78 results on '"Hisanori Taniguchi"'
Search Results
2. MP36-01 AN ANALYSIS OF THE PSYCHOLOGICAL BOTHER IN MEN WITH PEYRONIE'S DISEASE
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Luis F. Novaes, Lawrence C. Jenkins, Jean E. Terrier, Hisanori Taniguchi, Bruno Nascimento, Sigrid Carlsson, Christian Nelson, Jose M. Flores, and John P. Mulhall
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Urology - Published
- 2023
3. Controversy and consensus on the management of elevated sperm DNA fragmentation in male infertility: a global survey, current guidelines, and expert recommendations
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Ala'a Farkouh, Ashok Agarwal, Taha Abo-Almagd Abdel-Meguid Hamoda, Parviz Kavoussi, Ramadan Saleh, Armand Zini, Mohamed Arafa, Ahmed M Harraz, Murat Gul, Vilvapathy Senguttuvan Karthikeyan, Damayanthi Durairajanayagam, Amarnath Rambhatla, Florence Boitrelle, Eric Chung, Ponco Birowo, Tuncay Toprak, Ramy Abou Ghayda, Rossella Cannarella, Nguyen Ho Vinh Phuoc, Fotios Dimitriadis, Giorgio I Russo, Ioannis Sokolakis, Taymour Mostafa, Konstantinos Makarounis, Imad Ziouziou, Shinnosuke Kuroda, Marion Bendayan, Raneen Sawaid Kaiyal, Andrian Japari 33, Mara Simopoulou 34, Lucia Rocco, Nicolas Garrido 36, Nazim Gherabi 37, Kadir Bocu 38, Oguzhan Kahraman 39, Tan V Le 27 28, Christine Wyns 40, Kelton Tremellen 41, Selcuk Sarikaya 42, Sheena Lewis 43, Donald P Evenson 44, Edmund Ko 45, Aldo E Calogero 25, Fahmi Bahar 46, Marlon Martinez 47, Andrea Crafa 25, Quang Nguyen 48 49, Rafael F Ambar 50 51, Giovanni Colpi 52, Mustafa Emre Bakircioglu 53, Ralf Henkel 54 55, Hussein Kandil 56, Ege Can Serefoglu 57, Abdullah Alarbid 13, Akira Tsujimura 58, Alireza Kheradmand 59, Christina Anagnostopoulou 60, Angelo Marino 61, Aram Adamyan 62, Birute Zilaitiene 63, Cevahir Ozer 39, Edoardo Pescatori 64, Paraskevi Vogiatzi 65, Gian Maria Busetto 66, Giancarlo Balercia 67, Haitham Elbardisi 9 10, Hamed Akhavizadegan 68, Hesamoddin Sajadi 69, Hisanori Taniguchi 70, Hyun Jun Park 71 72, Israel Maldonado Rosas 73, Mohamed Al-Marhoon 74, Mohammad Ali Sadighi Gilani 69, Naif Alhathal 75, Germar-Michael Pinggera 76, Priyank Kothari 77, Nasser Mogharabian 78, Sava Micic 79, Sheryl Homa 80, Sara Darbandi 81 82, Tran Quang Tien Long 83, Wael Zohdy 10, Widi Atmoko 22, Marjan Sabbaghian 69, Wael Ibrahim 84, Ryan P Smith 85, Christopher Chee Kong Ho 86, Jean de la Rosette 87, Ahmed I El-Sakka 88, Mirko Preto 89, Cătălina Zenoaga-Barbăroșie 90, Saad Mohammed Abumelha 91, Aykut Baser 92, Kaan Aydos 93, Liliana Ramirez-Dominguez 73, Vijay Kumar 94, Teng Aik Ong 95, Tiago Cesar Mierzwa 96, Ricky Adriansjah 97, Saleem A Banihani 98, Kasonde Bowa 99, Shinichiro Fukuhara 100, Marcelo Rodriguez Peña 101, Mohamad Moussa 102 103, Umut Çağın Ari 104, Chak-Lam Cho 105, Nicholas N Tadros 106, Muhammet Rasit Ugur 107, Edouard Amar 108, Marco Falcone 109, Frederic Romain Santer 76, Arif Kalkanli 110, Keshab Kumar Karna 111, Kareim Khalafalla 9 112 113, Ranjit B Vishwakarma 114, Federica Finocchi 67, Carlo Giulioni 115, Erman Ceyhan 39, Gökhan Çeker 116, Chadi Yazbeck 117, Osvaldo Rajmil 118, Mehmet Yilmaz 119, Baris Altay 120, Trenton L Barrett 121, Kay Seong Ngoo 122, Shubhadeep Roychoudhury 123, Gianmaria Salvio 67, Haocheng Lin 124, Ates Kadioglu 125, Massimiliano Timpano 109, Tomer Avidor-Reiss 126 127, Lukman Hakim 128, Puneet Sindhwani 128, Giorgio Franco 129, Rajender Singh 130, Filippo Giacone 131, Mikhail Ruzaev 132, Raghavender Kosgi 133, Nikolaos Sofikitis 134, Ayad Palani 135, Gokhan Calik 87, Deniz Kulaksız 136, Davor Jezek 137, Manaf Al Hashmi 138 139, Panagiotis Drakopoulos 140 141, Huda Omran 142, Sofia Leonardi 143, Ciler Celik-Ozenci 144, Nur Dokuzeylül Güngör 145, Jonathan Ramsay 146, Toshiyasu Amano 147, Emrullah Sogutdelen 148, Gede Wirya Kusuma Duarsa 149, Koji Chiba 150, Sunil Jindal 151, Missy Savira 22, Luca Boeri 152, Edson Borges 153, Deepak Gupte 154, Fatih Gokalp 155, Guadalupe Hernández Hebrard 73, Suks Minhas 156, Rupin Shah 114, Global Andrology Forum, Farkouh, Ala'A, Agarwal, Ashok, Abo-Almagd Abdel-Meguid Hamoda, Taha, Kavoussi, Parviz, Saleh, Ramadan, Zini, Armand, Arafa, Mohamed, M Harraz, Ahmed, Gul, Murat, Senguttuvan Karthikeyan, Vilvapathy, Durairajanayagam, Damayanthi, Rambhatla, Amarnath, Boitrelle, Florence, Chung, Eric, Birowo, Ponco, Toprak, Tuncay, Abou Ghayda, Ramy, Cannarella, Rossella, Ho Vinh Phuoc, Nguyen, Dimitriadis, Fotio, I Russo, Giorgio, Sokolakis, Ioanni, Mostafa, Taymour, Makarounis, Konstantino, Ziouziou, Imad, Kuroda, Shinnosuke, Bendayan, Marion, Sawaid Kaiyal, Raneen, Japari 33, Andrian, Simopoulou 34, Mara, Rocco, Lucia, Garrido 36, Nicola, Gherabi 37, Nazim, Bocu 38, Kadir, Kahraman 39, Oguzhan, V Le 27 28, Tan, Wyns 40, Christine, Tremellen 41, Kelton, Sarikaya 42, Selcuk, Lewis 43, Sheena, P Evenson 44, Donald, Ko 45, Edmund, E Calogero 25, Aldo, Bahar 46, Fahmi, Martinez 47, Marlon, Crafa 25, Andrea, Nguyen 48 49, Quang, F Ambar 50 51, Rafael, Colpi 52, Giovanni, Emre Bakircioglu 53, Mustafa, Henkel 54 55, Ralf, Kandil 56, Hussein, Can Serefoglu 57, Ege, Alarbid 13, Abdullah, Tsujimura 58, Akira, Kheradmand 59, Alireza, Anagnostopoulou 60, Christina, Marino 61, Angelo, Adamyan 62, Aram, Zilaitiene 63, Birute, Ozer 39, Cevahir, Pescatori 64, Edoardo, Vogiatzi 65, Paraskevi, Maria Busetto 66, Gian, Balercia 67, Giancarlo, 9 10, Haitham Elbardisi, Akhavizadegan 68, Hamed, Sajadi 69, Hesamoddin, Taniguchi 70, Hisanori, Jun Park 71 72, Hyun, Maldonado Rosas 73, Israel, Al-Marhoon 74, Mohamed, Ali Sadighi Gilani 69, Mohammad, Alhathal 75, Naif, Pinggera 76, Germar-Michael, Kothari 77, Priyank, Mogharabian 78, Nasser, Micic 79, Sava, Homa 80, Sheryl, Darbandi 81 82, Sara, Quang Tien Long 83, Tran, Zohdy 10, Wael, Atmoko 22, Widi, Sabbaghian 69, Marjan, Ibrahim 84, Wael, P Smith 85, Ryan, Chee Kong Ho 86, Christopher, de la Rosette 87, Jean, I El-Sakka 88, Ahmed, Preto 89, Mirko, Zenoaga-Barbăroșie 90, Cătălina, Mohammed Abumelha 91, Saad, Baser 92, Aykut, Aydos 93, Kaan, Ramirez-Dominguez 73, Liliana, Kumar 94, Vijay, Aik Ong 95, Teng, Cesar Mierzwa 96, Tiago, Adriansjah 97, Ricky, A Banihani 98, Saleem, Bowa 99, Kasonde, Fukuhara 100, Shinichiro, Rodriguez Peña 101, Marcelo, Moussa 102 103, Mohamad, Çağın Ari 104, Umut, Cho 105, Chak-Lam, N Tadros 106, Nichola, Rasit Ugur 107, Muhammet, Amar 108, Edouard, Falcone 109, Marco, Romain Santer 76, Frederic, Kalkanli 110, Arif, Kumar Karna 111, Keshab, 9 112 113, Kareim Khalafalla, B Vishwakarma 114, Ranjit, Finocchi 67, Federica, Giulioni 115, Carlo, Ceyhan 39, Erman, Çeker 116, Gökhan, Yazbeck 117, Chadi, Rajmil 118, Osvaldo, Yilmaz 119, Mehmet, Altay 120, Bari, L Barrett 121, Trenton, Seong Ngoo 122, Kay, Roychoudhury 123, Shubhadeep, Salvio 67, Gianmaria, Lin 124, Haocheng, Kadioglu 125, Ate, Timpano 109, Massimiliano, Avidor-Reiss 126 127, Tomer, Hakim 128, Lukman, Sindhwani 128, Puneet, Franco 129, Giorgio, Singh 130, Rajender, Giacone 131, Filippo, Ruzaev 132, Mikhail, Kosgi 133, Raghavender, Sofikitis 134, Nikolao, Palani 135, Ayad, Calik 87, Gokhan, Kulaksız 136, Deniz, Jezek 137, Davor, Al Hashmi 138 139, Manaf, Drakopoulos 140 141, Panagioti, Omran 142, Huda, Leonardi 143, Sofia, Celik-Ozenci 144, Ciler, Dokuzeylül Güngör 145, Nur, Ramsay 146, Jonathan, Amano 147, Toshiyasu, Sogutdelen 148, Emrullah, Wirya Kusuma Duarsa 149, Gede, Chiba 150, Koji, Jindal 151, Sunil, Savira 22, Missy, Boeri 152, Luca, Borges 153, Edson, Gupte 154, Deepak, Gokalp 155, Fatih, Hernández Hebrard 73, Guadalupe, Minhas 156, Suk, Shah 114, Rupin, and Andrology Forum, Global
- Abstract
PURPOSE: Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. MATERIALS AND METHODS: An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method. RESULTS: A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4-6 months and 38.1% recommend 3 months. For men with unexplained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respondents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical varicocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated. CONCLUSIONS: This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians.
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- 2023
4. Testosterone Therapy for Late-Onset Hypogonadism Improves Erectile Function: A Systematic Review and Meta-Analysis
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Hisanori Taniguchi, Hidefumi Kinoshita, and Seiji Shimada
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medicine.medical_specialty ,business.industry ,Urology ,Testosterone (patch) ,Cochrane Library ,Placebo ,medicine.disease ,Confidence interval ,law.invention ,Erectile dysfunction ,Randomized controlled trial ,law ,Meta-analysis ,Internal medicine ,medicine ,Metabolic syndrome ,business - Abstract
Introduction: Randomized controlled trials (RCTs) of testosterone therapy (TTh) for late-onset hypogonadism are systematically reviewed and a meta-analysis to assess the efficacy of TTh in improving erectile function is performed. Methods: The PubMed, Cochrane Library, and Web of Science databases were searched to identify RCTs published from 2007. RCTs that assessed erectile function using the erectile function domain of the International Index of Erectile Function (IIEF-EFD) were included in the meta-analysis. Results: The systematic review included 18 RCTs and the meta-analysis included 6 studies that enrolled a total of 1,458 patients. The overall meta-analysis revealed that the IIEF-EFD score was significantly improved in the TTh group compared with the placebo group (mean difference 1.86; 95% confidence interval 1.01–2.72; p < 0.0001). Compared with patients receiving placebo, there was a significant improvement in the IIEF-EFD of patients who received TTh using testosterone gel, those who received TTh for over 30 weeks, and those without diabetes mellitus or metabolic syndrome. Conclusion: TTh achieved a significant improvement in the IIEF-EFD score of hypogonadal men compared with placebo, especially in those who received testosterone gel, were treated for over 30 weeks, and had no comorbidities.
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- 2021
5. Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma
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Takashi, Yoshida, Chisato, Ohe, Junichi, Ikeda, Naho, Atsumi, Ryoichi, Saito, Hisanori, Taniguchi, Haruyuki, Ohsugi, Motohiko, Sugi, Koji, Tsuta, Tadashi, Matsuda, and Hidefumi, Kinoshita
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Adult ,Male ,clear cell renal cell carcinoma ,Nephrectomy ,histology ,Necrosis ,Predictive Value of Tests ,Biomarkers, Tumor ,Pathology ,Humans ,RB1-214 ,Carcinoma, Renal Cell ,Aged ,Retrospective Studies ,Aged, 80 and over ,Gene Expression Profiling ,Forkhead Box Protein M1 ,Reproducibility of Results ,Original Articles ,Middle Aged ,molecular subtype ,Kidney Neoplasms ,Neuropilin-1 ,Treatment Outcome ,immunohistochemistry ,Female ,Original Article ,Transcriptome ,prognostic classification ,RGS Proteins - Abstract
Molecular mechanisms of progression of clear cell renal cell carcinoma (ccRCC) have been proven with recent genomic or transcriptional analyses. However, it is still difficult to apply these analyses to daily clinical practice owing to economical and practical issues. Here, we established a pathology‐based, postoperative prognostic classification based on the well‐validated transcriptional classifier, ClearCode34, in ccRCC. A total of 342 cases with available tissue were identified and randomly allocated into a discovery cohort (n = 138) and a validation cohort (n = 204). Levels of mRNA were quantified using a nCounter Digital Analyzer, and the ccA/ccB subtypes were determined. Histological and immunohistochemistry (IHC) analyses were subsequently performed to establish a pathology‐based classification based on the mRNA levels. Finally, the prognostic ability of the new classifier was evaluated in both the discovery and validation cohorts. Of 138 cases in the discovery cohort, 78 (56.5%) and 60 (43.5%) were assigned to the ccA and ccB subtypes, respectively. Proangiogenic genes, neuropilin 1 (NRP1) and regulator of G protein signalling 5 (RGS5), were especially overexpressed in all ccRCC samples and were enriched in ccA‐assigned tumours. Histologically, tumour necrosis and the sarcomatoid feature were associated with the ccB subtype. In IHC analyses, expression of NRP1, RGS5, and forkhead box M1 (FOXM1), an epithelial–mesenchymal transition‐related factor, significantly correlated with the ccA/ccB subtypes. Combining these three IHC factors and tumour necrosis, we developed the IHC/histology‐based classifier, which showed good concordance with the ClearCode34 classifier with an accuracy of 0.80. The established classification significantly stratified relapse‐free, cancer‐specific, and overall survival rates in both the discovery and validation cohorts. The novel molecular pathology classifier integrating NRP1, RGS5, FOXM1, and tumour necrosis may enable the stratification of oncological outcomes for patients with ccRCC undergoing resection surgery.
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- 2021
6. Integration of <scp>NRP1</scp> , <scp>RGS5,</scp> and <scp>FOXM1</scp> expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma
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Chisato Ohe, Ryoichi Saito, Junichi Ikeda, Haruyuki Ohsugi, Motohiko Sugi, Takashi Yoshida, Koji Tsuta, Naho Atsumi, Hidefumi Kinoshita, Tadashi Matsuda, and Hisanori Taniguchi
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Oncology ,medicine.medical_specialty ,Necrosis ,Molecular pathology ,business.industry ,Concordance ,Histology ,medicine.disease ,Pathology and Forensic Medicine ,Clear cell renal cell carcinoma ,Internal medicine ,Cohort ,medicine ,FOXM1 ,Immunohistochemistry ,medicine.symptom ,business - Abstract
Molecular mechanisms of progression of clear cell renal cell carcinoma (ccRCC) have been proven with recent genomic or transcriptional analyses. However, it is still difficult to apply these analyses to daily clinical practice owing to economical and practical issues. Here, we established a pathology-based, postoperative prognostic classification based on the well-validated transcriptional classifier, ClearCode34, in ccRCC. A total of 342 cases with available tissue were identified and randomly allocated into a discovery cohort (n = 138) and a validation cohort (n = 204). Levels of mRNA were quantified using a nCounter Digital Analyzer, and the ccA/ccB subtypes were determined. Histological and immunohistochemistry (IHC) analyses were subsequently performed to establish a pathology-based classification based on the mRNA levels. Finally, the prognostic ability of the new classifier was evaluated in both the discovery and validation cohorts. Of 138 cases in the discovery cohort, 78 (56.5%) and 60 (43.5%) were assigned to the ccA and ccB subtypes, respectively. Proangiogenic genes, neuropilin 1 (NRP1) and regulator of G protein signalling 5 (RGS5), were especially overexpressed in all ccRCC samples and were enriched in ccA-assigned tumours. Histologically, tumour necrosis and the sarcomatoid feature were associated with the ccB subtype. In IHC analyses, expression of NRP1, RGS5, and forkhead box M1 (FOXM1), an epithelial-mesenchymal transition-related factor, significantly correlated with the ccA/ccB subtypes. Combining these three IHC factors and tumour necrosis, we developed the IHC/histology-based classifier, which showed good concordance with the ClearCode34 classifier with an accuracy of 0.80. The established classification significantly stratified relapse-free, cancer-specific, and overall survival rates in both the discovery and validation cohorts. The novel molecular pathology classifier integrating NRP1, RGS5, FOXM1, and tumour necrosis may enable the stratification of oncological outcomes for patients with ccRCC undergoing resection surgery.
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- 2021
7. Predictors of Pursuing Intralesional Xiaflex in Peyronie’s Disease Patients
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Hisanori Taniguchi, Eduardo Miranda, Jose Flores, Lawrence C. Jenkins, Carolyn A. Salter, Nahid Punjani, John P. Mulhall, Bruno Nascimento, and Jean E. Terrier
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Male ,medicine.medical_specialty ,Reconstructive surgery ,Duplex ultrasonography ,Urology ,Endocrinology, Diabetes and Metabolism ,Penile Induration ,Injections, Intralesional ,Logistic regression ,Single Center ,Article ,Endocrinology ,Internal medicine ,Humans ,Medicine ,Depression (differential diagnoses) ,Retrospective Studies ,business.industry ,Standard treatment ,medicine.disease ,Comorbidity ,Psychiatry and Mental health ,Microbial Collagenase ,Treatment Outcome ,Reproductive Medicine ,Peyronie's disease ,business ,Penis - Abstract
Background Intralesional collagenase such as Xiaflex (ILX) has become a standard treatment for Peyronie’s disease (PD). Many robust studies have demonstrated its clear efficacy in the treatment algorithm. Aim To examine predictors of the patient decision to pursue ILX in PD patients. Methods The study included PD patients (i) with stable disease (ii) who had doppler duplex ultrasonography (DUS) at least 6 months prior to analysis date and (iii) did not choose an operation. All patients received a standard discussion regarding treatment options, specifically, observation, ILX and penile reconstructive surgery (plication, plaque incision and grafting, implant surgery). Patients who opted to use ILX were compared to those who opted against it. Comorbidity, demographic and PD characteristics were recorded at the initial PD visit. All patients completed three validated questionnaires including the PD questionnaire (PDQ), Self-Esteem and Relationship (SEAR) questionnaire and a depression questionnaire (CES-D). Logistic regression was used to determine predictors of ILX use. Outcomes Predictors of ILX utilization. RESULTS Four hundred and fifty stable PD men had DUS completed 6 months before to allow sufficient time for treatment decision. Of these, 111 (24.7%) patients had ILX treatment and 339 (75.3%) did not. Mean age, relationship status and pain occurrence were similar between groups, but ILX patients had less bother defined as PDQ ≥ 9 (46.8% vs 53.7%, P = .02). ILX patients had more complex curves (79.3% vs 47.8%, P < .01) and more severe instability (32.4% vs 15.3%, P = .01). ILX patients also had higher PDQ domain scores (Psychological 11.5 ± 6.4 vs 7.5 ± 6.2, P < .01; Pain 6.2 ± 6.0 vs 4.3 ± 5.6, P = .02; and Bother 9.8 ± 4.7 vs 6.6 ± 4.8, P < .01). On univariable statistics, significant bother (OR 2.41, 95% CI 1.36–4.28, P Clinical Implications Educates providers as to which patients are more likely to choose ILX. Strengths & Limitations Our study has a large sample size and all patients received the same standardized treatment discussion. Our study is limited by the absence of insurance data on all patients, and its retrospective single center design. CONCLUSION ILX was chosen by the minority of stable PD patients. While moderate to severe instability and significant bother is predictive of ILX use, other demographic factors including relationship status, sexual orientation or pain were not.
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- 2021
8. PD52-02 EXTENDED CORPORAL DILATION (ECD) OF MEN WITH PEYRONIE’S DISEASE (PD) AT THE TIME OF INFLATABLE PENILE IMPLANT SURGERY (IPP)
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Hisanori Taniguchi, Jose Flores, Carolyn Salter, Helen Bernie, and John Mulhall
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Urology - Published
- 2022
9. PD28-05 3-PIECE INFLATABLE PENILE IMPLANT PUMP MALFUNCTION: MANAGEMENT USING PUMP REPLACEMENT ALONE
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Hisanori Taniguchi, John Sullivan, Jose Flores, Carolyn Salter, Helen Bernie, Lawrence Jenkins, and John Mulhall
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Urology - Published
- 2022
10. Evaluation of sexual function after dutasteride treatment in patients with once-negative prostate biopsy and benign prostate hyperplasia
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Hisanori Taniguchi, Takaaki Inoue, Gen Kawa, Takashi Murota, Hiromasa Tsukino, Koji Yoshimura, Toshiyuki Kamoto, Osamu Ogawa, Tadashi Matsuda, and Hidefumi Kinoshita
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General Medicine - Abstract
Introduction: Patients with benign prostatic hyperplasia are usually treated with 5α-reduced inhibitors (5ARIs) such as finasteride and dutasteride. However, studies on the influence of 5ARIs on sexual function have been controversial. In this study, we evaluated the impact of dutasteride treatment for erectile function in patients with once-negative prostate biopsy and benign prostate hyperplasia. Patients and methods: 81 patients with benign prostate hyperplasia were enrolled in a one-armed prospective study. They were administrated 0.5 mg/day of dutasteride for 12 months. Patient characteristics and changes of International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF)-15 scores at baseline and 12 months after dutasteride administration were examined. Results: The mean ± standard deviation (SD) age of the patients was 69.4 ± 4.9 years and the prostate volume was 56.6 ± 21.3 mL, respectively. The mean ± SD prostate volume and PSA levels were decreased 25.0 and 50.9%, respectively, after 12 months of dutasteride administration. IPSS total, voiding subscore, storage subscore, and quality of life score significantly improved after 12 months of dutasteride administration. No statistically significant change in IIEF-total score from 16.3 ± 13.5 to 18.8 ± 16.0 ( p = 0.14), IIEF-EF score from 5.1 ± 6.9 to 6.4 ± 8.3 ( p = 0.13) were observed. There was no decrease in erectile function severity. Conclusion: Twelve months administration of dutasteride for patients with BPH improved urinary function and did not increase the risk of sexual dysfunction.
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- 2023
11. Clinical Practice Guideline Recommendation on the Use of Low Intensity Extracorporeal Shock Wave Therapy and Low Intensity Pulsed Ultrasound Shock Wave Therapy to Treat Erectile Dysfunction: The Asia-Pacific Society for Sexual Medicine Position Statement
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Hisanori Taniguchi, Hui Liang Zhou, Joe Lee, Eric Chung, Chia Chu Liu, and Hyun Jun Park
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safety ,Aging ,medicine.medical_specialty ,Extracorporeal shock wave therapy ,erectile dysfunction ,Urology ,Population ,030232 urology & nephrology ,clinical outcome ,lcsh:Medicine ,Review Article ,Low-intensity pulsed ultrasound ,lcsh:RC870-923 ,03 medical and health sciences ,0302 clinical medicine ,Asia pacific ,Sexual medicine ,medicine ,Pharmacology (medical) ,education ,Intensive care medicine ,low intensity pulsed ultrasound ,education.field_of_study ,030219 obstetrics & reproductive medicine ,business.industry ,Health Policy ,low intensity shock wave therapy ,lcsh:R ,Public Health, Environmental and Occupational Health ,Guideline ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Intensity (physics) ,Psychiatry and Mental health ,Erectile dysfunction ,Reproductive Medicine ,shock wave machine ,business ,Male Sexual Health and Dysfunction - Abstract
Published literature shows low intensity extracorporeal shock wave therapy (LIESWT) and low intensity pulsed ultrasound (LIPUS) therapy to improve erectile function and penile hemodynamic by inducing neovascularisation and promoting tissue regeneration. Key opinion leaders across the Asia Pacific region attended the recent biennial meeting of the Asia Pacific Society for Sexual Medicine in Australia, and presented the current evidence on LIESWT and LIPUS for erectile dysfunction (ED). The clinical findings were internally discussed, and the quality of evidence was graded based on the Oxford Centre for Evidence- Based Medicine recommendations. Existing literature supports the use of LIESWT and LIPUS in men with ED, with many clinical studies reported encouraging results with improved erectile function, good safety profile and short-term durability. However, controversial exists due to sampling heterogeneity, non-standardised treatment protocol and lack of large multiinstitutional studies. There is a need to better define which subgroup of ED population is best-suited, and specific treatment protocol to optimise shock wave energy delivery. More stringent and larger multi-institutional randomised placebo-controlled trials are warranted before clinical adoption of LIESWT and LIPUS as the new standard of care for men with ED.
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- 2021
12. Predictors of Curvature Improvement in Men With Peyronie's Disease Treated With Intralesional Collagenase Clostridium Histolyticum
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Jose M. Flores, Bruno Nascimento, Nahid Punjani, Carolyn A. Salter, Helen L. Bernie, Hisanori Taniguchi, Eduardo Miranda, Jean-Etienne Terrier, Elizabeth Schofield, Lawrence Jenkins, and John P. Mulhall
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Male ,Urology ,Endocrinology, Diabetes and Metabolism ,Penile Induration ,Middle Aged ,Injections, Intralesional ,Article ,Psychiatry and Mental health ,Endocrinology ,Microbial Collagenase ,Treatment Outcome ,Reproductive Medicine ,Humans ,Clostridium histolyticum ,Retrospective Studies ,Penis - Abstract
Introduction Penile curvature is the most common abnormality that is observed by men with Peyronie's disease (PD). Collagenase Clostridium histolyticum (CCH) has become a standard treatment for PD patients. Aim To identify predictor factors associated with improvements of penile curvature outcomes in men with PD treated with CCH. Methods We retrospectively collected the data of patients with PD treated with CCH up to 8 injections divided into 4 cycles between January 2014 and July 2020. Per protocol, penile curvature was assessed at baseline, and after the second and ford CCH cycle. If after cycle 2, curvature demonstrated no improvement, or penile curvature was significantly improved and the patient was happy, no further treatment was recommended. However, if penile curvature was significantly improved and the patient remained dissatisfied, 4 cycles were completed. Three categories of response were evaluated: improvement (≥10 degrees or ≥20%, either 1 happens), unchanged (±10 degrees or ±20%) or worsened (≥10 degrees or ≥20%, either 1 happens). Logistic regression analyses were performed to evaluate predictive factors associated with penile curvature improvements. Outcomes Degrees of the curvature changes between the baseline and after the cycles of CCH. Results A total of 114 patients underwent CCH treatment. Median age was 57 years. Median PD duration was 11 months. At baseline, mean curvature was 47 degrees, 65% had dorsal curvature, 53% mid-shaft location, and 15% calcification. After CCH treatment, the mean final curvature was 40 degrees. A total of 44% improved the curvature, 39% had no change while 17% worsened after CCH treatment. Of men who had penile curvature improvement with CCH treatment, the mean curvature decreasing in degrees and percentage were 22 degrees and 41%, respectively. Men with baseline curvature ≤ 30, 31–59, and ≥ 60 degrees, the percentage curvature improvement were 29%, 43%, and 60%, respectively. Baseline curvature was the only significant predictor of penile curvature improvement after CCH (OR 1.33, 95% CI = 1.1, 1.7). Clinical Implications We confirmed baseline penile curvature is the most important predictive factor, and this is the first report describing proportions of penile curvature improvement with CCH treatment. Strengths and Limitations This study has several strengths, including the use of validated instruments. Nonetheless, there are limitations: the retrospective nature of the study, a single institution; and modelling device was not controlled. Conclusion Penile curvature improvement was significantly more common in patients with greater baseline curvature, reaching up to 60% for patients with ≥ 60 degrees.
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- 2022
13. Establishment of a novel assessment of the quality of human spermatozoa measuring mitochondrial oxygen metabolism
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Hisanori Taniguchi, Yoshiyuki Matsuo, Kayo Shimoi, Masahiro Yoshimura, Kiichi Hirota, and Hidefumi Kinoshita
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Male ,Oxygen ,endocrine system ,Oxygen Consumption ,urogenital system ,Sperm Motility ,Humans ,General Medicine ,Spermatozoa ,reproductive and urinary physiology ,General Biochemistry, Genetics and Molecular Biology ,Mitochondria - Abstract
Objective We aimed to establish a novel sperm quality evaluation technology by measuring mitochondrial oxygen metabolism in human spermatozoa. Results Normozoospermic human sperm samples were used. After establishing the optimal parameters for measuring the oxygen metabolism of human sperm cells using the extracellular flux analyzer, we measured the oxygen consumption rate (OCR) of human spermatozoa exposed to different storage temperatures. Although sperm motility was significantly lower at 4 °C when compared with sperm motility at 37 °C, there were no significant differences in sperm vitality and the OCR under both conditions. The present study established a methodology for human sperm quality evaluation using extracellular flux analysis technology. The OCR evaluation could be a reliable measurement tool for assessing human sperm quality.
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- 2022
14. [A Case of Retroperitoneal Bronchogenic Cyst Diagnosed by Fluorescence in situ Hybridization]
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Kenji, Amano, Hisanori, Taniguchi, Junichi, Ikeda, Yuri, Noda, Chisato, Ohe, Chika, Miyasaka, Koji, Tsuta, and Hidefumi, Kinoshita
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Bronchogenic Cyst ,Adrenal Gland Neoplasms ,Humans ,Female ,Retroperitoneal Space ,Middle Aged ,Magnetic Resonance Imaging ,In Situ Hybridization, Fluorescence - Abstract
A 50-year-old woman was referred to our hospital for consultation for a suspected left adrenal tumor detected by ultrasonography during a health check. Computed tomography and magnetic resonance imaging revealed a 4.7×3.4 cm tumor in the retroperitoneal space near the adrenal gland. The patient subsequently underwent laparoscopic tumor resection. Using fluorescence in situ hybridization (FISH), the resected tumor was diagnosed as a retroperitoneal bronchial cyst. Here we present a case of a definitive diagnosis of a retroperitoneal bronchial cyst using FISH, and review the cases of retroperitoneal bronchial cyst in the literature.
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- 2022
15. Evaluating the Impact of Penile Girth Discrepancy on Patient Bother in Men with Peyronie's Disease: An Observational Study
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H.L. Bernie, Jean-Etienne Terrier, Elizabeth Schofield, Hisanori Taniguchi, Bruno Nascimento, Lawrence C. Jenkins, Carolyn A. Salter, John P. Mulhall, and Eduardo Miranda
- Subjects
Adult ,Male ,medicine.medical_specialty ,Urology ,Endocrinology, Diabetes and Metabolism ,Penile Induration ,030232 urology & nephrology ,Logistic regression ,Article ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Surveys and Questionnaires ,Sexual medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,business.industry ,Retrospective cohort study ,Girth (graph theory) ,Odds ratio ,Middle Aged ,Center for Epidemiologic Studies Depression Scale ,medicine.disease ,humanities ,Psychiatry and Mental health ,Treatment Outcome ,Reproductive Medicine ,Physical therapy ,Peyronie's disease ,business ,Psychosocial ,Penis - Abstract
Background Men with Peyronie's disease (PD) may experience penile narrowing. Little data on penile girth changes and their psychosocial impact exist. Aim To assess girth discrepancy in men with PD and its association with patient bother. Methods This was a retrospective observational study. All patients with PD at our institution who were seen in the sexual medicine clinic and who completed 3 validated instruments the PD questionnaire (PDQ), Self-Esteem and Relationship (SEAR) questionnaire, and a depression questionnaire, the Center for Epidemiologic Studies Depression Scale (CES-D), and a curvature assessment were included. Patient and PD characteristics are described. Associations of instability and bother to girth differences are assessed. 2 outcomes for girth differences are classified as (i) girth difference of ≥ 1 cm vs less and (ii) girth differences of ≥10% vs less. Unadjusted and adjusted effects of PD and patient characteristics are assessed on the outcome of high bother using logistic regression models. Outcomes The main outcomes of this study were penile girth changes, instability, and questionnaire scores. High bother was defined as a PDQ bother score of ≥9. Results A total of131 men had midshaft curvature and were the focus of the study. Their mean age was 59 ± 9 (range 31–78) years. PD duration was 16 ± 25 (range 1–180) months, with a mean degree of primary curvature of 37 ± 20o. Mean girth difference between base and point of maximum curvature was 0.78 ± 0.53 cm equating to a mean girth difference at point of maximum curvature of 6 ± 4%. Instability was present in 53% of men. There were 54 men with a girth difference of ≥ 1 cm and 23 men with a ≥10% change in girth. There was no difference in CES-D, SEAR, or PDQ domain scores or high bother in men with significant girth changes. Univariable analysis of predictors of high bother included the degree of curvature (odds ratio [OR]: 1.06; P Clinical Implications Penile girth changes have little impact on overall psychosocial well-being. The degree of penile curvature is the primary predictor of patient bother. Strengths and Limitations Strengths include a large patient population and use of validated questionnaires. Limitations include single-center, retrospective study and subjective instability grading. Conclusions Penile girth discrepancy in men with PD has limited psychosocial impact. Clinically significant bother was associated with the degree of primary curvature.
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- 2020
16. Robot‐assisted laparoscopic vesicule prostatectomy for mixed epithelial–stromal tumor of seminal vesicle
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Hidefumi Kinoshita, Tomoaki Matsuzaki, Hisanori Taniguchi, Chika Miyasaka, Tadashi Matsuda, Yuki Masuo, and Chisato Ohe
- Subjects
medicine.medical_specialty ,Stromal cell ,Urology ,medicine.medical_treatment ,Case Report ,robot‐assisted laparoscopic prostatectomy ,Case Reports ,lcsh:RC870-923 ,mixed epithelial–stromal tumor ,Seminal vesicle ,Prostate ,medicine ,seminal vesicle ,Stromal tumor ,Right Seminal Vesicle ,prostate ,business.industry ,Prostatectomy ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,medicine.anatomical_structure ,Pelvic tumor ,Pouch ,business ,robot‐assisted laparoscopic vesicle prostatectomy - Abstract
Introduction Mixed epithelial-stromal tumor is a biphasic tumor with stromal and benign epithelial components. Only 40 cases of mixed epithelial-stromal tumor originating from a seminal vesicle have previously been published in English. Case presentation A 52-year-old man was transferred to our hospital for evaluation of a 3.0-cm pelvic tumor detected incidentally by computed tomography. Robot-assisted laparoscopic vesicle prostatectomy was performed. We approached the Retzius space from both levels of the pouch of Douglas and peritoneal top of the bladder to clarify the tumor's environment. Pathologically, the tumor was diagnosed as a low-grade mixed epithelial-stromal tumor originating from the right seminal vesicle. There was no evidence of disease recurrence within 51 months. Conclusion This is the first report of robot-assisted laparoscopic vesicle prostatectomy for a seminal vesicle mixed epithelial-stromal tumor. Long-term observation is warranted due to the lack of reports with sufficient follow-up to ensure the procedure's safety.
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- 2020
17. Sexual Activity of Patients Undergoing Testicular Sperm Extraction
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Yoshiharu Morimoto, Hisanori Taniguchi, Tadashi Matsuda, and Yoshiharu Nakaoka
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Infertility ,medicine.medical_specialty ,Urology ,Endocrinology, Diabetes and Metabolism ,030232 urology & nephrology ,lcsh:Medicine ,Dermatology ,Sexual Activity ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Endocrinology ,Erectile Dysfunction ,Patient age ,Medicine ,Testosterone ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,lcsh:R ,Outcome measures ,Testosterone (patch) ,Mean age ,lcsh:Other systems of medicine ,medicine.disease ,lcsh:RZ201-999 ,Testicular sperm extraction ,Psychiatry and Mental health ,Erectile dysfunction ,Reproductive Medicine ,Male patient ,business ,Testicular Sperm Extraction - Abstract
Introduction For couples who wish for a baby, sexual activity (through intercourse) is the only way to conceive naturally. However, the sexual activity of men undergoing testicular sperm extraction (TESE) and factors that influence it among affected couples are not clearly understood. Aim To examine sexual activity among infertile men undergoing TESE and to identify factors that influenced it. Methods Married Japanese male patients undergoing TESE were included. Sexual activity during the previous month was surveyed using a questionnaire, and potential predictive factors influencing sexual activity were examined. Main Outcome Measures Two hundred twenty-six married men who answered a questionnaire regarding sexual frequency were reviewed retrospectively. Results The patient mean age was 35.8 ± 7.5 years (range 23–67) and the mean age of their partners was 32.9 ± 4.5 years (range 23–44). Most couples (n = 193) were in their first marriage, and 33 were remarried. The mean marriage duration was 52.6 ± 42.2 months (range 1–192). Microdissection TESE and conventional TESE were performed for 152 and 74 patients, respectively. Overall, the mean sexual activity during the last month was 3.6 ± 2.6 times (range 0–15). Marriage duration was negatively correlated with the frequency of sexual activity (r = −0.23; P < .01). There were no correlations between sexual activity and patient age, partner age, marriage type (first marriage or remarried), testicular volume, or serum total testosterone concentration. Regression analysis showed that marriage duration (odds ratio = 1.01; 95% CI, 1.003–1.019; P = .009) and testicular volume (odds ratio = 0.94; 95% CI, 0.88–0.99; P = .033) were significant predictors of low sexual activity (0–1 times/month). Conclusion The sexual activity of patients undergoing TESE was almost the same as reported previously. Patient age, partner age, testicular volume, and serum total testosterone concentration had no correlation with the reported frequency of sexual activity.
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- 2020
18. A randomized, open-label, controlled trial of monthly oral minodronate or semiannual subcutaneous injection of denosumab for bone loss by androgen deprivation in Asian men with prostate cancer: the PRevention of Osteopenia with Minodronate And DEnosumab (PROMADE) study
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Hisanori Taniguchi, Hidehumi Kinoshita, Tadashi Matsuda, M Yanishi, Takashi Yoshida, and M Sugi
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Male ,musculoskeletal diseases ,0301 basic medicine ,medicine.medical_specialty ,Injections, Subcutaneous ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Urology ,030209 endocrinology & metabolism ,Bone remodeling ,Androgen deprivation therapy ,03 medical and health sciences ,0302 clinical medicine ,Bone Density ,Humans ,Medicine ,Femoral neck ,Bone mineral ,Bone Density Conservation Agents ,Diphosphonates ,business.industry ,Imidazoles ,Prostatic Neoplasms ,Bone metastasis ,Androgen Antagonists ,Bisphosphonate ,medicine.disease ,Osteopenia ,Bone Diseases, Metabolic ,Denosumab ,medicine.anatomical_structure ,Androgens ,030101 anatomy & morphology ,business ,medicine.drug - Abstract
There is still a lack of evidence that minodronate or denosumab prevents bone loss due to androgen deprivation therapy (ADT) in non-Western patients. This study showed that both drugs significantly improved lumbar spine and total hip bone mineral density in Asian men with prostate cancer who received ADT. To evaluate whether monthly oral minodronate or semiannual subcutaneous injection of denosumab improves bone mineral density (BMD) in Asian men with prostate cancer (PCa) receiving ADT. A multicenter, open-label, randomized, controlled study including patients with hormone-sensitive PCa without bone metastasis receiving ADT was performed. Patients were randomized (1:1:1) to minodronate, denosumab, or no agent control groups. The primary end point was the mean percentage change in BMD at the lumbar spine at 12 months. Secondary end points were the mean percentage change in BMD at the femoral neck and total hip and changes in bone turnover markers. Statistical comparison was performed using analysis of covariance. Of the 147 subjects enrolled in this study, 102 were randomly assigned into the minodronate (n = 36), denosumab (n = 36), and control (n = 30) groups. The percentage change in BMD at the lumbar spine was significantly improved in the minodronate (2.5%, p
- Published
- 2020
19. Clinical outcomes of microdissection testicular sperm extraction and intracytoplasmic sperm injection in Japanese men with Y chromosome microdeletions
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Kentaro Ichioka, Satoru Kanto, Hisanori Taniguchi, Tetsuaki Hara, Hiroaki Yoshida, K. Yamaguchi, S. Mizuta, Shoji Kokeguchi, Sumihide Okamoto, Hiroshi Masuda, Tomomoto Ishikawa, Hidehiko Matsubayashi, Takehiko Matsuyama, Toshihiro Kawamura, Takumi Takeuchi, Fumiko Tawara, Toshihiro Habara, Hatsuki Hibi, and Masakazu Ohashi
- Subjects
0301 basic medicine ,endocrine system ,lcsh:QH471-489 ,Y chromosome microdeletion ,medicine.medical_treatment ,intracytoplasmic sperm injection ,azoospermia factor ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Intracytoplasmic sperm injection ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,Human fertilization ,medicine ,lcsh:Reproduction ,Microdissection ,reproductive and urinary physiology ,embryo transfer ,Azoospermia factor ,lcsh:RC648-665 ,030219 obstetrics & reproductive medicine ,testicular sperm extraction ,business.industry ,urogenital system ,Y chromosome microdeletions ,Cell Biology ,Original Articles ,medicine.disease ,Embryo transfer ,Testicular sperm extraction ,030104 developmental biology ,Reproductive Medicine ,Sperm Retrieval ,Original Article ,business - Abstract
Purpose We investigated the clinical results of Japanese men with Y chromosome microdeletions. Methods This study retrospectively examined 2163 azoospermic or severe oligozoospermic patients. We investigated the frequency of azoospermia factor (AZF) deletions and sperm retrieval rate (SRR) by microTESE in patients with these deletions, then analyzed the ICSI outcomes. Results Azoospermia factor deletions were found in 201 patients. SRR was significantly higher than that of the control group (74.0% vs 20.4%, P
- Published
- 2020
20. Adherent Perinephric Fat Is a Surgical Risk Factor in Laparoscopic Single-Site Donor Nephrectomy: Analysis Using Mayo Adhesive Probability Score
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Motohiko Sugi, Takao Mishima, Masaaki Yanishi, Hisanori Taniguchi, Tadashi Matsuda, Hidefumi Kinoshita, and Yuya Koito
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Adipose tissue ,Tissue Adhesions ,Intra-Abdominal Fat ,Kidney ,Nephrectomy ,Risk Assessment ,Body Mass Index ,Adipose capsule of kidney ,Postoperative Complications ,Risk Factors ,medicine ,Humans ,Kidney surgery ,Retrospective Studies ,Transplantation ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Surgery ,Dissection ,Tissue and Organ Harvesting ,Female ,Laparoscopy ,Tomography, X-Ray Computed ,business ,Body mass index ,Dyslipidemia - Abstract
Background The host-related risk factors for surgical difficulty of partial nephrectomy include the presence of thick and adherent adipose tissue surrounding the kidney (adherent perinephric fat [APF]). The kidney and perirenal fat must be isolated in donor nephrectomy. Thus, APF is an important surgery-related factor. We analyzed whether the Mayo adhesive probability (MAP) score is related to APF and surgical outcomes in laparoscopic single-site donor nephrectomy (LESS-DN). Methods Forty-six donors who underwent LESS-DN were selected. Determination of APF was based on a retrospective review of video-recorded surgical procedures during anterior perinephric fat dissection. The MAP score was evaluated from computed tomography images. Data regarding patient characteristics and operative outcomes were collected. We then examined the MAP score, APF, and related factors. Results Eleven patients (23.9%) had APF. The patients were divided into 2 groups (MAP score of 0 points and ≥ 1 point). The 2 groups showed significant differences in sex, age, body mass index, history of hypertension, and history of dyslipidemia. The operation time was significantly longer and the estimated blood loss volume was higher in patients with a MAP score of ≥ 1. Eight of 9 patients with a MAP score of ≥ 1 had APF. The only significant differences between patients with and without APF were in the body mass index, history of hypertension, and history of dyslipidemia. The operation time was significantly longer and the estimated blood loss volume was larger in patients with APF. Conclusions The MAP score could be useful when predicting surgical difficulty in patients undergoing LESS-DN.
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- 2020
21. Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
- Author
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Sajal Gupta, Rakesh Sharma, Ashok Agarwal, Florence Boitrelle, Renata Finelli, Ala'a Farkouh, Ramadan Saleh, Taha Abo-Almagd Abdel-Meguid, Murat Gül, Birute Zilaitiene, Edmund Ko, Amarnath Rambhatla, Armand Zini, Kristian Leisegang, Shinnosuke Kuroda, Ralf Henkel, Rossella Cannarella, Ayad Palani, Chak-Lam Cho, Christopher C.K. Ho, Daniel Suslik Zylbersztejn, Edoardo Pescatori, Eric Chung, Fotios Dimitriadis, Germar-Michael Pinggera, Gian Maria Busetto, Giancarlo Balercia, Gianmaria Salvio, Giovanni M. Colpi, Gökhan Çeker, Hisanori Taniguchi, Hussein Kandil, Hyun Jun Park, Israel Maldonado Rosas, Jean de la Rosette, Joao Paulo Greco Cardoso, Jonathan Ramsay, Juan Alvarez, Juan Manuel Corral Molina, Kareim Khalafalla, Kasonde Bowa, Kelton Tremellen, Evangelini Evgeni, Lucia Rocco, Marcelo Gabriel Rodriguez Peña, Marjan Sabbaghian, Marlon Martinez, Mohamed Arafa, Mohamed S. Al-Marhoon, Nicholas Tadros, Nicolas Garrido, Osvaldo Rajmil, Pallav Sengupta, Paraskevi Vogiatzi, Parviz Kavoussi, Ponco Birowo, Raghavender Kosgi, Saleem Bani-Hani, Sava Micic, Sijo Parekattil, Sunil Jindal, Tan V. Le, Taymour Mostafa, Tuncay Toprak, Yoshiharu Morimoto, Vineet Malhotra, Azin Aghamajidi, Damayanthi Durairajanayagam, Rupin Shah, Gupta, S., Sharma, R., Agarwal, A., Boitrelle, F., Finelli, R., Farkouh, A., Saleh, R., Abdel-Meguid, T. A. -A., Gul, M., Zilaitiene, B., Ko, E., Rambhatla, A., Zini, A., Leisegang, K., Kuroda, S., Henkel, R., Cannarella, R., Palani, A., Cho, C. -L., Ho, C. C. K., Zylbersztejn, D. S., Pescatori, E., Chung, E., Dimitriadis, F., Pinggera, G. -M., Busetto, G. M., Balercia, G., Salvio, G., Colpi, G. M., Ceker, G., Taniguchi, H., Kandil, H., Park, H. J., Rosas, I. M., de la Rosette, J., Cardoso, J. P. G., Ramsay, J., Alvarez, J., Molina, J. M. C., Khalafalla, K., Bowa, K., Tremellen, K., Evgeni, E., Rocco, L., Pena, M. G. R., Sabbaghian, M., Martinez, M., Arafa, M., Al-Marhoon, M. S., Tadros, N., Garrido, N., Rajmil, O., Sengupta, P., Vogiatzi, P., Kavoussi, P., Birowo, P., Kosgi, R., Bani-Hani, S., Micic, S., Parekattil, S., Jindal, S., Le, T. V., Mostafa, T., Toprak, T., Morimoto, Y., Malhotra, V., Aghamajidi, A., Durairajanayagam, D., and Shah, R.
- Subjects
Aging ,Urology ,Antibodie ,DIAGNOSIS ,Antibodies ,Endocrinology & Metabolism ,male ,FERTILIZATION ,FERTILITY ,Pharmacology (medical) ,Andrology ,Survey ,PREDNISOLONE TREATMENT ,COUPLES ,Science & Technology ,Health Policy ,Public Health, Environmental and Occupational Health ,CHRONIC PROSTATITIS ,Urology & Nephrology ,SEMEN PARAMETERS ,Infertility, male ,Sperm agglutination ,Spermatozoa ,digestive system diseases ,Psychiatry and Mental health ,PREGNANCY RATES ,Health Care Sciences & Services ,surgical procedures, operative ,Reproductive Medicine ,Infertility ,SPERM AUTOANTIBODIES ,Life Sciences & Biomedicine ,SUBFERTILE MEN - Abstract
Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reaction, and immunobead binding test) was described in the WHO manual 5th edition and is most recently listed among the extended semen tests in the WHO manual 6th edition. The relationship between ASA and infertility is somewhat complex. The presence of sperm agglutination, while insufficient to diagnose immunological infertility, may indicate the presence of ASA. However, ASA can also be present in the absence of any sperm agglutination. The andrological management of ASA depends on the etiology and individual practices of clinicians. In this article, we provide a comprehensive review of the causes of ASA production, its role in immunological male infertility, clinical indications of ASA testing, and the available therapeutic options. We also provide the details of laboratory procedures for assessment of ASA together with important measures for quality control. Additionally, laboratory and clinical scenarios are presented to guide the reader in the management of ASA and immunological male infertility. Furthermore, we report the results of a recent worldwide survey, conducted to gather information about clinical practices in the management of immunological male infertility.
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- 2022
22. MP49-19 ACCURATE CALCULATION OF TUMOR VOLUME AND TUMOR CROSSING OF THE AXIAL RENAL MIDLINE ARE PREOPERATIVE PREDICTORS OF REDUCED ESTIMATED GLOMERULAR FILTRATION RATE AFTER ROBOTIC PARTIAL NEPHRECTOMY
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Haruyuki Ohsugi, Motohiko Sugi, Tadashi Matsuda, Hidefumi Kinoshita, Hisanori Taniguchi, and Masaaki Yanishi
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medicine.anatomical_structure ,business.industry ,Urology ,medicine.medical_treatment ,medicine ,Renal function ,Radius ,Nuclear medicine ,business ,Collection system ,Nephrectomy ,Sinus (anatomy) ,Volume (compression) - Abstract
INTRODUCTION AND OBJECTIVE:The ability of nephrometry scoring systems, such as the R.E.N.A.L. (radius, exophytic/ endophytic, nearness to collecting system or sinus, anterior/posterior, and locatio...
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- 2021
23. Tumor Volume and Tumor Crossing of the Axial Renal Midline as Preoperative Predictors of Reduced Estimated Glomerular Filtration Rate After Robotic Partial Nephrectomy
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Hisanori Taniguchi, Kyojiro Akiyama, Masaaki Yanishi, Hidefumi Kinoshita, Tadashi Matsuda, Haruyuki Ohsugi, and Motohiko Sugi
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medicine.medical_specialty ,Text mining ,Volume (thermodynamics) ,business.industry ,medicine.medical_treatment ,Urology ,Medicine ,Renal function ,business ,Nephrectomy - Abstract
The ability of nephrometry scoring systems, including the radius, exophytic/endophytic, nearness to collecting system or sinus, anterior/posterior, and location relative to polar lines (R.E.N.A.L.), to predict loss of renal function after robotic partial nephrectomy (RPN) is still controversial. Therefore, we verified which combination of factors from nephrometry scoring systems, including tumor volume, was the most significant predictor of postoperative renal function. Patients who underwent RPN for cT1 renal tumors in our hospital were reviewed retrospectively (n=163). The preoperative clinical data (estimated glomerular filtration rate [eGFR], comorbidities, and nephrometry scoring systems including R.E.N.A.L.) and perioperative outcomes were evaluated. We also calculated the tumor volume using the equation applied to an ellipsoid by three-dimensional computed tomography. The primary outcome was reduced eGFR, which was defined as an eGFR reduction of ≥20% from baseline to 6 months after RPN. Multivariate logistic regression analyses were used to evaluate the relationships between preoperative variables and reduced eGFR. Of 163 patients, 24 (14.7%) had reduced eGFR. Multivariate analyses indicated that tumor volume (cutoff value≥14.11 cm3, indicating a sphere with a diameter≥approximately 3 cm) and tumor crossing of the axial renal midline were independent factors for reduced eGFR (odds ratio [OR], 4.57; P=0.003 and OR, 3.21; P=0.034, respectively). Our classification system using these two factors showed a higher area under the receiver operating characteristic curve (AUC) than previous nephrometry scoring systems (AUC=0.786 vs. 0.653–0.719), and it may provide preoperative information for counseling patients about renal function after RPN.
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- 2021
24. Tumor volume and tumor crossing of the axial renal midline predict renal function after robotic partial nephrectomy
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Tadashi Matsuda, Kyojiro Akiyama, Haruyuki Ohsugi, Motohiko Sugi, Masaaki Yanishi, Hisanori Taniguchi, and Hidefumi Kinoshita
- Subjects
Male ,medicine.medical_specialty ,Science ,medicine.medical_treatment ,Urology ,Renal function ,Logistic regression ,Kidney ,Nephrectomy ,Severity of Illness Index ,Article ,Robotic Surgical Procedures ,Medicine ,Cutoff ,Humans ,Postoperative Period ,Aged ,Retrospective Studies ,Multidisciplinary ,Receiver operating characteristic ,business.industry ,Odds ratio ,Perioperative ,Robotics ,Middle Aged ,Confidence interval ,Kidney Neoplasms ,Tumor Burden ,Oncology ,Risk factors ,Area Under Curve ,Multivariate Analysis ,Female ,business ,Glomerular Filtration Rate - Abstract
There are several nephrometry scoring systems for predicting surgical complexity and potential perioperative morbidity. The R.E.N.A.L. scoring system, one of the most well-known nephrometry scoring systems, emphasizes the features on which it is based (Radius, Exophytic/endophytic, Nearness to collecting system or sinus, Anterior/posterior, and Location relative to polar lines). The ability of these nephrometry scoring systems to predict loss of renal function after robotic partial nephrectomy (RPN) remains controversial. Therefore, we verified which combination of factors from nephrometry scoring systems, including tumor volume, was the most significant predictor of postoperative renal function. Patients who underwent RPN for cT1 renal tumors in our hospital were reviewed retrospectively (n = 163). The preoperative clinical data (estimated glomerular filtration rate [eGFR], comorbidities, and nephrometry scoring systems including R.E.N.A.L.) and perioperative outcomes were evaluated. We also calculated the tumor volume using the equation applied to an ellipsoid by three-dimensional computed tomography. The primary outcome was reduced eGFR, which was defined as an eGFR reduction of ≥ 20% from baseline to 6 months after RPN. Multivariable logistic regression analyses were used to evaluate the relationships between preoperative variables and reduced eGFR. Of 163 patients, 24 (14.7%) had reduced eGFR. Multivariable analyses indicated that tumor volume (cutoff value ≥ 14.11 cm3, indicating a sphere with a diameter ≥ approximately 3 cm) and tumor crossing of the axial renal midline were independent factors associated with a reduced eGFR (odds ratio [OR] 4.57; 95% confidence interval [CI] 1.69–12.30; P = 0.003 and OR 3.50; 95% CI 1.30–9.46; P = 0.034, respectively). Our classification system using these two factors showed a higher area under the receiver operating characteristic curve (AUC) than previous nephrometry scoring systems (AUC = 0.786 vs. 0.653–0.719), and it may provide preoperative information for counseling patients about renal function after RPN.
- Published
- 2021
25. Laparoendoscopic Single-Site Surgery for Urachal Remnants: A Single-Center Experience
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Takashi Yoshida, Tadashi Matsuda, Haruyuki Ohsugi, Motohiko Sugi, Masaaki Yanishi, Hisanori Taniguchi, Tomoaki Matsuzaki, and Hidefumi Kinoshita
- Subjects
Adult ,Male ,Laparoscopic surgery ,medicine.medical_specialty ,Adolescent ,Urology ,medicine.medical_treatment ,Operative Time ,030232 urology & nephrology ,Single Center ,Urachus ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Blood loss ,Pneumoperitoneum ,Humans ,Medicine ,Child ,Surgical treatment ,Aged ,Retrospective Studies ,Pain, Postoperative ,Umbilicus ,business.industry ,Open surgery ,Cosmesis ,Length of Stay ,Middle Aged ,Surgery ,030220 oncology & carcinogenesis ,Single site surgery ,Operative time ,Female ,Laparoscopy ,Patient Safety ,business - Abstract
Introduction: Urachal remnants are relatively rare. Generally, urachal remnants are detected in young people, and the removed specimen is small, comprising a good indication for laparoscopic surgery. Laparoendoscopic single-site surgery (LESS) for urachal remnants is considered to be safe and result in an excellent cosmetic outcome. Therefore, we report our single-center experience with LESS for urachal remnants. Methods: We retrospectively reviewed 30 patients with urachal remnants who underwent LESS from January 2011 to December 2017. The patients’ characteristics, surgical data, postoperative pain, and cosmetic assessment results were retrospectively collected and analyzed. Results: Mean total operative time was 151 min, mean pneumoperitoneal surgery time was 83 min, and mean estimated blood loss was 5.0 mL. All patients were started on an oral diet and began ambulating on postoperative day 1. Mean hospital stay was 5.5 days. LESS was completed successfully in all patients, with no conversion to conventional or open surgery. Conclusions: LESS is a viable option for the surgical treatment of urachal remnants. This technique may result in less pain than conventional techniques. Further accumulation of surgical outcomes (especially regarding safety and cosmesis) is required for LESS to become an established treatment for urachal remnants.
- Published
- 2019
26. Testosterone Profiles After Brachytherapy for Localized Prostate Cancer
- Author
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Takashi Murota, Shigenari Kawakita, Hidefumi Kinoshita, Tadashi Matsuda, and Hisanori Taniguchi
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Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Brachytherapy ,030232 urology & nephrology ,Androgen deprivation therapy ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Primary outcome ,medicine ,Humans ,Testosterone ,Aged ,Retrospective Studies ,business.industry ,Radiation dose ,Follow up studies ,Prostatic Neoplasms ,medicine.disease ,030220 oncology & carcinogenesis ,business ,After treatment ,Follow-Up Studies - Abstract
Objective To evaluate patients’ serum total testosterone levels (STLs) after brachytherapy (BT) for prostate cancer. Methods We enrolled 102 men who underwent permanent interstitial BT using I125 without androgen deprivation therapy for localized prostate cancer. Seed BT radiation dose was 145 Gy. Patients were followed for 24-60 months after BT. The primary outcome was STL kinetics after BT. Predictors of testosterone decrease were also analyzed. Results Median preimplantation STL was 4.18 ng/mL. STL decreased significantly to a median nadir of 89.4% of baseline (3.72 ng/mL) occurring at 6 months, and then recovered to baseline at 18 months after BT. The group of patients whose STLs fell below 3.00 ng/mL (biochemical hypogonadism) after BT started with lower baseline STLs (median: 3.54 ng/mL) than patients whose STLs did not fall below 3.00 ng/mL (median: 4.90 ng/mL). The group of patients whose STLs decreased by more than 1.00 ng/mL over the study period had significantly higher median baseline STLs (median: 5.05 ng/mL) than the group whose STLs decreased by less than 1.00 ng/mL (median: 3.64 ng/mL). Conclusion Although STL decreased significantly after I125-based BT, STL decline after treatment for localized prostate cancer was not large and recovered over time.
- Published
- 2019
27. PREDICTORS OF DEPRESSION IN MEN WITH PEYRONIE’S DISEASE SEEKING EVALUATION
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Lawrence C. Jenkins, Eduardo Miranda, John P. Mulhall, Bruno Nascimento, Nahid Punjani, Jean E. Terrier, Hisanori Taniguchi, and Carolyn A. Salter
- Subjects
medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,business.industry ,Urology ,Endocrinology, Diabetes and Metabolism ,030232 urology & nephrology ,Disease ,medicine.disease ,Single Center ,Logistic regression ,Article ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Endocrinology ,Erectile dysfunction ,Reproductive Medicine ,Internal medicine ,Deformity ,Medicine ,Peyronie's disease ,medicine.symptom ,business ,Psychosocial ,Depression (differential diagnoses) - Abstract
BACKGROUND: Peyronie’s disease (PD) has negative impacts on the psychosocial status of men including depression warranting clinical evaluation in up to 50% of men. AIM: To examine predictors of depression in patients with early PD seeking evaluation. METHODS: All PD patients at a high-volume PD practice underwent screening and curvature assessment after intracavernosal injection. Complex deformity was defined as any degree of multiplanar curvature, curvature >60 degrees, or presence of hourglass deformity. Men completed the PD questionnaire (PDQ), a validated depression questionnaire (CES-D) as well as the Self-Esteem and Relationship (SEAR) questionnaire. Scores of ≥16 on CES-D were considered indicative of moderate/severe depression. Predictors of the presence of depression were defined using univariable and multivariable logistic regression. OUTCOMES: Demographic, bother and curve related predictors of depression in men with PD. RESULTS: 408 men completed all questionnaires. Mean age was similar between depressed and non-depressed groups (57±10 years overall, p=0.60 between groups). Proportions of erectile dysfunction were similar between groups (p=0.96). Mean PD duration was similar between groups (19±35 months overall, p=0.46 between groups). Mean degree of curvature was 38±2 degrees in the depressed vs 33±1 degrees in the non-depressed groups (p=0.03). A complex deformity was seen in 64.5% in the depressed vs 61.5% in the non-depressed (p=0.56). A total of 110 (27%) patients had CESD scores ≥16. 74% depressed men were in relationships compared to 84% non-depressed men (p
- Published
- 2021
28. Sperm Vitality and Necrozoospermia: Diagnosis, Management, and Results of a Global Survey of Clinical Practice
- Author
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Yoshiharu Morimoto, Kasonde Bowa, Israel Maldonado Rosas, Marjan Sabbaghian, Ralf Henkel, Juan Manuel Corral Molina, Chak-Lam Cho, Kristian Leisegang, Hisanori Taniguchi, Mohamed Ali Sadighi Gilani, Germar-Michael Pinggera, Sunil Jindal, Christopher Chee Kong Ho, Gianmaria Salvio, Marlon Martinez, Juan Carlos Alvarez, Taha A. Abdel-Meguid, Jean de la Rosette, Taymour Mostafa, Mohamed S. Al-Marhoon, Sava Micic, Ashok Agarwal, Jonathan Ramsay, Samantha B. Schon, Ala'a Farkouh, Kareim Khalafalla, Gian Maria Busetto, Nicholas N. Tadros, Sajal Gupta, Edoardo Pescatori, Gökhan Çeker, Renata Finelli, Ayad Palani, Damayanthi Durairajanayagam, Marcelo Gabriel Rodriguez, Florence Boitrelle, Rupin Shah, Eric Chung, Mohamed Arafa, Ramadan A Saleh, Christina Anagnostopoulou, Shinnosuke Kuroda, Parviz Kavoussi, Shinichiro Fukuhara, Armand Zini, Giovanni M. Colpi, Paraskevi Vogiatzi, Neel Parekh, Hussein Kandil, Tan V. Le, Raghavender Kosgi, Ponco Birowo, Rossella Cannarella, Giancarlo Balercia, Mara Simopoulou, Sijo Parekattil, Ettore Caroppo, Aldo E. Calogero, Mesut Berkan Duran, Osvaldo Rajmil, Amarnath Rambhatla, Haitham Elbardisi, Hyun Jun Park, Saleem Ali Banihani, Fotios Dimitriadis, Edmund Y. Ko, Rakesh Sharma, Cleveland Clinic, CHI Poissy-Saint-Germain, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hamad Medical Corporation [Doha, Qatar], Weill Cornell Medicine [Qatar], The Chinese University of Hong Kong [Hong Kong], Henry Ford Health System, Imperial College London, University of the Western Cape, The University of Texas at San Antonio (UTSA), Loma Linda University, Fakih IVF Fertility Center, University of Garmian, Università Politecnica delle Marche [Ancona] (UNIVPM), Cairo University - Faculty of Medicine, Fundació Puigvert [Barcelona, Spain], Jordan University of Science and Technology [Irbid, Jordan], University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Pham Ngoc Thach Medical University [Ho Chi Minh city, Vietnam] (PNTUM), Faculty of Medicine [Jakarta, Indonesia], Universitas Indonesia [Jakarta, Indonesia], Taylor's University Malaysia, University of Catania [Italy], Hamad medical corporation, McGill University = Université McGill [Montréal, Canada], University of Queensland [Brisbane], Aristotle University of Thessaloniki, Innsbruck Medical University [Austria] (IMU), Università degli Studi di Foggia - University of Foggia, Kansai Medical University, Pusan National University, Hammersmith Hospital NHS Imperial College Healthcare, National and Kapodistrian University of Athens (NKUA), Royan Institute for Reproductive Biomedicine [Tehran, Iran], UNIVERSITY OF SANTO TOMAS MANILA PHL, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Sultan Qaboos University (SQU), Università degli studi di Catania [Catania], Osaka University [Osaka], University of Central Florida [Orlando] (UCF), Minia University, King Abdulaziz University, and Lilavati Hospital and Research Centre
- Subjects
Aging ,Vitality ,0302 clinical medicine ,Pharmacology (medical) ,TESTICULAR SPERMATOZOA ,Andrology ,Sperm motility ,0303 health sciences ,030219 obstetrics & reproductive medicine ,Spermatozoon ,Health Policy ,Urology & Nephrology ,Spermatozoa ,3. Good health ,Psychiatry and Mental health ,medicine.anatomical_structure ,Asthenozoospermia ,EosineYellowish-(YS) ,Eosine Yellowish-(YS) ,Life Sciences & Biomedicine ,Infertility ,medicine.medical_specialty ,endocrine system ,Urology ,Semen ,ICSI ,PARAMETERS ,03 medical and health sciences ,Endocrinology & Metabolism ,medicine ,Intensive care medicine ,030304 developmental biology ,Nigrosin ,Science & Technology ,SEMINAL PLASMA ,business.industry ,urogenital system ,MALE-INFERTILITY ,Public Health, Environmental and Occupational Health ,[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology ,medicine.disease ,Sperm ,VIABILITY ,IMMOTILE ,Health Care Sciences & Services ,Reproductive Medicine ,DNA-DAMAGE ,SEMEN QUALITY ,Etiology ,business ,HYPOOSMOTIC SWELLING TEST - Abstract
International audience; Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. Several methods can be used to test sperm vitality, such as the eosin-nigrosin (E-N) stain or the hypoosmotic swelling (HOS) test. In the 6th (2021) edition of the WHO Laboratory Manual, sperm vitality assessment is mainly recommended if the total motility is less than 40%. Hence, a motile spermatozoon is considered alive, however, in certain conditions an immotile spermatozoon can also be alive. Therefore, the differentiation between asthenozoospermia (pathological decrease in sperm motility) and necrozoospermia (pathological decrease in sperm vitality) is important in directing further investigation and management of infertile patients. The causes leading to necrozoospermia are diverse and can either be local or general, testicular or extra-testicular. The andrological management of necrozoospermia depends on its etiology. However, there is no standardized treatment available presently and practice varies among clinicians. In this study, we report the results of a global survey to understand current practices regarding the physician order of sperm vitality tests as well as the management practices for necrozoospermia. Laboratory and clinical scenarios are presented to guide the reader in the management of necrozoospermia with the overall objective of establishing a benchmark ranging from the diagnosis of necrozoospermia by sperm vitality testing to its clinical management.
- Published
- 2021
29. PBRM1 Immunohistochemical Expression Profile Correlates with Histomorphological Features and Endothelial Expression of Tumor Vasculature for Clear Cell Renal Cell Carcinoma
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Kazuho Saiga, Chisato Ohe, Takashi Yoshida, Haruyuki Ohsugi, Junichi Ikeda, Naho Atsumi, Yuri Noda, Yoshiki Yasukochi, Koichiro Higasa, Hisanori Taniguchi, Hidefumi Kinoshita, and Koji Tsuta
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Cancer Research ,Oncology ,clear cell renal cell carcinoma ,histomorphological features ,PBRM1 ,immunohistochemistry ,architectural patterns ,endothelial cells - Abstract
Loss of the polybromo-1 (PBRM1) protein has been expected as a possible biomarker for clear cell renal cell carcinoma (ccRCC). There is little knowledge about how PBRM1 immunohistochemical expression correlates with the histomorphological features of ccRCC and the endothelial expression of tumor vasculature. The present study evaluates the association of architectural patterns with the PBRM1 expression of cancer cells using a cohort of 425 patients with nonmetastatic ccRCC. Furthermore, we separately assessed the PBRM1 expression of the endothelial cells and evaluated the correlation between the expression of cancer cells and endothelial cells. PBRM1 loss in cancer cells was observed in 148 (34.8%) patients. In the correlation analysis between architectural patterns and PBRM1 expression, macrocyst/microcystic, tubular/acinar, and compact/small nested were positively correlated with PBRM1 expression, whereas alveolar/large nested, thick trabecular/insular, papillary/pseudopapillary, solid sheets, and sarcomatoid/rhabdoid were negatively correlated with PBRM1 expression. PBRM1 expression in vascular endothelial cells correlated with the expression of cancer cells (correlation coefficient = 0.834, p < 0.001). PBRM1 loss in both cancer and endothelial cells was associated with a lower recurrence-free survival rate (p < 0.001). Our PBRM1 expression profile indicated that PBRM1 expression in both cancer and endothelial cells may be regulated in an orchestrated manner.
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- 2022
30. DEFINING THE IMPACT OF PEYRONIE’S DISEASE ON THE PSYCHOSOCIAL STATUS OF GAY MEN
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Carolyn A. Salter, Bruno Nascimento, Hisanori Taniguchi, H.L. Bernie, Lawrence C. Jenkins, John P. Mulhall, Eduardo P. Miranda, Jean-Etienne Terrier, and Elizabeth Schofield
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education.field_of_study ,business.industry ,Urology ,Endocrinology, Diabetes and Metabolism ,Population ,Sexual relationship ,medicine.disease ,humanities ,Article ,Endocrinology ,Reproductive Medicine ,Sexual medicine ,Sexual orientation ,Medicine ,Peyronie's disease ,business ,education ,Psychosocial ,Depression (differential diagnoses) ,Reproductive health ,Clinical psychology - Abstract
BACKGROUND Little sexual health research has been conducted in gay men. Anecdotally, this population seems to experience more bother related to Peyronie's disease (PD). OBJECTIVES To examine the impact of PD on psychosocial factors in gay vs straight men. MATERIALS AND METHODS All PD patients who were seen in the sexual medicine clinic were included. They completed three instruments: the PD questionnaire (PDQ), Self-Esteem and Relationship (SEAR) questionnaire, and a depression questionnaire (CES-D). We described demographics and sexual variables by sexual orientation. We then compared PDQ items and summary scores by sexual orientation, using a series of independent samples t tests. RESULTS 34 consecutive gay and 464 straight men were included. Age and baseline characteristics were similar between the two cohorts, with the exception that fewer gay men were partnered (56% vs 87%, P
- Published
- 2020
31. Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in Japan
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Hisanori Taniguchi, Yoshikazu Sato, and Shin-ichi Hisasue
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Urology ,Endocrinology, Diabetes and Metabolism ,Pneumonia, Viral ,Immunology ,MEDLINE ,Commentay ,Article ,Betacoronavirus ,Endocrinology ,Japan ,Political science ,Sexual medicine ,Pandemic ,Humans ,Pandemics ,biology ,SARS-CoV-2 ,COVID-19 ,biology.organism_classification ,Virology ,Microbiology, Virology & Host Pathogen Interaction ,Psychiatry and Mental health ,Reproductive Medicine ,Commentary ,Coronavirus Infections - Abstract
The COVID‐19 pandemic has spread to many countries around the world, but the infection and death rates vary widely. One country that appeared to have kept the infection under control despite limited societal restrictions is Japan. This commentary explores why Japan may have, up to now, been spared an escalation of the SARS‐CoV‐2 infections.
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- 2020
32. Nationwide survey of urological specialists regarding male infertility: results from a 2015 questionnaire in Japan
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Takeshi Shin, Hisanori Taniguchi, Yasushi Yumura, Koji Shiraishi, Akira Tsujimura, Takashi Imamoto, Yukihiro Umemoto, Yasushi Miyagawa, Teruaki Iwamoto, Koji Chiba, and Hideyuki Kobayashi
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Infertility ,medicine.medical_specialty ,lcsh:QH471-489 ,medicine.medical_treatment ,etiology ,030232 urology & nephrology ,Reproductive medicine ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,male infertility ,Male infertility ,03 medical and health sciences ,nationwide survey ,0302 clinical medicine ,Epidemiology ,medicine ,lcsh:Reproduction ,Seminal tract ,Gynecology ,030219 obstetrics & reproductive medicine ,lcsh:RC648-665 ,business.industry ,Incidence (epidemiology) ,General surgery ,Vasovasostomy ,Cell Biology ,Original Articles ,medicine.disease ,postsurgical outcome ,Reproductive Medicine ,Etiology ,Original Article ,epidemiology ,business - Abstract
Purpose To investigate the incidence, etiology, treatment indications, and outcomes regarding infertile male patients in Japan. Methods Between April, 2014 and March, 2015, the authors contacted 47 clinical specialists in male infertility who had been certified by the Japan Society for Reproductive Medicine. The participating clinicians were sent a questionnaire regarding information on their infertile patients, according to etiology and the number and success rates of male infertility operations that had been performed in their practice. Results Thirty-nine specialists returned the questionnaire and provided information regarding 7268 patients. The etiology of infertility included testicular factors, sexual disorders, and seminal tract obstruction. During the study year, the clinicians performed varicocelectomies, testicular sperm extractions (TESEs), and re-anastomoses of the seminal tract. The rate of successful varicocelectomies was >70%. The sperm retrieval rates with conventional TESE and microdissection TESE were 98.3% and 34.0%, respectively, while the patency rates with vasovasostomy and epididymovasostomy were 81.8% and 61.0%, respectively. Conclusion Surgical outcomes for infertile male patients are favorable and can be of great clinical benefit for infertile couples. To achieve this, urologists should work in collaboration with gynecological specialists in order to optimize the treatment of both partners.
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- 2018
33. Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts
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Yuya Koito, Motohiko Sugi, Hiroyasu Tsukaguchi, Takao Mishima, Nguyen Thanh Huan, Kenji Yoshida, Hidefumi Kinoshita, Tadashi Matsuda, Hisanori Taniguchi, and Masaaki Yanishi
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Adult ,Male ,medicine.medical_specialty ,030232 urology & nephrology ,Urology ,Kidney Volume ,Nephron ,030230 surgery ,Kidney ,Muscle hypertrophy ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Living Donors ,medicine ,Humans ,Transplantation, Homologous ,Glomerular volume ,Kidney transplantation ,Aged ,Retrospective Studies ,Proteinuria ,business.industry ,Graft Survival ,Hypertrophy ,General Medicine ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Surgery ,Transplantation ,surgical procedures, operative ,medicine.anatomical_structure ,Nephrology ,Renal transplant ,Female ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Glomerular Filtration Rate - Abstract
Aim Optimizing nephron supply to recipient demand is a non-immunologic determinant of renal allograft outcome. Nephron reduction is usually caused by physical donor-recipient mismatch, but its pathologic relevance remains to be determined. Methods: Thirty-one recipients of living donor renal transplants were divided into three subgroups: those who received transplants from the same gender (n = 6, Group 1) and those who underwent male-to-female (n = 8, Group 2) and female-to-male (n = 17, Group 3) transplants. Renal mass was evaluated by three-dimensional computed tomography (3D-CT) volumetry before and one year after transplantation. Glomerular volume was determined from protocol biopsies obtained one hour and one year after transplantation. Results Histologically determined glomerular volume in biopsied tissues showed a significant linear correlation with allograft size on 3D-CT volumetry (p
- Published
- 2017
34. The Prevalence and Predictors of Penile Pain in Men with Peyronie's Disease
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Hisanori Taniguchi, Carolyn A. Salter, Jose Flores, Bruno Nascimento, Eduardo Miranda, John P. Mulhall, Jean-Etienne Terrier, H.L. Bernie, Elizabeth Schofield, and Lawrence C. Jenkins
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medicine.medical_specialty ,Sexual Dysfunction ,Urology ,Endocrinology, Diabetes and Metabolism ,Population ,Penile Pain ,Dermatology ,Other systems of medicine ,Behavioral Neuroscience ,Endocrinology ,Erectile Dysfunction ,Internal medicine ,medicine ,education ,Depression (differential diagnoses) ,Original Research ,Penile pain ,education.field_of_study ,Peyronie's Disease ,Depression ,business.industry ,Center for Epidemiologic Studies Depression Scale ,medicine.disease ,Psychiatry and Mental health ,Erectile dysfunction ,Sexual dysfunction ,Reproductive Medicine ,Medicine ,Peyronie's disease ,medicine.symptom ,business ,Psychosocial ,RZ201-999 - Abstract
Introduction Penile pain is one of the most stressful symptoms in men with Peyronie's disease (PD). Aim To evaluate the prevalence, clinical presentation and risk factors associated with penile pain in men with PD as well as to assess the psychosocial impact. Methods We revised our institution's database of men diagnosed with PD. The information collected included penile pain assessments, and the scores of the PD Questionnaire (PDQ), Self-Esteem and Relationship Questionnaire (SEAR) and Center for Epidemiologic Studies Depression Scale Questionnaire (CES-D). Descriptive and comparative statistics were used. Logistic regression analyses were performed to evaluate predictive factors associated with penile pain. Main outcome measures Penile pain descriptive assessment and factors associated with penile pain in men with PD. Comparison of SEAR, CES-D and PDQ domain scores of men with and without penile pain. Results 431 men with PD were included for this analysis with a mean age of 55.9 years. Penile pain was reported by 36.7%; 65.2% of those had painful erection, 7% pain with flaccid state only, and 20% in both stages. The median pain severity was 3 with erection and 1 with flaccid stage. After adjusted logistic regression analyses, advanced age was associated with less pain (OR 0.94, P ≤ 0.001). Men with penile pain had no significant difference in CES-D and SEAR mean scores compared to men without penile pain. The PDQ scores for the physical/psychological symptoms domain and the bother domain were significantly higher in men with penile pain (12 vs 8.7; P < 0.01 and 9 vs 7.1; P < 0.01 respectively). Men with penile pain had a higher rate of clinically significant bother scores than men without penile pain (52% vs 35%, P ≤ 0.001). Conclusion Penile pain is common in men with PD. It was more common in young men and was associated with physical and psychological bothers in this population. Flores JM, Salter CA, Nascimento B, et al. The Prevalence and Predictors of Penile Pain in Men with Peyronie's Disease. Sex Med 2021;9:100398.
- Published
- 2021
35. Factors Associated With the Development of Sarcopenia in Kidney Transplant Recipients
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Masaaki Yanishi, Yutaka Kimura, Hidehumi Kinoshita, Hiroyasu Tsukaguchi, Takao Mishima, Y. Fukushima, Motohiko Sugi, Yuya Koito, Tadashi Matsuda, and Hisanori Taniguchi
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Adult ,Male ,Sarcopenia ,medicine.medical_specialty ,Time Factors ,Multivariate analysis ,medicine.medical_treatment ,030232 urology & nephrology ,Walking ,Kidney ,Kidney transplant ,Body Mass Index ,Young Adult ,03 medical and health sciences ,Absorptiometry, Photon ,Postoperative Complications ,0302 clinical medicine ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Muscle Strength ,030212 general & internal medicine ,Young adult ,Muscle, Skeletal ,Kidney transplantation ,Dialysis ,Aged ,Transplantation ,Hand Strength ,business.industry ,Age Factors ,Middle Aged ,musculoskeletal system ,medicine.disease ,Kidney Transplantation ,Transplant Recipients ,body regions ,Endocrinology ,Multivariate Analysis ,Female ,Surgery ,business ,human activities ,Body mass index - Abstract
Introduction Sarcopenia is characterized by an involuntary loss of skeletal muscle mass, strength, and function. Previous studies suggest that it is generally associated with aging and chronic kidney diseases. The focus of this study was on the association between sarcopenia and pre-sarcopenia in kidney transplant recipients. Methods Fifty-one patients who underwent kidney transplantation at Kansai Medical University Hospital were enrolled, and their sarcopenia status was evaluated between April and July 2016. Sarcopenia was defined according to the criteria for the Asia Working Group for Sarcopenia. Skeletal muscle mass index was measured by using dual-energy radiograph absorptiometry; the cutoff points were Results Fifty-one recipients (36 men and 15 women) who met the inclusion criteria were enrolled in the study. The mean age of the recipients was 46.2 ± 12.8 years, and the mean duration of dialysis was 2.72 ± 3.61 years. Overall, 6 recipients (11.8%) had sarcopenia, and 25 recipients (49.0%) had pre-sarcopenia; 20 (39.2%) did not have sarcopenia. There were significant differences in age, duration of dialysis, body mass index, and triglyceride levels between the subgroups of recipients with and without sarcopenia. Multivariate regression analysis showed that age and duration of dialysis were independent variables for sarcopenic status. Conclusions Our observations indicate that age and duration of dialysis before transplantation were independent determinants of sarcopenia and pre-sarcopenia in these kidney transplant recipients.
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- 2017
36. Influence of scars on body image consciousness with respect to gender following laparoendoscopic single-site versus conventional laparoscopic surgery
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Takao Mishima, Kaneki Yasuda, Yoshihiro Komai, Masaaki Yanishi, Hidefumi Kinoshita, Tadashi Matsuda, Kenji Yoshida, Hisanori Taniguchi, Motohiko Sugi, and Masato Watanabe
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Adult ,Male ,Laparoscopic surgery ,medicine.medical_specialty ,Pyeloplasty ,Adolescent ,Esthetics ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Scars ,Urachus ,Cicatrix ,Young Adult ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Surveys and Questionnaires ,Body Image ,medicine ,Humans ,Kidney Pelvis ,Laparoscopy ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Cosmesis ,Retrospective cohort study ,Middle Aged ,Urachal Remnant ,Surgery ,medicine.anatomical_structure ,Nephrology ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,business ,Ureteral Obstruction - Abstract
The aim of this study was to evaluate and compare the cosmetic outcomes of laparoscopic single-site surgery (LESS) and conventional laparoscopy (CL) in the treatment of ureteropelvic junction obstruction (UPJO) and urachal remnant removal. LESS is thought to produce better cosmetic results than CL; however, patients' perception of their scars has not been assessed. This study compared the subjective body image and cosmesis ratings of patients who had undergone LESS or CL for UPJO and urachal remnant removal.Fifty patients who underwent LESS or CL for UPJO or urachal remnant removal between June 2008 and June 2015 were included. Cosmetic outcomes were evaluated using the Body Image Questionnaire (BIQ) and Photo-Series Questionnaire (PSQ).The body image and cosmetic scores were significantly higher for patients who underwent LESS than for those who underwent CL, for both pyeloplasty and urachal remnant removal (p .05 each). When performed for either a pyeloplasty or urachal remnant removal, significantly greater BIQ and PSQ scores were observed in females after LESS compared to CL, but not in males.LESS for UPJO and urachal remnant removal has better self-reported body image and cosmesis ratings than CL. This trend is particularly strong in female patients.
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- 2016
37. Intraoperative Intracavernosal Liposomal Bupivacaine (Exparel) Injection Does Not Affect Systemic Hemodynamics
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John P. Mulhall and Hisanori Taniguchi
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Male ,Urology ,Endocrinology, Diabetes and Metabolism ,030232 urology & nephrology ,Injections ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Blood loss ,Interquartile range ,Pain assessment ,Medicine ,Humans ,In patient ,Anesthetics, Local ,Scrotal approach ,Aged ,Pain Measurement ,Retrospective Studies ,Pain, Postoperative ,030219 obstetrics & reproductive medicine ,business.industry ,Hemodynamics ,Perioperative ,Middle Aged ,Liposomal Bupivacaine ,Bupivacaine ,Psychiatry and Mental health ,Reproductive Medicine ,Systemic hemodynamics ,Anesthesia ,Penile Prosthesis ,business - Abstract
Introduction The systemic effect of intracavernosal liposomal bupivacaine (Exparel) injection during inflatable penile prosthesis (IPP) implantation on systemic hemodynamics has not been clarified. Aim To evaluate whether intraoperative intracavernosal Exparel injection affects systemic hemodynamics. Methods We studied 56 consecutive patients who underwent IPP implantation under general anesthesia using the transverse scrotal approach. Exparel [10 mL of 1.3% (13.3 mg/mL)] was instilled bilaterally intracavernosally via a 25-gauge needle around 30 min after starting the surgery. All patients graded their postoperative pain using a standard 10-point scale. Main Outcome Measure Perioperative vital signs at defined time intervals and postoperative pain were monitored. The degree of postoperative pain were analyzed using a standard 10-point scale. Results Medians and interquartile ranges (IQRs) of the patients' age [64 years (57.3–69.3)], operation time [85 min (78–96)], and estimated blood loss [75 mL (29–100)] were recorded. Although the median preoperative systolic noninvasively measured blood pressure of 131 mm/Hg (IQR: 122–139) fell by 25% to 98 mm/Hg (IQR: 90–100) (P Clinical Implications Intraoperative intracavernosal Exparel injection is safe and effective in patients undergoing IPP implantation surgery. Strength & Limitations This is the first report to describe systemic hemodynamics of intracavernosal Exparel injection. Limitations are lack of blood concentration of Exparel at various time points and long-term follow-up for pain assessment. Conclusion Although limited by a lack of the blood concentration of Exparel and short follow-up for pain assessment, we concluded that intraoperative intracavernosal Exparel injection does not affect systemic hemodynamics.
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- 2019
38. Application of Sex Aids in Men With Sexual Dysfunction: A Review
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John P. Mulhall, Eduardo P. Miranda, Gert Martin Hald, Emmanuele A. Jannini, David L. Cao, and Hisanori Taniguchi
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Male ,Vacuum ,Urology ,Endocrinology, Diabetes and Metabolism ,Sexual Behavior ,030232 urology & nephrology ,Orgasmic Disorder ,Scientific literature ,Article ,03 medical and health sciences ,Dildos ,0302 clinical medicine ,Endocrinology ,Settore MED/13 ,Acquired immunodeficiency syndrome (AIDS) ,Erectile Dysfunction ,Sexual medicine ,Sex Aids ,medicine ,Erotica ,Pornography ,Humans ,Sexual Dysfunctions, Psychological ,Lubricants ,030219 obstetrics & reproductive medicine ,business.industry ,Penile Erection ,Vacuum Device ,Sexual Dysfunctions ,medicine.disease ,Constriction Bands ,Play and Playthings ,Clinical Practice ,Psychiatry and Mental health ,Sexual dysfunction ,Erectile dysfunction ,Reproductive Medicine ,Vibrators ,Psychological ,medicine.symptom ,business ,Photic Stimulation ,Clinical psychology ,Medical literature ,Penis - Abstract
Background Although sex aids have been used in clinical practice for ages, the scientific literature assessing their application in men with sexual dysfunction is limited. Aim To summarize medical literature regarding scientific uses of the most common sex aids in men with sexual dysfunction and assess their clinical applicability. Methods An extensive literature review was performed with regard to the use of sex aids in sexual medicine. Our search included journal articles, books, and guidelines in different databases: Embase, PubMed, and Cochrane. The key words were “sex aids,” “sex toys,” “pornography,” “lubricants,” “constriction bands,” “dildos,” “vibrators,” “vacuum devices,” “external penile devices,” and “sex swings” were searched. Date of last search was December 4, 2018. Main Outcome Measures We assessed the utility of sex aids in men with sexual dysfunction and formulated recommendations for clinicians. Results Various sex aids are available for men with sexual dysfunction. We present a comprehensive review of the most common sex aids currently available: pornography, lubricants, constriction bands, dildos, vibrators, vacuum devices, external erectile support devices, and aids to positioning. We discuss their indications, outcomes, precautions, and complications. Clinical implications This review is intended to provide sexual medicine practitioners and academics an overview of sex aids for men with sexual dysfunction for use in both clinical practice and research. Strengths & Limitations This is a compilation of scientific data for a topic that has broad application in sexual medicine and yet has been poorly addressed in the scientific literature. Because of the lack of sufficient data and the heterogeneous nature of different sex aids, a systematic review could not be performed. Conclusion Having a comprehensive understanding of the sexual dynamics of individuals and couples combined with the appropriate integration of sex aids may have a positive effect in the treatment of male sexual dysfunctions.
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- 2019
39. MP58-01 TESTOSTERONE PROFILES AFTER BRACHYTHERAPY FOR LOCALIZED PROSTATE CANCER
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Takashi Murota, Tadashi Matsuda, Hidefumi Kinoshita, Shigenari Kawakita, and Hisanori Taniguchi
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Radiation therapy ,medicine.medical_specialty ,Prostate cancer ,business.industry ,Urology ,medicine.medical_treatment ,Brachytherapy ,medicine ,Testosterone (patch) ,business ,medicine.disease ,After treatment - Abstract
INTRODUCTION AND OBJECTIVES:Serum total testosterone profiles after treatment of radiation therapy (RT) for prostate cancer has not been clearly understood. This study was undertaken to evaluate th...
- Published
- 2019
40. MP65-12 DEFINING THE IMPACT OF PEYRONIE’S DISEASE ON PSYCHOSOCIAL STATUS IN GAY VERSUS HETEROSEXUAL MEN
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Elizabeth Schofield, Carolyn A. Salter, Eduardo Miranda, Hisanori Taniguchi, John P. Mulhall, Helen Levey Bernie, Lawrence C. Jenkins, Bruno Nascimento, and Jean-Etienne Terrier
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business.industry ,Urology ,medicine ,Peyronie's disease ,medicine.disease ,business ,Psychosocial ,Clinical psychology - Published
- 2019
41. MP65-02 EVALUATING THE IMPACT OF PENILE GIRTH DISCREPANCY ON PENILE INSTABILITY AND PATIENT BOTHER IN MEN WITH PEYRONIE’S DISEASE
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Elizabeth Schofield, Bruno Nascimento, Carolyn A. Salter, Helen Levey Bernie, Lawrence C. Jenkins, Eduardo Miranda, John P. Mulhall, Hisanori Taniguchi, and Jean-Etienne Terrier
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medicine.medical_specialty ,business.industry ,Urology ,medicine ,Girth (graph theory) ,Peyronie's disease ,medicine.disease ,business ,Surgery - Published
- 2019
42. Urinary <scp>l</scp>-type fatty acid-binding protein is a predictor of early renal function after partial nephrectomy
- Author
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Hisanori Taniguchi, Tadashi Matsuda, Kaneki Yasuda, Takao Mishima, Motohiko Sugi, Hidefumi Kinoshita, Masato Watanabe, Masaaki Yanishi, Yoshihiro Komai, and Kenji Yoshida
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Kidney Function Tests ,urologic and male genital diseases ,Critical Care and Intensive Care Medicine ,Nephrectomy ,Renal Artery ,0302 clinical medicine ,Japan ,Ischemia ,urinary biomarker ,Prospective Studies ,Aged, 80 and over ,General Medicine ,Middle Aged ,Nephrology ,Biomarker (medicine) ,lipids (amino acids, peptides, and proteins) ,Female ,l-Type fatty acid-binding protein ,Adult ,medicine.medical_specialty ,renal injury ,partial nephrectomy ,Urinary system ,Urology ,Renal function ,Fatty Acid-Binding Proteins ,Fatty acid-binding protein ,03 medical and health sciences ,Renal injury ,medicine.artery ,medicine ,Humans ,Renal artery ,Aged ,business.industry ,renal function ,Nephrons ,Effective renal plasma flow ,Surgery ,Linear Models ,Clinical Study ,Laparoscopy ,business ,Biomarkers - Abstract
Purpose: Urinary biomarkers of renal injury urinary may identify loss of renal function following nephron-sparing surgery (NSS). This study was designed to evaluate whether urinary l-type fatty acid-binding protein (l-FABP) is an early biomarker of loss of renal function after NSS. Specifically, the kinetics of urinary l-FABP level after NSS and its correlation with factors related to ischemic renal injury were analyzed. Methods: This study prospectively evaluated 18 patients who underwent NSS between July and December 2014, including 12 who underwent laparoscopic and six who underwent robot-assisted partial nephrectomy. Urinary l-FABP concentrations were measured preoperatively and 1, 2, 3, 6, 12, 24, 48, and 72 h after renal artery declamping. Loss of renal function loss was calculated by comparing the effective renal plasma flow, as determined by 99mTc-mercaptoacetyltriglycine (MAG3) clearance, on the operated and normal sides. The decrease in estimated glomerular filtration rate from before surgery to six months after surgery was also measured. Results: Urinary l-FABP concentration peaked within 2 h of declamping, which may quantify nephron damage caused by ischemia. The decrease in MAG3 reduction ratio correlated with both the ischemia time and peak urinary l-FABP concentration. Peak urinary l-FABP concentration showed a significant correlation with MAG3 reduction ratio. Conclusions: l-FABP is a suitable urinary biomarker for predicting the extent of ischemic renal injury.
- Published
- 2016
43. Microscopic visualization of testosterone in mouse testis by use of imaging mass spectrometry
- Author
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Kyoji Furuta, Shuichi Shimma, Seiji Ito, Hisanori Taniguchi, Tadashi Matsuda, Ikuko Yao, Alu Konno, and Henri-Obadja Kumada
- Subjects
Male ,0301 basic medicine ,Analytical chemistry ,Sulfuric Acid Esters ,Mass spectrometry ,Chorionic Gonadotropin ,01 natural sciences ,Biochemistry ,Mass spectrometry imaging ,Analytical Chemistry ,Human chorionic gonadotropin ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Ionization ,Animals ,Humans ,Testosterone ,Derivatization ,Chromatography ,Chemistry ,Cholesterol ,010401 analytical chemistry ,Leydig Cells ,Molecular Imaging ,0104 chemical sciences ,Betaine ,030104 developmental biology ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Reagent - Abstract
Testosterone is one of the androgens synthesized from cholesterol as a precursor in the Leydig cells of testes. Since the ionization efficiency of testosterone in matrix-assisted laser desorption ionization (MALDI) is quite low, visualization of testosterone by using MALDI-imaging mass spectrometry (MALDI-IMS) has been considered difficult. To overcome this problem, we used two types of on-tissue derivatization techniques, which were achieved by pyridine sulfur trioxide and Girard's T (GT) reagent, to introduce a polar group into testosterone molecule with the aim to increase the sensitivity. Derivatization by use of GT reagent provided excellent results, superior to those obtained with pyridine sulfur trioxide, in terms of ionization efficiency, molecular specificity, and tissue damage. In GT derivatized testis tissues of mice treated with human chorionic gonadotropin (hCG), testosterone was broadly observed both inside and outside the seminiferous tubules by using an iMScope. To evaluate our imaging results, we performed quantification experiments of underivatized testosterone extracted from hCG-treated testes and control testes using LC-MS/MS. We confirmed the 256-fold concentration change between hCG-treated tissues and control tissues. We also confirmed the 228-fold change in detected peak intensities between hCG-treated tissue sections and control tissue sections in imaging results. We consider our tissue preparation methods for IMS provide high sensitivity with high precision. In addition, high-spatial definition IMS was also available, and we confirmed testosterone had mainly accumulated on the surface of the Leydig cells. Graphical abstract Girard's T-testosterone (GT-Ts) provides the fragment ion at m/z 343.24. Clear GT-Ts signal was detected in hCG treated mouse testis not only as spectra but also as a mass image.
- Published
- 2016
44. Comparison of Cosmesis and Body Image After Laparoendoscopic Single-Site Versus Conventional Laparoscopic Donor Nephrectomy
- Author
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Takao Mishima, Takashi Yoshida, Hisanori Taniguchi, Kenji Yoshida, Motohiko Sugi, Masaaki Yanishi, Tadashi Matsuda, Gen Kawa, Hidehumi Kinoshita, and Takahiro Nakamoto
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Analgesic ,030232 urology & nephrology ,Body Image Scale ,Kidney ,Nephrectomy ,Cicatrix ,03 medical and health sciences ,0302 clinical medicine ,Single site ,Surveys and Questionnaires ,Body Image ,Living Donors ,medicine ,Humans ,Endoscopy, Digestive System ,Laparoscopy ,Aged ,Retrospective Studies ,Analgesics ,Transplantation ,medicine.diagnostic_test ,business.industry ,Cosmesis ,Retrospective cohort study ,Middle Aged ,Surgery ,Endoscopy ,030220 oncology & carcinogenesis ,Tissue and Organ Harvesting ,Female ,business - Abstract
Background This study used a questionnaire to objectively assess the body image of donors who underwent conventional laparoscopic donor nephrectomy (L-DN) or laparoscopic single-site donor nephrectomy (LESS-DN). Surgical outcomes were compared between the two groups. Methods Twenty patients underwent L-DN and 20 underwent LESS-DN. The postoperative outcomes of the two approaches were retrospectively compared and evaluated for differences in cosmesis and body image. The questionnaire comprised a body image questionnaire, including a body image scale (BIS) and cosmetic scale (CS), and a photo-series questionnaire (PSQ). A higher score indicated a more favorable assessment. Pain was assessed by comparing the number of times an analgesic was administered during hospitalization. Results There were no significant differences in operative outcomes between L-DN and LESS-DN. The average BIS score (maximum possible, 20 points) was 18.5 points for patients who underwent L-DN and 19.5 points for patients who underwent LESS-DN (P = .025). Patients who underwent L-DN had a median CS score (maximum possible, 24 points) of 17.5 points, whereas patients who underwent LESS-DN had a median CS score of 19.0 points (P = .113). The average PSQ score was 7.1 points for patients who underwent L-DN and 8.8 points for patients who underwent LESS-DN (P = .01). Patients who underwent LESS-DN were administered an analgesic was significantly number of times less than patients who underwent DN (P = .01). Conclusions LESS-DN results in a better body image and better cosmetic appearance than does L-DN, indicating the clinical usefulness of LESS-DN.
- Published
- 2016
45. 157 Defining the Impact of Peyronie's Disease on Psychosocial Status in Gay versus Heterosexual Men
- Author
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Jean-Etienne Terrier, Eduardo Miranda, John P. Mulhall, H.L. Bernie, Lawrence C. Jenkins, Bruno Nascimento, Hisanori Taniguchi, Carolyn A. Salter, and Elizabeth Schofield
- Subjects
Psychiatry and Mental health ,Endocrinology ,Reproductive Medicine ,business.industry ,Urology ,Endocrinology, Diabetes and Metabolism ,medicine ,Peyronie's disease ,medicine.disease ,business ,Psychosocial ,Clinical psychology - Published
- 2020
46. MP85-07 TESTOSTERONE PROFILES AFTER RADIATION THERAPY FOR PROSTATE CANCER
- Author
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Hisanori Taniguchi and John P. Mulhall
- Subjects
Oncology ,Radiation therapy ,Prostate cancer ,medicine.medical_specialty ,business.industry ,Urology ,medicine.medical_treatment ,Internal medicine ,Medicine ,Testosterone (patch) ,business ,medicine.disease - Published
- 2018
47. The narrow vesicourethral angle measured on postoperative cystography can predict urinary incontinence after robot-assisted laparoscopic radical prostatectomy
- Author
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Masato Watanabe, Yoshihiro Komai, Takao Mishima, Hisanori Taniguchi, Hidefumi Kinoshita, Motohiko Sugi, Kenji Yoshida, Tadashi Matsuda, Masaaki Yanishi, and Takashi Yoshida
- Subjects
Male ,medicine.medical_specialty ,Cystography ,Urology ,Urinary system ,medicine.medical_treatment ,Urinary Bladder ,030232 urology & nephrology ,Urinary incontinence ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Robotic Surgical Procedures ,Urethra ,Predictive Value of Tests ,medicine ,Vesicourethral anastomosis ,Humans ,Postoperative Period ,Aged ,Retrospective Studies ,Prostatectomy ,medicine.diagnostic_test ,business.industry ,Anastomosis, Surgical ,Middle Aged ,Urinary Incontinence ,ROC Curve ,Nephrology ,030220 oncology & carcinogenesis ,Robot assisted laparoscopic radical prostatectomy ,Laparoscopy ,medicine.symptom ,business - Abstract
Radical prostatectomy is associated with complications including urinary incontinence. A significant association between specific features of the vesicourethral anastomosis and urinary incontinence after radical prostatectomy has been demonstrated. The aim of this study was to identify the most useful predictor of postoperative urinary incontinence after robot-assisted laparoscopic radical prostatectomy (RALP) according to the features of the vesicourethral anastomosis as determined by postoperative cystography.The final study cohort consisted of 150 patients. Postoperative cystography was performed within 1 week after RALP. The ratio between the longitudinal and horizontal lengths (L/H) of the bladder, the position of the urethrovesical junction (UVJ) and the bladder neck angle as seen on the cystogram were evaluated. Postoperative continence status was evaluated by a 1 h pad test 1 day after catheter removal and by the use of safety pads, retrieved retrospectively from patient records. The association between these variables and urinary incontinence was then analyzed. All patients were followed for at least 1 year postoperatively.The continence rates on the 1 h pad test and 1 month and 1 year after RALP were 31.3%, 56% and 93.3%, respectively. In multivariate analyses, urinary incontinence was significantly associated with nerve sparing, L/H and the vesical angle as determined on the 1 h pad test, but only with the vesical angle at 1 month and 1 year postoperatively.A narrow vesical angle measured on cystography is a useful predictor of postoperative urinary incontinence after RALP.
- Published
- 2018
48. 274 Outcomes Of Intralesional Collagenase Clostridium Histolyticum (CCH) In Peyronie’s Disease
- Author
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H.L. Bernie, Jean-Etienne Terrier, John P. Mulhall, Eduardo P. Miranda, Patrick E. Teloken, Bruno Nascimento, and Hisanori Taniguchi
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,Endocrinology, Diabetes and Metabolism ,medicine.disease ,Gastroenterology ,Psychiatry and Mental health ,Endocrinology ,Collagenase clostridium histolyticum ,Reproductive Medicine ,Internal medicine ,medicine ,Peyronie's disease ,business ,medicine.drug - Published
- 2019
49. Laparoendoscopic single-site surgery for treatment of urachal remnants
- Author
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Masaaki, Yanishi, Hidefumi, Kinoshita, Takashi, Yoshida, Hisanori, Taniguchi, Kenji, Yoshida, Takao, Mishima, Yoshihiro, Komai, Kaneki, Yasuda, Motohiko, Sugi, and Tadashi, Matsuda
- Subjects
Adult ,Male ,Pain, Postoperative ,Adolescent ,Operative Time ,Blood Loss, Surgical ,Endoscopy ,Middle Aged ,Urachus ,Young Adult ,Humans ,Female ,Laparoscopy ,Child ,Aged ,Retrospective Studies - Abstract
To evaluate safety and excellent cosmetic outcome with laparoendoscopic single-site surgery (LESS). In this study, we compared the usefulness and efficacy of LESS versus conventional laparoscopic surgery for the treatment of urachal remnants.We retrospectively reviewed the medical records of 20 consecutive patients who underwent either conventional laparoscopic surgery or LESS from January 2007 to February 2015 at Kansai Medical University Hospital. Ten patients underwent surgery using the standard laparoscopic 3-port technique, and 10 patients underwent LESS. The patients included 12 males and 8 females (mean age, 24.5 years; range, 10-68 years). The patients' characteristics, surgical data, and postoperative pain assessment results were retrospectively collected and analyzed.The median operative time, pneumoperitoneal surgery time, and estimated blood loss did not differ between the LESS and conventional laparoscopic groups. However, the total incision length was longer in the conventional laparoscopic group than in the LESS group. The degree of pain at 2 to 5 days postoperatively according to the Wong-Baker FACES Pain Rating Scale was lower in the LESS group than in the conventional laparoscopic group (p0.05).Less is a possible option in the surgical treatment for urachal remnants. In this very small cohort, there is no conversion to traditional laparoscopic surgery or open surgery. This technique is possibly feasible and may achieve less pain. Accumulation of surgical outcomes especially in safety and cosmesis is required to be an established method.
- Published
- 2017
50. [Devices to Perform Laparo-Endoscopic Single Site Surgery for Urachal Remnants without Additional Ports]
- Author
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Masaaki, Yanishi, Hidefumi, Kinoshita, Yuya, Koito, Hisanori, Taniguchi, Takao, Mishima, Kaneki, Yasuda, Yoshihiro, Komai, Masato, Watanabe, Motohiko, Sugi, and Tadashi, Matsuda
- Subjects
Adult ,Male ,Young Adult ,Adolescent ,Operative Time ,Urinary Bladder Diseases ,Humans ,Female ,Laparoscopy ,Middle Aged ,Child ,Urachus - Abstract
The laparoscopic management of urachal remnants has gradually become a common practice. Recently, laparoscopic single-site surgery (LESS), a minimally invasive approach that provides excellent cosmetic results, has been adopted in several surgical procedures for treating urachal remnants. However, when suturing the bladder wall or peritoneal defect during LESS it may be difficult to conduct the procedure manually, and such cases require an additional port for suturing. Our strategy, however, employs a knot pusher to perform the suturing without the need for an additional port. We compared and examined the perioperative parameters of the patients with the additional port and one without it (knot-pusher group). For the additional-port and knot-pusher groups, the average operative time, was 146.8 and 161.7 minutes respectively, pneumoperitoneal surgery time was 90.8 and 88.0 minutes, respectively, suturing time for the bladder wall was 577 and 502 seconds, respectively suturing time for peritoneal defect was 758 vs 779 seconds, respectively, and estimated blood loss was 19 and 9.6 ml, respectively ; there being no significant difference between the two groups. We report our knot-pusher method because it can achieve comparable results without compromising the surgical outcome.
- Published
- 2017
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