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Association of visceral adiposity index with new-onset type 2 diabetes and impaired fasting glucose in hypertensive Chinese adults

Authors :
Zhou, Chun
Zhang, Zhuxian
Liu, Mengyi
Zhang, Yuanyuan
He, Panpan
Li, Qinqin
Xie, Di
Liang, Min
Wang, Guobao
Nie, Jing
Liu, Chengzhang
Song, Yun
Liu, Lishun
Wang, Binyan
Wang, Xiaobin
Xu, Xiping
Qin, Xianhui
Source :
Eating and Weight Disorders: Studies on Anorexia, Bulimia and Obesity; March 2022, Vol. 27 Issue: 2 p505-514, 10p
Publication Year :
2022

Abstract

Purpose: Visceral adiposity index (VAI) is a reliable indicator for the distribution and function of adipose tissue in the body. The relation of VAI with new-onset type 2 diabetes and new-onset impaired fasting glucose (IFG) remains uncertain. We aimed to investigate the prospective relation of VAI with new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive adults. Methods: A total of 14,838 hypertensive adults free of type 2 diabetes at baseline were included from the China Stroke Primary Prevention Trial. The primary outcome was new-onset type 2 diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose ≥ 7.0 mmol/L at the exit visit. The secondary outcome was new-onset IFG, defined as fasting glucose < 6.1 mmol/L at baseline, while fasting glucose ≥ 6.1 mmol/L and < 7.0 mmol/L at the exit visit. Results: Over a median of 4.5 years’ follow-up, 1612 (10.9%) participants developed type 2 diabetes. When VAI was categorized into quartiles, compared with participants in quartile 1–3 (< 2.80), significantly higher risk of new-onset type 2 diabetes (OR 1.30; 95% CI 1.08–1.56) and new-onset IFG (OR 1.28; 95% CI 1.08–1.52) was found in those in quartile 4 (≥ 2.80). Moreover, the positive associations were consistent in participants with or without single abnormal VAI components, including general obesity, abdominal obesity, elevated triglycerides and low high-density lipoprotein cholesterol (HDL-C) levels; or with different numbers of abnormal VAI components (all P interactions > 0.05). Conclusion: Our study suggested a positive relation of VAI with the risk of new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive patients, independent of its components. Level of evidence: Level III, a well-designed cohort.

Details

Language :
English
ISSN :
11244909 and 15901262
Volume :
27
Issue :
2
Database :
Supplemental Index
Journal :
Eating and Weight Disorders: Studies on Anorexia, Bulimia and Obesity
Publication Type :
Periodical
Accession number :
ejs55806891
Full Text :
https://doi.org/10.1007/s40519-021-01187-4