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Complete Response of Highly Advanced Colon Cancer with Multiple Lymph Node Metastases to Irinotecan Combined with UFT: Report of a Case
- Source :
- Surgery Today. 36:1133-1138
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due to colon cancer, is extremely rare. We herein report a case of such systemic lymph node metastasis that was successfully treated with a combination of irinotecan (CPT-11) and UFT, a combination drug of tegafur and uracil. The patient was a 57-year-old woman who had a tumor in the ascending colon, and massively swollen para-aortic and supraclavicular lymph node metastasis. She was treated with combination chemotherapy of CPT-11 and UFT. The main tumor was detected as a decompressed scar, and the supraclavicular and para-aortic lymph nodes had completely disappeared after the second cycle of treatment. A histopathological examination and immunohistochemistry with cytokeratin showed complete remission of adenocarcinoma in the tumor and para-aortic lymph nodes. She remains alive without recurrence 52 months after chemotherapy. Combination chemotherapy of CPT-11 and UFT may be of potential value in the treatment of advanced colorectal carcinoma, and both histopathological and immunohistochemical confirmation of a complete remission may indicate prolonged disease-free survival.
- Subjects :
- Oncology
medicine.medical_specialty
Colorectal cancer
Adenocarcinoma
Irinotecan
Tegafur
Metastasis
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Prodrugs
Enzyme Inhibitors
Uracil
Lymph node
business.industry
Combination chemotherapy
Colonoscopy
General Medicine
Middle Aged
medicine.disease
Supraclavicular lymph nodes
medicine.anatomical_structure
Lymphatic Metastasis
Colonic Neoplasms
Camptothecin
Female
Surgery
Lymph
Radiology
Tomography, X-Ray Computed
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 14362813 and 09411291
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Surgery Today
- Accession number :
- edsair.doi.dedup.....27f03a99c1060adfe5ebc7f77c2aae32