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Construction with cementitious materials via 3D printing requires a highly thixotropic behavior, which is a challenge for construction industry. In this work a facile and low-cost gelatin-modified thermal responsive smart cement paste formulation was developed for extrusion-based 3D printing in cold environments The paste's temperature-dependent rheological properties were characterised, and the underlying mechanism was explored. At room temperature, the modified paste presents similar rheological properties as the reference cement paste. After resting for 10 min at 5 °C, the modified cement paste has a yield stress of 1900 Pa which is 10 times that of the reference paste. Moreover, the mechanical properties of the modified paste are comparable to or higher than that of the reference paste at later age. Our approach may inspire a facile manipulation of paste rheology through temperature, which facilitates smartly controlled 3D concrete printings.

Fish-inspired motion is an important research area with many applications in real-world tasks such as underwater vehicles or robotic fish control design. Owing to robust, smooth, and coordinated oscillatory signals generated by Central Pattern Generators (CPGs) for locomotion control of robots with multiple degrees of freedom, CPGs are the most versatile solution for robotic control systems, especially in robotic fish. However, tuning central pattern generator parameters is difficult for complex mechanical system designs. Besides, most current CPG-based methods only consider one aspect (e.g., speed), which widens the gap between theory and practice in robotic fish design. Also, it may affect the practical applicability of the designed motion model to a certain extent. This paper addresses this problem by constructing a multi-objective evolutionary design of a central pattern generator network to control the proposed biomimetic robotic fish. A new CPG model is proposed to help biomimetic robotic fish swim efficiently. In addition, an efficient multi-objective evolutionary algorithm proposed in our previous work is also applied to assist the biomimetic robotic fish in obtaining faster-swimming speed, good stability of the head, and higher propulsive efficiency simultaneously. Considering that the result of multi-objective optimization is a set of non-dominated solutions rather than a solution, a screening method based on fuzzy theory is adopted to assist decision-makers in selecting the most appropriate solution. Based on this, the control model of biomimetic robotic fish is constructed. The proposed control model is simulated and compared with seven well-known algorithms and a series of robotic fish designs. After that, the proposed control model is validated with extensive experiments on the actual biomimetic robotic fish. Simulations and experiments demonstrate the proposed control model’s effectiveness and good performance, especially when the control model has been applied to the real biomimetic robotic fish.

In January 2016, a piece of news spread widely across the media—a man injected HIV three months after his marriage because the Premarital Medical Examination Organization had not informed him that his wife was suspected of having AIDS. The organization said that unauthorized disclosure would violate the privacy rights of the parties. As the primary institution that knows the inspection results, when the results are abnormal, and the parties do not voluntarily fulfill the obligation of informing stipulated in Article 1053 of the Civil Code of the People’s Republic of China, in order to balance the right to privacy and the right to know of the parties in such incidents, should the law add the corresponding obligation of informing? This paper refers to the classification of premarital medical examination in the Maternal and Infant Health Care Law and centers on Article 1053 of the Civil Code. It is suggested that a dual informing system should be established to combine personal and premarital medical examination organization. Plus, this paper presents that the formulation of infectious disease requirements that may infringe on the life and health of the other party and even the public interest should be compulsorily informed by the premarital medical examination organizations, and the secondary information should be advised by the doctor to inform the parties to do it voluntarily.

It has been reported that LXR agonist can inhibit Aβ generation and alleviate Aβ-induced various adverse reactions in vivo and in vitro experiments, but the mechanisms have not been clarified. The study aimed to observe the effect of LXR agonist TO901317 on the cognitive function of AD transgenic mice fed with cholesterol-rich diet (CRD), and to explore the possible mechanism. Methods: 32 male 6-month-old double transgenic AD mice were enrolled and randomly divided into 4 groups: control (normal diet) group, CRD treatment group, TO901317 treatment group and GSK2033 treatment group. After 3 month, Morris water maze was for the changes of spatial exploration and memory ability; ELISA was for detecting the production of Aβ42 in the brain; the concentration of total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) in serum were detected by cholesterol enzyme colorimetry; Finally, the expression of LXR-β, RXR-α, ABCA1, caveolin-1, BACE1 and APP at protein level in the brains was measured by Western blotting.Compared with the control group, the learning, memory ability and spatial exploration ability of the mice were more significantly serious in the CRD group (P0.05); The contents of TC and LDL in the serum and the production of Aβ42 in the brains were significantly increased (P0.05), but HDL was remarkably decreased (P0.05); The protein levels of LXR-β, RXR-α and ABCA1 were also significantly decreased (P0.05); The expression of caveolin-1, APP and BACE1 were evidently increased (P0.05). However, after treatment with TO901317, the impaired learning and memory and spatial exploration ability of the mice were significantly improved (P0.05); The contents of TC and LDL in serum and the production of Aβ42 in the brains were significantly decreased (P0.05), but HLD was increased (P0.05); The protein levels of LXR-β, RXR-α, ABCA1were all significantly increased (P0.05), while, the expression of caveolin-1, APP and BACE1 were all significantly decreased (P0.05). All the changes were reversed by GSK2033 (P0.05).TO901317 attenuated the more serious impairment of spatial exploration, learning and memory in transgenic AD mice induced by CRD, and the mechanism may be that TO901317 could activate the LXR-β/RXR-α/ABCA1 transmembrane transport system, promote the cholesterol efflux, and decreased caveolin-1, APP and BACE1, further reduce Aβ42 in the brains.

Background Higher vocational college students face more life stress, which can easily result in depression and hinder their healthy growth. This study aimed to explore the roles of survival situation and personality temperament in the relationship between life stress and depression. Methods A self-compiled "College Students' Life Stress and Mental Health Questionnaire" was used to survey 4800 students in a Chinese higher vocational college. The questionnaire consisted of five subscales: life stressors scale, stress response scale, depression scale, personality temperament types scale, and survival situations scale. The sample included 4705 students, of whom 3449 (73.30%) were males and 1256 (26.70%) were females, with 990 urban students (21.04%), 3715 rural students (78.96%). The age of the participants ranged from 17 to 33 years. The data were analyzed using SPSS v26, PROCESS v3.3, and AMOS v23. Results (1) The depression rate of higher vocational students was 18.10% (with a severe depression rate of 1.60%). Life stress could explain 43.80% of depressive episodes (p p Conclusion Prosperity and sanguine temperament are protective factors of depression caused by life stress in higher vocational students. Dilemma, adversity and melancholic temperament are risk factors of depression caused by life stress in higher vocational students.

BackgroundExcision repair cross-complementing group 1 (ERCC1) was considered a potential candidate gene for ischemic stroke, and its polymorphisms might be associated with the susceptibility to ischemic stroke.MethodsA total of 513 patients with ischemic stroke and 550 control subjects were recruited. The expression levels of ERCC1 messenger RNA (mRNA) in peripheral blood mononuclear cells and its protein in plasma were detected by quantitative real-time PCR (qPCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Rs3212986 polymorphism of ERCC1 was detected by PCR-restriction fragment length polymorphism (RFLP-PCR) and was confirmed by sequencing. The association between the ERCC1 rs3212986 polymorphism or its expression and ischemic stroke was further analyzed.ResultsThe ERCC1 mRNA level in patients with ischemic stroke was lower than that in the control group (P < 0.05). However, the ERCC1 protein level in patients with ischemic stroke was higher than that in the control group (P < 0.05). The A allele of rs3212986 was associated with increased ischemic stroke risk (OR = 1.287, 95% CI = 1.076–1.540, P = 0.006). The association between rs3212986 polymorphism and ischemic stroke susceptibility was found in both recessive (OR = 2.638, 95% CI = 1.744–3.989, P < 0.001) and additive models (OR = 1.309, 95% CI = 1.028–1.667, P = 0.031), respectively. Similar results were obtained in the recessive model (OR = 2.015, 95% CI = 1.087–3.704, P = 0.026) after adjusting for demographic information and other variables. Additionally, the level of ERCC1 mRNA in the CC/CA genotype was higher than that in the AA genotype (P < 0.05).ConclusionIt was suggested that the ERCC1 rs3212986 polymorphism was associated with ischemic stroke susceptibility in a Chinese Han population and that an A allele of rs3212986 was related to increased ischemic stroke risk. The altered ERCC1 expression level caused by the rs3212986 polymorphism might participate in the pathophysiological process of ischemic stroke.

Although equity is one of the core aims of the Institute of Medicine’s (IOM) measurement of health care quality, it has not received as much attention due to its novelty and complexity. However, a high-quality healthcare system cannot allow everyone to reach their full health potential without achieving equity. Providing more equity-oriented care increases patients’ confidence in preventing and managing their health problems, leading to increased quality of life, decreased chronic pain disability, and improved mental health.

Long COVID hinders people from normal life and work, posing significant medical and economic challenges. Nevertheless, comprehensive studies assessing its impact on large populations in Asia are still lacking. We tracked over 20,000 patients infected with COVID-19 for the first time during the Omicron BA.2 outbreak in Shanghai from March-June 2022 for one year. Of the 21,799 COVID-19 patients who participated in the 6-month telephone follow-up, 1939 (8.89%) had self-reported long COVID symptoms. 450 long COVID patients participated in the 6-month outpatient follow-up. Participants underwent healthy physical examinations and questionnaires focused on long-COVID-related symptoms and mental health. Mobility problem (P < 0.001), personal care problem (P = 0.003), usual activity problem (P < 0.001), pain/discomfort (P < 0.001), anxiety/depression (P = 0.001) and PTSD (P = 0.001) were more prevalent in long COVID patients than in healthy individuals, but no significant differences were found between the two groups on chest CT and laboratory examinations. Of the 856 long COVID patients who participated in the 12-month follow-up, 587 (68.5%) had their symptoms resolved. In the multivariable logistic analysis, females (P < 0.001), youth (age P < 0.001), ≥ 2 comorbidities (P = 0.009), and severe infection in the acute phase (P = 0.006) were risk factors for developing long COVID. Middle age (40–60 years) was a risk factor for persistent long COVID one year after hospital discharge (P = 0.013). The study found that long COVID mainly manifested as subjective symptoms and impacts partial patients’ quality of life and mental status. After one year, most (68.5%) of the patients recovered from long COVID with no impairment of organ function observed.

Stable stimulus-responsive materials are highly desirable due to their widespread potential applications and growing demand in recent decades. Despite the fact that viologen derivatives have long been known as excellent photochromic and electrochromic materials, the development of stable viologen-based multifunctional smart materials with short coloration times remains an exciting topic. To obtain photochromic and electrochromic dual responsive materials, embedding the viologen ligand into a robust metal oxide cluster to increase its stability and sensitivity is an effective strategy. Herein, a viologen-based metal-organic polyhedron (MOP) {[Zr

Layup temperature is a vital factor that affects the production quality of automated fiber placement for thermoset composites. For high quality production, this paper proposes a new prediction model of layup temperature by considering the structure of infrared heater of automatic fiber placement equipment. The model was first verified by comparing with the temperature results of layup experiments. Then a prediction on the effects of heater structure arrangement on layup temperature was conducted in the model. The research shows that the length of infrared tube and the radian of reflective-film have significant influences, rather than other parameters. According to this investigation, a heater structure-based heating strategy was presented in the paper to efficiently achieve constant temperature control in variable speed layup process.

We report a method for the synthesis of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This reacts with various nucleophiles to give SCD3 analogues with high deuterium levels (>99% D).

We advocate triplet–triplet annihilation upconverters as candidates for blue FuLEDs (OLEDs enhanced by triplet-fusion), demonstrating here with the sky-blue DPBF. Its TTA or triplet-fusion behaviour is explored in both solutions and FuLED devices.

A versatile organocatalytic atroposelective N-alkylation has been developed to access axially chiral sulfonamides bearing an allene and allyl entity, and biaryl amino phenols with high efficiency.

The probe displays a fast response time (< 2 s), high sensitivity and high selectivity for HOCl.

[ES] Durante los últimos años, la transformación digital se ha convertido en un proceso vital en el ámbito empresarial, y para llevar acabo esta tarea de la manera más efectiva, surgieron los CRM (Gestión de la Relación con el Cliente), y en concreto, Salesforce es una de las soluciones más destacadas en el mercado actual. Salesforce tiene un abanico de funciones que podemos customizar para sacar el máximo rendimiento en cuando a la gestión de ventas y servicios dentro de una compañía. Cabe destacar que este tipo de servicios están basados en Cloud Computing, computación en la nube, característica que los hace escalable y flexible, dado que solo necesitan la conexión a Internet para el acceso. Por ello, este trabajo se basa en la implementación de Salesforce para la gestión de una empresa de distribución, dicha aplicación contendrá todos los datos relacionados a la administración de la empresa, servicios ofrecidos y oportunidades potenciales., [EN] In recent years, digital transformation has become a vital process in the business environment, and to carry out this task in the most effective way, CRM (Customer Relationship Management) emerged, and specifically, Salesforce it is one of the most outstanding solutions in the current market. Salesforce has a range of functions that we can customize to get the most out of sales and service management within a company. It should be noted that these types of services are based on Cloud Computing, a characteristic that makes them scalable and flexible, since they only need an Internet connection for access. For this reason, this work is based on the implementation of Salesforce for the management of a distribution company, said application will contain all the data related to the administration of the company, services offered and potential opportunities.

Hexagonal boron nitride (hBN) is a remarkable two-dimensional (2D) material that hosts solid-state spins and has great potential to be used in quantum information applications, including quantum networks. However, in this application, both the optical and spin properties are crucial for single spins but have not yet been discovered simultaneously for hBN spins. Here, we realize an efficient method for arraying and isolating the single defects of hBN and use this method to discover a new spin defect with a high probability of 85%. This single defect exhibits outstanding optical properties and an optically controllable spin, as indicated by the observed significant Rabi oscillation and Hahn echo experiments at room temperature. First principles calculations indicate that complexes of carbon and oxygen dopants may be the origin of the single spin defects. This provides a possibility for further addressing spins that can be optically controlled., 10 pages, 5 figures

AIM: To evaluate the role of internal limiting membrane (ILM) peeling in preventing secondary epiretinal membrane (ERM) formation in pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR). METHODS: This retrospective study analyzed the medical records of patients who underwent PPV for PDR and were followed up for minimum 3mo. ILM peeling was performed based on the intraoperative surgeons' judgments. ERM was assessed by optical coherence tomography photography. The relationship between ILM peeling and postoperative ERM was analyzed. RESULTS: In total, 212 eyes from 197 patients were included in this study. The incidence of secondary ERM in the ILM non-peeling group was significantly higher than that in the ILM peeling group (37.0% vs 14.0%; P

The propagation characteristics of odd and even Laguerre Gaussian beams in nonlocal nonlinear media are studied numerically. It is found that the Laguerre Gaussian beams of mode (0,1) can propagate stably long distances as soliton. The beams of other modes are unstable and break up rapidly during the propagation. Although the waveforms of other modes distort and the beams may evolve into chaotic state, the broken beams of some modes will form chaoticons. Espesially, the chaoticons which exhibit solitonlike properties can propagate longer distances. The positive maximal Lyapunov exponents and spatial decoherence illustrate the chaotic properties, while the invariance of beam width and beam profile proves that they are chaoticons.

Among the various kinds of spin defects in hBN, the negatively charged boron vacancy ($\rm V_B^-$) spin defect that can be deterministically generated is undoubtedly a potential candidate for quantum sensing, but its low quantum efficiency restricts its %use in practical applications. Here, we demonstrate a robust enhancement structure with advantages including easy on-chip integration, convenient processing, low cost and suitable broad-spectrum enhancement for $\rm V_B^-$ defects. %Improved photoluminescence (PL) intensity and optically detected magnetic resonance (ODMR) contrast of $\rm V_B^-$ defect arrays. In the experiment, we used a metal reflective layer under the hBN flakes, filled with a transition dielectric layer in the middle, and adjusted the thickness of the dielectric layer to achieve the best coupling between the reflective dielectric cavity and the hBN spin defect. Using a reflective dielectric cavity, we achieved a PL enhancement of approximately 7-fold, and the corresponding ODMR contrast achieved 18\%. Additionally, the oxide layer of the reflective dielectric cavity can be used as an integrated material for micro-nano photonic devices for secondary processing, which means that it can be combined with other enhancement structures to achieve stronger enhancement. This work has guiding significance for realizing the on-chip integration of spin defects in two-dimensional materials.

Two-dimensional (2D) ferromagnets with out-of-plane (OOP) magnetic anisotropy are potential candidates for realizing the next-generation memory devices with ultra-low power consumption and high storage density. However, a scalable approach to synthesize 2D magnets with OOP anisotropy directly on the complimentary metal-oxide semiconductor (CMOS) compatible substrates has not yet been mainly explored, which hinders the practical application of 2D magnets. This work demonstrates a cascaded space confined chemical vapor deposition (CS-CVD) technique to synthesize 2D FexGeTe2 ferromagnets. The weight fraction of iron (Fe) in the precursor controls the phase purity of the as-grown FexGeTe2. As a result, high-quality Fe3GeTe2 and Fe5GeTe2 flakes have been grown selectively using the CS-CVD technique. Curie temperature (TC) of the as-grown FexGeTe2 can be up to ∼ 280 K, nearly room temperature. The thickness and temperature-dependent magnetic studies on the Fe5GeTe2 reveal a 2D Ising to 3D XY behavior. Also, Terahertz spectroscopy experiments on Fe5GeTe2 display the highest conductivity among other FexGeTe2 2D magnets. The results of this work indicate a scalable pathway for the direct growth and integration of 2D ternary magnets on CMOS-based substrates to develop spintronic memory devices.

Propagation of ultrasonic wave in Carbon Fiber Reinforced Polymer (CFRP) is greatly influenced by the material’s matrix, resins and fiber volume ratio. Laser ultrasonic broadband spectral technique has been demonstrated for porosity and fiber volume ratio extraction on unidirection aligned CFRP laminates. Porosity in the matrix materials can be calculated by longitudinal wave attenuation and accurate fiber volume ratio can be derived by combined velocity through the high strength carbon fiber and the matrix material with further consideration of porosity effects. The results have been benchmarked by pulse-echo ultrasonic tests, gas pycnometer and thermal gravimetric analysis (TGA). The potentials and advantages of the laser ultrasonic technique as a non-destructive evaluation method for CFRP carbon fiber volume fraction evaluation were demonstrated.

A high-speed (HS) permanent magnet (PM) synchronous motor (HSPMSM) with a carbon fiber-reinforced plastic (CFRP) protective sleeve in the surface-mounted rotor was explored in this study. In view of retaining the PMs at HS operations, the high-strength CFRP sleeve was designed on the basis of a process that could be summarized as follows. First, a multi-physics analysis of the rotor was conducted. The requirements to the CFRP sleeve were obtained from electromagnetic analysis, loss analysis, heat flow coupling computational fluid dynamics analysis, structural analysis, and rotor dynamics analysis. Second, the CFRP sleeve was designed by theoretical analysis. From the results, the thickness values of the carbon fibers in the circumferential and helical directions were chosen to be 4 and 1 mm, respectively, while the helical angle of carbon fibers was chosen to be 70°. Then, a plate-shaped CFRP product and a cylindrical CFRP product were fabricated to verify the strength and stiffness of the CFRP sleeve. The performance test results show that the hoop strength and elastic modulus and the axial strength and elastic modulus of the plate-shaped CFRP products at 20 °C are 1963 MPa @ 156 GPa and 550 MPa @ 36 GPa, respectively. The hoop strain and axial strain of the cylindrical CFRP product under 35 MPa are about 3000 and 1900 μe, which meet the design requirements of the HSPMSM.

Antibiotics are a kind of chief contaminants in water, which have severe effects on the environment and mortal health. The achievement of easy and promising methods for antibiotic sensing is vastly desirable but still challenging. Fast, facile, and dependable recognition of these hazardous antibiotic contaminants by luminescent probes have importance in environmental safety. Herein, we synthesized a highly luminescent cadmium-based MOF [Cd(BPDC)(BP4VA)·2DMF]n (1) using 9,10-bis((E)-2-(pyridin-4-yl)vinyl)anthracene (BP4VA) and biphenyl-4,4′-dicarboxylic acid (H2BPDC) as ligands. The as-prepared compound is highly stable in water within a wide range of pH (2–12). The attained LOD values up to μM level shows higher selectivity towards antibiotics. 1 exhibits attractive detection sensitivity (Ksv = 106 M−1) towards selected antibiotics among earlier reported MOF-based luminescent probes.

The Golgi apparatus (GA) is a vital organelle in biological systems and excess reactive oxygen species (ROS) is produced during stress in the Golgi apparatus. Hypochlorous acid (HOCl) is a significant reactive oxygen species and has strong oxidative and antibacterial activity, but excessive secretion of hypochlorous acid can affect Golgi structure or function abnormally, it will lead to a series of diseases including Alzheimer's disease, neurodegenerative diseases, autoimmune diseases, and Parkinson's disease. In present work, a novel fluorescent probe for Golgi localization utilizing naphthalimide derivatives was constructed to detect hypochlorous acid. The fluorescent probe used a derivatived 1,8-naphthalimide as the emitting fluorescence group, phenylsulfonamide as the localization group and dimethylthiocarbamate as the sensing unit. When HOCl was absent, the intramolecular charge transfer (ICT) process of the developed probe was hindered and the probe exhibited a weak fluorescence. When HOCl was present, the ICT process occurred and the probe showed strong green fluorescence. When the HOCl concentration was altered from 5.0 × 10

A robust fiber sensor for salinity measurement based on encapsulated long-period grating in microfiber is proposed. The long-period grating is fabricated in microfiber by inducing periodical deformation with CO2 laser, which is then encapsulated in a holey capillary tube. The encapsulation tube is designed to effectively protect the microfiber from external interference, but does not change the optical properties of the fiber and the response speed of the sensor, which makes the sensor more robust for real applications. Experimental results show that the sensor can achieve a sensitivity of 2.16 nm/% with a good linearity for concentration from 0% to 20%. It is theoretically proved that the sensitivity can be further improved by optimizing the diameter parameters. Such structure may be used as low loss evanescent-wave-coupled optical absorption, fluorescent and gain cells, photoacoustic cells, and etc.

Social media play increasingly important roles in changing young people’s learning styles. The most significant implication for moral and citizenship education would be that young people nowadays are employing social media for cybercivic participation and learning, constructing to both online and offline communities. This paper, based on a virtual ethnographic study, examines how Chinese university students participate in civic discussions and activities by the use of online forums and social network sites. It further explores youth capabilities of learning to be responsible, reciprocal, and reflective citizens. The paper presents three potential learning paradigms, namely dutiful, actualising, and reflective cybercivic learning, and argues that each paradigm has its advantages and limitations in developing moral and civic knowledge, values, and skills. To integrate three learning paradigms into the institutional education system would be an innovation of moral and citizenship education in the age of social media.

In the age of digital media, to understand ‘digital youth’ becomes a task of growing importance for academics and educators. This current issue of Beijing International Review of Education (bire) brings together contributions from a group of international scholars to discuss the usage of mobile phones, computers, iPads and the Internet among young people in their daily life, which suggests possible directions to improve education for the younger generation. Based on a review of relevant literature and collected papers of the special issue, this introduction shares some of our responses to the questions referring to the digital changes of young people’s identities, cultures, lifestyles, learning patterns, ways of socialisation and public engagement. It argues that future education innovation must pay attention to a spatiotemporal and sociocultural complexity of young people’s living, learning and literacy in the digital age, which needs a new philosophy of education for the digital youth.

Analyze the clinical and genetic characteristics of a rare Chinese family with Multiple synostoses syndrome and identify the causative variant with the high-throughput sequencing approach.The medical history investigation, physical examination, imaging examination, and audiological examination of the family members were performed. DNA samples were extracted from the family members. The candidate variant was identified by performing whole-exome sequencing of the proband, then verified by Sanger sequencing in the family.The family named HBSY-018 from Hubei province had 18 subjects in three generations, and six subjects were diagnosed with conductive or mixed hearing loss. Meanwhile, characteristic features including short philtrum, hemicylindrical nose, and hypoplastic alae nasi were noticed among those patients. Symptoms of proximal interdigital joint adhesion and inflexibility were found. The family was diagnosed as Multiple synostoses syndrome type 1 (SYNS1).The inheritance pattern of this family was autosomal dominant. A novel mutation in the NOG gene c.533GA was identified by performing whole-exome sequencing of the proband. The substitution of cysteine encoding 178th position with tyrosine (p.Cys178Tyr) was caused by this mutation, which was conserved across species. Co-segregation of disease phenotypes was demonstrated by the family verification.The family diagnosed as SYNS1 was caused by the novel mutation (c.533GA) of NOG. The combination of clinical diagnosis and molecular diagnosis had improved the understanding of this rare disease and provided a scientific basis for genetic counseling in the family.

Terahertz (THz) spectroscopy technique has been applied in ex vivo biomechanical properties analysis of human corneas. Upon the application of light pressure on the cornea, the photo elastic birefringent effect, anisotropic deformation, thickness changes and hydration levels will contribute to the sudden phase changes of terahertz time domain signal. The shelf lifetime study shows that the phase shift is reduced and cornea loose the biomechanical properties with the increase of hydration level. Mechanical behaviors have been further studied based on the “fresh” cut corneas with the similar hydration levels. THz signal was collected by focusing inside of the cornea to avoid the phase shift due to light stress caused movement of the corneal surface. By this way, the amount of THz signal refractive index variation is correlated to the elastic property of the corneas. The correlation between the THz signal phase shift and refractive index shift due to the corneal strain can be used to derive the elastic Young’s modulus. Our results demonstrated the THz spectroscopy, as a non-contact and non-invasive detection method, could be potential for understanding the mechanism of corneal deformation under the action of intraocular pressure in the physiological environment in future.

Weight sharing based and predictor based methods are two major types of fast neural architecture search methods. In this paper, we propose to jointly use weight sharing and predictor in a unified framework. First, we construct a SuperNet in a weight-sharing way and probabilisticly sample architectures from the SuperNet. To increase the correctness of the evaluation of architectures, besides direct evaluation using the inherited weights, we further apply a few-shot predictor to assess the architecture on the other hand. The final evaluation of the architecture is the combination of direct evaluation, the prediction from the predictor and the cost of the architecture. We regard the evaluation as a reward and apply a self-critical policy gradient approach to update the architecture probabilities. To further reduce the side effects of weight sharing, we propose a weakly weight sharing method by introducing another HyperNet. We conduct experiments on datasets including CIFAR-10, CIFAR-100 and ImageNet under NATS-Bench, DARTS and MobileNet search space. The proposed WPNAS method achieves state-of-the-art performance on these datasets.

We have established a practical and concise method for the straightforward access of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This odourless electrophilic SCD

Optically addressable spins in two-dimensional hexagonal boron nitride (hBN) attract widespread attention for their potential advantage in on-chip quantum devices, such as quantum sensors and quantum network. A variety of spin defects have been found in hBN, but no convenient and deterministic generation methods have been reported for other defects except negatively charged boron vacancy ($V_B^-$). Here we report that by using femtosecond laser direct writing technology, we can deterministically create spin defect ensembles with spectra range from 550 nm to 800 nm on nanoscale hBN flakes. Positive single-peak optically detected magnetic resonance (ODMR) signals are detected in the presence of magnetic field perpendicular to the substrate, and the contrast can reach 0.8%. With the appropriate thickness of hBN flakes, substrate and femtosecond laser pulse energy, we can deterministically and efficiently generate bright spin defect array. Our results provide a convenient deterministic method to create spin defects in hBN, which will motivate more endeavors for future researches and applications of spin-based technologies such as quantum magnetometer array.

[ES] Durante los últimos años, la transformación digital se ha convertido en un proceso vital en el ámbito empresarial, y para llevar acabo esta tarea de la manera más efectiva, surgieron los CRM (Gestión de la Relación con el Cliente), y en concreto, Salesforce es una de las soluciones más destacadas en el mercado actual. Salesforce tiene un abanico de funciones que podemos customizar para sacar el máximo rendimiento en cuando a la gestión de ventas y servicios dentro de una compañía. Cabe destacar que este tipo de servicios están basados en Cloud Computing, computación en la nube, característica que los hace escalable y flexible, dado que solo necesitan la conexión a Internet para el acceso. Por ello, este trabajo se basa en la implementación de Salesforce para la gestión de una empresa de distribución, dicha aplicación contendrá todos los datos relacionados a la administración de la empresa, servicios ofrecidos y oportunidades potenciales. [EN] In recent years, digital transformation has become a vital process in the business environment, and to carry out this task in the most effective way, CRM (Customer Relationship Management) emerged, and specifically, Salesforce it is one of the most outstanding solutions in the current market. Salesforce has a range of functions that we can customize to get the most out of sales and service management within a company. It should be noted that these types of services are based on Cloud Computing, a characteristic that makes them scalable and flexible, since they only need an Internet connection for access. For this reason, this work is based on the implementation of Salesforce for the management of a distribution company, said application will contain all the data related to the administration of the company, services offered and potential opportunities.

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and serious disorder among children. Video games have shown potential for aiding in child healthcare. Video games could contribute to the assessment and management of ADHD, but there are no previous reviews on this topic. Here, we systematically review the evidence about video game-based assessment tools and interventions for children diagnosed with ADHD. This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The review protocol was registered in PROSPERO database. We searched four databases-PubMed, PsycInfo, Embase and clinicaltrials.gov-to identify original studies exploring either video game-based interventions or video game-based assessment tools in children with ADHD. After initial screening, full text revision and study selection, 22 articles were finally included in the review. Most studies used PC as platform, with a minority using a video console, pad, or 3D device. Video game-based assessment tools were generally effective in discriminating ADHD cases from controls, and in discriminating between ADHD subtypes. Video game-based therapeutic interventions were well accepted and generally effective in improving cognitive areas and decreasing ADHD symptoms. Gamification and cognitive training could be the main mechanisms underlying the usefulness and effectiveness of video game-based assessment tools and interventions. Software optimization and greater collaboration between developers and healthcare professionals are some of the priorities for future research in this area.

Sea-level reconstructions over the past two millennia provide a pre-industrial context to assess whether the magnitude and rate of modern sea-level change is unprecedented. Sea-level records from the Indian Ocean over the past 2,000 years are sparse, while records from the Atlantic and Pacific Oceans show variations less than 0.25 m and no significant negative excursions. Here, we present evidence of two low sea-level phases in the Maldives, Indian Ocean, based on fossil coral microatolls. Microatoll growth is constrained by low water levels and, consequently, they are robust recorders of past sea level. U–Th dating of the Maldivian corals identified lowstands at ad 234–605 and ad 1481–1807 when sea level fell to maximum depths of −0.88 m and −0.89 m respectively. These lowstands are synchronous with reductions in radiative forcing and sea surface temperature associated with the Late Antiquity Little Ice Age and the Little Ice Age. Our results provide high-fidelity observations of lower sea levels during these cool periods and show rates of change of up to 4.24 mm yr−1. Our data also confirm the acceleration of relative sea-level rise over the past two centuries and suggest that the current magnitude and rate of sea-level rise is not unprecedented. National Research Foundation (NRF) Accepted version We thank LaMer Group and the Small Island Research Centre, Fares-Maathodaa, Huvadhoo atoll for logistical support, Government of the Maldives for research permission and A. Vila-Concejo, E. Beetham and T. Turner for field assistance. X.W. acknowledges funding support from the National Research Foundation of Singapore (grant nos. NRF2017NRF-NSFC001-047 and NRF-NRFF2011-08) and the Earth Observatory of Singapore.

Background Timely and precise etiology diagnosis is crucial for optimized medication regimens and better prognosis in central nervous system infections (CNS infections). We aimed to analyze the impact of mNGS tests on the management of patients with CNS infections. Methods We conducted a single-center retrospective cohort study to analyze the value of mNGS in clinical application. Three hundred sixty-nine patients with a specific CNS infection diagnosis were enrolled, and their clinical data were collected. CDI and DDI were defined in our study to describe the intensity of drug use in different groups. We also used LOH and mRS to evaluate whether the application of mNGS could benefit CNS infection patients. Results mNGS reported a 91.67% sensitivity in culture-positive patients and an 88.24% specificity compared with the final diagnoses. Patients performed with the mNGS test had less drug use, both total (58.77 vs. 81.18) and daily (22.6 vs. 28.12, p

Being able to see into walls is crucial for diagnostics of building health; it enables inspections of wall structure without undermining the structural integrity. However, existing sensing devices do not seem to offer a full capability in mapping the in-wall structure while identifying their status (e.g., seepage and corrosion). In this paper, we design and implement SiWa as a low-cost and portable system for wall inspections. Built upon a customized IR-UWB radar, SiWa scans a wall as a user swipes its probe along the wall surface; it then analyzes the reflected signals to synthesize an image and also to identify the material status. Although conventional schemes exist to handle these problems individually, they require troublesome calibrations that largely prevent them from practical adoptions. To this end, we equip SiWa with a deep learning pipeline to parse the rich sensory data. With an ingenious construction and innovative training, the deep learning modules perform structural imaging and the subsequent analysis on material status, without the need for parameter tuning and calibrations. We build SiWa as a prototype and evaluate its performance via extensive experiments and field studies; results confirm that SiWa accurately maps in-wall structures, identifies their materials, and detects possible failures, suggesting a promising solution for diagnosing building health with lower effort and cost., 14 pages

Quantum technology grown out of quantum information theory, including quantum communication, quantum computation and quantum sensing, not only provides powerful research tools for numerous fields, but also is expected to go to civilian use in the future. Solid-state spin-active defects are one of promising platforms for quantum technology, and the host materials include three-dimensional diamond and silicon carbide, and the emerging two-dimensional hexagonal boron nitride (hBN) and transition-metal dichalcogenides. In this review, we will focus on the spin defects in hBN, and summarize theoretical and experimental progresses made in understanding properties of these spin defects. In particular, the combination of theoretical prediction and experimental verification is highlighted. We also discuss the future advantages and challenges of solid-state spins in hBN on the path towards quantum information applications.

A Novel scalable approach using Terahertz (THz) waves together with the electromagnetic field simulation was applied to investigate four rabbits of eight rabbit corneas in vivo. One eye of each rabbits' corneas was edema induced; the other eye of the corneas served as the control. The simulation revealed the propagation of THz waves at a certain distance along the sub-surface of the cornea. THz spectra have been collected close to the corneal surface by deviating the direct reflection of the THz beam for the edema cornea, the reflected wave intensity for edema corneas is generally larger compared with the control cornea. Upon edema becomes severe at the end of the observation, the reflected wave intensities obtained by detector corresponding to the corneal deep stroma layer approach to the same value for all observed corneas. Good correlation is observed between central corneal thickness measurements and THz wave reflection signal intensities. Our results demonstrated that THz spectroscopy technique could obtain the information from different corneal sublayers.