malignant cells eventually develop drug-resistance. Reduced chemotherapeutic sensitivity is primarily caused by endogenous and exogenous resistance during the treatment. Cuproptosis is a newly discovered immunogenic cell death (ICD), characterized by accumulation of copper (Cu) ions inside tumor cells. However, intracellular Cu ion concentrations can hardly reach desired levels to induce cuproptosis due to limited import via existing Cu ionophores and synchronous export via ATP-Cu pump. Herein, our research developed an elesclomol (ES) loaded cuprous oxide (Cu 2 O) nanocomposite, called PEG@Cu 2 O-ES, to solve this dilemma. Our designed PEG@Cu 2 O-ES could efficiently enter the breast cancer cells, release encapsulated ES and Cu 2 O, while the photothermal (PTT) effect of Cu 2 O induced by near-infrared II region (NIR-II) radiation could in turn accelerate the releasing process. Cu 2 O discharged substantial amounts of Cu in cytoplasm, which directly engaged in the tricarboxylic acid (TCA) cycle in mitochondria, resulting in cuproptosis to some extent. As a result of PTT-enhanced Fenton-like reactions, Cu 2 O generated a substantial quantity of reactive oxygen species (ROS) that attacked the ATP-Cu pump on cancer cells' membranes, thereby reducing the outflow of Cu ions and aggravating cuproptosis. Additionally, free ES further promoted Cu from the tumor microenvironment (TME) to enter breast cancer cells, and exacerbated cuproptosis with higher efficiency. In vivo , PEG@Cu 2 O-ES nanocomposites showed strong anti-tumor effect by inducing cuproptosis, as well as the ability to reprogram the TME and increase the response-sensitivity to programmed cell death protein-1 antibody (αPD-1). In conclusion, this study provides a promising strategy by combining a nano-drug with αPD-1 for sensitizing immunotherapy of chemotherapy-resistant breast cancer. [Display omitted] • PEG@Cu 2 O-ES discharged substantial amounts of Cu in cytoplasm, which directly engaged in TCA cycle in mitochondria to induce cuproptosis. • PEG@Cu 2 O-ES with PTT and CDT effects could generate ROS to attack ATP-Cu pump, thereby reducing the outflow of Cu ions and aggravating cuproptosis. • Released ES from PEG@Cu 2 O-ES further promoted Cu from TME to enter breast cancer cells, and exacerbated cuproptosis with higher efficiency. • PEG@Cu 2 O-ES showed strong anti-tumor effect by inducing cuproptosis, reprogramming TME and thus increasing the response-sensitivity to αPD-1. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Scene text detection via decoupled feature pyramid networks
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Liang, Min, Hou, Jie-Bo, Zhu, Xiaobin, Yang, Chun, and Qin, Jingyan
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Detecting arbitrary shape scene texts is challenging mainly due to the varied aspect ratios, curves, and scales. In this paper, we propose a novel arbitrary shape scene text detection method via Decoupled Feature Pyramid Networks (DFPN) and regression-based linking (RegLink). Our innovative DFPN decouples the width and height of feature maps generated by FPN to enhance the discriminability of features for varied aspect ratios. As quadrilateral regression results cannot directly represent curve text, we propose a simple yet effective RegLink to link pixels into text instances because pixels in the same curve text have an identical target quadrilateral. Thus, our RegLink can extend the ability of the rotated rectangles text detector for detecting curve text. Besides, we propose a Feature Scale Module to enhance the robustness of features for varied scales. In this way, our method can effectively detect scene texts in arbitrary shapes. Meanwhile, experimental results on three publicly available challenging datasets demonstrate the effectiveness of our method. The code and model of our method is available at https://github.com/lmplayer/DFPN-master.
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- 2022
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30. U-shaped association between dietary copper intake and new-onset hypertension.
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He, Panpan, Li, Huan, Liu, Chengzhang, Liu, Mengyi, Zhang, Zhuxian, Zhang, Yuanyuan, Zhou, Chun, Li, Qinqin, Ye, Ziliang, Wu, Qimeng, Jiang, Jianping, Wang, Guobao, Liang, Min, Nie, Jing, Hou, Fan Fan, and Qin, Xianhui
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To investigate the relationship of dietary copper intake with new-onset hypertension among Chinese adults. A total of 12,245 participants who were free of hypertension at baseline from the China Health and Nutrition Survey (CHNS) were included. Dietary intake was measured by 3 consecutive 24-h dietary recalls combined with a household food inventory. New-onset hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up. During a median follow-up of 6.1 years, 4304 participants developed new-onset hypertension. Overall, the associations between dietary copper intake and new-onset hypertension followed a U-shape (P for nonlinearity <0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary copper intake (per SD increment: HR, 0.71; 95% CI, 0.57–0.88) in participants with copper intake <1.57 mg/day, and increased with the increment of dietary copper intake (per SD increment: HR, 1.09; 95% CI: 1.07–1.12) in participants with copper intake ≥1.57 mg/day. There was a U-shaped association between dietary copper intake and new-onset hypertension in general Chinese adults, with an inflection point at about 1.57 mg/day. Our results emphasized the importance of maintaining optimal copper intake levels for the primary prevention of hypertension. [ABSTRACT FROM AUTHOR]
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- 2022
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31. Low ankle–brachial index is associated with higher cardiovascular mortality in individuals with nonalcoholic fatty liver disease
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Xiong, Guang, Guo, Liuqing, Li, Liwei, and Liang, Min
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Background and aims: Ankle brachial index (ABI) is a risk factor for cardiovascular mortality, but it is unclear whether ABI is associated with cardiovascular mortality in patients with nonalcoholic fatty liver disease (NAFLD). The current study aimed to evaluate the association between ABI with cardiovascular and all-cause mortality in patients with NAFLD. Methods: We performed a cohort study using the data of the1999–2004 National Health and Nutrition Examination Survey data of adults. Mortality data were followed up to December 2015. NAFLD was defined by the hepatic steatosis index or the US fatty liver index. ABI was classified into three groups: ABI ≤ 0.9 (low value); 0.9 < ABI ≤ 1.1 (borderline value); ABI greater than 1.1 (normal value). Results: We found that low ABI was associated with an increased risk of cardiovascular mortality in patients with NAFLD (HR: 2.42, 95% CI 1.10–5.33 for low value ABI vs normal value ABI, P for trend = 0.04), and the relationship was linearly and negatively correlated in the range of ABI < 1.4. However, low ABI was not associated with all-cause mortality in patients with NAFLD. Stratified by cardiovascular disease, ABI remains inversely correlated with cardiovascular mortality in NAFLD patients without cardiovascular disease. Stratified by diabetes, ABI is inversely correlated with cardiovascular mortality in NAFLD patients regardless of diabetes status. Conclusions: Low ABI is independently associated with higher cardiovascular mortality in NAFLD cases. This correlation remains significant even in the absence of pre-existing cardiovascular disease or diabetes.
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- 2024
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32. Prevalence and Mortality due to COVID-19 in HIV Co-Infected Population: A Systematic Review and Meta-Analysis.
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Liang, Min, Luo, Ning, Chen, Mafeng, Chen, Chunna, Singh, Shivank, Singh, Shantanu, and Tan, Shifan
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- 2021
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33. Genomes of Meniocus linifoliusand Tetracme quadricornisreveal the ancestral karyotype and genomic features of core Brassicaceae
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Liu, Jie, Zhou, Shi-Zhao, Liu, Yun-Long, Zhao, Bin-Yan, Yu, Dongmei, Zhong, Mi-Cai, Jiang, Xiao-Dong, Cui, Wei-Hua, Zhao, Jiu-Xia, Qiu, Juan, Liu, Liang-Min, Guo, Zhen-Hua, Li, Hong-Tao, Tan, Dun-Yan, Hu, Jin-Yong, and Li, De-Zhu
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Brassicaceae represents an important plant family from both a scientific and economic perspective. However, genomic features related to the early diversification of this family have not been fully characterized, especially upon the uplift of the Tibetan Plateau, which was followed by increasing aridity in the Asian interior, intensifying monsoons in Eastern Asia, and significantly fluctuating daily temperatures. Here, we reveal the genomic architecture that accompanied early Brassicaceae diversification by analyzing two high-quality chromosome-level genomes for Meniocus linifolius(Arabodae; clade D) and Tetracme quadricornis(Hesperodae; clade E), together with genomes representing all major Brassicaceae clades and the basal Aethionemeae. We reconstructed an ancestral core Brassicaceae karyotype (CBK) containing 9 pseudochromosomes with 65 conserved syntenic genomic blocks and identified 9702 conserved genes in Brassicaceae. We detected pervasive conflicting phylogenomic signals accompanied by widespread ancient hybridization events, which correlate well with the early divergence of core Brassicaceae. We identified a successive Brassicaceae-specific expansion of the class I TREHALOSE-6-PHOSPHATE SYNTHASE 1(TPS1) gene family, which encodes enzymes with essential regulatory roles in flowering time and embryo development. The TPS1s were mainly randomly amplified, followed by expression divergence. Our results provide fresh insights into historical genomic features coupled with Brassicaceae evolution and offer a potential model for broad-scale studies of adaptive radiation under an ever-changing environment.
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- 2024
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34. Highly stable Brillouin laser with controllable tuning based on fiber ring resonator
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Liang, Min, Liu, Wenyao, Pan, Ziwen, Wang, Rong, Xing, Enbo, Zhou, Yanru, Tang, Jun, and Liu, Jun
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The design and fabrication processes of the stimulated Brillouin laser (SBL) are complex, and it is affected by many factors such as temperature and resonance shift. In this study, we have fabricated a Brillouin laser using a fiber ring resonator with Qfactor = 7.1 × 108and resonance depth (h) = 96%. The free spectral range automatic feedback control technology is proposed to realize the accurate matching of the resonant mode and the Stokes mode. The influence of temperature on the SBL frequency shift is suppressed. The fluctuation range of SBL’s frequency decreases by 5 times. The maximum steady state output of the SBL at the best matching position is realized, and the output power fluctuation range decreases by 15 times. The power stability of the SBL reaches 4.85 × 10−6, which is improved by two orders of magnitude. This simple scheme provides convenience for the application of the SBL, such as sensing and other applications.
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- 2024
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35. Association of visceral adiposity index with new-onset type 2 diabetes and impaired fasting glucose in hypertensive Chinese adults
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Zhou, Chun, Zhang, Zhuxian, Liu, Mengyi, Zhang, Yuanyuan, He, Panpan, Li, Qinqin, Xie, Di, Liang, Min, Wang, Guobao, Nie, Jing, Liu, Chengzhang, Song, Yun, Liu, Lishun, Wang, Binyan, Wang, Xiaobin, Xu, Xiping, and Qin, Xianhui
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Purpose: Visceral adiposity index (VAI) is a reliable indicator for the distribution and function of adipose tissue in the body. The relation of VAI with new-onset type 2 diabetes and new-onset impaired fasting glucose (IFG) remains uncertain. We aimed to investigate the prospective relation of VAI with new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive adults. Methods: A total of 14,838 hypertensive adults free of type 2 diabetes at baseline were included from the China Stroke Primary Prevention Trial. The primary outcome was new-onset type 2 diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose ≥ 7.0 mmol/L at the exit visit. The secondary outcome was new-onset IFG, defined as fasting glucose < 6.1 mmol/L at baseline, while fasting glucose ≥ 6.1 mmol/L and < 7.0 mmol/L at the exit visit. Results: Over a median of 4.5 years’ follow-up, 1612 (10.9%) participants developed type 2 diabetes. When VAI was categorized into quartiles, compared with participants in quartile 1–3 (< 2.80), significantly higher risk of new-onset type 2 diabetes (OR 1.30; 95% CI 1.08–1.56) and new-onset IFG (OR 1.28; 95% CI 1.08–1.52) was found in those in quartile 4 (≥ 2.80). Moreover, the positive associations were consistent in participants with or without single abnormal VAI components, including general obesity, abdominal obesity, elevated triglycerides and low high-density lipoprotein cholesterol (HDL-C) levels; or with different numbers of abnormal VAI components (all P interactions > 0.05). Conclusion: Our study suggested a positive relation of VAI with the risk of new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive patients, independent of its components. Level of evidence: Level III, a well-designed cohort.
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- 2022
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36. Self-Perceived Psychological Stress and Risk of First Stroke in Treated Hypertensive Patients
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Li, Huan, He, Panpan, Zhang, Yuanyuan, Lin, Tengfei, Liu, Chengzhang, Xie, Di, Liang, Min, Wang, Guobao, Nie, Jing, Song, Yun, Liu, Lishun, Wang, Binyan, Zhang, Yan, Li, Jianping, Huo, Yong, Wang, Xiaobin, Hou, Fan Fan, Xu, Xiping, and Qin, Xianhui
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- 2022
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37. Relationship of several serum folate forms with the risk of mortality: A prospective cohort study.
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Liu, Mengyi, Zhang, Zhuxian, Zhou, Chun, Li, Qinqin, He, Panpan, Zhang, Yuanyuan, Li, Huan, Liu, Chengzhang, Liang, Min, Wang, Xiaobin, Xu, Xiping, Hou, Fan Fan, and Qin, Xianhui
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We aim to examine the relation of several folate forms (5-methyltetrahydrofolate [5-mTHF], unmetabolized folic acid [UMFA], non-methyl folate, and MeFox [pyrazino-s-triazine derivative of 4α-hydroxy-5-methyltetrahydrofolate]) with the risk of mortality. Using data from National Health and Nutrition Examination Survey 2011–2014, a total of 10,661 people with folate forms data were recruited. Death information was obtained from the National Death Index until 2015. Cox proportional hazards regression models were developed to evaluate the relationship between folate forms and mortality. During 2.99 years of follow-up, 344 (2.6%) deaths occurred. Overall, significantly higher risks of all-cause mortality were found in participants with higher level of serum 5-mTHF (≥51.3 nmol/L [quartile 4] vs. 23.9–51.3 nmol/L [quartile 2–3]; HR, 1.61; 95% CI: 1.03–2.53), UMFA (≥1.1 nmol/L [quartile 4] vs. <1.1 nmol/L [quartile 1–3]; HR, 1.55; 95% CI: 1.15–2.09), non-methyl folate (≥1.7 nmol/L [quartile 4] vs. 1.2–1.7 nmol/L [quartile 3]; HR, 1.62; 95% CI: 1.06–2.48), or MeFox (≥2.5 nmol/L [quartile 4] vs. <2.5 nmol/L [quartile 1–3]; HR, 1.54; 95% CI: 1.11–2.12). In addition, there was an increased risk of all-cause mortality for those with low level of serum 5-mTHF (<23.9 nmol/L [quartile 1] vs. 23.9–51.3 nmol/L [quartile 2–3]; HR, 1.66; 95% CI: 1.12–2.47). Most importantly, none of any folate forms significantly modified the association between other folate forms and mortality (all P for interactions >0.05). Higher levels of serum folate forms (5-mTHF, UMFA, non-methyl folate, and MeFox) were associated with higher risk of mortality while 5-mTHF insufficiency also showed a negative impact on mortality. Our findings emphasized the importance of monitoring the folate forms concentrations and may help counsel future related clinical trials. [ABSTRACT FROM AUTHOR]
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- 2021
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38. Microstructure and mechanical properties of AZ31 alloy prepared by cyclic expansion extrusion with asymmetrical extrusion cavity
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LIANG, Min-jie, ZHENG, Jie, LIU, Huan, and YAO, Bao-xing
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The microstructure, texture evolution and mechanical properties of AZ31 magnesium alloy were investigated during the cyclic expansion extrusion with the asymmetrical extrusion cavity (CEE-AEC) process. The results show that continuous dynamic recrystallization (CDRX) and discontinuous dynamic recrystallization (DDRX) occur during the CEE-AEC process. After 3 passes, the microstructures of the deformed samples are refined, and the average grain size of the alloys in asymmetrical cavity region is 6.9 μm. The maximum intensities of the basal textures increase with the increase in the number of passes, and the basal textures are deflected during the deformation process. The basal texture of the alloys in asymmetrical cavity region is tilted by approximately ±45° from the normal direction (ND) to the extrusion direction (ED). Grain refinement strengthening and texture deflection significantly improve the comprehensive mechanical properties of the deformed alloys. After 3 passes, tensile yield strength (TYS), ultimate tensile strength (UTS) and elongation-to-failure of the alloy in the asymmetric cavity region are 146 MPa, 230 MPa and 29.7%, respectively.
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- 2022
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39. Hydrogel adhesive formed viamultiple chemical interactions: from persistent wet adhesion to rapid hemostasisElectronic supplementary information (ESI) available: SEM images; schematic structure; FTIR spectra; UV-vis spectra; thermogravimetric analyses; rheological analyses; tensile test results; shear adhesion strength and interfacial toughness of the hydrogel matrixes; preparation photographs; interfacial toughness of the hydrogel adhesive; relative cell viability results; fluorescence images of live/dead cells; burst pressure results; comparison of adhesion properties for the existing hydrogel adhesives. See DOI: 10.1039/d1bm01848e
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Liang, Min, Wei, Dandan, Yao, Zhangyu, Ren, Pengfei, Dai, Jidong, Xu, Li, Zhang, Tianzhu, and Zhang, Qianli
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To date, the robust and durable adhesion capability of hydrogel adhesives in wet environments remains a huge challenge. Herein, a physicochemically double-network crosslinked hydrogel matrix was prepared by mixing acrylic acid (AAc), chitosan (CS) and tannic acid (TA) as the main components and the subsequent in situpolymerization of AAc. The abundant reactive sites on the surface of the hydrogel matrix facilitate rapid, strong and repeatable adhesion to different surfaces of engineering solids and biological tissues in an aquatic environment. The formation of amide covalent bonds resulting from the addition of the bridging agent further expands the long-term application of the hydrogel in tissue repair, and the constructed hydrogel-tissue adhesive interface still has robust adhesion energy after soaking in a physiological environment for up to one month. Moreover, the hydrogel showed fantastic hemostatic performance due to its characteristics of platelet adhesion and high burst pressure. Overall, the persistent adhesion and excellent cytocompatibility of the hydrogel adhesive make it potentially applicable in medical adhesives.
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- 2022
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40. Blocking CD47 with restructured peptide nanoparticles for motivating phagocytosis to inhibit tumor progressionElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2bm00189f
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Xia, Yiyi, Wang, Tiantian, Wu, Linjie, Zhong, Haiqing, Zhou, Yi, Ke, Peng, Bao, Xiaoyan, Dai, Qi, Yang, Qiyao, Lu, Yiying, Xu, Donghang, Liang, Min, and Han, Min
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Phagocytosis checkpoints, especially targeting CD47, have shown encouraging therapeutic effects. However, there are currently many shortcomings and challenges with immune checkpoint blockades (ICBs). Inspired by the phenomenon of molecular self-assembly, we modify the CD47 targeting peptide (4N1K) onto the self-assembled peptide FY4, as well as the concatenation of PEG at the other terminal viathe AZO group to construct hypoxia-responsive nanoparticles (PEG-AZO-FY4-4N1K, PAP NPs), utilizing the peptide as a part of the anti-tumor therapy machine. After degradation, PAP NPs can self-assemble to form fibrous networks and anchor CD47 on the surface of tumor cells, promoting their recognition and phagocytosis by macrophages and relieving immune escape. Self-assembled peptides can interweave on the surface of tumor cells, fully exploiting their morphological advantages to impede normal cell interaction and metastasis. The PAP NPs work synergistically with Doxorubicin (DOX) to further maximize the efficacy of chemoimmunotherapy. In conclusion, this strategy pioneers the progress of self-assembled peptides in biomedicine and promises a novel breakthrough in the development of checkpoint inhibitor therapies.
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- 2022
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41. Modulation method of air-gap permeance with sinusoidal regularity change for time-grating angular displacement sensor
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Xia, Haojie, Yang, Lian X., Yu, Liandong, Liang, Min, Wang, Yangyang, Zhang, Tianheng, and Peng, Donglin
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- 2021
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42. Interaction of serum calcium and folic acid treatment on first stroke in hypertensive males.
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Wu, Hongxu, Zhang, Yuanyuan, Li, Huan, Li, Jianping, Zhang, Yan, Liang, Min, Nie, Jing, Wang, Binyan, Wang, Xiaobin, Huo, Yong, Hou, Fan Fan, Xu, Xiping, and Qin, Xianhui
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The role of serum calcium on the risk of stroke is still uncertain. We aimed to evaluate the effect of serum calcium on first stroke risk, and on the efficacy of folic acid treatment in prevention of first stroke among hypertensive patients. Our analyses included a total of 19,644 eligible hypertensive adults from the China Stroke Primary Prevention Trial (CSPPT). In the CSPPT, a total of 20,702 hypertensive patients were randomly assigned to a double-blind, daily treatment with either 10 mg enalapril and 0.8 mg folic acid or 10 mg enalapril alone. The primary outcome was a first stroke. Over a median of 4.5 years, among those not receiving folic acid, a significantly higher risk of first stroke was found in hypertensive males with baseline albumin-corrected serum calcium ≥2.43 mmol/L (median) (vs. <2.43 mmol/L; 6.5% vs. 2.3%; adjusted HR, 2.47; 95% CI: 1.72, 3.55). For those with enalapril and folic acid treatment, compared with the enalapril only group, the risk of first stroke was reduced from 6.5% to 3.0% (adjusted HR, 0.49; 95% CI: 0.35, 0.68) in hypertensive males with baseline albumin-corrected serum calcium ≥2.43 mmol/L, whereas there was no significant effect among hypertensive males with baseline albumin-corrected serum calcium <2.43 mmol/L. However, among hypertensive females, serum calcium did not significantly affect the first stroke risk and the efficacy of folic acid in prevention of first stroke. Among Chinese hypertensive males, those with elevated serum calcium levels had increased risk of first stroke, and this risk was reduced by 51% with folic acid treatment. [ABSTRACT FROM AUTHOR]
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- 2021
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43. Relationship of visceral adiposity index with new-onset proteinuria in hypertensive patients.
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Liu, Mengyi, Zhou, Chun, Zhang, Zhuxian, He, Panpan, Zhang, Yuanyuan, Xie, Di, Nie, Jing, Liang, Min, Song, Yun, Liu, Chengzhang, Liu, Lishun, Huo, Yong, Wang, Binyan, Wang, Xiaobin, Xu, Xiping, and Qin, Xianhui
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Visceral adiposity index (VAI) is a sex-specific surrogate marker of adipose tissue distribution and function. Little is known about the longitudinal relationship between VAI and proteinuria. This study aimed to examine the prospective relationship of baseline VAI with new-onset of proteinuria in hypertensive patients without major cardiovascular diseases. A total of 10 699 hypertensive patients without proteinuria (negative urine dipstick reading) at baseline from the renal sub-study of the China Stroke Primary Prevention Trial (CSPPT) were included. Participants were randomly assigned to a double-blind daily treatment with 10 mg enalapril and 0.8 mg folic acid or 10 mg enalapril alone. Participants were followed every 3 months after randomization. The primary outcome was new-onset proteinuria, defined as a urine dipstick reading of ≥1+ at the exit visit. The secondary outcome was progression of proteinuria, defined as a urine dipstick reading of trace or ≥1+ at the exit visit. During a median follow-up duration of 4.4 years, a total of 396 (3.7%) participants developed new-onset proteinuria, while 1236 (11.6%) participants met progression of proteinuria. When VAI was categorized into quartiles, compared with participants in quartile 1–3 (<2.99), a significantly higher risk of new-onset proteinuria (OR, 1.43; 95%CI: 1.07–1.91) and progression of proteinuria (OR, 1.23; 95%CI: 1.03–1.46) was found in those in quartile 4 (≥2.99). Moreover, the positive association was consistent in participants with or without general obesity, abdominal obesity, and dyslipidemia (all P -interactions > 0.05). There was a positive association between VAI levels and the risk of new-onset proteinuria in hypertensive patients. [ABSTRACT FROM AUTHOR]
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- 2021
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44. Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasis
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Zhang, Ming-xiao, Zhang, Li-zhen, Fu, Liang-min, Yao, Hao-hua, Tan, Lei, Feng, Zi-hao, Li, Jia-ying, Lu, Jun, Pan, Yi-hui, Shu, Guan-nan, Li, Peng-ju, Tang, Yi-ming, Liao, Zhuang-yao, Wei, Jin-huan, Chen, Wei, Guo, Jian-ping, Luo, Jun-hang, and Chen, Zhen-hua
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Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal cell carcinoma (ccRCC). PVT1 is an important oncogenic lncRNA which has critical effects on onset and development of various cancers, however, the underlying mechanism of PVT1 functioning in ccRCC remains largely unknown. VHLdeficiency-induced HIF2α accumulation is one of the major factors for ccRCC. Here, we identified the potential molecular mechanism of PVT1 in promoting ccRCC development by stabilizing HIF2α. PVT1 was significantly upregulated in ccRCC tissues and high PVT1 expression was associated with poor prognosis of ccRCC patients. Both gain-of-function and loss-of function experiments revealed that PVT1 enhanced ccRCC cells proliferation, migration, and invasion and induced tumor angiogenesis in vitro and in vivo. Mechanistically, PVT1 interacted with HIF2α protein and enhanced its stability by protecting it from ubiquitination-dependent degradation, thereby exerting its biological significance. Meanwhile, HIF2α bound to the enhancer of PVT1 to transactivate its expression. Furthermore, HIF2α specific inhibitor could repress PVT1 expression and its oncogenic functions. Therefore, our study demonstrates that the PVT1/ HIF2α positive feedback loop involves in tumorigenesis and progression of ccRCC, which may be exploited for anticancer therapy.
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- 2021
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45. The Effects of Oral Energy-Dense Supplements on Nutritional Status in Nondiabetic Maintenance Hemodialysis Patients
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Yang, Yaya, Qin, Xianhui, Chen, Junzhi, Wang, Qi, Kong, Yaozhong, Wan, Qijun, Tao, Huiqin, Liu, Aiqun, Li, Youbao, Lin, Zizhen, Huang, Yan, He, Yanhuan, Lei, Zihan, and Liang, Min
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- 2021
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46. Association of Depressive Symptoms with Rapid Kidney Function Decline in Adults with Normal Kidney Function
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Zhang, Zhuxian, He, Panpan, Liu, Mengyi, Zhou, Chun, Liu, Chengzhang, Li, Huan, Zhang, Yuanyuan, Li, Qinqin, Ye, Ziliang, Wu, Qimeng, Wang, Guobao, Liang, Min, and Qin, Xianhui
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- 2021
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47. A Visible Light Cross‐Linked Underwater Hydrogel Adhesive with Biodegradation and Hemostatic Ability
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Liang, Min, Wei, Dandan, Ren, Pengfei, Xu, Li, Tao, Yinghua, Yang, Liuxin, Jiao, Guanhua, Zhang, Tianzhu, and Serizawa, Takeshi
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Hydrogel adhesives with integrated functionalities are still required to match their ever‐expanding practical applications in the field of tissue repair and regeneration. A simple and effective safety strategy is reported, involving an in situ injectable polymer precursor and visible light‐induced cross‐linking. This strategy enables the preparation of a hydrogel adhesive in a physiological environment, offering wet adhesion to tissue surfaces, molecular flexibility, biodegradability, biocompatibility, efficient hemostatic performance, and the ability to facilitate liver injury repair. The proposed one‐step preparation process of this polymer precursor involves the mixing of gelatin methacryloyl (GelMA), poly(thioctic acid) [P(TA)], poly(acrylic acid)/amorphous calcium phosphate (PAAc/ACP, PA) and FDA‐approved photoinitiator solution, and a subsequent visible light irradiation after in situ injection into target tissues that resulted in a chemically‐physically cross‐linked hybrid hydrogel adhesive. Such a combined strategy shows promise for medical scenarios, such as uncontrollable post‐traumatic bleeding. An injectable precursor solution containing a light initiator forms an adhesive hydrogel on tissues. Notably, the hydrogel possesses both biocompatibility and biodegradability, enabling safe and efficient prevention of tissue bleeding while promoting the repair of liver injuries.
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- 2024
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48. High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C.
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Huang, Xin, Kuang, Shuhong, Shen, Zongshan, Liang, Min, and Lin, Zhengmei
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Background: Hyperglycemic micro-environment induced by diabetes could regulate the response of periodontal tissues to pathogenic microorganisms in which disruption of autophagy lysosomal pathway (ALP) may participate. This study aimed to explore the mechanisms underlying how high glucose (HG) regulates ALP in gingival epithelial cells (GECs).Methods: Human gingival tissues in healthy group (C), periodontitis group (P), diabetes group (DM), and diabetes + periodontitis group (DP) were collected and were applied to observe the fusion of autophagy and lysosome. Diabetic mouse model with periodontitis was established and RNA-seq was applied to investigate the expression of ALP-associated genes in gingival epithelium. To explore the key role of ATPase transmembrane v0 domain, subunit c (ATP6V0C) in the disruption of ALP by HG, human gingival epithelial cells (HGECs) were cultured in 5.5 mM/25 mM glucose medium for 48 hours and followed by Porphyromonas gingivalis stimulation for 0, 6, and 12 hours. HBLV-h-ATP6V0C was transfected in HGECs that were stimulated by 25 mM HG condition.Results: Immunofluorescence double staining exhibited the disruption of ALP in human gingival epithelium in diabetes groups and HGECs under 25 mM glucose condition, accompanied with significantly downregulated lysosomal acidity. RNA-seq of mouse gingival epithelium screened out Atp6v0c. Compared with HGECs in normal culture medium, ATP6V0C expression and LC3-II/I expression ratio were significantly downregulated, with an upregulated expression of P62, IL-1β in HGECs under HG condition. Over-expression of ATP6V0C rescued HG-induced disruption of ALP in HBLV-h-ATP6V0C transfected HGECs, with significantly upregulation of LC3-II/I and downregulation of P62, IL-1β.Conclusion: ATP6V0C mediates HG-induced ALP disruption in HGECs, eventually exacerbates periodontal inflammation. [ABSTRACT FROM AUTHOR]- Published
- 2020
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49. U-shaped association between serum albumin and development of chronic kidney disease in general hypertensive patients.
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Jiang, Chongfei, Wang, Binyan, Li, Youbao, Xie, Liling, Zhang, Xianglin, Wang, Jiancheng, Yu, Yaren, Song, Yun, Liang, Min, Wang, Guobao, Li, Jianping, Zhang, Yan, Liu, Lishun, Liu, Chengzhang, Tang, Genfu, Huo, Yong, Xu, Xiping, and Qin, Xianhui
- Abstract
We aimed to examine the association between serum albumin (SAlb) and the development of chronic kidney disease (CKD), and examine any possible effect modifiers in general hypertensive patients with normal renal function and with no previous cardiovascular diseases (CVD). This is a post-hoc analysis (performed at May, 2018) of 12,621 hypertensive adults with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m
2 and SAlb ≥35.0 g/L from the renal sub-study of the China Stroke Primary Prevention Trial (CSPPT), conducted from May 2008 to August 2013. The primary outcome was development of CKD, defined as a decrease in eGFR of ≥30% and to a level of <60 mL/min/1.73 m2 ; or end stage renal disease. The median follow-up duration was 4.4 years. Overall, the association between SAlb levels and risk of the primary outcome followed a U-shape. The risk of CKD development significantly decreased with the increment of SAlb (per g/L: OR = 0.92; 95% CI: 0.88–0.96) in participants with SAlb <51.4 g/L, and increased with the increment of SAlb (per g/L: OR = 1.06; 95%CI: 1.01–1.11) in participants with SAlb ≥51.4 g/L. Moreover, in participants with SAlb <51.4 g/L, the association between SAlb and CKD development remained significant in participants without proteinuria (per g/L: OR = 0.93; 95% CI: 0.88–0.99). The association between SAlb and CKD development was not significantly modified by age, sex, folic acid treatment, proteinuria, systolic blood pressure (SBP) at baseline and time-averaged SBP during the treatment period (all P -interactions>0.05). There was a U-shaped association between SAlb levels and risk of CKD development among general hypertensive patients with normal renal function and without CVD, with a turning point at about 51.4 g/L. [ABSTRACT FROM AUTHOR]- Published
- 2020
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50. Plasma selenium levels and risk of new-onset diabetes in hypertensive adults.
- Author
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Zhang, Yuanyuan, Li, Huan, Lin, Tengfei, Guo, Huiyuan, Jiang, Chongfei, Xie, Liling, Li, Youbao, Zhou, Ziyi, Song, Yun, Wang, Binyan, Liu, Chengzhang, Liu, Lishun, Li, Jianping, Zhang, Yan, Wang, Guobao, Liang, Min, Cui, Yimin, Huo, Yong, Yang, Yan, and Ling, Wenhua
- Subjects
SELENIUM ,DIABETES ,ADULTS ,REGRESSION analysis ,ODDS ratio ,PEOPLE with diabetes - Abstract
• High plasma selenium (≥94.8 μg/L) may increase the risk of new-onset diabetes. • No clear trend was evident when plasma selenium was lower than 94.8 μg/L. • Our findings lent further support that high normal plasma selenium may be harmful. The association between plasma selenium and new-onset diabetes in hypertensive adults is still unclear. We aimed to evaluate the relationship of baseline plasma selenium with new-onset diabetes and examine possible effect modifiers in a post-hoc analysis of the China Stroke Primary Prevention Trial (CSPPT). A total of 2367 hypertensive, non-diabetic patients with plasma selenium measurements at baseline were included. The primary outcome was new-onset diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during the follow-up period, or fasting glucose (FG) ≥126.0 mg/dL at the exit visit. At baseline, higher FG levels were found among participants with plasma selenium in quartile 4 (≥94.8 μg/L) (β, 1.64 mg/dL; 95%CI: 0.54, 2.73) compared to those in quartiles 1–3. During a median follow-up duration of 4.5 years, new-onset diabetes occurred in 270 (11.4%) participants. Graphic plot showed a positive association between baseline selenium levels and risk of new-onset diabetes. This was further confirmed by adjusted regression analyses; the odds ratios (OR) for new-onset diabetes comparing quartile 4 (≥94.8 μg/L) to quartiles 1–3 was 1.36 (95%CI: 1.01, 1.83). No clear trend was evident across quartiles 1–3. Our data suggest that high plasma selenium (≥94.8 μg/L) was associated with increased risk of new-onset diabetes in hypertensive patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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