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The crush cytology of a pituicytoma is reported. The lesion was resected from a 54-yr-old man with a 7-mo history of headache. The intraoperative crush smears revealed plump spindle cells with elongated, nonwavy nuclei, and moderate, finely granular cytoplasm with distinct cytoplasmic borders. These cells were arranged in cohesive fascicles exhibiting a storiform pattern focally. Cytologically, this lesion can be differentiated from pituitary adenoma, astrocytoma, meningioma, and schwannoma.

The cytologic and histologic features of a rare case of small-cell carcinoma arising in Barrett's esophagus are reported. The patient presented with progressive dysphagia and an endoscopy revealed a distal esophageal mass with luminal constriction. The brushing smears showed small-cell carcinoma and dysplastic glandular epithelium. The concomitant biopsy confirmed the diagnosis of small-cell carcinoma arising in Barrett's esophagus.

The clinicopathologic features of an appendiceal adenocarcinoid that metastasized to the ovary and peritoneum after a 5-year disease-free interval are presented. A review of the literature reveals that appendiceal adenocarcinoid in women has a high frequency (32%) of ovarian metastasis. Among 18 cases with ovarian metastasis, the ovarian metastasis was diagnosed at initial presentation in 13 cases. In the remaining 5 cases the ovarian metastasis developed after disease-free intervals ranging from 6 months to 8 years. In most cases, the ovarian metastasis was the main clinical presentation of the patients. In 5 cases the ovary was the only site of metastasis clinically when metastasis was first diagnosed. There is no known effective treatment for disseminated adenocarcinoid. It is advisable that oophorectomy be included routinely in the initial surgical treatment of appendiceal adenocarcinoid, with the possible exception of the rare pure tubular variant.

An angiomyolipoma arising in the vaginal apex and presenting as a pelvic mass is reported and compared with other reported cases of extrarenal angiomyolipoma. This case appears to be the second case of angiomyolipoma arising in the vaginal wall.

A 54 year old white male died three months after hospitalization for hematemesis and melena due to a duodenal ulcer and two months after the subsequent onset of progressive ascites and edema. At necropsy, lesions characteristic of "lymphomatoid granulomatosis" as delineated by Liebow et al. were found in the liver, retroperitoneal lymph nodes, and mesenteric and retroperitoneal adipose tissue. This case appears to be the first case of "lymphomatoid granulomatosis" confined to the abdomen. This report further broadens the clinical spectrum of the newly delineated "lymphomatoid granulomatosis" and adds another situation to the differential diagnosis of space occupying lesions of the liver.

A case of extragenital malignant mixed müllerian tumor that appeared to represent a second primary tumor in a patient previously treated for disseminated ovarian serous papillary carcinoma is reported and compared with other reported cases of extragenital malignant mixed müllerian tumor.

A 59-year-old woman had carcinosarcoma of the salivary gland. Salivary gland tumors of this type are aggressive and rare. Most patients die of the tumor, but surgical cure has been reported in one case.

The clinicopathologic features of a rare case of hepatic "inflammatory pseudotumor" are described and compared with those of three similar cases reported in the literature. In all four cases symptoms were systemic. The marked reduction in tumor size and the changing cellular composition, from a predominance of fibroblasts to a predominance of histiocytes, confirmed the reactive nature of the lesion in the present case. The etiology is obscure, and the significance of the associated occlusive phlebitis remains to be determined.

A case of biphasic malignant mesothelioma of the tunica vaginalis occurring in a sixty-four-year-old man is described. The tumor metastasized widely and led to the patient's death two and one-half years after diagnosis. Review of the literature revealed 7 cases of malignant mesothelioma of tunica vaginalis. These tumors appeared highly aggressive with early onset of metastasis. Histologically, the tumors may be epithelial, fibrous, or biphasic. In contrast to the benign variants of mesotheliomas, these tumors often show significant nuclear atypia, mitotic activity, and invasion of the epididymis, spermatic cord, lymphatic spaces, or the fibrous tissue of the tunica.

A prostatic tumor is presented that histologically resembles adenomatoid tumor arising in other sites. The intraprostatic location and positive prostatic acid phosphatase immunoperoxidase staining support prostatic epithelial origin of the tumor. This study further confirms the histogenetic heterogeneity of the adenomatoid tumor.

A rare case of primary clear cell carcinoma of the salivary gland is described, and the literature is reviewed. All primary clear cell tumors of the salivary glands are at least low-grade carcinomas. Morphologically, these tumors can be divided into two variants: bimorphic and monomorphic clear cell carcinomas. The bimorphic variant, of which the present case is an example, is morphologically unique and is composed of tubules lined by an inner layer of eosinophilic cells and an outer layer of clear cells. The monomorphic variant is composed of solid nests and cords of clear cells. The clear cells in both variants are nonmucinous and may or may not contain abundant glycogen. The clear cells in one bimorphic tumor showed features of myoepithelial differentiation ultrastructurally, but no such features were found in several cases of monomorphic tumor similarly studied. However, a close histogenetic relationship between these two tumor types is suggested by the occurrence of tumors that contained elements of both.

Multiple genital tract tumors, including bilateral ovarian sex cord tumors with annular tubules, adenoma malignum of the cervix, and bilateral ovarian mucinous tumors, developed in a female patient with Peutz-Jeghers syndrome. Although each of these tumor types has been reported to occur in this syndrome, the present case appears to be the first in which the syndrome was complicated by tumors of all three types.

The clinicopathologic features of two rare cases of nodular fasclitis presenting as parotid tumor are described, and the literature is reviewed. In 1% of the nodular fascilitis cases, the lesion presents as a parotid mass. Pathologists and otolaryngologists should include nodular fasclitis In the differential diagnosis of parotid mesenchymal tumors so that misdiagnoses and the resulting unnecessary surgeries may be avoided.

A 30-year-old man with a 6-month history of flank pain was found to have a large retroperitoneal seminoma. A subsequent ultrasound examination revealed an inhomogeneous echo pattern in the normal-sized right testicle, which on orchiectomy showed extensive intratubular germ cell neoplasia. Level sectioning of the entire testicle revealed no extratubular extension of the tumor cells. The retroperitoneal and testicular lesions could represent double primaries. However, the possibility exists that an apparently intratubular germ cell neoplasm may not actually be an in situ lesion and that the retroperitoneal tumor in our case represents a metastasis from the intratubular germ cell neoplasia of the testicle.

A case of adenomatous polyp of the colon with focal squamous metaplasia is reported. Squamous metaplasia has been described in both neoplastic and non-neoplastic conditions of the colon. However, it has not previously been documented to occur in adenomatous polyp. The histogenesis, possible predisposing factors, and clinical significance of the lesion are discussed.

A patient with Hodgkin's disease associated with low glucocerebrosidase levels in the peripheral leukocytes, and Gaucher's cells in the bone marrow and lymph nodes, is described. After MOPP therapy, complete remission of Hodgkin's disease was accompanied by normalization of the glucocerebrosidase level and disappearance of Gaucher's cells. This observation appears unique when compared with the four cases of combined Hodgkin's and Gaucher's disease reported in earlier literature in which Gaucher's disease remained unchanged after chemotherapy. We conclude that our patient had Hodgkin's disease and acquired Gaucher's cells with diminished glucocerebrosidase levels, rather than a combination of Hodgkin's disease and Gaucher's disease.

A 37-year old man had laryngeal myxoma arising from the lingual surface of the epiglottis. Laryngeal myxoma appears to be rare, as the authors' review of the literature failed to reveal any cases reported in the past two decades.

A case of carcinoma arising in a membranous type of monomorphic adenoma of the parotid gland is reported, and the literature is reviewed. This may represent the first unequivocal case of carcinoma arising in a nonadenolymphomatous and nonsebaceous monomorphic adenoma of the salivary gland.

An intramuscular lipoma of the larynx was diagnosed in a 59-year-old man who had a five-year history of constant and progressive hoarseness. This case appears to be the first reported case of laryngeal intramuscular lipoma.

Benign tracheal tumors are rare but important to recognize early because they are curable. A 70-year-old man had a brief history of asthma-like symptoms. Bronchoscopy showed a mass in the lower trachea. The biopsy specimen was interpreted as a benign spindle cell tumor, defined histologically as leiomyoma. This appears to be the 11th report of tracheal leiomyoma.

A case of multifocal oncocytoma of the kidney is reported. A review of the literature revealed only 2 other cases with multifocal tumors. The occurrence of these multicentric tumors should discourage the attempt of performing partial renal resection as recently advocated by some authors.

The clinicopathologic features of a case of fibroxanthosarcoma of the kidney are reported. This case represents the third reported case in the literature. The nine-year disease-free survival following nephrectomy in this case suggests that this tumor may have a prognosis different from that of the renal cell adenocarcinoma and that reporting of additional cases should be encouraged.

A case of classic (large vessel) polyarteritis nodosa in which the disease was apparently confined in the kidneys is described. The findings in this case support the concept of renal-limited polyarteritis nodosa.

A rare case of coccidioidomycosis involving the epididymis is described and compared with the 12 clinically diagnosed cases reported in the literature. With 1 exception, the disease appeared to be limited to the genital organs and the adjacent tissue. Surgical excision of the involved tissue appeared to be curative. Bilateral epididymal involvement occurred in 4 cases and it was the cause of the treatment failure in 2 of the 3 cases in which the local disease was treated unsuccessfully by surgery. The efficacy of antifungal chemotherapy remains to be determined.