Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD3-containing scaffolds

Authors :: Xiao Xiao
Yin-Qiu Huang
Hong-Yu Tian
Jun Bai
Fei Cheng
Xu Wang
Miao-Lin Ke
Fen-Er Chen
Source :: Chemical Communications. 58:3015-3018
Publication Year :: 2022
Publisher :: Royal Society of Chemistry (RSC), 2022.
Abstract: We report a method for the synthesis of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This reacts with various nucleophiles to give SCD3 analogues with high deuterium levels (>99% D).

Subjects :: Materials Chemistry
Metals and Alloys
Ceramics and Composites
General Chemistry
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials

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