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988 results on '"LAURIA, A"'

1. TEMI E CATEGORIE DI STORIA DI GENERE NELLE FONTI RELATIVE A ILARIA DI LAURIA († POST 1342).

Author

LAMBOGLIA, ROSANNA

Abstract

Copyright of Nuova Rivista Storica is the property of Societa Editrice Dante Alighieri s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

2. FORME E VEICOLI DELL'APPARTENENZA L'OBBLIGAZIONE PROPTER ANIMAM DELL'AMMIRAGLIO RUGGERO DI LAURIA.

Author

LAMBOGLIA, ROSANNA

Abstract

The paper offers a critical edition of the well-known Testamento de Roger a transcription made by M. J. Quintana from a parchment stored until at the beginning of the XIX century at the archive of the Monastery of Santa Maria de Santes Creus (Aiguamúrcia, Catalonia). The transcription is a will in a solemn form signed by the admiral Roger of Lauria (Kingdom of Sicily, 1245/1250 ca - Valencia, on 17th January 1305), his witnesses and the notary, Michael Gasol, at Lerida, on 10th September 1291. The paper discusses the formal characteristics of the document and finally defines it like a simple instrumentum with which Roger of Lauria commits his body after the death to the monastery. The paper continues with an analysis of the contents in relation to the medieval practice of the commitments for the soul ante mortem and to the historical context that is the War of the Sicilian Vespers (from 1282 to 1302). [ABSTRACT FROM AUTHOR]

Published
2015

6. Experimental and Modeling Investigation of the Temperature Activation of TDDB in Galvanic Isolators Based on Polymeric Dielectrics

Author

Mazzola, Jurij L., Greatti, Matteo, Monzio Compagnoni, Christian, Spinelli, Alessandro S., Paci, Dario, Speroni, Fabrizio, Marano, Vincenzo, Lauria, Michele, and Malavena, Gerardo

Abstract

We report experimental evidence revealing a nonmonotonic temperature dependence of time-dependent dielectric breakdown (TDDB) in galvanic isolators based on polymeric dielectrics. In particular, the lifetime of the device under TDDB stress decreases when temperature rises from room temperature (RT) to $100~^{\circ }$ C and then steeply increases above the latter temperature. This effect, which introduces a turnaround in the Arrhenius plot of device lifetime, is explained as a result of two competing processes leading to the weakening and strengthening of polymeric chains in the dielectric material, respectively. The proposed physical picture is further supported by a simple numerical model that allows to investigate the temperature dependence of TDDB in galvanic isolators based on polymeric dielectrics under various working conditions.

Published
2024
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7. Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study

Author

Torres Silva, Mayara Secco, Torres, Thiago Silva, Coutinho, Carolina, Ismério Moreira, Ronaldo, da Costa Leite, Iuri, Cunha, Marcelo, da Costa Leite, Pedro Henrique Amparo, Cáceres, Carlos F, Vega-Ramírez, Hamid, Konda, Kelika A, Guanira, Juan, Valdez Madruga, José, Wagner Cardoso, Sandra, Benedetti, Marcos, Pimenta, Maria Cristina, Hoagland, Brenda, Grinsztejn, Beatriz, Gonçalves Veloso, Valdilea, Lacerda, Marcus Vinicius, Madruga, José Valdez, Farias, Alessandro, Lima, Josué N, Zonta, Ronaldo, Lauria, Lilian, Urbaez-Brito, J. David, d'Albuquerque, Polyana, Palombo, Claudio, Alencastro, Paulo Ricardo, Ito, Raquel Keiko de Luca, Moreira, Júlio, Benedetti, João L., Maria, Fabio V., Luz, Paula M., Freitas, Lucilene, Geraldo, Kim, Derrico, Monica, Nazer, Sandro, Kristic, Tania, Girade, Renato, Lima, Renato, Carvalho, Antônio R., Rocha, Carla, Leite, Pedro, Lessa, Marcio, Santini-Oliveira, Marilia, Bezerra, Daniel R.B., Souza, Cleo de Oliveira, Corrêa, Jacinto, Alves, Marcelo, Souza, Carolina, Portugal, Camilla, Valões, Mônica dos Santos, Mota, Gabriel Lima, Gomes, Joyce Alves, Falcão, Cynthia Ferreira Lima, Riberson, Fernanda Falcão, Melo, Luciano, Oliveira, Talita Andrade, Oliveira Júnior, Agnaldo Moreira, Fonseca, Bruna, Lannoy, Leonor Henriette, Carlos, Ludymilla Anderson Santiago, Cunha, João Paulo, Coracini, Sonia Maria de Alencastro, Rodrigues, Thiago Oliveira, Mettrau, Emília Regina Scharf, Meira, Kelly Vieira, Tavares, Heder, Valeiras, Ana Paula Nunes Viveiros, Rocha, Taiane Miyake Alves de Carvalho, Amorim, Alex, Sabadini, Patrícia, Córdoba, Luiz Gustavo, Gusmão, Caio, Faustino, Erika, Hansen, Julia Soares da Silva, Cunha, Agatha Mirian, Nishimura, Neuza Uchiyama, Santos, Jaime Eduardo Flygare Razo Prereira, Cano, Aline Barnabé, Dias, Willyam Magnum Telles, Tonhon, Magô, Rezende, Tania Regina, Gomes, Alex, Rodrigues, Eloá dos Santos, Carneiro, Maria das Dores Aires, Castilho, Alexandre, Carvalho, Mariana, Bautista-Aredondo, Sergio, Vermandere, Heleen, Diaz, Steven, Diaz-Sosa, Dulce, Guillen-Diaz-Barriga, Centli, Robles, Rebeca, Medina-Mora, Maria Elena, González, Marcela, Icelo, Ivonne Huerta, Davalos, Araczy Martinez, Castro, José Gomez, Valdez, Luis Obed Ocampo, Barajas, Fernanda Ramírez, González, Verónica Ruiz, Guadarrama, Galileo Vargas, Macías, Israel, Sánchez, Jehovani Tena, Noriega, Juan Pablo Osuna, Moheno M., H. Rodrigo, Ramírez, Jorge M. Bernal, Juarez, Víctor Dante Galicia, Vizcaíno, Gerardo, Arjona, Francisco Javier, Osco Tamayo, Cesar Vidal, Salvatierra Flores, Hector Javier, Cabrera Santa Cruz, Yovanna Margot, Moreno Aguayo, Ricardo Martín, Calvo, Gino, Vargas, Silver, Elorreaga, Oliver, Gutierrez, Ximena, Olivos, Fernando, Caviedes, Damaris, Adriazola, Daniella, Juárez, Eduardo, Mariño, Gabriela, Qquellon, Jazmin, Vasquez, Francesca, Jiron, Jean Pierre, Flores, Sonia, and Campos, Karen

Abstract

The global burden of sexually transmitted infections (STIs) poses a challenge in the context of HIV pre-exposure prophylaxis (PrEP) programmes. We aimed to explore factors associated with prevalent, incident, and recurrent STIs in men who have sex with men (MSM) and transgender women on PrEP in Brazil, Mexico, and Peru.

Published
2024
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9. Genetic break in Lauria cylindracea (Da Costa 1778) (Gastropoda: Stylommatophora: Lauriidae)

Author

Renker, Carsten

Abstract

Im Rahmen der vorliegenden Arbeit wurde die intraspezifische Variation unterschiedlicher Populationen von Lauria cylindracea (Da Costa 1778) basierend auf Unterschieden im Bereich des Internal Transcribed Spacers 2 der nuklear ribosomalen DNA untersucht. In die molekularen Untersuchungen wurden Tiere aus Deutschland, Griechenland und Irland einbezogen. Nördliche und südliche Populationen von L. cylindracea können anhand eines Minisatelliten-Motivs (TGGAAGTG) unterschieden werden, das bei Tieren aus südlichen Populationen zweimal, bei solchen aus nördlichen Populationen dreimal hintereinander auftritt. Die Grenze dieses Musters verläuft durch Deutschland, wo die nördlichen Populationen entlang der Ostseeküste das dreifache und die südlichen Populationen in Rheinland-Pfalz das zweifache Motiv aufweisen. Morphologische Untersuchungen erbrachten zwar stellenweise signifikante Größenunterschiede zwischen einzelnen Populationen, ließen jedoch keine Rückschlüsse auf die Zugehörigkeit zu den molekular unterschiedenen Populationen zu.

Published
2007
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11. One plan to address the reversible causes of traumatic cardiac arrest and evaluate the need for escalation of care.

Author

Winniford, Cody and Lauria, Michael J.

Subjects
CARDIAC arrest, HEART diseases, CARDIAC resuscitation, HYPOVOLEMIA, CARDIAC tamponade, PNEUMOTHORAX
Abstract

The article focuses on improving outcomes in traumatic cardiac arrest (TCA) through targeted management of reversible causes and re-evaluation of resuscitation strategies. Topics include the historical challenges in treating TCA, the evolution of treatment paradigms from generic resuscitative efforts to specific interventions addressing hypovolemia, cardiac tamponade, and tension pneumothorax. The CAVE checklist provides a structured approach for prehospital providers.

Published
2024

12. Short- and long-term resistance to desiccation in a minute litter-dwelling land snail <e1>Lauria cylindracea</e1> (Pulmonata: Pupillidae)

Author

Arad, Zeev, Goldenberg, Shoshana, and Heller, Joseph

Abstract

This study examines the water economy and resistance to desiccation in a minute (5 mg snail mass; 3 mm shell height) litter-dwelling land snail Lauria cylindracea (Pupillidae). As expected from its small size and from its moist habitat, L. cylindracea exposed to normothermic desiccation lost water at the highest rate revealed so far in our studies of resistance to desiccation in some 30 Israeli species and populations of land snails—22.7% of the whole snail mass within 5 days. This high water loss was selectively contributed by the extra-pallial (free) compartment while soft body water content was closely maintained, without catabolism of body tissue as a source of metabolic water. Surprisingly, however, samples of L. cylindracea survived long periods (2–4 months) of aestivation when left undisturbed in the laboratory, sustaining a mass loss of 25–40%. This long-term aestivation revealed a different pattern of water compartmentalization, as the snails also lost water from the soft body tissue. Samples of these snails were rehydrated for 48 h and then exposed to an identical desiccation regime as the original, field-collected snails. Most of the water taken up during rehydration was lost within the first 24 h of desiccation, after which the rate of water loss dropped sharply. We conclude that short-term water regulatory responses to experimental desiccation differ from long-term responses to aestivation. We suggest that during long-term aestivation, a new set-point of water economy is established, in association with a metabolic depression, and that an extended period of contact with moisture is needed to change this set-point.

Published
1998

14. Implementation of a Rapid Sequence Intubation Checklist Improves First-Pass Success and Reduces Peri-Intubation Hypoxia in Air Medical Transport.

Author

Olvera, David J., Lauria, Michael, Norman, Jeremy, Gothard, M. David, Gothard, Andrew D., and Weir, William Bradley

Abstract

Rapid sequence intubation (RSI) is a critical skill commonly performed by air medical teams in the United States. To improve safety and reduce potential patient harm, checklists have been implemented by various institutions in intensive care units, emergency departments, and even prehospital air medical programs. However, the literature suggests that checklist use before RSI has not shown improvement in clinically important outcomes in the hospital. It is unclear if RSI checklist use by air medical crews in prehospital environments confers any clinically important benefit. This institutional review board–approved project is a before-and-after observational study conducted within a large helicopter ambulance company. The RSI checklist was used by flight crewmembers (flight paramedic/nurse) for over 3 years. Data were evaluated for 8 quarters before and 8 quarters after checklist implementation, spanning December 2014 to March 2019. Data were collected, including the self-reported use of the checklist during intubation attempts, the reason for intubation, and correlation with difficult airway predictors (HEAVEN [Hypoxemia, Extremes of size, Anatomic disruption, Vomit, Exsanguination, Neck mobility/Neurologic injury] criteria), and compared with airway management before the implementation of the checklist. The primary outcome was improved first-pass success (FPS) when compared among those who received RSI before the checklist versus those who received RSI with the checklist. The secondary outcome was a definitive airway sans hypoxia improvement noted on the first pass among adult patients as measured before and after RSI checklist implementation. Post-RSI outcome scenarios were recorded to analyze and validate the effectiveness of the checklist. Ten thousand four hundred five intubations were attempted during the study. FPS was achieved in 90.9% of patients before RSI checklist implementation, and 93.3% achieved FPS postimplementation of the RSI checklist (P ≤.001). In the preimplementation epoch, 36.2% of patients had no HEAVEN predictors versus 31.5% after RSI checklist implementation. These data showed that before RSI checklist implementation, airways were defined as less difficult than after implementation. The implementation of a standardized RSI checklist provided a better identification of deterring factors, affording efficient and accurate actions promoting FPS. Our data suggest that when a difficult airway is identified, using the RSI checklist improves FPS, thereby reducing adverse events. [ABSTRACT FROM AUTHOR]

Published
2024
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21. The multicenter experience in the multidisciplinary Italian breast units: a review and update

Author

Magnoni, Francesca, Tinterri, Corrado, Corso, Giovanni, Curigliano, Giuseppe, Leonardi, Maria Cristina, Toesca, Antonio, Rocco, Nicola, Catalano, Francesca, Bianchi, Beatrice, Lauria, Federica, Caldarella, Pietro, Pagani, Gianmatteo, Galimberti, Viviana, and Veronesi, Paolo

Abstract

A breast unit is a multidisciplinary center specialized in the management of women with breast diseases, including breast cancer (BC). It represents a care path, passing from screening activities to diagnostic investigations, from surgery to the definition of the therapeutic strategy, from psychophysical rehabilitation to long-term checks (follow-up), and up to genetic counseling. Since 2006, following a resolution issued by the European Parliament to urge member states to activate multidisciplinary breast centers by 2016, work has been underway throughout Italy to improve the management of women with BC. In Italy, the State-Regions agreement was signed on 18 December 2014, sanctioning the establishment of breast units. These centers must adhere to specific quality criteria and requirements. In 2020, the experts of the EUSOMA group (European Society of Breast Cancer Specialists), in their latest document published, expanded the requirements of the breast units. Furthermore, Senonetwork was founded in 2012 with the aim of allowing BC to be treated in breast units that comply with European requirements to ensure equal treatment opportunities for all Italian women. Indeed, the available data indicate that the BC patient has a greater chance of better treatment in the breast units with a multidisciplinary team, thus increasing the survival rate with a better quality of life, compared to those managed in nonspecialized structures. The present review is a perspective on the current Italian reality of breast units, updated with the available literature and the most recent epidemiological data from Senonetwork and AgeNaS.

Published
2024
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22. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Author

Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz, Bata, Iqbal, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beutel, Manfred E, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Anne A, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Blychfeld Magnazu, Moran, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boer, Jolanda MA, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Botomba, Steve, Bourne, Rupert RA, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Braithwaite, Tasanee, Brajkovich, Imperia, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de León, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula c, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajús, José A, Casanueva, Felipe F, Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Charchar, Fadi J, Charles, Marie-Aline, Chaturvedi, Himanshu K, Chaturvedi, Nish, Che Abdul Rahim, Norsyamlina, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Cojocaru, Cosmin R, Colorado-Yohar, Sandra, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Cortés, Lilia Yadira, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Csányi, Tamás, Csilla, Semánová, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva, Alanna G, Dacica, Liliana, Dahm, Christina C, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Backer, Guy, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, De Neve, Jan-Walter, Duarte de Oliveira, Paula, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, de Sá, Ana Carolina MGN, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent Jr, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Devrishov, Ruslan D, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Díaz Fernández, Pedro, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Dörr, Marcus, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duleva, Vesselka L, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dwyer, Terence, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Elliott, Paul, Enang, Ofem, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Evans, Roger G, Faeh, David, Fagherazzi, Guy, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farrugia Sant'Angelo, Victoria, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Fras, Zlatko, Fraser, Brooklyn, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Gafencu, Mihai, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Gao, Pei, Garcia-de-la-Hera, Manoli, García Mérida, María José, García Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, George, Ronnie, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gieger, Christian, Gill, Tiffany K, Giovannelli, Jonathan, 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Schröder, Helmut, Schultsz, Constance, Schultz, Gry, Schulze, Matthias B, Schutte, Aletta E, Sebert, Sylvain, Sedaghattalab, Moslem, Selamat, Rusidah, Sember, Vedrana, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sequera, Guillermo, Serra-Majem, Luis, Servais, Jennifer, Ševčíková, Ľudmila, Sewpaul, Ronel, Shalnova, Svetlana, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shaw, Jonathan E, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shimony, Tal, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Sidossis, Labros S, Silitrari, Natalia, Silva, Antonio M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Silva, Kelly Samara, Sim, Xueling, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöberg, Agneta, Sjöström, Michael, Skoblina, Elena V, Skoblina, Natalia A, Slazhnyova, Tatyana, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Söderberg, Stefan, Soekatri, Moesijanti YE, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Solovieva, Yuliya V, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Soofi, Sajid, Sørensen, Thorkild IA, Sørgjerd, Elin P, Sossa Jérome, Charles, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Sovic, Slavica, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Spencer, Phoebe R, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A, Stamm, Hanspeter, Stang, Andreas, Starc, Gregor, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Steinsbekk, Silje, Stergiou, George S, Stessman, Jochanan, Stevanović, Ranko, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suárez-Medina, Ramón, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sugiyama, Mindy, Suka, Machi, Sulo, Gerhard, Sun, Chien-An, Sun, Liang, Sund, Malin, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Sweis, Nabil William G, Swinburn, Boyd A, Sy, Rody G, Sylva, René Charles, Szponar, Lucjan, Tabone, Lorraine, Tai, E Shyong, Takuro, Furusawa, Tambalis, Konstantinos D, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanrygulyyeva, Maya, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Taylor, Anne, Taylor, Julie, Tchibindat, Félicité, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Tessema, Masresha, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thomas, Nihal, Thorand, Barbara, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Tomaszewski, Maciej, Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Udoji, Nwannedimma, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K, Vasques, Daniel G, Vatasescu, Radu, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Viriyautsahakul, Napaphan, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Vourli, Georgia, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja GM, Vuletić, Silvije, Wade, Alisha N, Waldhör, Thomas, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid

Abstract

Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.

Published
2024
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25. Hairy cell leukemia variant and WHO classification correspondence Re: 5thedition WHO classification haematolymphoid tumors: lymphoid neoplasms

Author

Grever, Michael, Andritsos, Leslie, Anghelina, Mirela, Arons, Evgeny, Banerji, Versha, Barrientos, Jacqueline, Bhat, Seema A., Blachly, James, Broccoli, Alessandro, Call, Timothy, Dearden, Claire, Dietrich, Sascha, Else, Monica, Epperla, Narendranath, Fagarasanu, Andrei, Falini, Brunangelo, Forconi, Francesco, Gozzetti, Alessandro, Hampel, Paul, Hermel, David J., Iyengar, Sunil, Johnston, James B., Juliusson, Gunnar, Kreitman, Robert J., Lauria, Francesco, Lozanski, Gerard, Oakes, Christopher C., Parikh, Sameer A., Park, Jae, Quest, Graeme, Rai, Kanti, Ravandi, Farhad, Robak, Tadeusz, Rogers, Kerry A., Saven, Alan, Seymour, John F., Tadmor, Tamar, Tallman, Martin S., Tam, Constantine S., Tiacci, Enrico, Troussard, Xavier, Wörmann, Bernhard, Zent, Clive S., Zenz, Thorsten, and Zinzani, Pier Luigi

Published
2024
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28. Closing the Organofluorine Mass Balance in Marine Mammals Using Suspect Screening and Machine Learning-Based Quantification

Author

Lauria, Mélanie Z., Sepman, Helen, Ledbetter, Thomas, Plassmann, Merle, Roos, Anna M., Simon, Malene, Benskin, Jonathan P., and Kruve, Anneli

Abstract

High-resolution mass spectrometry (HRMS)-based suspect and nontarget screening has identified a growing number of novel per- and polyfluoroalkyl substances (PFASs) in the environment. However, without analytical standards, the fraction of overall PFAS exposure accounted for by these suspects remains ambiguous. Fortunately, recent developments in ionization efficiency (IE) prediction using machine learning offer the possibility to quantify suspects lacking analytical standards. In the present work, a gradient boosted tree-based model for predicting log IEin negative mode was trained and then validated using 33 PFAS standards. The root-mean-square errors were 0.79 (for the entire test set) and 0.29 (for the 7 PFASs in the test set) log IEunits. Thereafter, the model was applied to samples of liver from pilot whales (n = 5; East Greenland) and white beaked dolphins (n = 5, West Greenland; n = 3, Sweden) which contained a significant fraction (up to 70%) of unidentified organofluorine and 35 unquantified suspect PFASs (confidence level 2–4). IE-based quantification reduced the fraction of unidentified extractable organofluorine to 0–27%, demonstrating the utility of the method for closing the fluorine mass balance in the absence of analytical standards.

Published
2024
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29. A New Particle Swarm Optimization Algorithm for Outlier Detection: Industrial Data Clustering in Wire Arc Additive Manufacturing

Author

Fang, Jingzhong, Wang, Zidong, Liu, Weibo, Lauria, Stanislao, Zeng, Nianyin, Prieto, Camilo, Sikstrom, Fredrik, and Liu, Xiaohui

Abstract

In this paper, a novel outlier detection method is proposed for industrial data analysis based on the fuzzy C-means (FCM) algorithm. An adaptive switching randomly perturbed particle swarm optimization algorithm (ASRPPSO) is put forward to optimize the initial cluster centroids of the FCM algorithm. The superiority of the proposed ASRPPSO is demonstrated over five existing PSO algorithms on a series of benchmark functions. To illustrate its application potential, the proposed ASRPPSO-based FCM algorithm is exploited in the outlier detection problem for analyzing the real-world industrial data collected from a wire arc additive manufacturing pilot line in Sweden. Experimental results demonstrate that the proposed ASRPPSO-based FCM algorithm outperforms the standard FCM algorithm in detecting outliers of real-world industrial data. Note to Practitioners—Electric arc (which is governed by the current and arc voltage) plays a significant role in monitoring the operating status of the wire arc additive manufacturing (WAAM) process. The nominal periodic current and voltage may occasionally change abruptly due to anomalies (such as arc instability, unstable metal transfer, geometrical deviations, and surface contaminations), which would affect the quality of the fabricated component. This paper focuses on detecting possible anomalies by analyzing the current and voltage during the WAAM process. A novel clustering-based outlier detection method is proposed for anomaly detection where abnormal and normal instances are categorized into two separate clusters. A new particle swarm optimization algorithm is put forward to optimize the initial cluster centroid so as to improve the detection accuracy. The proposed outlier detection method is applied to real-world data collected from a WAAM pilot line for detecting abnormal instances. Experimental results demonstrate the effectiveness of the proposed outlier detection method. The proposed outlier detection method can be applied to other industrial applications including electrical engineering, mechanical engineering and medical engineering. In the future, we aim to develop an online outlier detection system based on the proposed method for real-time for anomaly detection and defect prediction.

Published
2024
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30. Outcomes of Arterial Bypass With the Human Acellular Vessel for Chronic Limb-Threatening Ischemia Performed Under the FDA Expanded Access Program

Author

Sen, Indrani, Clouse, W. Darrin, Lauria, Alexis L., Calderon, Daniel R., Anderson, Peter B., DeMartino, Randall R., and Rasmussen, Todd E.

Abstract

To report outcomes of the human acellular vessel (HAV) implanted for limb salvage through the Food and Drug Administration (FDA) Expanded Access Program for patients with chronic limb-threatening ischemia with no autologous conduit.

Published
2024
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33. Management of Postpartum Hemorrhage in Critical Care Transport.

Author

Haering, Donald, Meador, Hallie, Lynch, Elizabeth, Lauria, Michael, Garchar, Elizabeth, and Braude, Darren

Abstract

• Critical care transport providers must understand the management of postpartum hemorrhage. • Critical care transport teams should be familiar with uterotonic medications and tranexamic acid. • Volume resuscitation and blood products are crucial for the management of postpartum hemorrhage. • Postpartum hemorrhage is primarily a clinical diagnosis. • Transport providers may be expected to manage uterine balloon tamponade. Postpartum hemorrhage is a relatively common and highly morbid complication of the postpartum period that often requires management by specialized providers at tertiary care facilities. Critical care transport teams may be tasked with transporting postpartum patients who are already experiencing postpartum hemorrhage, but they should also be aware that other peripartum patients may be at risk for developing postpartum hemorrhage while in the process of transport. As such, it is imperative that transport providers understand the signs, symptoms, causes, and complications of postpartum hemorrhage as well as the options for intervention and treatment. This article reviews the current clinical evidence regarding resuscitation and medical management strategies that transport teams should be familiar with as well as more advanced and invasive management techniques they may encounter and be expected to monitor during transport, such as balloon tamponade and aortic balloon occlusion. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Management of Hantavirus Cardiopulmonary Syndrome in Critical Care Transport: A Review.

Author

Essex, Kyle, Mullen, Jace, Lauria, Michael J., and Braude, Darren A.

Abstract

In 1993, the Southwest found itself staring down a disease then known as "unexplained adult respiratory syndrome." During the outbreak, 12 of 23 known patients died. What we now recognize as hantavirus cardiopulmonary syndrome still remains a rare and deadly disease. Although no cure exists, modern supportive techniques such as extracorporeal membrane oxygenation have increased survival among these patients. Early diagnosis has become the primary factor in patient survival. The initial presentation of hantavirus is similar to acute respiratory distress syndrome, necessitating a high index of suspicion to afford the patient the best chance of survival. Diagnosis is further complicated by prolonged and nonspecific incubation periods making it difficult to pinpoint an exposure. Familiarizing oneself with common clinical presentations, diagnostic strategies, and testing is the best way to increase patient survival. Because hantavirus has a predilection for rural areas, transport to a tertiary facility is paramount to provide the resources necessary to care for these complex patients. Rapid sequence intubation, although common in airway-compromised patients, could prove fatal in the setting of the severe hemodynamic instability found in hantavirus cardiopulmonary syndrome. Anticipation of significant pressor use and fluid administration could likely mean the difference in patient mortality during transport. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Takotsubo Cardiomyopathy Syndrome in Critical Care Transport: A Case and Critical Review.

Author

Standifird, Colin, Kaisler, Sean, Gottula, Adam L., Lauria, Michael J., and Dean III, James T.

Abstract

Takotsubo cardiomyopathy syndrome, or simply takotsubo syndrome (TTS), is a form of stress cardiomyopathy thought to be caused by excess catecholamines in association with physical or emotional stress. Providers should maintain a high index of suspicion for TTS in patients with symptoms of acute coronary syndrome, acute decompensated heart failure, substernal chest pain, or dyspnea. However, TTS is a diagnosis of exclusion, and patients should initially be evaluated and treated for other causes, such as acute myocardial infarction. Critical care transport crews may encounter patients with TTS during their primary presentation, before diagnosis, or after the formal diagnosis is made in the catheterization laboratory. Therefore, crews should be familiar with unique aspects of the pathophysiology, diagnosis, and management of TTS. This article presents a case and provides a critical review of TTS for critical care transport clinicians. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Tonantzitlolone B Modulates the Endogenous Opioid System to Promote Antinociception in Mice

Author

do Espírito-Santo, Renan Fernandes, Santos, Dourivaldo Silva, Sales Lauria, Pedro Santana, de Lima, Alyne Almeida, Abreu, Lucas Silva, Tavares, Josean Fechine, Castilho, Marcelo Santos, Pereira Soares, Milena Botelho, and Villarreal, Cristiane Flora

Abstract

Tonantzitlolone B (TZL-B) is a diterpene isolated from the roots of Stillingia loranthacea. Its antinociceptive effects were investigated in male Swiss mice using the following models of pain: formalin test, inflammation induced by Complete Freund’s Adjuvant (CFA), tail flick test, and cold plate test. The influence of TZL-B on the opioid system was assessed in vivo, using opioid antagonists; in silico, investigating the chemical similarity among TZL-B and opioid agonists; and ex vivo, measuring preproenkephalin (PENK) gene expression in the spinal cord by RT-qPCR. TZL-B (10–1000 μg/kg) promoted antinociception in the four experimental models without impairing mice’s motor function. TZL-B did not alter paw edema during CFA-induced inflammation. The antinociceptive effects of TZL-B in the tail flick and cold plate tests were diminished by the opioid antagonists naloxone (5 mg/kg), NOR-BNI (0.5 mg/kg), naltrindole (3 mg/kg), and CTOP (1 mg/kg), indicating the involvement of κ-, δ-, and μ-opioid receptors. TZL-B showed no significant chemical similarity to opioid agonists, but the treatment with TZL-B (1000 μg/kg) increased PENK gene expression in the spinal cord of mice. These data suggest that TZL-B promotes antinociception by enhancing the transcription of PENK, hence modulating the endogenous opioid system.

Published
2023
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38. Management of Acute Upper Gastrointestinal Bleeding in Critical Care Transport.

Author

Tafoya III, Louis A., McGee, John C., Kaisler, Sean, Gottula, Adam L., Lauria, Michael J., and Braude, Darren A.

Abstract

Upper gastrointestinal bleeding is a relatively common and life-threatening condition encountered by critical care transport crews. It is of paramount importance that transport crews understand the underlying pathophysiology of variceal and nonvariceal gastrointestinal bleeding as well as the nuanced management of this patient population. This article reviews the current clinical evidence on initial resuscitation, medical management, and advanced invasive therapies (such as balloon tamponade devices) that transport crews should be familiar with to manage these patients. In addition, we present a novel method of continuous balloon pressure monitoring of balloon tamponade devices that is applicable to the transport environment. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Evaluation of novel hemostatic agents in a coagulopathic swine model of junctional hemorrhage

Author

Gerling, Kimberly A., Kersey, Alexander J., Lauria, Alexis L., Mares, John A., Hutzler, Justin D., White, Paul W., Abel, Biebele, Burmeister, David M., Propper, Brandon, and White, Joseph M.

Abstract

Most novel hemostatic agents demonstrated comparable efficacy compared to the currently military standard hemostatic dressing, Combat Gauze, in a hemorrhagic, coagulopathic swine model.

Published
2023
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40. 3D Bitemark Analysis in Forensic Odontology Utilizing a Smartphone Camera and Open-Source Monoscopic Photogrammetry Surface Scanning.

Author

Kurniawan, Arofi, Chusida, An’nisaa, Utomo, Haryono, Marini, Maria Istiqomah, Rizky, Beta Novia, Widayati Prakoeswa, Beshlina Fitri, Hamdani, Janice, Salazar-Gamarra, Rodrigo, Dib, Luciano Lauria, Alias, Aspalilah, Yusmiaidil Putera Mohd Yusof, Mohd., and Marya, Anand

Subjects
FORENSIC dentistry, SMARTPHONES, PHOTOGRAMMETRY, THREE-dimensional imaging, CRIMINAL procedure
Abstract

Bitemark analysis is a challenging procedure in the field of criminal case investigation. The unique characteristics of dentition are used to find the best match between the existing patterned injury and the suspected perpetrator in bitemark identification. Bitemark analysis accuracy can be influenced by various factors, including biting pressure, tooth morphology, skin elasticity, dental cast duplication, timing, and image quality. This review article discusses the potential of a smartphone camera as an alternative method for 3D bitemark analysis. Bitemark evidence on human skin and food should be immediately recorded or duplicated to retrieve long-lasting proof, allowing for a sufficient examination period. Various studies utilizing twodimensional (2D) and three-dimensional (3D) technologies have been developed to obtain an adequate bitemark analysis. 3D imaging technology provides accurate and precise analysis. However, the currently available method using an intraoral scanner (IOS) requires high-cost specialized equipment and a well-trained operator. The numerous advantages of monoscopic photogrammetry may lead to a novel method of 3D bitemark analysis in forensic odontology. Smartphone cameras and monoscopic photogrammetry methodology could lead to a novel method of 3D bitemark analysis with an efficient cost and readily available equipment. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Ultraviolet C as a method of disinfecting medical silicone used in facial prostheses: An in vitro study – Part 2.

Author

Malateaux, Gabriela, Salazar-Gamarra, Rodrigo Ernesto, de Souza Silva, Jefferson, Pecorari, Vanessa Gallego Arias, Suffredini, Ivana Barbosa, Netto, Francisco Perinni, Neves, Cintia Riva, Rodrigues de Souza, Isabela, de Mello Mesquita, Alfredo Mikail, and Dib, Luciano Lauria

Abstract

Disinfection is an important factor in preserving facial prostheses and maintaining tissue health. However, whether disinfection with ultraviolet C is an effective disinfection method is unclear. The purpose of this in vitro study was to evaluate the effectiveness of irradiation with different exposure durations of an ultraviolet-C light-emitting diode in the disinfection of the silicone (A-588–1; Factor II) used in facial prostheses. A total of 216 specimens were prepared, contaminated by multispecies biofilm, and divided into 9 groups (n=24) for different treatments: chlorhexidine 0.12% (G CHG), ultraviolet-C light-emitting diode for 5 minutes (G UVC5), ultraviolet-C light-emitting diode for 10 minutes (G UVC10), ultraviolet-C light-emitting diode for 20 minutes (G UVC20), their respective untreated controls (Gcontrol CHG, Gcontrol UVC5, Gcontrol UVC10, Gcontrol UVC20), and dimethyl sulfoxide (G DMSO) as the negative control. Cell viability was measured by using the methyl tetrazolium salt (MTT) method. Two statistical analyses were performed. First, a 2×3 ANOVA was carried out to compare the control groups (Gcontrol UVC5, Gcontrol UVC10, and Gcontrol UVC20) and the experimental groups of UV-C LED light with different exposure durations (G UVC5, G UVC10, and G UVC20). The second analysis was performed using generalized linear models to compare the optical density of the groups (G UVC5, G UVC10, G UVC20, G CHG, and G DMSO). Cell viability results demonstrated a microbial reduction after exposure to the ultraviolet-C light-emitting diode for 20 minutes (G UVC20) compared with untreated controls (P <.05). The 5- and 10-minute exposures were statistically similar to their respective control groups (P >.05). The 20 minutes exposure had the lowest average optical density value, being statistically different from the 5-minute exposure (P <.05). A 20-minute exposure to the ultraviolet-C light-emitting diode (G UVC20) was similarly effective when compared with the standard disinfection treatment (G CHG) and dimethyl sulfoxide (G DMSO) (P >.05). Irradiation with an ultraviolet-C light-emitting diode for 20 minutes decreased the in vitro microbial cell viability on the medical silicone used in facial prostheses. [ABSTRACT FROM AUTHOR]

Published
2024
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42. From lava to leaf: Physiological responses and trace element mobility in Tilia cordata L. trees grown in volcanic ash amended urban soil.

Author

Lo Piccolo, Ermes, Ceccanti, Costanza, Lauria, Giulia, Santonocito, Gianluca, Rosellini, Irene, Pezzarossa, Beatrice, Guidi, Lucia, Laudicina, Vito Armando, Baglieri, Andrea, Remorini, Damiano, Massai, Rossano, and Landi, Marco

Subjects
URBAN soils, LIME (Fruit), SOIL conditioners, SOIL amendments, VOLCANIC ash, tuff, etc.
Abstract

This study investigates the potential of utilizing volcanic ash (VA), classified as special waste, as an inorganic soil amendment to enhance tree growth and resilience in urban areas near volcanic regions. Lime trees were transplanted into pots filled with urban soil (Cnt) or amended with 10 % VA. Tree's physiological traits were monitored over the growing season. Notably, VA-treated trees showed improved net CO 2 assimilation (P n) and stomatal conductance (g s) during the leaf senescent stage. The analysis of ash, and Cnt and VA soils, showed low concentrations of trace elements. In addition, trace element accumulation in the leaves of VA trees was not observed. In summer, during a 12-day drought stress test, VA-stressed trees exhibited enhanced water absorption, reduced lipid peroxidation, and higher P n and g s values in the initial days compared to control-stressed trees. Importantly, the VA also promoted a 33 % larger tree root system, potentially enhancing drought resilience. This could offer an important advantage for trees, especially during the tree's critical establishment phase. Thus, VA could be a promising amendment for urban soils to bolster tree tolerance to drought. [Display omitted] • Volcanic ash (VA) in landfills represents a high cost for municipalities. • No accumulation of trace elements was observed in VA-amended plants. • The root apparatus increased by 33 % in trees grown in soil amended with VA. • VA trees increased Tillia cordata tolerance to drought stress. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Tissue memory relies on stem cell priming in distal undamaged areas

Author

Levra Levron, Chiara, Watanabe, Mika, Proserpio, Valentina, Piacenti, Gabriele, Lauria, Andrea, Kaltenbach, Stefan, Tamburrini, Annalaura, Nohara, Takuma, Anselmi, Francesca, Duval, Carlotta, Elettrico, Luca, Donna, Daniela, Conti, Laura, Baev, Denis, Natsuga, Ken, Hagai, Tzachi, Oliviero, Salvatore, and Donati, Giacomo

Abstract

Epithelial cells that participated in wound repair elicit a more efficient response to future injuries, which is believed to be locally restricted. Here we show that cell adaptation resulting from a localized tissue damage has a wide spatial impact at a scale not previously appreciated. We demonstrate that a specific stem cell population, distant from the original injury, originates long-lasting wound memory progenitors residing in their own niche. Notably, these distal memory cells have not taken part in the first healing but become intrinsically pre-activated through priming. This cell state, maintained at the chromatin and transcriptional level, leads to an enhanced wound repair that is partially recapitulated through epigenetic perturbation. Importantly wound memory has long-term harmful consequences, exacerbating tumourigenesis. Overall, we show that sub-organ-scale adaptation to injury relies on spatially organized memory-dedicated progenitors, characterized by an actionable cell state that establishes an epigenetic field cancerization and predisposes to tumour onset.

Published
2023
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44. Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn’s disease: results from an Italian multicenter study

Author

Mocci, Giammarco, Tursi, Antonio, Maconi, Giovanni, Cataletti, Giovanni, Mantia, Beatrice, Serio, Mariaelena, Scarcelli, Antonella, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Pranzo, Giuseppe, Luppino, Ileana, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Ferronato, Antonio, Perini, Barbara, Savarino, Edoardo, Onidi, Francesca Maria, Binaghi, Laura, Usai Satta, Paolo, Schiavoni, Elisa, Napolitano, Daniele, Scaldaferri, Franco, Pugliese, Daniela, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Rodino, Stefano, Sebkova, Ladislava, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Gaiani, Federica, De Angelis, Gianluigi, Kayali, Stefano, Fanigliulo, Libera, Lorenzetti, Roberto, Allegretta, Leonardo, Scorza, Stefano, Cuomo, Antonio, Donnarumma, Laura, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Antonelli, Elisabetta, Bassotti, Gabrio, Iannelli, Chiara, Luzza, Francesco, Aragona, Giovanni, Perazzo, Patrizia, Lauria, Angelo, Piergallini, Simona, Colucci, Raffaele, Bianco, Maria Antonia, Meucci, Costantino, Giorgetti, Gianmarco, Clemente, Valeria, Fiorella, Serafina, Penna, Antonio, De Medici, Antonio, Picchio, Marcello, and Papa, Alfredo

Abstract

ABSTRACTBackgroundVedolizumab (VDZ) can be used to treat refractory ulcerative colitis (UC) and Crohn’s disease (CD). We assessed whether there are differences in treating UC vs CD with VDZ.Research design and methods Mayo score in UC and the Harvey-Bradshaw Index (HBI) in CD scored the clinical activity. Achievement and maintenance of clinical remission during the follow-up, and safety were the primary endpoints.Results729 patients (475 with UC and 254 with CD), median follow-up of 18 (IQR 6-36) months, were enrolled. Clinical remission at the 6thmonth of treatment was achieved in 488 (66.9%) patients (74.4% in CD vs 62.9% in UC, p<0.002) while, during the follow-up, no difference was found (81.5% in the UC group and 81.5% pts in the CD group; p=0.537). The clinical remission at the 6thmonth of treatment (p=0.001) and being naïve to biologics (p<0.0001) were significantly associated with prolonged clinical remission. The clinical response was significantly higher in UC (90.1%) vs CD (84.3%) (p=0.023), and surgery occurred more frequently in CD (1.9% in UC vs 5.1% in CD, p=0.016).ConclusionWe found differences when using VDZ in UC vs CD in real life. These parameters can help the physician predict this drug’s longterm efficacy.

Published
2023
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45. FINGER: A Novel Approach to Teaching Simple Thoracostomy.

Author

Merelman, Andrew, Zink, Natalie, Fisher, Andrew D., Lauria, Michael, and Braude, Darren

Abstract

For decades, most prehospital clinicians have only been armed with needle thoracostomy to treat a tension pneumothorax, which has a significant failure rate. Following recent changes by the US military, more ground and air transport agencies are adopting simple thoracostomy, also commonly referred to as finger thoracostomy, as a successful alternative. However, surgical procedures performed by prehospital clinicians remain uncommon, intimidating, and challenging. Therefore, it is imperative to adopt a training strategy that is comprehensive, concise, and memorable to best reduce cognitive load on clinicians while in a high-acuity, low-frequency situation. We suggest the following mnemonic to aid in learning and retention of the key procedural steps: FINGER (Find landmarks; Inject lidocaine/pain medicine; No infection allowed; Generous incision; Enter pleural space; Reach in with finger, sweep, reassess). This teaching aid may help develop and maintain competence in the simple thoracostomy procedure, leading to successful treatment of both a tension pneumothorax and hemothorax. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Automated Tumor Segmentation in Radiotherapy.

Author

Savjani, Ricky R., Lauria, Michael, Bose, Supratik, Deng, Jie, Yuan, Ye, and Andrearczyk, Vincent

Abstract

Autosegmentation of gross tumor volumes holds promise to decrease clinical demand and to provide consistency across clinicians and institutions for radiation treatment planning. Additionally, autosegmentation can enable imaging analyses such as radiomics to construct and deploy large studies with thousands of patients. Here, we review modern results that utilize deep learning approaches to segment tumors in 5 major clinical sites: brain, head and neck, thorax, abdomen, and pelvis. We focus on approaches that inch closer to clinical adoption, highlighting winning entries in international competitions, unique network architectures, and novel ways of overcoming specific challenges. We also broadly discuss the future of gross tumor volumes autosegmentation and the remaining barriers that must be overcome before widespread replacement or augmentation of manual contouring. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Impact of Ischemia Duration on Lower Limb Salvage in Combat Casualties.

Author

Perkins, Zane B., Kersey, Alexander J., White, Joseph M., Lauria, Alexis L., Propper, Brandon W., Tai, Nigel R.M., and Rasmussen, Todd E.

Abstract

Introduction: The 6-hour threshold to revascularization of an ischemic limb is ubiquitous in the trauma literature, however, contemporary evidence suggests that this threshold should be less. This study aims to characterize the relationship between the duration of limb ischemia and successful limb salvage following lower extremity arterial trauma. Methods: This is a cohort study of the United States and UK military service members injured while serving in Iraq or Afghanistan between 2003 and 2013. Consecutive patients who sustained iliac, femoral, or popliteal artery injuries, and underwent surgery to attempt revascularization, were included. The association between limb outcome and the duration of limb ischemia was assessed using the Kaplan-Meier method. Results: One hundred twenty-two patients (129 limbs) who sustained iliac (2.3%), femoral (56.6%), and popliteal (41.1%) arterial injuries were included. Overall, 87 limbs (67.4%) were successfully salvaged. The probability of limb salvage was 86.0% when ischemia was ≤1 hour; 68.3% when between 1 and 3 hours; 56.3% when between 3 and 6 hours; and 6.7% when >6 hours (P <0.0001). Shock more than doubled the risk of failed limb salvage [hazard ratio=2.42 (95% confidence interval: 1.27–4.62)]. Conclusions: Limb salvage is critically dependent on the duration of ischemia with a 10% reduction in the probability of successful limb salvage for every hour delay to revascularization. The presence of shock significantly worsens this relationship. Military trauma systems should prioritize rapid hemorrhage control and early limb revascularization within 1 hour of injury. [ABSTRACT FROM AUTHOR]

Published
2022
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50. D.1 Efficacy, safety, and tolerability of subcutaneous efgartigimod in chronic inflammatory demyelinating polyneuropathy: results from the ADHERE trial

Author

Siddiqi, Z, Allen, JA, Basta, I, Eggers, C, Guptill, J, Gwathmey, K, Hewamadduma, C, Hofman, E, Hussain, Y, Kuwabara, S, Leypoldt, F, Lin, J, Lipowska, M, Lowe, M, Lauria Pinter, G, Querol, L, Suresh, N, Chang, T, Tse, A, Ulrichts, P, van Doorn, PA, Van Hoorick, B, Yamasaki, R, and Lewis, RA

Abstract

Background: Efgartigimod, a human immunoglobulin G (IgG)1 antibody Fc fragment, blocks the neonatal Fc receptor, decreasing IgG recycling and reducing pathogenic IgG autoantibody levels. ADHERE assessed the efficacy and safety of efgartigimod PH20 subcutaneous (SC; co-formulated with recombinant human hyaluronidase PH20) in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: ADHERE enrolled participants with CIDP (treatment naive or on standard treatments withdrawn during run-in period) and consisted of open-label Stage A (efgartigimod PH20 SC once weekly [QW]), and randomized (1:1) Stage B (efgartigimod or placebo QW). Primary outcomes were clinical improvement (assessed with aINCAT, I-RODS, or mean grip strength; Stage A) and time to first aINCAT score deterioration (relapse; Stage B). Secondary outcomes included treatment-emergent adverse events (TEAEs) incidence. Results: 322 participants entered Stage A. 214 (66.5%) were considered responders, randomized, and treated in Stage B. Efgartigimod significantly reduced the risk of relapse (HR: 0.394; 95% CI: 0.25–0.61) versus placebo (p=0.000039). Reduced risk of relapse occurred in participants receiving corticosteroids, intravenous or SC immunoglobulin, or no treatment before study entry. Most TEAEs were mild to moderate; 3 deaths occurred, none related to efgartigimod. Conclusions: Participants treated with efgartigimod PH20 SC maintained a clinical response and remained relapse-free longer than those treated with placebo.

Published
2024
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