62 results on '"Hiroki Fukunaga"'
Search Results
2. Clinical Impact of Two-Week Placement of a Subcutaneous Suction Drain in Preventing Incisional Surgical Site Infection in Open Gastrointestinal Surgery with Class 4 Dirty Wound: A Retrospective Study
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Genta, Sawada, Ho Min, Kim, Yoshitoshi, Ichikawa, Rie, Hayashi, Akihiro, Takata, Masahiro, Murakami, Hiroki, Fukunaga, and Shunji, Morita
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Microbiology (medical) ,Infectious Diseases ,Risk Factors ,Drainage ,Humans ,Surgical Wound Infection ,Steroids ,Surgery ,Suction ,Digestive System Surgical Procedures ,Retrospective Studies - Published
- 2022
3. 5 Lanes 5 Fingers Portable Touch-Typing Interface 'ParoTone' for Efficient Sensorimotor Learning: Musical Performance Acquisition Much Faster than Piano
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Shinjiro Mita, Nayuta Sato, Morio Fujimoto, Shunichi Sugimoto, Taiga Fujimoto, Makoto Ozawa, Hiroki Fukunaga, Zenjiro Mita, and Satoru Iwasaki
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Human-Computer Interaction ,Human Factors and Ergonomics ,Computer Science Applications - Published
- 2022
4. Comparison of 5‐year postoperative outcomes after Billroth I and Roux‐en‐Y reconstruction following distal gastrectomy for gastric cancer: Results from a multi‐institutional randomized controlled trial
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Koichi Demura, Motohiro Hirao, Jin Matsuyama, Takafumi Hirao, Atsushi Takeno, Yukinori Kurokawa, Junya Fujita, Makoto Yamasaki, Hidetoshi Eguchi, Hiroshi Imamura, Kentaro Kishi, Hiroki Fukunaga, Yutaka Kimura, Jota Mikami, Yuichiro Doki, and Shuji Takiguchi
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medicine.medical_specialty ,RD1-811 ,medicine.medical_treatment ,Distal gastrectomy ,RC799-869 ,Gastroenterology ,Roux‐en‐Y reconstruction ,law.invention ,body weight ,Randomized controlled trial ,Quality of life ,law ,distal gastrectomy ,Internal medicine ,medicine ,Billroth I ,Reflux esophagitis ,business.industry ,gastric cancer ,Cancer ,Original Articles ,Billroth I reconstruction ,Diseases of the digestive system. Gastroenterology ,medicine.disease ,Roux-en-Y anastomosis ,humanities ,Diarrhea ,Original Article ,Surgery ,medicine.symptom ,business - Abstract
Aim We previously reported in a randomized controlled trial that Billroth I and Roux‐en‐Y reconstructions were generally equivalent regarding body weight change and nutritional status 1 year after distal gastrectomy for gastric cancer. We describe the long‐term follow‐up data 5 years after distal gastrectomy. Methods We analyzed consecutive gastric cancer patients who were randomly assigned to undergo Billroth I or Roux‐en‐Y reconstruction after distal gastrectomy. We evaluated body weight change, nutritional status, late complications, quality of life (QOL) using the European Organization for Research and Treatment of Cancer Core QOL Questionnaire, and dysfunction using the Dysfunction After Upper Gastrointestinal Surgery for Cancer, 5 years after surgery. Results A total of 228 patients (Billroth I = 105; Roux‐en‐Y = 123) were eligible for efficacy analyses in this study. Body weight loss 5 years after surgery did not differ significantly between the Billroth I and Roux‐en‐Y groups (10.0% ± 7.9% and 9.6% ± 8.4%, respectively; P = .70). There were no significant differences in other aspects of nutritional status between the two groups. Reflux esophagitis occurred in 19.0% of the patients in the Billroth I group vs 4.9% in the Roux‐en‐Y group (P = .002). Regarding QOL, Billroth I was significantly inferior to Roux‐en‐Y on the diarrhea scale (Billroth I: 28.6, Roux‐en‐Y: 16.0; P = .047). Regarding dysfunction, no score differed significantly between the two groups. Conclusions Billroth I and Roux‐en‐Y reconstructions were generally equivalent regarding body weight change, nutritional status, and QOL 5 years after distal gastrectomy, although Roux‐en‐Y more effectively prevented reflux esophagitis and diarrhea., Billroth I and Roux‐en‐Y reconstructions were generally equivalent regarding body weight change, nutritional status, and quality of life 5 years after distal gastrectomy, excluding reflux esophagitis and diarrhea.
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- 2021
5. Multicenter prospective trial of total gastrectomy versus proximal gastrectomy for upper third cT1 gastric cancer
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Y. Doki, C Ebisui, Atsushi Takeno, Shuichi Fukuda, Kentaro Kishi, Shuji Takiguchi, Tomoko Saito, Tsuyoshi Takahashi, Kazuyuki Okada, Hiroshi Imamura, Hiroki Fukunaga, O Takayama, Motohiro Hirao, Makoto Yamasaki, Noriko Matsuura, Jin Matsuyama, Shinichi Adachi, Hidetoshi Eguchi, Jyunya Fujita, Yusuke Akamaru, Yukinori Kurokawa, Tai Omori, Masahiko Yano, Shigeyuki Tamura, Ko Takachi, Kazumasa Fujitani, Takafumi Hirao, and Koichi Demura
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Operative Time ,Anastomosis ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Weight loss ,Internal medicine ,Weight Loss ,medicine ,Clinical endpoint ,Humans ,Prospective Studies ,Reflux esophagitis ,Aged ,Neoplasm Staging ,Aged, 80 and over ,business.industry ,Incidence (epidemiology) ,Anastomosis, Surgical ,Stomach ,Reflux ,General Medicine ,Middle Aged ,Prognosis ,Survival Rate ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Abdominal surgery - Abstract
The appropriate surgical procedure for patients with upper third early gastric cancer is controversial. We compared total gastrectomy (TG) with proximal gastrectomy (PG) in this patient population. A multicenter, non-randomized trial was conducted, with patients treated with PG or TG. We compared short- and long-term outcomes between these procedures. Between 2009 and 2014, we enrolled 254 patients from 22 institutions; data from 252 were included in the analysis. These 252 patients were assigned to either the PG (n = 159) or TG (n = 93) group. Percentage of body weight loss (%BWL) at 1 year after surgery, i.e., the primary endpoint, in the PG group was significantly less than that of the TG group (− 12.8% versus − 16.9%; p = 0.0001). For short-term outcomes, operation time was significantly shorter for PG than TG (252 min versus 303 min; p
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- 2020
6. Differences in risk factors for surgical site infection between laparotomy and laparoscopy in gastrointestinal surgery
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Momoe Utsumi, Terumasa Yamada, Kazuo Yamabe, Yoshiteru Katsura, Nariaki Fukuchi, Hiroki Fukunaga, Masahiro Tanemura, Junzo Shimizu, Yoshinori Kagawa, Shogo Kobayashi, Hidekazu Takahashi, Koji Tanaka, Tsunekazu Mizushima, Hidetoshi Eguchi, Nana Nakayama, Kiyoko Makimoto, and Yuichiro Doki
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Laparotomy ,Multidisciplinary ,Risk Factors ,Humans ,Surgical Wound Infection ,Laparoscopy ,Colectomy - Abstract
Extensive gastrointestinal surgery surveillance data in Japan were analyzed to examine the differences in the risk factors for surgical site infection (SSI) between laparotomy and laparoscopic abdominal procedures. Surgical procedures investigated in the study were gastrectomy, cholecystectomy, colectomy, rectal resection, and appendectomy. A total of 32,629 patients were included in the study. The study participants were divided into two groups according to the year of surgery, 2003–2009 (first study period) and 2010–2015 (second study period), due to the increase in the number of laparoscopic surgeries in the second study period. The incidence of SSI was stratified by three SSI classifications (superficial incisional, deep incisional, and organ/space SSI). Multiple logistic regression analysis was performed to predict the risk factors for SSI. The percentage of laparoscopic surgeries performed has increased linearly since 2010. Patients in the second study period were significantly older and had a higher prevalence of SSI risk factors compared with those in the first study period. In addition, the predictive factors changed substantially in most surgical procedures between the two study periods. Wound class ≥ 3 was a ubiquitous risk factor for superficial incisional SSI (SI-SSI) and organ/space SSI (OS-SSI) in both open (laparotomy) and laparoscopic procedures in the first study period. Meanwhile, in the second study period, operative duration was a ubiquitous risk factor in both procedures. The risk factors for SI-SSI differed from those for OS-SSI in the five abdominal surgeries investigated in the study. Periodic examination of risk factors for SSI is recommended in an aging society.
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- 2022
7. The Synergic Role of Actomyosin Architecture and Biased Detachment in Muscle Energetics: Insights in Cross Bridge Mechanism Beyond the Lever-Arm Swing
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Toshio Yanagida, Mitsuhiro Iwaki, Lorenzo Marcucci, and Hiroki Fukunaga
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0301 basic medicine ,Isometric exercise ,Rotation ,Quantitative Biology::Cell Behavior ,Protein filament ,0302 clinical medicine ,Models ,Myosin ,Biology (General) ,Spectroscopy ,Physics ,Adenosine Triphosphatases ,Muscles ,General Medicine ,Mechanics ,Actomyosin ,Computer Science Applications ,Chemistry ,medicine.symptom ,Monte Carlo Method ,Muscle contraction ,Muscle Contraction ,muscle energetics ,QH301-705.5 ,3D geometry ,Thermal fluctuations ,Models, Biological ,Article ,Catalysis ,Inorganic Chemistry ,Quantitative Biology::Subcellular Processes ,03 medical and health sciences ,medicine ,Torque ,Animals ,Humans ,Physical and Theoretical Chemistry ,QD1-999 ,Molecular Biology ,Mechanical energy ,Monte Carlo simulation ,Brownian ratchets ,Organic Chemistry ,Biological ,Mechanism (engineering) ,Kinetics ,030104 developmental biology ,DNA origami ,Muscle energetics ,030217 neurology & neurosurgery - Abstract
Muscle energetics reflects the ability of myosin motors to convert chemical energy into mechanical energy. How this process takes place remains one of the most elusive questions in the field. Here we combined experimental measurements of in vitro sliding velocity based on DNA-origami built filaments carrying myosins with different lever arm length and simulations based on a Monte-Carlo model which accounts for three basic components: (i) the geometrical hindrance, (ii) the mechano-sensing mechanism, and (iii) the biased kinetics for stretched or compressed motors. The model simulations showed that the geometrical hindrance due to acto-myosin spatial mismatching and the preferential detachment of compressed motors are synergic in generating the rapid increase in the ATP-ase rate from isometric to moderate velocities of contraction, thus acting as an energy-conservation strategy in muscle contraction. The velocity measurements on a DNA-origami filament that preserves the motors’ distribution showed that geometrical hindrance and biased detachment generate a non-zero sliding velocity even without rotation of the myosin lever-arm, which is widely recognized as the basic event in muscle contraction. Because biased detachment is a mechanism for the rectification of thermal fluctuations, in the Brownian-ratchet framework, we predict that it requires a non-negligible amount of energy to preserve the second law of thermodynamics. Taken together, our theoretical and experimental results elucidate non-conventional components in the chemo-mechanical energy transduction in muscle.
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- 2021
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8. Community-acquired fulminant Clostridioides (Clostridium) difficile infection by ribotype 027 isolate in Japan: a case report
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Hayato Kimura, Hiroki Fukunaga, Masayuki Hiraki, Nobuo Tanaka, Rei Suzuki, Masaru Murata, Shusaku Tsutsui, Shunji Morita, and Yoshinori Kinoshita
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Helicobacter pylori eradication therapy ,medicine.medical_specialty ,RD1-811 ,Fulminant ,medicine.medical_treatment ,Case Report ,Gastroenterology ,Ischemic colitis ,Clostridioides (Clostridium) difficile infection ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,030212 general & internal medicine ,Colitis ,PCR-ribotype 027 ,0303 health sciences ,Community-acquired CDI ,biology ,030306 microbiology ,Septic shock ,business.industry ,Proctocolectomy ,Pseudomembranous colitis ,Helicobacter pylori ,Clostridium difficile ,medicine.disease ,biology.organism_classification ,Fulminant colitis ,Surgery ,business - Abstract
Background Clostridioides (Clostridium) difficile infection (CDI) has become an increasingly significant disease not only as healthcare-associated infection, but also as community-acquired (CA) infection worldwide. CDI caused by the NAP1/BI/027 strain is reported to be more severe, difficult to cure, and frequently associated with recurrences in North America and Europe. Case presentation A 68-year-old woman was referred to our hospital for continuous lower abdominal pain 4 weeks after eradication therapy against Helicobacter pylori. While she was treated with fasting on the suspicion of ischemic colitis, she experienced septic shock. Emergent subtotal proctocolectomy revealed fulminant pseudomembranous C. difficile colitis. The C. difficile isolate recovered from the patient was identified as ribotype 027, which has been reported to be uncommon in Japan. Conclusion We report a rare case of CA fulminant pseudomembranous colitis caused by ribotype 027 C. difficile after H. pylori eradication therapy.
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- 2021
9. The association between the increased performance of laparoscopic colon surgery and a reduced risk of surgical site infection
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Toshinori Ito, Shogo Kobayashi, Tsunekazu Mizushima, Makoto Yamasaki, Hiroki Fukunaga, Koji Umeshita, Atsushi Miyamoto, Yuichiro Doki, Daisaku Yamada, Junzo Shimizu, Mitsunobu Imazato, Yoshinori Kagawa, Kazuo Yamabe, and Masaki Mori
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Laparoscopic surgery ,Adult ,Male ,Risk ,medicine.medical_specialty ,Reduced risk ,Multivariate analysis ,Adolescent ,Colon ,medicine.medical_treatment ,Endoscopy, Gastrointestinal ,03 medical and health sciences ,Colonic Diseases ,Young Adult ,0302 clinical medicine ,Colon surgery ,Colorectal surgery ,Medicine ,Humans ,Surgical Wound Infection ,Colonic disease ,Aged ,Retrospective Studies ,Aged, 80 and over ,Analysis of Variance ,Cross Infection ,business.industry ,Open surgery ,General Medicine ,Middle Aged ,University hospital ,Surgery ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Original Article ,Female ,Laparoscopy ,business ,Surgical site infection - Abstract
Purpose Surgical site infection (SSI) is the most frequently occurring nosocomial infection. Remarkable surgical progress has recently been made in laparoscopic surgery. Therefore, our objective was to investigate the association between increased rates of laparoscopic colon surgery and SSI. Methods We retrospectively investigated SSI surveillance data from July 2003 to December 2015. Two university hospitals and 25 university-affiliated hospitals participated in prospective SSI surveillance. Univariate and multivariate analyses were performed to detect significant associations. Results We investigated 9655 colon surgeries. The year in which surgery was performed was significantly associated with the SSI rate (p = 0.0381). The rate of laparoscopic surgery gradually increased during the study period, and by 2012 it was routinely used for > 50% of colon surgeries. Laparoscopic surgery became a significant factor associated with reduced SSI rates compared with conventional open surgery once the performance rate of laparoscopic surgery reached > 50%. Conclusions Increasing rates of laparoscopic colon surgery tended to be associated with a reduction in the SSI risk after surgical treatment of colonic disease. The results of this study might encourage surgeons to view laparoscopic surgical techniques as an evidence-based approach for reducing the risk of SSI. Electronic supplementary material The online version of this article (10.1007/s00595-019-1760-1) contains supplementary material, which is available to authorized users.
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- 2019
10. Magnetic Correlation Engineering in Spin-Sandwiched Layered Magnetic Frameworks
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Honoka Nemoto, Kunihisa Sugimoto, Wataru Kosaka, Hitoshi Miyasaka, Kouji Taniguchi, Shogo Kawaguchi, and Hiroki Fukunaga
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Spins ,010405 organic chemistry ,Chemistry ,Magnetism ,Organic Chemistry ,Supramolecular chemistry ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Ruthenium ,Crystallography ,Ferrimagnetism ,Magnet ,Isostructural ,Spin (physics) - Abstract
The insertion of "sandwiched spins" between magnetic layers could efficiently affect the interlayer magnetic correlations, but doing so increases the complexity in the interlayer spin alignment because of competition between the inserted spin-layer interaction JNNI and the interlayer through-space interaction JNNNI if the magnitude of JNNI is of the same order as JNNNI with reciprocal signs of the respective interactions. Herein, systematic tuning of the magnetic phase variations by JNNI and JNNNI in two kinds of metal-variable isostructural series of supramolecular pillared layer magnets [MCp*2 ][{Ru2II,II (2,3,5,6-F4 CO2 )4 }2 (TCNQ)]⋅2 DCE (M=Co, Fe, Cr; 2,3,5,6-F4 PhCO2- =2,3,5,6-tetrafluorobenzoate; TCNQ=7,7,8,8-tetracyano-p-quinodimethane; DCE=1,2-dichloroethane) and their DCE-free series, in which [MCp*2 ]+ (Cp*=η5 -C5 Me5 ) species with S=0, 1/2, and 3/2 for M=Co, Fe, Cr, respectively, are sandwiched between ferrimagnetic layers of [{Ru2 }2 (TCNQ)]- , is demonstrated. The results showed that the flexible magnetic natures of these magnets are changeable in dependence on JNNI and JNNNI , as well as on interlayer inserted spins M.
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- 2020
11. [A Case of Successful Surgical Treatment for Paraaortic Lymph Nodes Recurrence of Gallbladder Cancer]
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Akihisa, Urahigashi, Hiroki, Fukunaga, Hirokazu, Sawami, Masayuki, Hiraki, Genta, Sawada, Masahiro, Murakami, Yoko, Chihara, Masayuki, Yamamoto, Hayato, Kimura, and Shunji, Morita
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Male ,Drug Combinations ,Oxonic Acid ,Lymphatic Metastasis ,Humans ,Lymph Node Excision ,Gallbladder Neoplasms ,Lymph Nodes ,Neoplasm Recurrence, Local ,Aged ,Tegafur - Abstract
Cholecystectomy with gallbladder bed resection and regional lymphadenectomy was performed in a 75-year-old man with advanced gallbladder cancer. Pathological examination revealed adenocarcinoma in the gallbladder with regional lymph node metastases. Cancer recurrence was found in paraaortic lymph nodes behind the duodenum 9 months after the surgery. Although chemotherapy using S-1 was initiated, the lymph nodes remained the same size after 2 courses without any new recurrent regions. Lymphadenectomy was then performed as a curative surgery. The patient has remained alive without recurrence for 46 months after the second surgery.
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- 2020
12. [The Current Status of Palliative Care for Cancer on a Questionnaire Survey]
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Hirokazu, Sawami, Masayuki, Hiraki, Genta, Sawada, Masahiro, Murakami, Rei, Suzuki, Hiroki, Fukunaga, and Shunji, Morita
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Patient Care Team ,Neoplasms ,Surveys and Questionnaires ,Palliative Care ,Humans ,Medical Oncology ,Referral and Consultation - Abstract
We evaluated the current status of palliative care for cancer by questionnaire survey in 34 medical institutions belonging to the Hyogo Society for Oncology of the Colon and Rectum. Although 29 institutions(85%)had palliative care teams, the profiles of team members differed between the institutions. The inclusion rates of psychiatrists, nutritionists, medical social workers, clinical psychologists, and rehabilitation therapists was half or less. Ten institutions had some positive screening systems for objective patients. Consultation from a surgical or medical oncologist to a palliative care doctor was most frequently performed at the end of chemotherapy(46%)but was widely distributed from the beginning of chemotherapy to the period of best supportive care. Most institutes positively adopted surgical palliation and palliative radiotherapy as non-pharmacological options. While palliative care teams were prevalent in this survey, the systematic supply of palliative care may be under development with limited resources.
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- 2020
13. 3D Vessel Image Reconstruction by MDCT for Surgical Indication and Timing of Strangulating Small Bowel Obstructions
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Akira Hagiwara, Nobuo Tanaka, Rei Suzuki, Hiroki Fukunaga, Akira Inoue, Hidekazu Takahashi, Masayuki Hiraki, Shunji Morita, Masaru Murata, and Hirokazu Sawami
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Adult ,Male ,medicine.medical_specialty ,Computed tomography ,Iterative reconstruction ,03 medical and health sciences ,0302 clinical medicine ,Imaging, Three-Dimensional ,medicine.artery ,Intestine, Small ,Multidetector Computed Tomography ,medicine ,Image Processing, Computer-Assisted ,Humans ,Superior mesenteric artery ,Medical diagnosis ,Vein ,Aged ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Vascular flow ,030211 gastroenterology & hepatology ,Surgery ,Female ,Imaging technique ,Radiology ,business ,Surgical interventions ,Intestinal Obstruction - Abstract
Patients with strangulating small bowel obstructions (SBOs) can rapidly deteriorate, in condition; therefore, immediate and appropriate diagnosis is required. However, some cases of SBO are difficult to diagnose using axial computed tomography (CT) images alone. The impact of 3D vessel imaging for the diagnosis, surgical indication, and timing of strangulating SBOs was investigated, prospectively. Clinical data were collected for 111 strangulating SBOs and 48 simple SBOs from patients receiving surgical interventions from January 2009 to March 2018. The accuracy of preoperative diagnoses for the type of SBO was evaluated. Among 159 patients, 27 underwent contrast-enhanced CT imaging as well as prospectively reconstructed 3D vessel imaging of the superior mesenteric artery, vein, and branches. The concordance rate of operative findings and preoperative diagnoses of the type of SBO were compared between axial CT imaging alone and combination of axial and 3D vessel imaging. Overall concordance rate of diagnosis for the type of SBO by axial imaging was 93.1% and that of strangulating and simple SBOs was 92.8% and 93.8%, respectively. Combined axial and 3D vessel imaging resulted in 100% accuracy of preoperative diagnoses for both types of SBO. In addition, abnormalities could be classified from 3D vessel images as central twists or peripheral twists, and deteriorated vascular flow could also be detected. The combination of axial imaging and 3D vessel imaging can be used to accurately diagnose SBOs, and this imaging technique may be useful for determining the surgical indication and suitable timing of strangulating SBOs.
- Published
- 2019
14. Charge-transfer Layered Assembly of a trans-Heteroleptic Paddlewheel-type Diruthenium(II, II) Complex with a TCNQ Derivative: Electrochemical Tuning of the Magnetism
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Hitoshi Miyasaka, Kouji Taniguchi, Nanami Shito, and Hiroki Fukunaga
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Trifluoromethyl ,010405 organic chemistry ,Magnetism ,General Chemistry ,010402 general chemistry ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,Crystallography ,Paramagnetism ,chemistry.chemical_compound ,chemistry ,Ferrimagnetism ,Phase (matter) ,Moiety ,Derivative (chemistry) - Abstract
The first example of a charge-transfer assembly based on a trans-heteroleptic paddlewheel-type diruthenium (II, II) complex with a TCNQ derivative is reported: [trans-{Ru2(CF3CO2)2(2,6-(CF3)2PhCO2)2}2TCNQ(OMe)2]·2CH2Cl2·2(p-xylene) (1; CF3CO2− = trifluoroacetate; 2,6-(CF3)2PhCO2– = 2,6-di(trifluoromethyl)benzoate; TCNQ(OMe)2 = 2,5-bis(methoxy)-7,7,8,8-tetracyanoquinodimethane) and its CH2Cl2-free compound (1'), where the TCNQ(OMe)2 moiety is neutral. Electrochemical magnetic tuning in 1' has been conducted using a Li-ion battery system, which induces a ferrimagnetic phase via the discharging process; in contrast, the pristine 1' complex is paramagnetic.
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- 2018
15. Magnetic Switching by the In Situ Electrochemical Control of Quasi-Spin-Peierls Singlet States in a Three-Dimensional Spin Lattice Incorporating TTF-TCNQ Salts
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Hiroki Fukunaga, Wataru Kosaka, Kouji Taniguchi, Masanori Tonouchi, Shojiro Kimura, and Hitoshi Miyasaka
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Spins ,Coordination polymer ,Organic Chemistry ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Paramagnetism ,chemistry.chemical_compound ,Crystallography ,chemistry ,Ferrimagnetism ,Molecule ,Singlet state ,0210 nano-technology ,Spin (physics) ,Tetrathiafulvalene - Abstract
Magnetic phase switching in a coordination polymer is reported, which is demonstrated by combining two processes: (A) the pre-organization of magnetic/redox-active molecules into a framework, and (B) a post-treatment through electrochemical tuning of the pre-organized molecules. A TTF.+ -TCNQ.- salt (TTF=tetrathiafulvalene; TCNQ=7,7,8,8-tetracyano-p-quinodimethane) was incorporated into a three-dimensional framework with paddlewheel-type dimetal(II, II) units ([M2II,II ]; M=Ru with S=1, 1; and Rh with S=0, 2), where the [M2II,II ] and TCNQ.- units form the coordinating framework, and TTF.+ is located in the pores of framework, forming an irregular π-stacking alternating column with the TCNQ.- in the framework. In 1, the spins of [Ru2II,II ] and TCNQ.- units make a magnetic correlation through the framework upon decreasing the temperature from 300 K, which is, however, suddenly suppressed below 137 K (=Td (1)) by the formation of a spin singlet in the TTF.+ -TCNQ.- columns, as seen in the spin-Peierls transition (Td (2)=200 K). This material was incorporated as a cathode in a Li-ion battery (LIB); a long-range ferrimagnetic correlation was formed through the three-dimensional [{Ru2II,II }2 TCNQ]- framework at Tc =78 K in the discharge process. The reversible magnetic phase switching between the non-volatile ferrimagnetic and paramagnetic states, resulting from the local spin tuning of quasi-spin-Peierls singlet, is demonstrated through the discharge/charge cycling of the LIB.
- Published
- 2018
16. Regulation of NO Uptake in Flexible Ru Dimer Chain Compounds with Highly Electron Donating Dopants
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Jun Zhang, Susumu Kitagawa, Hiroki Fukunaga, Hitoshi Miyasaka, Wataru Kosaka, and Masaki Takata
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Dopant ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Dimer ,Doping ,Phenazine ,Electron ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,Crystallography ,chemistry.chemical_compound ,Adsorption ,Molecule ,Physical and Theoretical Chemistry ,Solid solution - Abstract
On-demand design of porous frameworks for selective capture of specific gas molecules, including toxic gas molecules such as nitric oxide (NO), is a very important theme in the research field of molecular porous materials. Herein, we report the achievement of highly selective NO adsorption through chemical doping in a framework (i.e., solid solution approach): the highly electron donating unit [Ru2(o-OMePhCO2)4] (o-OMePhCO2– = o-anisate) was transplanted into the structurally flexible chain framework [Ru2(4-Cl-2-OMePhCO2)4(phz)] (0; 4-Cl-2-OMePhCO2– = 4-chloro-o-anisate and phz = phenazine) to obtain a series of doped compounds, [{Ru2(4-Cl-2-OMePhCO2)4}1–x{Ru2(o-OMePhCO2)4}x(phz)] (x = 0.34, 0.44, 0.52, 0.70, 0.81, 0.87), with [Ru2(o-OMePhCO2)4(phz)] (1) as x = 1. The original compound 1 was made purely from a “highly electron donating unit” but had no adsorption capability for gases because of its nonporosity. Meanwhile, the partial transplant of the electronically advantageous [Ru2(o-OMePhCO2)4] unit wi...
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- 2016
17. Geometrical Constraints Associated to Mechano-sensing Induced Dual-filament Regulation Improve In-silico Explanation of Power Output in Muscle Modelling
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Mitsuhiro Iwaki, Hiroki Fukunaga, Lorenzo Marcucci, and Toshio Yanagida
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Physics ,Protein filament ,In silico ,Biophysics ,Power output ,Biological system ,Dual (category theory) - Published
- 2020
18. Stress-strain response and martensitic transformation for SUS304 stainless steel obtained by biaxial bulge test
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Kohei Iwanaga, Hiroki Fukunaga, and Hiroshi Hamasaki
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Materials science ,Bulge test ,Diffusionless transformation ,Stress–strain curve ,Composite material - Published
- 2020
19. Frontispiece: Magnetic Switching by the In Situ Electrochemical Control of Quasi-Spin-Peierls Singlet States in a Three-Dimensional Spin Lattice Incorporating TTF-TCNQ Salts
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Hiroki Fukunaga, Masanori Tonouchi, Kouji Taniguchi, Wataru Kosaka, Shojiro Kimura, and Hitoshi Miyasaka
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Organic Chemistry ,General Chemistry ,Catalysis - Published
- 2018
20. Electron-Transferred Donor/Acceptor Ferrimagnet with TC = 91 K in a Layered Assembly of Paddlewheel [Ru2] Units and TCNQ
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Hitoshi Miyasaka, Wataru Kosaka, and Hiroki Fukunaga
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Inorganic Chemistry ,Crystallography ,Dipole ,Ferromagnetism ,Ferrimagnetism ,Chemistry ,Antiferromagnetism ,Ionic bonding ,Nanotechnology ,Physical and Theoretical Chemistry ,Spin (physics) ,Ground state ,Acceptor - Abstract
The donor (D)/acceptor (A) assembly reaction of the paddlewheel-type diruthenium(II,II) complex [Ru2(2,4,6-F3PhCO2)4(THF)2] (2,4,6-F3PhCO2(-) = 2,4,6-trifluorobenzoate; abbreviated hereafter as [Ru2]) with 7,7,8,8-tetracyano-p-quinodimethane (TCNQ) in a p-xylene/CH2Cl2 solvent system led to the formation of a two-dimensional layered compound, [{Ru2(2,4,6-F3PhCO2)4}2(TCNQ)]·2(p-xylene)·2CH2Cl2 (1). As expected from this D/A combination, 1 has a one-electron-transfer ionic state with the D(0.5+)2A(-) formulation. This state formally derives a heterospin state composed of S = 1 for [Ru(II,II)2], S = 3/2 for [Ru(II,III)2](+), and S = ½ for TCNQ(•-), possibly causing intralayer ferrimagnetic spin ordering. Most of these types of compounds have an antiferromagnetic ground state because of the coupling of ferrimagnetically ordered layers in dipole antiferromagnetic interactions. However, 1 became a three-dimensional ferrimagnet with T(C) = 91 K because of the presence of interlayer ferromagnetic interactions.
- Published
- 2015
21. A charge-disproportionate ordered state with δ = 0.75 in a chemically sensitive donor/acceptor Dδ+2A2δ− layered framework
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Hitoshi Miyasaka, Takafumi Yoshino, Hiroki Fukunaga, Hajime Sagayama, Jun-ichi Yamaura, Wataru Kosaka, and Taka-hisa Arima
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Chemistry ,Inorganic chemistry ,Metals and Alloys ,Charge (physics) ,General Chemistry ,State (functional analysis) ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Crystallography ,Oxidation state ,Materials Chemistry ,Ceramics and Composites ,Donor acceptor - Abstract
A novel charge-disproportionation state with δ = 0.75 was observed in an electron-donor (D)/-acceptor (A) D(δ+)2A(2δ-) layered framework by chemically tuning the electron-donating affinity of D at the boundary between D(0.5+)2A(-) and D(+)2A(2-) phases, which was pressure-sensitive due to the formation of the D(+)2A(2-) oxidation state.
- Published
- 2015
22. [A Case of Metachronous Liver Metastases of Gall Bladder Cancer Successfully Treated by Liver Resection]
- Author
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Kensuke, Asai, Masaru, Murata, Kazuhiro, Saso, Moyuru, Yamada, Hirokazu, Sawami, Rei, Suzuki, Hiroki, Fukunaga, Nobuo, Tanaka, Masayuki, Yamamoto, and Masahiro, Hiratsuka
- Subjects
Antimetabolites, Antineoplastic ,Chemotherapy, Adjuvant ,Liver Neoplasms ,Hepatectomy ,Humans ,Cholecystectomy ,Female ,Gallbladder Neoplasms ,Deoxycytidine ,Gemcitabine ,Aged - Abstract
A 73-year-old woman was diagnosed with gall bladder cancer by contrast enhanced CT images.The tumor was detected at the fundus of the gall bladder and enhanced heterogeneously.She underwent radical cholecystectomy including Japanese D2 lymph node dissection for gall bladder cancer.After 4 courses of oral S-1(80mg/m2 administered for 4 weeks and then stopped for 2 weeks)as adjuvant chemotherapy, a liver metastasis at segment 5 appeared 11 months postoperatively.It showed a ring enhanced tumor on contrast enhanced CT images.FDG accumulated in a similar lesion on PET-CT images.The patient successfully underwent partial hepatectomy of segment 5 of the liver.However, another liver metastasis at segment 7 appeared 5 months after the second operation, but it was resected successfully.The primary lesion and both liver metastases showed similar microscopic appearances.Seven courses of gemcitabine therapy(gemcitabine 1,000mg/m2 once every week for 3 weeks and then stopped for 1 week)were administered as adjuvant chemotherapy.She is now doing well without any sign of recurrence 2 years after the initial operation and 14 months after the secondary liver resection.
- Published
- 2017
23. Comparison between S-1 monotherapy and S-1 plus cisplatin as postoperative chemotherapy after R0 resection for stage IV gastric cancer patients with oligometastasis: A multicenter retrospective study
- Author
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Kazuaki Tanabe, Masanori Terashima, Toshifumi Yamaguchi, Gen Yunome, Hiroki Taniguchi, M. Watanabe, Takahiro Kinoshita, Takanobu Yamada, Takeshi Sakamoto, Yasuyuki Kawachi, Narikazu Boku, Hiroki Fukunaga, Koshiro Ishiyama, Yosuke Kano, Atsuo Takashima, Kazuhiro Nishikawa, Koshi Kumagai, Kengo Nagashima, and Hiroshi Yabusaki
- Subjects
Cisplatin ,Cancer Research ,medicine.medical_specialty ,Postoperative chemotherapy ,business.industry ,Cancer ,Retrospective cohort study ,medicine.disease ,Surgery ,Metastasis ,Oncology ,Medicine ,Stage (cooking) ,business ,Stage iv ,R0 resection ,medicine.drug - Abstract
123 Background: Gastric cancer (GC) with liver metastasis (M1: HEP) and para-aortic lymph node metastasis (M1: LYM) is categorized as stage IV. Based on the retrospective reports, surgical resection is weakly recommended for oligo-metastasis (O-Meta), if resectable, in the Japanese GC Treatment Guidelines 2018. Whereas S-1 monotherapy as adjuvant chemotherapy after surgery for stage II/III GC and S-1 plus cisplatin (SP) as palliative chemotherapy for unresectable stage IV GC are standard treatments, there is no consensus about post-operative chemotherapy (Post-Cx) after R0 resection of stage IV GC with O-Meta. Methods: The criteria for this retrospective study were: 1) no prior treatment for GC, 2) R0 resection including O-Meta (HEP or LYM) at 20 institutions in the Stomach Cancer Group of the Japan Clinical Oncology Group between 2007 and 2012, 3) histological confirmation of adenocarcinoma for primary tumor and O-Meta (M1: HEP or LYM), 4) no other distant metastasis such as peritoneal metastasis. Results: A total of 110 patients were collected. Of the 94 eligible patients, 84 patients underwent gastrectomy followed by Post-Cx with S-1 (S-1 group: n = 55), SP (SP group: n = 22) or others (Others group: n = 7), and 10 patients did not receive post-Cx (non-Cx group). Median age for the S-1, SP, Others and non-Cx groups were 66, 60, 61, and 79 years old. Sites of oligo-metastasis (HEP/LYM) was 21/34, 9/13, 2/5, and 7/3 in the S-1, SP, Others and non-Cx groups. The 3- / 5-year overall and relapse free survival (OS and PFS) rates of all the patients were 45.6/31.4% and 24.5/21.3%, respectively. Median OS was 28.5 and 36.5 months in the S-1 and SP groups (HR 0.99; 95% CI 0.54-1.82, p = 0.986). In multivariate analysis, no Post-Cx, over 70 years old were identified as the independent poor prognostic factor for OS (p < 0.05). Conclusions: R0 resection followed by Post-Cx for GC patients with O-Meta showed favorable survival, while there seems no additional benefit of cisplatin to S-1 alone.
- Published
- 2019
24. A Case of Chronic Intestinal Pseudo-obstruction
- Author
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Takayuki Ogino, Giichi Maeura, Yujiro Fujie, Hiroki Fukunaga, and Hirofumi Ota
- Subjects
Intestinal pseudo-obstruction ,medicine.medical_specialty ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,Surgery ,business ,medicine.disease - Abstract
症例は40歳代の男性で,25歳頃より腸閉塞の診断で入退院を繰り返し,保存的療法で改善していた.2008年6月にS状結腸過長症と診断され,他院で腹腔鏡下S状結腸切除術を施行された.しかし同年7月に再び腸閉塞症状のため当院に入院した.入院3日目に腹膜炎症状が出現し,緊急手術を施行した.上行結腸が捻転しており同部位より口側結腸が拡張していたため,結腸右半切除術を施行した.術後も腸閉塞状態が改善せず,腹部膨満症状を改善するため,回腸人工肛門造設を施行した.その後,慢性偽性大腸閉塞症を考え,同年12月に結腸全摘術を施行した.症状の改善は認めたが,術後も腹部単純X線検査で小腸は著明に拡張した状態であったため,慢性偽性小腸閉塞症と最終診断した.術後1年経過した現在,蠕動促進薬を内服して日常生活を送っている状態である.
- Published
- 2010
25. Magnetic Sponge with Neutral-Ionic Phase Transitions
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Hitoshi Miyasaka, Yusuke Takahashi, Wataru Kosaka, Hiroki Fukunaga, Masaki Nishio, and Keisuke Narushima
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Phase transition ,Materials science ,General Chemical Engineering ,General Physics and Astronomy ,Medicine (miscellaneous) ,Ionic bonding ,010402 general chemistry ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Paramagnetism ,Molecule ,host–guest chemistry ,General Materials Science ,neutral–ionic phase transitions ,donor–acceptor systems ,Full Paper ,010405 organic chemistry ,Transition temperature ,General Engineering ,Charge density ,Full Papers ,Atmospheric temperature range ,0104 chemical sciences ,Dipole ,Chemical physics ,chain structures ,magnetic properties - Abstract
Phase transitions caused by the charge instability between the neutral and ionic phases of compounds, i.e., N–I phase transitions, provide avenues for switching the intrinsic properties of compounds related to electron/spin correlation and dipole generation as well as charge distribution. However, it is extremely difficult to control the transition temperature (T c) for the N–I phase transition, and only chemical modification based on the original material have been investigated. Here, a design overview of the tuning of N–I phase transition by interstitial guest molecules is presented. This study reports a new chain coordination‐polymer [Ru2(3,4‐Cl2PhCO2)4TCNQ(EtO)2]∙DCE (1‐DCE; 3,4‐Cl2PhCO2 − = 3,4‐dichlorobenzoate; TCNQ(EtO)2 2,5‐diethoxy‐7,7,8,8‐tetracyanoquinodimethane; and DCE = 1,2‐dichloroethane) that exhibits a one‐step N–I transition at 230 K (= T c) with the N‐ and I‐states possessing a simple paramagnetic state and a ferrimagnetically correlated state for the high‐ and low‐temperature phases, respectively. The T c continuously decreases depending on the content of DCE, which eventually disappears with the complete evacuation of DCE, affording solvent‐free compound 1 with the N‐state in the entire temperature range (this behavior is reversible). This is an example of tuning the in situ T c for the N–I phase transition via the control of the interstitial guest molecules.
- Published
- 2017
26. [Two cases of radiotherapy-induced sarcoma after breast cancer surgery]
- Author
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Shigeyuki, Hojo, Setsuko, Yoshioka, Yasuhiro, Toyoda, Fumiyoshi, Kojima, Toshiki, Noma, Hiromichi, Miyagaki, Hiroki, Matsunaga, Hisashi, Nishida, Tatsushi, Shingai, Hiroki, Fukunaga, Takayuki, Fukuzaki, Hiroaki, Ohigashi, and Yoshiichi, Maeura
- Subjects
Fatal Outcome ,Neoplasms, Radiation-Induced ,Radiotherapy ,Humans ,Breast Neoplasms ,Female ,Sarcoma ,Middle Aged ,Mastectomy, Segmental - Abstract
We report 2 cases of radiotherapy-induced sarcoma of the residual breast after breast cancer surgery. In 1 case, the patient was a 64-year-old woman. She underwent breast-conserving surgery and axillary lymph node dissection followed by irradiation to the residual breast in July 2001. A 1.1 × 1.0-cm tumor was noted in the residual breast 7 years 5 months after radiotherapy. An excisional biopsy was performed, and a histological diagnosis of angiosarcoma was made. She died of lung and peritoneal metastases 3 years 2 months after the diagnosis. In the other case, the patient was also 64 years old. She underwent breast-conserving surgery and sentinel lymph node biopsy followed by irradiation to the residual breast in October 2006. A 5.7 × 3.9-cm induration was noted in the residual breast 3 years 5 months after radiotherapy. A core needle biopsy was performed, and a histological diagnosis of sarcoma was made. Mastectomy was performed, and the histological diagnosis was malignant fibrous histiocytoma. She died of chest wall and intrapleural tumor recurrence 3 months after the mastectomy. Although radiotherapy-induced sarcoma is rare, early detection of the tumor in the irradiation area is important, as radiotherapy is often performed for breast cancer patients.
- Published
- 2015
27. [Locoregional recurrence of HER2-positive breast cancer - treatment after complete remission and long-term clinical benefits]
- Author
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Setsuko, Yoshioka, Shigeyuki, Hojo, Yasuhiro, Toyoda, Toshiki, Noma, Hiroki, Matsunaga, Hiromichi, Miyagaki, Hisashi, Nishida, Tatushi, Shingai, Hiroki, Fukunaga, Takayuki, Fukuzaki, Hiroaki, Ohigashi, and Yoshiichi, Maeura
- Subjects
Adult ,Treatment Outcome ,Receptor, ErbB-2 ,Recurrence ,Remission Induction ,Quality of Life ,Humans ,Breast Neoplasms ,Middle Aged ,Neoplasm Metastasis ,Aged - Abstract
We report 7 cases of locoregional recurrence in human epidermal growth factor receptor 2 (HER2)-positive breast cancer that we treated. An early complete response (CR) and long-term response was achieved in 5 cases. There were 4 HER2- subtype and 3 Luminal HER2-type cases. Metastasis and recurrence were detected in the residual breast tissue and the supraclavicular, axillary, and parasternal lymph nodes. Chemotherapy consisting of trastuzumab was administered as first-line treatment. A CR was observed 3-4 months after the initiation of therapy in 4 cases, and the time to progression was 27.6- 65.8 months. After achieving a CR, 3 patients terminated treatment and 2 patients continued to take trastuzumab. However, due to adverse effects associated with the chemotherapy, 1 patient changed to endocrine therapy. A second, long-term, CR was achieved in 2 relapsed CR patients by re-challenging with the same chemotherapy regimen. Two patients did not achieve CR and died due to distant metastases. For a better quality of life, it is advisable to continue treatment after a clinical CR for solitary or more complex locoregional recurrences. Following the first-line therapy and a so-called chemoholiday, the patient's disease can be re-challenged using the previously sensitive regimen with careful observation.
- Published
- 2015
28. Complete Response of Highly Advanced Colon Cancer with Multiple Lymph Node Metastases to Irinotecan Combined with UFT: Report of a Case
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Masayuki Ohue, Iwao Seshimo, Masakazu Ikenaga, Morito Monden, Masataka Ikeda, Mitsugu Sekimoto, Yujiro Fujie, Hirofumi Yamamoto, Ichiro Takemasa, Tatsushi Shingai, Seiichi Hirota, Hiroki Fukunaga, Koji Ezumi, Masayoshi Yasui, Taishi Hata, and Osamu Takayama
- Subjects
Oncology ,medicine.medical_specialty ,Colorectal cancer ,Adenocarcinoma ,Irinotecan ,Tegafur ,Metastasis ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Prodrugs ,Enzyme Inhibitors ,Uracil ,Lymph node ,business.industry ,Combination chemotherapy ,Colonoscopy ,General Medicine ,Middle Aged ,medicine.disease ,Supraclavicular lymph nodes ,medicine.anatomical_structure ,Lymphatic Metastasis ,Colonic Neoplasms ,Camptothecin ,Female ,Surgery ,Lymph ,Radiology ,Tomography, X-Ray Computed ,business ,Follow-Up Studies ,medicine.drug - Abstract
Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due to colon cancer, is extremely rare. We herein report a case of such systemic lymph node metastasis that was successfully treated with a combination of irinotecan (CPT-11) and UFT, a combination drug of tegafur and uracil. The patient was a 57-year-old woman who had a tumor in the ascending colon, and massively swollen para-aortic and supraclavicular lymph node metastasis. She was treated with combination chemotherapy of CPT-11 and UFT. The main tumor was detected as a decompressed scar, and the supraclavicular and para-aortic lymph nodes had completely disappeared after the second cycle of treatment. A histopathological examination and immunohistochemistry with cytokeratin showed complete remission of adenocarcinoma in the tumor and para-aortic lymph nodes. She remains alive without recurrence 52 months after chemotherapy. Combination chemotherapy of CPT-11 and UFT may be of potential value in the treatment of advanced colorectal carcinoma, and both histopathological and immunohistochemical confirmation of a complete remission may indicate prolonged disease-free survival.
- Published
- 2006
29. Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal Cancer
- Author
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Mitsuaki Tatsumi, Jinyu Gu, Morito Monden, Masataka Ikeda, Mitsugu Sekimoto, Hiroki Fukunaga, Tsunehiko Nishimura, Hirofumi Yamamoto, Ichiro Takemasa, Jun Hatazawa, and Katsuki Danno
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Physiology ,Colorectal cancer ,Standardized uptake value ,Adenocarcinoma ,Sensitivity and Specificity ,Correlation ,Fluorodeoxyglucose F18 ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm Invasiveness ,Aged ,Glucose Transporter Type 1 ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Gastroenterology ,Middle Aged ,Hypoxia (medical) ,Hepatology ,Prognosis ,medicine.disease ,Primary tumor ,Gene Expression Regulation, Neoplastic ,Positron emission tomography ,Depth of invasion ,Positron-Emission Tomography ,Disease Progression ,Female ,Radiopharmaceuticals ,medicine.symptom ,Colorectal Neoplasms ,business - Abstract
We investigated the wide variability of 18F-2-fluoro-2-deoxy-D: -glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of PET in CRC diagnosis was 100%, with a mean SUV of 8.0 (3.1-11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85%) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion.
- Published
- 2006
30. Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer
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Mitsugu Sekimoto, Masataka Ikeda, Osamu Takayama, Ichiro Higuchi, Jun Hatazawa, Morito Monden, Masayuki Ohue, Hiroki Fukunaga, Mitsuaki Tatsumi, Masayoshi Yasui, Iwao Seshimo, Masakazu Ikenaga, Tsunehiko Nishimura, and Hirofumi Yamamoto
- Subjects
Adult ,Male ,Curative resection ,medicine.medical_specialty ,Colorectal cancer ,Computed tomography ,Adenocarcinoma ,Fluorodeoxyglucose F18 ,Surgical oncology ,Image Processing, Computer-Assisted ,medicine ,Humans ,In patient ,Colectomy ,Aged ,Fusion image ,medicine.diagnostic_test ,Rectal Neoplasms ,business.industry ,Middle Aged ,medicine.disease ,Patient management ,Oncology ,Positron emission tomography ,Positron-Emission Tomography ,Female ,Surgery ,Radiology ,Neoplasm Recurrence, Local ,Radiopharmaceuticals ,Tomography, X-Ray Computed ,business ,Nuclear medicine - Abstract
The aim of this study was to evaluate the clinical and therapeutic value of digital fusion image (FI) of positron emission tomography (PET) using (18)F-fluorodeoxy glucose and computed tomography (CT) in patients who were suspected of having a local recurrence of rectal cancer.Forty-two patients (32 men and 10 women; mean age, 61.4 years, range, 40-79 years) with a suspicion of local recurrence after curative resection of rectal cancer were prospectively recruited and underwent (18)F-fluorodeoxy glucose-PET and CT. The FI was reconstructed with a commercially available digital software program, T-B Fusion. Wilcoxon signed rank test was used to compare FI with CT alone or PET alone.FI yielded a correct diagnosis in 39 (93%) of 42 patients, whereas CT alone and PET alone did so in 33 (79%) and 37 (88%) patients, respectively. FI had better diagnostic accuracy than CT alone (P = .0138) and PET alone (P = .0156). Overall, FI altered patient management in 11 (26.2%) patients on the basis of additional information, including differentiation of the tumor from the postoperative scar in 6 patients, exact anatomical location in 3 patients, and both in 2 patients.FI has a potential clinical value in the treatment of suspected local recurrence of rectal cancer.
- Published
- 2005
31. Gamma camera coincidence imaging with [18F]fluorodeoxyglucose in the pretreatment evaluation of patients with oesophageal cancer
- Author
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Asit Kr Paul, T Yasuda, Tsunehiko Nishimura, Mitsuaki Tatsumi, Ichiro Higuchi, and Hiroki Fukunaga
- Subjects
Male ,medicine.medical_specialty ,Esophageal Neoplasms ,Pathological staging ,Radiography ,Sensitivity and Specificity ,Metastasis ,Fluorodeoxyglucose F18 ,Biopsy ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Neoplasms, Squamous Cell ,Radionuclide Imaging ,Aged ,Aged, 80 and over ,Fluorodeoxyglucose ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Positron emission tomography ,Female ,Lymph ,Radiology ,Radiopharmaceuticals ,business ,Tomography, Emission-Computed ,medicine.drug - Abstract
This study investigated the role of [18F]fluorodeoxyglucose (FDG) dual-head gamma camera coincidence imaging (GCI) in the pretreatment evaluation of patients with oesophageal cancer. Twenty-two patients (20 men; mean age, 64 years) with untreated, biopsy proven squamous cell carcinoma of the oesophagus underwent positron emission tomography (PET) and GCI 1 and 3 h after a single injection of FDG, respectively. Computed tomography (CT) was performed within 2 weeks of the FDG imaging. The sensitivity of lesion detection was compared between GCI and PET. Regional (N) and distant (M) metastases detected by GCI were evaluated with reference to PET and CT. The staging obtained by each modality was also compared with pathological staging in nine patients who underwent surgery. FDG PET detected 22 primary tumours, 34 metastatic lymph nodes and four organ metastases. Of them, GCI detected all primary tumours, 24 (71%) metastatic lymph nodes, and none of the organ metastases. Lymph nodes missed by GCI were smaller in size and the majority of them were located in the thoracic region. GCI provided N and M staging identical to CT and PET in eight patients and improved staging over CT in four patients. On the other hand, GCI missed metastases detected by both PET and CT in five patients. The addition of GCI to CT could improve detection of patients with metastasis to 82% (18/22) compared with 64% (14/22) detected by CT alone. In patients with pathological staging (n = 9), GCI could influence management changes in two patients (22%). In conclusion, FDG GCI has a role that is complementary to CT in the initial staging of patients with oesophageal cancer, and due to the additional detection of nodal metastasis, GCI can provide staging information, which may influence changes in management.
- Published
- 2003
32. Magnet design by integration of layer and chain magnetic systems in a π-stacked pillared layer framework
- Author
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Hitoshi Miyasaka and Hiroki Fukunaga
- Subjects
Chemistry ,business.industry ,Charge (physics) ,Electron donor ,Nanotechnology ,General Chemistry ,General Medicine ,Crystal engineering ,Acceptor ,Catalysis ,chemistry.chemical_compound ,Chain (algebraic topology) ,Magnet ,Optoelectronics ,Anisotropy ,business ,Layer (electronics) - Abstract
The control of inter-lattice magnetic interactions is a crucial issue when long-range ordered magnets that are based on low-dimensional magnetic frameworks are designed. A "pillared layer framework (PLF)" model could be an efficient system for this purpose. In this report, A magnet based on a π-stacked PLF with a phase transition temperature of 82 K, which can be increased to 107 K by applying a pressure of 12.5 kbar, is rationally constructed. Two types of low-dimensional magnetic framework systems, an electron donor/acceptor magnetic layer and a charge transfer [FeCp*2](+)TCNQ(.-) columnar magnet ([FeCp*2](+) = decamethylferrocenium; TCNQ = 7,7,8,8-tetracyano-p-quinodimethane), are integrated to fabricate the magnet. This synthetic strategy employing a combination of layers and chains is widely useful not only for magnet design, but also for the creation of multifunctional materials with pores and anisotropic frameworks.
- Published
- 2014
33. [A case of coexisting borderline phyllodes tumor and non-invasive ductal carcinoma]
- Author
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Yasuhiro, Toyoda, Shigeyuki, Hojo, Setsuko, Yoshioka, Fumiyoshi, Kojima, Hiroki, Matsunaga, Yujiro, Fujie, Hiroki, Fukunaga, Hirofumi, Ota, Wakio, Endo, and Yoshiichi, Maeura
- Subjects
Adult ,Carcinoma, Ductal ,Treatment Outcome ,Phyllodes Tumor ,Biopsy, Needle ,Humans ,Breast Neoplasms ,Female ,Combined Modality Therapy - Abstract
A 36-year-old woman with benign phyllodes tumor of the left breast had undergone lumpectomy 1 year ago and was admitted to our hospital because of a left breast mass on the operation scar. Ultrasonography showed a 35 mm low-echoic, elliptical mass with a high depth to width( D/W) ratio in the C area and a 10 mm low-echoic, polygonal mass with a high D/W ratio in the E area. Histological examination of an ultrasonography-guided vacuum-assisted biopsy specimen indicated recurrent phyllodes tumor. Since both tumors were assumed to be recurrent phyllodes tumors, quadrantectomy was performed. Finally, the mass in the C area was diagnosed as a recurrent phyllodes tumor and the mass in the E area was diagnosed as a fibroadenoma. A non-invasive ductal carcinoma was incidentally detected between the 2 tumors, and the surgical margin was negative. Radiotherapy was performed on the remnant breast tissue.
- Published
- 2014
34. [The efficacy of early diagnosis of brain metastasis and systemic treatment after radiotherapy in patients with metastatic breast cancer]
- Author
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Setsuko, Yoshioka, Shigeyuki, Hojo, Yasuhiro, Toyoda, Toshiki, Noma, Hiroki, Matsunaga, Yujiro, Fujie, Tatsushi, Shingai, Hiroki, Fukunaga, Hirofumi, Ota, Wakio, Endo, Hiroaki, Ohigashi, and Yoshiichi, Maeura
- Subjects
Adult ,Salvage Therapy ,Brain Neoplasms ,Humans ,Breast Neoplasms ,Middle Aged ,Prognosis ,Radiosurgery ,Early Detection of Cancer ,Aged - Abstract
We treated 9 patients diagnosed with brain metastasis from breast cancer. Although 1 patient was initially diagnosed as having Stage IV disease, 5 had Stage I/II early breast cancer. All patients had defined brain metastasis after chemotherapy. Brain metastasis was symptomatic in 7 patients, 4 of whom had brain edema, and asymptomatic in 2 patients. The median survival time from breast cancer metastasis was 23 days for patients who did not receive radiotherapy and 19.6 months for those who received radiotherapy. Among the patients treated with radiotherapy, the median survival time was 4.3 months for patients who did not receive further treatment and 19.7 months for those who received chemotherapy or chemotherapy with trastuzumab. One patient with a solitary brain metastasis underwent stereotactic radiosurgery, and treatment is being continued for 1 of the 2 patients who received systemic therapy after whole-brain radiotherapy and additional stereotactic radiosurgery at recurrence to control brain disease. Systemic treatment after radiotherapy is important for brain metastasis from breast cancer, and early diagnosis of brain metastasis facilitates the use of various available treatments.
- Published
- 2014
35. [A case of liposarcoma of the abdominal wall complicated by thrombocytpenia as a paraneoplastic syndrome]
- Author
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Yasuhiro, Toyoda, Wakio, Endo, Fumiyoshi, Kojima, Hiroki, Matsunaga, Kaori, Shimizu, Akiko, Yoshioka, Yujiro, Fujie, Hiroki, Fukunaga, Shigeyuki, Hojo, Setsuko, Yoshioka, Hirofumi, Ota, Hiroaki, Terada, and Yoshiichi, Maeura
- Subjects
Paraneoplastic Syndromes ,Abdominal Neoplasms ,Abdominal Wall ,Humans ,Female ,Liposarcoma ,Middle Aged ,Thrombocytopenia - Abstract
A 59-year-old woman was admitted to our hospital because of right chest pain. CT scan showed a mass on the right abdominal wall and bilateral pleural effusion. The histological diagnosis following core needle biopsy was undifferentiated sarcoma. The right pleural effusion gradually increased despite negative cytology. Although we planned chemotherapy for the clinically diagnosed pleural invasion, thrombocytopenia as a paraneoplastic syndrome appeared. The minimum thrombocyte count was 4,000/mm3. While transfusion was not effective, per os dexamethasone at 2.0 mg/day kept the thrombocyte count at around 6×10 4/mm3. Anti-thrombocyte antibody was negative. Tumor resection surgery with partial diaphragm resection and 11th and 12th rib resection, and abdominal wall plasty with mesh was performed. The final histological diagnosis was dedifferentiated liposarcoma. The thrombocyte count returned to the normal range just after the operation. However, she died of pleural dissemination, peritoneal dissemination, and local recurrence 69 days after the operation.
- Published
- 2012
36. [Two cases of stromal sarcoma, so-called malignant fibrous histiocytoma of breast treated with reduction surgery]
- Author
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Yasuhiro, Toyoda, Shigeyuki, Hojo, Setsuko, Yoshioka, Kaori, Shimizu, Yujiro, Fujie, Hiroki, Fukunaga, Hirofumi, Ota, Wakio, Endo, Fumiyoshi, Kojima, and Yoshiichi, Maeura
- Subjects
Fatal Outcome ,Biopsy ,Humans ,Breast Neoplasms ,Female ,Histiocytoma, Malignant Fibrous ,Middle Aged ,Tomography, X-Ray Computed ,Mastectomy ,Neoplasm Staging - Abstract
CASE 1: A 64-year-old woman with right breast cancer had a partial mastectomy and radiotherapy four years ago was admitted to our hospital because of right breast mass. The vacuum associated biopsy of tumor resulted in breast sarcoma, thus a nipple-spearing mastectomy was performed. The final histological diagnosis was stromal sarcoma, and was identical to histological findings of malignant fibrous histiocytoma. Three months after the operation, a chest wall recurrence appeared. Although tumor resection with latissimus dorsi flap was performed, there were pleural dissemination and malignant pleural effusion. She died six months after the first surgery. CASE 2: A 60-year-old woman was admitted to our hospital because of left breast mass, but she refused a further clinical examination. She readmitted fourteen months later due to a huge sized left breast mass with necrosis and smelling discharge. CT scan showed a huge tumor of left breast and multiple lung metastases. Biopsy of the tumor resulted in breast sarcoma. Total mastectomy with split thickness skin grafting was performed. The final histological diagnosis was identical to the first case. A local recurrence appeared thirty days after the operation, and she died fifty-one days after the operation.
- Published
- 2011
37. [Postoperative axillary-lymph-node recurrence in breast cancer patients]
- Author
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Setsuko, Yoshioka, Yoshiichi, Maeura, Shigeyuki, Hojou, Yasuhiro, Toyoda, Kaori, Shimizu, Yujiro, Fujie, Hiroki, Fukunaga, Hirofumi, Ota, and Wakio, Endo
- Subjects
Adult ,Aged, 80 and over ,Recurrence ,Lymphatic Metastasis ,Axilla ,Humans ,Breast Neoplasms ,Female ,Lymph Nodes ,Middle Aged ,Prognosis ,Aged - Abstract
We investigated 13 cases of axillary-lymph-node recurrence, who received an operation for an early stage breast cancer. They are the first recurrence of only regional without metastatic disease; the 4 patients, who had sentinel-lymph-node by biopsy at first operation, received an axillary lymph adenectomy, and 5 patients received re-lymph-adectomy after axillary lymph node dissection. The other 4 patients received only systemic therapy. Receptor conversion between primary and lymph-node recurrent site was identified for ER in 2 patients; one showed a lower expression of ER and the other showed for HER2. These led to a change in the subsequent treatment plan; 6 patients had systemic chemotherapy after recurrence, 1 patient had endocrine, 2 patients had trastuzumab and 4 patients continued the same treatment prior to surgery. Ten out of 13 patients were alive without recurrence, and 3 patients were with distant metastasis. However, one of the 3 patients who had a distant metastasis died due to brain and lung metastasis. Axillary node recurrence should be treated with axillary dissection, if possible, and receptor measurement in primary and recurrent site is useful for subsequent treatment.
- Published
- 2011
38. [A clinical case of the esophagogastric malignancy palliated with covered metallic stent with anti-reflux mechanism]
- Author
-
Hiroki, Fukunaga, Wakio, Endo, Hirofumi, Ota, Setsuko, Yoshioka, Shigeyuki, Hojo, Yujiro, Fujie, Akiko, Yoshioka, Yasuhiro, Toyoda, Kaori, Shimizu, Masayoshi, Horimoto, Yorihide, Okuda, Yasukazu, Goto, Shoko, Arimitsu, Tatsunori, Mizuno, Kazunori, Takayama, Daisuke, Yamaguchi, Makiyo, Ota, Kunio, Suzuki, and Yoshiichi, Maeura
- Subjects
Male ,Fatal Outcome ,Esophageal Neoplasms ,Stomach Neoplasms ,Palliative Care ,Esophageal Stenosis ,Gastroesophageal Reflux ,Humans ,Stents ,Esophagogastric Junction ,Tomography, X-Ray Computed ,Aged - Abstract
Esohophageal stents are often used in treating malignant stricture. But, when stents are placed across the esophagogastric junction, they may lead to esophagogastric reflux. We report a case of successfully treated esophagogastric strictures using the new stent with anti-reflux mechanism (long cover type Niti-S™ esophageal stent). A 78-year-old man presenting with severe strictures from the lower esophagus to cardiac part of stomach was histopathologically diagnosed as adenocarcinoma. CT scan images showed multiple liver metastatic tumors. However, he refused chemotherapy. Palliation using long cover type Niti-S™ esophageal stent was performed. No adverse effect was occurred. He started solid meals on the 7th postoperative day. He was thereafter able to ingest solid meals without the symptom of esophgogastric reflux and stenosis until he died of the primary disease two month later.
- Published
- 2011
39. [Three cases of breast cancer with skin metastasis after mastectomy treated by radiotherapy]
- Author
-
Setsuko, Yoshioka, Shigeyuki, Hojou, Yasuhiro, Toyoda, Takayuki, Ogino, Kaori, Shimizu, Akiko, Yoshioka, Yujiro, Fujie, Hiroki, Fukunaga, Hirofumi, Ota, Wakio, Endo, and Yoshiichi, Maeura
- Subjects
Aged, 80 and over ,Skin Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Breast Neoplasms ,Female ,Middle Aged ,Combined Modality Therapy ,Mastectomy - Abstract
We reported three cases of patient with triple negative skin metastasis after mastectomy of breast cancer. All three cases had received radiotherapy for skin metastasis. Radiation therapy was effective for recurrent sites, and could improve patient's QOL. After radiotherapy, 2 patients died due to a distant metastasis. Case 1 was resistant to chemotherapy. Case 2 was no indication of chemotherapy because of dementia metastases. Case 3 was the only one continued chemotherapy. It appears that a further consideration was needed for the timing of radiotherapy to be performed among the treatments of locoregional recurrence and distant metastasis of breast cancer.
- Published
- 2011
40. [Two cases of bronchiolitis obliterans organizing pneumonia (BOOP) induced radiotherapy after surgery of breast cancer]
- Author
-
Shigeyuki, Hojo, Setsuko, Yoshioka, Yasuhiro, Toyoda, Kaori, Shimizu, Akiko, Yoshioka, Yujiro, Fujie, Hiroki, Fukunaga, Hirofumi, Ota, Wakio, Endo, and Yoshiichi, Maeura
- Subjects
Radiotherapy ,Cryptogenic Organizing Pneumonia ,Humans ,Breast Neoplasms ,Female ,Middle Aged ,Mastectomy, Segmental ,Combined Modality Therapy - Abstract
We report two cases of bronchiolitis obliterans organizing pneumonia (BOOP) induced radiotherapy after surgery of breast cancer. One of the patients was a 58-year-old woman. She underwent a conserving surgery for bilateral breast cancers, and received radiation therapy to the remaining part of bilateral breasts. Two months after the termination of irradiation, cough, fever and general fatigue developed. We clinically diagnosed this case as BOOP after radiation therapy. After initiation of oral steroid therapy, the clinical symptoms and radiographic findings disappeared. Another patient was a 57-year-old woman. She underwent radical mastectomy for right breast cancer. A month after the operation, she suffered from local recurrence, so radiation therapy to the thoracic wall was performed. After irradiation, resection of the thoracic wall lesion was performed because of malignancy from local skin biopsy specimen. Two months after the termination of irradiation, cough, dyspnea and fever developed. We clinically diagnosed this case as radiation-induced BOOP by BAL and TBLB findings. After an initiation of steroid therapy, the clinical symptoms and radiographic findings disappeared. It is important to be aware of BOOP as a complication in the patient who was given radiation after surgery of breast cancer.
- Published
- 2011
41. [A clinical case of lymph node recurrence after resection of gastric cancer successfully treated by combination chemotherapy with irinotecan and cisplatin]
- Author
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Hiroki, Fukunaga, Wakio, Endo, Yujiro, Fujie, Kaori, Shimizu, Yasuhiro, Toyoda, Akiko, Yoshioka, Setsuko, Yoshioka, Shigeyuki, Hojou, Hirofumi, Ota, and Yoshiichi, Maeura
- Subjects
Antimetabolites, Antineoplastic ,Antineoplastic Agents ,Middle Aged ,Irinotecan ,Antineoplastic Agents, Phytogenic ,Drug Combinations ,Oxonic Acid ,Gastrectomy ,Stomach Neoplasms ,Lymphatic Metastasis ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Lymph Node Excision ,Camptothecin ,Female ,Cisplatin ,Neoplasm Recurrence, Local ,Tegafur - Abstract
A 60-year-old female who was diagnosed as gastric cancer underwent distal gastrectomy and received adjuvant chemotherapy (S-1 therapy). After 6 months, the tumor marker (CEA) was elevated. CT revealed para-aortic lymph nodes enlargement. Lymph node metastasis was confirmed. The patient was administered combination chemotherapy with irinotecan (CPT-11) and cisplatin (CDDP) Seven months later, CT revealed lymph node metastasis had disappeared. After judgment of complete response (CR), we continued the treatment for 22 months. The patient was followed without any recurrence in May 2010.
- Published
- 2011
42. [A case of surgical approach to the recurrence of the para-aortic lymph nodes after resection of rectal cancer]
- Author
-
Hiroki, Fukunaga, Hirofumi, Ota, Yujirou, Fujie, Kaori, Shimizu, Takayuki, Ogino, Yasuhiro, Toyoda, Akiko, Yoshioka, Setsuko, Yoshioka, Shigeyuki, Hojou, Wakio, Endo, Aki, Kakutani, and Yoshiichi, Maeura
- Subjects
Organoplatinum Compounds ,Rectal Neoplasms ,Lymphatic Metastasis ,Antineoplastic Combined Chemotherapy Protocols ,Leucovorin ,Humans ,Female ,Aorta, Abdominal ,Fluorouracil ,Middle Aged ,Combined Modality Therapy - Abstract
A 63-year-old female diagnosed as rectal cancer underwent low anterior resection and received adjuvant chemotherapy (folinate/tegafur/uracil therapy). After 6 months, lymph node metastasis was confirmed by an elevation of the tumor marker (CEA) and a FDG-PET image. After administration of 37 courses of mFOLFOX6 therapy, surgical excision was performed to the lymph node recurrence, because it was difficult to continue mFOLFOX6 therapy with grade 3 neuropathy. After 8 months from the last operation, no lymph node metastasis was appeared in the para-aortic area.
- Published
- 2009
43. [The efficacy of surgical resection and chemo-endocrine therapy for patients with local recurrence or axillary lymph node metastasis of breast cancer]
- Author
-
Shigeyuki, Hojo, Setsuko, Yoshioka, Akiko, Yoshioka, Yujiro, Fujie, Hiroki, Fukunaga, Yoshihiro, Okada, Hirofumi, Ota, Wakio, Endo, and Yoshiichi, Maeura
- Subjects
Adult ,Aged, 80 and over ,Survival Rate ,Lymphatic Metastasis ,Humans ,Lymph Node Excision ,Breast Neoplasms ,Endocrine System ,Middle Aged ,Neoplasm Recurrence, Local ,Prognosis ,Aged - Abstract
We evaluated a surgical resection and chemo-endocrine therapy and prognosis for patients with local recurrence or axillary lymph node metastasis of breast cancer. Twenty-one patients with local recurrence or axillary lymph node metastasis without a distant metastasis were enrolled in this study. Thirteen of the 21 patients underwent a surgical resection. Resection of recurrent lesion in residual breast after breast conserving therapy for six of the 13 patients, axillary lymph node dissection (ALND) for four, and resection of thoracic wall lesion for three were performed. Five of the patients who underwent resection of residual breast lesion, four of the patients who underwent ALND and two of the patients who underwent resection of thoracic wall lesion have survived. One of the patients who underwent resection of residual breast lesion and one of the patients who underwent resection of thoracic wall lesion were dead. In eight non-operable patients, five were dead and three have survived. Median recurrence free interval was 24 months in operable patients and 27 months in non-operable patients. Median survival time after recurrence was 29 months in operable patients and 12 months in non-operable patients. The surgical with chemo-endocrine therapy promises to control well to local recurrence or axillary lymph node metastasis for the patients we selected.
- Published
- 2008
44. Standardized uptake value on FDG-PET as a marker for disease activity in patients with non-Hodgkin's lymphoma: comparison with serum soluble interleukin-2 receptor values
- Author
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Hiroki Fukunaga, Hironobu Nakamura, Mitsuaki Tatsumi, Yuzuru Kanakura, Hiroyuki Sugahara, Jun Hatazawa, and Ichiro Higuchi
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Standardized uptake value ,Gastroenterology ,immune system diseases ,Fluorodeoxyglucose F18 ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Tumor marker ,Aged ,Fluorodeoxyglucose ,medicine.diagnostic_test ,business.industry ,Lymphoma, Non-Hodgkin ,Glucose analog ,Receptors, Interleukin-2 ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Lymphoma ,Non-Hodgkin's lymphoma ,Oncology ,Positron emission tomography ,Positron-Emission Tomography ,Surgery ,Female ,Radiopharmaceuticals ,business ,Emission computed tomography ,medicine.drug - Abstract
We compared standardized uptake values (SUVs) on positron emission tomography with a glucose analog, 2-[F-18] fluoro-2-deoxy-D-glucose (FDG-PET) and serum soluble interleukin-2 receptor (sIL-2R) values in patients with non-Hodgkin's lymphoma (NHL) in the pre-, mid- (after three or four cycles), and post-treatment periods of chemotherapy (pre, mid, and post, respectively), and we examined whether the SUV was a useful tumor marker for NHL.The SUVs on PET and sIL-2R values were retrospectively evaluated based on all the clinical information available in 40 patients (31 in pre, 24 in mid, and 24 in the post periods). Patients in complete remission status were classified as group A and those with active residual disease in the mid and post periods were classified as group B.In pre, the SUV and sIL-2R values exhibited sensitivity of 100% and 84%, respectively. In mid, the SUV was lower in group A than in group B, while sIL-2R was not different. The SUV yielded better specificity than sIL-2R (88% vs. 25%, respectively), though the difference was not significant. In mid, the SUV in patients later assigned to group A in post was lower than than the SUV in group B, whereas sIL-2R was not different. In post, the specificity and accuracy of SUV were better than those of sIL-2R (95 vs. 47%, and 96 vs. 58%, respectively). Both the SUV and sIL-2R were lower in group A than in group B.The SUV on PET was better than the serum sIL-2R as a marker to evaluate the disease status of NHL, and was considered to be a useful tumor marker for NHL.
- Published
- 2008
45. [Two patients having recurrent breast cancer with brain metastases well controlled with a gamma knife radio-surgery]
- Author
-
Shigeyuki, Hojo, Yoshiichi, Maeura, Setsuko, Yoshioka, Yujiro, Fujie, Hiroki, Fukunaga, Yoshihiro, Okada, Hirofumi, Ota, and Wakio, Endo
- Subjects
Paclitaxel ,Brain Neoplasms ,Liver Neoplasms ,Breast Neoplasms ,Anastrozole ,Middle Aged ,Triazoles ,Radiosurgery ,Antineoplastic Combined Chemotherapy Protocols ,Nitriles ,Hepatectomy ,Humans ,Infusions, Intra-Arterial ,Female ,Pleurisy ,Mastectomy ,Pleurodesis - Abstract
We report two patients having recurrent breast cancer with brain metastases that was controlled well with a gamma knife radio-surgery. The patient is a 50-year-old woman. She underwent radical mastectomy for right breast cancer in September 1993. She suffered from multiple liver metastases in June 2000, so CEF therapy contained hepatic arterial infusion chemotherapy, and extended right lobectomy of the liver were performed in December 2001. Afterward, pleurodesis was carried out to the carcinomatous pleurisy. Then she underwent simple total hysterectomy and bilateral oophorectomy for torsion of the metastatic ovarian tumor. MRI study revealed brain metastases with a diameter of 1 cm in her right midbrain in April 2005, so a gamma knife radio-surgery was performed. After the radio-surgery, a weekly paclitaxel therapy followed by peroral chemotherapy with capecitabine was started, and she took the regimen continuously. Another patient is a 56-year-old woman. She underwent skin sparing mastectomy with axillary lymph node dissection for right breast cancer in November 2002. Metastases to the base of her skull were found in October 2004, so a gamma knife radio-surgery was carried out. After the radio-surgery, a weekly paclitaxel therapy with anastrozole was started. In both of the two patients, the metastatic brain tumors have not shown growth so far and are under good control as of March 2006.
- Published
- 2007
46. [A case of femoral artery pseudoaneurysm occurring in the site of a reservoir port for hepatic arterial infusion]
- Author
-
Hirofumi, Ota, Takashi, Nakamura, Wakio, Endoh, Shigeyuki, Hojo, Setsuko, Yoshioka, Yoshihiro, Okada, Hiroki, Fukunaga, and Yoshiichi, Maeura
- Subjects
Male ,Venous Thrombosis ,Hematoma ,Liver Neoplasms ,Neoplasms, Second Primary ,Cecal Neoplasms ,Femoral Artery ,Radiography ,Hepatic Artery ,Chemotherapy, Adjuvant ,Humans ,Infusions, Intra-Arterial ,Emergencies ,Aneurysm, False ,Aged - Abstract
A 73-year-old man underwent partial hepatic resection (55) for metachronous metastatic liver tumor from cecal cancer in November 2005. A reservoir port for hepatic arterial infusion (HAI) adjuvant chemotherapy was placed in the right femoral artery and the HAI chemotherapy was carried out. In January 2006, he had swellings of the right lower leg and inguinal region and was admitted to our hospital for a hematoma in the site of the reservoir port and deep venous thrombosis. The swelling of the right lower leg went down with a bed rest in a couple of days. However, the hematoma of the reservoir port site was increased. The hematoma was removed and sutured to stop bleeding and then compression homeostasis was applied for a week. An enhanced pelvic CT scan showed a pseudoaneurysm in the femoral artery and an impending rupture was suspected. He was immediately referred to a vascular surgeon and underwent emergency surgery. Intraoperative angiography showed a pseudoaneurysm, 2.5 cm in diameter, in the femoral artery. An approximate 1 cm tear around the catheter insertion site was found and a primary suture was performed. A rapid diagnosis and treatment are required when a pseudoaneurysm is suspected during HAI chemotherapy.
- Published
- 2007
47. Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization
- Author
-
Hirofumi Yamamoto, Ichiro Takemasa, Morito Monden, Masataka Ikeda, Nariaki Matsuura, Hiroki Fukunaga, I. Bernard Weinstein, Jinyu Gu, Mitsugu Sekimoto, Makiko Maeda, Masayoshi Yasui, Bazarragchaa Damdinsuren, Chew Yee Ngan, Yurika Sugita, and Yasushi Fujio
- Subjects
Cancer Research ,Small interfering RNA ,Transplantation, Heterologous ,Mice, Nude ,Biology ,Oligodeoxyribonucleotides, Antisense ,Neovascularization ,chemistry.chemical_compound ,Mice ,Structure-Activity Relationship ,Cyclin D1 ,Cell Line, Tumor ,medicine ,Animals ,Humans ,RNA, Small Interfering ,Cell Proliferation ,Tube formation ,Neovascularization, Pathologic ,Cell growth ,Vascular Endothelial Growth Factors ,Endothelial Cells ,Xenograft Model Antitumor Assays ,Vascular endothelial growth factor ,Endothelial stem cell ,Disease Models, Animal ,Oncology ,chemistry ,Cancer cell ,Cancer research ,Female ,medicine.symptom - Abstract
Purpose: Our aim was to determine the effects of cyclin D1 inhibition on tumor-associated neovascularization and endothelial cell growth. Experimental Design: We have generated adenovirus system for antisense to cyclin D1 (AS CyD1) and evaluated in vitro and in vivo effects. Small interfering RNA against cyclin D1 was also used to analyze cyclin D1 inhibition-associated vascular endothelial growth factor (VEGF) regulation. Results: The xenografts treated with adenoviral AS CyD1 showed less vessel density and displayed smaller tumor size in colon cancer cell lines HCT116 and DLD1. In vitro studies indicated that AS CyD1 decreased VEGF protein expression in DLD1 but not in HCT116. Cyclin D1 small interfering RNA caused a decrease in VEGF expression at protein and RNA levels in DLD1. A modest decrease was noted in the VEGF promoter activity, with inactivation of the STAT3 transcription factor through dephosphorylation. On the hand, the cyclin D1 inhibition plus STAT3 inhibitor markedly decreased VEGF expression in HCT116, although VEGF did not change by the STAT3 inhibitor alone. In cultures of human umbilical vein endothelial cells (HUVEC), VEGF augmented cyclin D1 expression and cell growth. AS CyD1 significantly inhibited HUVEC growth even in the presence of VEGF. AS CyD1 also significantly suppressed in vitro tube formation in VEGF-treated HUVEC and in vivo macroaneurysm formation in VEGF-treated Matrigel plug. Conclusions: Our results suggest that cyclin D1 may play a role in the maintenance of VEGF expression and that AS CyD1 could be potentially useful for targeting both cancer cells and their microenvironment of tumor vessels.
- Published
- 2006
48. Adenocarcinoma arising below an ileoanal anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case
- Author
-
Yoshiichi Maeura, Shigeru Okamoto, Hirofumi Ota, Setsuko Yoshioka, Hiroki Fukunaga, Wakio Endoh, Yoshihiro Okada, Shigeyuki Hojo, Nobuhisa Ueda, and Keiji Yamazaki
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Anastomosis ,Postoperative Complications ,Ileum ,medicine ,Humans ,Intestinal Mucosa ,business.industry ,Proctocolectomy ,Abdominoperineal resection ,Anastomosis, Surgical ,Proctocolectomy, Restorative ,Rectum ,General Medicine ,Colonoscopy ,Middle Aged ,medicine.disease ,Anus ,Anus Neoplasms ,Total mesorectal excision ,Ulcerative colitis ,Adenocarcinoma, Mucinous ,Surgery ,medicine.anatomical_structure ,Adenocarcinoma ,Colitis, Ulcerative ,Pouch ,business ,Follow-Up Studies - Abstract
We report a case of adenocarcinoma developing in remnant rectal mucosa below a hand-sewn ileal pouch–anal anastomosis (IPAA) after restorative proctocolectomy for ulcerative colitis (UC). To our knowledge, this is the first such case to be reported from Japan. A 60-year-old man with a 13-year history of UC underwent proctocolectomy with a hand-sewn IPAA and mucosectomy for anal stenosis and serious tenesmic symptoms. About 7 years later, a follow-up endoscopy showed a flat elevated malignant lesion, 2 cm in diameter, below the ileoanal anastomosis. He was treated by abdominoperineal resection of the pouch and anus with total mesorectal excision. Histopathological examination of the resected specimen confirmed the presence of a well-differentiated adenocarcinoma but there were no metastatic lymph nodes. He recovered uneventfully and remains well without evidence of recurrent disease 2 years and 3 months after his last operation.
- Published
- 2006
49. [Two patients of recurrent breast cancer with carcinomatous pleurisy well controlled pleural effusion]
- Author
-
Shigeyuki, Hojo, Yoshiichi, Maeura, Hiroki, Fukunaga, Setsuko, Yoshioka, Hirofumi, Ota, Wakio, Endo, and Keiji, Yamazaki
- Subjects
Picibanil ,Paclitaxel ,Antineoplastic Combined Chemotherapy Protocols ,Drainage ,Humans ,Antineoplastic Agents ,Breast Neoplasms ,Female ,Middle Aged ,Neoplasm Recurrence, Local ,Antineoplastic Agents, Phytogenic ,Pleurisy ,Pleural Effusion, Malignant - Abstract
We report two patients of recurrent breast cancer with carcinomatous pleurisy well controlled pleural effusion. One patient is a 49-year-old woman. She underwent radical mastectomy for right breast cancer in September 1993. She suffered from multiple liver metastases in June 2000, so CEF therapy contained hepatic arterial infusion chemotherapy and extended right lobectomy of the liver were performed in December 2001. Right pleural effusion was detected in December 2003, then, pleurodesis was carried out with OK-432 after thoracic drainage. After pleurodesis, a weekly paclitaxel therapy was started and she was taking the regimen continuously. Another patient is a 55-year-old woman. She underwent radical mastectomy for left breast cancer in September 1999. Local recurrent lesions on the left chest and left pleural effusion were found in May 2003. After thoracic drainage, infectious pleurisy was complicated, so the drainage tube was removed after the therapy for preventing infection. After pleurodesis, CE therapy followed by peroral chemo-endocrine therapy was performed. Both of the two patients are receiving outpatient treatment without recurrent pleural effusion as of July 2005.
- Published
- 2005
50. Clinical usefulness of oral granisetron hydrochloride for alleviation of delayed nausea and vomiting induced by CPT-11
- Author
-
Hirofumi Yamamoto, Masayuki Ohue, Osamu Takayama, Iwao Seshimo, Masakazu Ikenaga, M. Sekimoto, Morito Monden, Hiroki Fukunaga, Masataka Ikeda, and Masayoshi Yasui
- Subjects
Adult ,Male ,Nausea ,Vomiting ,medicine.medical_treatment ,Administration, Oral ,Pilot Projects ,Granisetron ,Irinotecan ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Humans ,Aged ,Chemotherapy ,business.industry ,Incidence (epidemiology) ,Granisetron Hydrochloride ,Middle Aged ,Regimen ,Oncology ,Anesthesia ,Antiemetics ,Camptothecin ,Female ,medicine.symptom ,business ,Colorectal Neoplasms ,medicine.drug - Abstract
This open label pilot study evaluated the safety and efficacy of the oral 5-HT3 receptor antagonist granisetron for prophylaxis of delayed chemotherapy-induced nausea and vomiting (CINV) in 30 patients with advanced or recurrent colorectal cancer. Patients were studied during two cycles of a 5-week regimen with irinotecan (CPT-11) and UFT. Patients received prophylactic anti-emetic therapy that included intravenous granisetron. If Grade 1 or higher severity gastrointestinal symptoms occurred during 6 days after CPT-11 administration in Cycle 1, then oral granisetron was administered daily for the following 5 days of CPT-11 in Cycle 2. Sixteen patients (53.3%) experienced delayed CINV in Cycle 1. The incidence of Grade 2 or higher vomiting was 32.1% and 27.7% in Cycles 1 and 2 in males (P = 0.554) respectively, and 54.6% and 32.4% in females (P = 0.001) respectively. Granisetron is effective against delayed Grade 2 or higher vomiting induced by CPT-11/UFT in female patients, although granisetron alone may not sufficiently control nausea induced by this regimen.
- Published
- 2005
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