Search

Using a moderate spinal cord injury paradigm combined with histological analyses and multiplexed behavioural analyses of gait, Griffin et al. show that pharmacological microtubule stabilization and rehabilitation act on complementary aspects of locomotion to enhance functional recovery. Microtubule stabilization through epothilones is a promising preclinical therapy for functional recovery following spinal cord injury that stimulates axon regeneration, reduces growth-inhibitory molecule deposition and promotes functional improvements. Rehabilitation therapy is the only clinically validated approach to promote functional improvements following spinal cord injury. However, whether microtubule stabilization can augment the beneficial effects of rehabilitation therapy or act in concert with it to further promote repair remains unknown. Here, we investigated the pharmacokinetic, histological and functional efficacies of epothilone D, epothilone B and ixabepilone alone or in combination with rehabilitation following a moderate contusive spinal cord injury. Pharmacokinetic analysis revealed that ixabepilone only weakly crossed the blood-brain barrier and was subsequently excluded from further investigations. In contrast, epothilones B and D rapidly distributed to CNS compartments displaying similar profiles after either subcutaneous or intraperitoneal injections. Following injury and subcutaneous administration of epothilone B or D, rats were subjected to 7 weeks of sequential bipedal and quadrupedal training. For all outcome measures, epothilone B was efficacious compared with epothilone D. Specifically, epothilone B decreased fibrotic scaring which was associated with a retention of fibronectin localized to perivascular cells in sections distal to the lesion. This corresponded to a decreased number of cells present within the intralesional space, resulting in less axons within the lesion. Instead, epothilone B increased serotonergic fibre regeneration and vesicular gluta

Ithaka S+R’s Research Support Services Program investigates how the research support needs of scholars vary by discipline. In 2017 and 2018 Ithaka S+R examined the changing research methods and practices of civil and environmental engineering scholars in the United States with the goal of identifying services to better support them. The goal of this report is to provide actionable findings for the organizations, institutions, and professionals who support the research processes of civil and environmental engineering scholars. The project was undertaken collaboratively with research teams at 11 academic libraries in the United States and Canada.[1] We are delighted to have the American Society of Civil Engineers (ASCE) as project partner and sponsor. Angela Cochran, Associate Publisher at ASCE, served as a project advisor. The project also relied on scholars who are leaders in the field to engage in an advisory capacity. We thank Franz-Joseph Ulm (Massachusetts Institute of Technology), Antonio Nanni (University of Miami), Anand Puppala (University of Texas at Arlington), and Roger Ghanem (University of Southern California) for their thoughtful contributions. Many of the challenges civil and environmental engineering researchers face are shared with other STEM disciplines – a competitive funding landscape, a fraught peer review system, complex data management requirements. Yet this applied field presents unique opportunities for academic support service providers. Fundamentally focused on finding practicable solutions to real-world problems, civil and environmental engineering is highly collaborative, interdisciplinary, and close to relevant industries. Yet these synergies are largely built on old-fashioned research infrastructures. Inefficient systems for sharing data impede innovation, tools for discovering data and gray literature are inadequate, and career incentives discourage investment in the industry partnerships that shape the field’s future directions. Succ

There is evidence that objects in and of the built environment function as barriers or facilitators to accessibility for people with disabilities. Although there are many existing sources of information about accessibility, they often lack clear criteria to describe accessibility, explanations of barriers and facilitators to mobility, and coverage of multiple physical environments. Researchers have argued that wayfinding services (e.g., Google Maps) can help people with disabilities prepare to travel through the built environment, yet current wayfinding services include little to no information about accessibility. This dissertation aims to study accessibility, in the context of wayfinding, in indoor, outdoor and transitional environments for people who travel in wheelchairs and people with low to no vision. To this end, a qualitative ontological analysis of multiple sources of information regarding accessibility was conducted including analyses of important categories associated with accessible wayfinding; different information providers’ views on accessibility; and specific barriers and facilitators to accessibility. The results indicate that (1) people with low to no vision and people who travel in wheelchairs have different core wayfinding information needs, (2) a gap exists between the information people with disabilities and researchers provide on accessibility and that provided by standard guidelines, and (3) conceptualizing accessibility requires capturing actions performed by people with disabilities during every day travel along with characteristics of environmental objects. The resulting ontology could be leveraged to generate new criteria describing accessibility, new routing algorithms, or to attach provenance to existing accessibility criteria. The findings have implications for people who design wayfinding services and collaborative maps and people collaboratively collecting data on the accessibility of specific places.

There is evidence that objects in and of the built environment function as barriers or facilitators to accessibility for people with disabilities. Although there are many existing sources of information about accessibility, they often lack clear criteria to describe accessibility, explanations of barriers and facilitators to mobility, and coverage of multiple physical environments. Researchers have argued that wayfinding services (e.g., Google Maps) can help people with disabilities prepare to travel through the built environment, yet current wayfinding services include little to no information about accessibility. This dissertation aims to study accessibility, in the context of wayfinding, in indoor, outdoor and transitional environments for people who travel in wheelchairs and people with low to no vision. To this end, a qualitative ontological analysis of multiple sources of information regarding accessibility was conducted including analyses of important categories associated with accessible wayfinding; different information providers’ views on accessibility; and specific barriers and facilitators to accessibility. The results indicate that (1) people with low to no vision and people who travel in wheelchairs have different core wayfinding information needs, (2) a gap exists between the information people with disabilities and researchers provide on accessibility and that provided by standard guidelines, and (3) conceptualizing accessibility requires capturing actions performed by people with disabilities during every day travel along with characteristics of environmental objects. The resulting ontology could be leveraged to generate new criteria describing accessibility, new routing algorithms, or to attach provenance to existing accessibility criteria. The findings have implications for people who design wayfinding services and collaborative maps and people collaboratively collecting data on the accessibility of specific places.

Methane-oxidizing cultures from five different inocula were enriched to be used for co-metabolic degradation of micropollutants. In a first screening, 18 different compounds were tested for degradation with the cultures as well as with four pure methane-oxidizing bacterial (MOB) strains. The tested compounds included pharmaceuticals, chemical additives, pesticides, and their degradation products. All enriched cultures were successful in the degradation of at least four different pollutants, but the compounds degraded most often were sulfamethoxazole (SMX) and benzotriazole (BTZ). Addition of acetylene, a specific methane monooxygenase (MMO) inhibitor, revealed that SMX and BTZ were mainly degraded co-metabolically by the present MOB. The pure MOB cultures exhibited less degradation potential, while SMX and BTZ were also degraded by three of the four tested pure strains. For MOB, copper (Cu2+) concentration is often an important factor, as several species have the ability to express a soluble MMO (sMMO) if the Cu2+ concentration is low. In literature, this enzyme is often described to have a broader compound range for co-metabolic degradation of pollutants, in particular when it comes to aromatic structures. However, this study indicated that co-metabolic degradation of the aromatic compounds SMX and BTZ was possible at high Cu2+ concentration, most probably catalyzed by pMMO.

Methane-oxidizing cultures from five different inocula were enriched to be used for co-metabolic degradation of micropollutants. In a first screening, 18 different compounds were tested for degradation with the cultures as well as with four pure methane-oxidizing bacterial (MOB) strains. The tested compounds included pharmaceuticals, chemical additives, pesticides, and their degradation products. All enriched cultures were successful in the degradation of at least four different pollutants, but the compounds degraded most often were sulfamethoxazole (SMX) and benzotriazole (BTZ). Addition of acetylene, a specific methane monooxygenase (MMO) inhibitor, revealed that SMX and BTZ were mainly degraded co-metabolically by the present MOB. The pure MOB cultures exhibited less degradation potential, while SMX and BTZ were also degraded by three of the four tested pure strains. For MOB, copper (Cu2+) concentration is often an important factor, as several species have the ability to express a soluble MMO (sMMO) if the Cu2+ concentration is low. In literature, this enzyme is often described to have a broader compound range for co-metabolic degradation of pollutants, in particular when it comes to aromatic structures. However, this study indicated that co-metabolic degradation of the aromatic compounds SMX and BTZ was possible at high Cu2+ concentration, most probably catalyzed by pMMO.

The growth of projects in libraries is pervasive. This short 1-credit course introduces LIS students to the discipline of project management in a hands-on way, so that they can begin applying project management methods immediately.

The growth of projects in libraries is pervasive. This short 1-credit course introduces LIS students to the discipline of project management in a hands-on way, so that they can begin applying project management methods immediately.

The growth of projects in libraries is pervasive. This short 1-credit course introduces LIS students to the discipline of project management in a hands-on way, so that they can begin applying project management methods immediately.

The growth of projects in libraries is pervasive. This short 1-credit course introduces LIS students to the discipline of project management in a hands-on way, so that they can begin applying project management methods immediately.

The growth of projects in libraries is pervasive. This short 1-credit course introduces LIS students to the discipline of project management in a hands-on way, so that they can begin applying project management methods immediately.

This paper builds on conversations about sustainability, sustainable design, and its relationship to LIS and does so through the lens of design thinking, a technique for solving complex problems in innovative ways.

This paper builds on conversations about sustainability, sustainable design, and its relationship to LIS and does so through the lens of design thinking, a technique for solving complex problems in innovative ways.

The distribution of persistent organic pollutants (POPs) within background soil profiles was investigated in boreal (Norway) and montane (Italy) areas. The typical build-up of slowly mineralizing humus layers, containing high amounts of soil organic matter (SOM) makes soils of such ecosystems an important global sink for POPs released to the environment. The study focused on evidence and implications of processes influencing the fate of POPs in soil. POP deposition, interaction with SOM, volatilization, leaching, degradation, and bioturbation are discussed. Results indicate that the less volatile POPs such as hexa- and higher chlorinated biphenyls (CBs) or polybrominated diphenyl ethers are very stable in soil profiles, undergoing little translocation or (re)transfer to other environmental compartments. In contrast, more volatile compounds (e.g., tri- and tetra-CBs) were found in soil layers below those formed from vegetation ever directly exposed to airborne POPs. This suggests the occurrence of downward transport and hence limited surface-air exchange of more volatile POPs as they are removed from the top layers. Such soils may therefore be able to retain higher amounts of these compounds than just addressed by the capacity of their surface layers.