1. Chemical Composition Determination and Evaluation of the Antimicrobial Activity of Essential Oil from Croton blanchetianus (Euphorbiaceae) against Clinically Relevant Bacteria.
- Author
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Nunes AKA, Araújo Malveira E, Lopes Andrade A, Barbosa da Silva WM, de Morais SM, Silva Dos Santos H, Cavalcanti de Albuquerque C, Holanda Teixeira E, do Nascimento Souza DN, and Alves de Vasconcelos M
- Subjects
- Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Ampicillin pharmacology, Staphylococcus aureus, Tetracyclines pharmacology, Biofilms, Microbial Sensitivity Tests, Oils, Volatile pharmacology, Oils, Volatile chemistry, Croton, Euphorbiaceae, Anti-Infective Agents pharmacology, Anti-Infective Agents chemistry
- Abstract
In this study, the chemical composition of the essential oil (EO) extracted from Croton blanchetianus Baill leaves was identified, and antimicrobial and antibiofilm activities against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli strains were determined. Moreover, the effects of EO in combination with ampicillin and tetracycline were investigated. Thirty-four components, mainly mono-and sesquiterpenes that represented 94.05 % of the chemical composition, were identified in the EO. The EO showed bacteriostatic and bactericidal activities against all strains tested. Furthermore, the EO showed a synergistic effect with ampicillin and tetracycline. EO significantly inhibited biofilm formation and reduced the number of viable cells in biofilms. The EO may be a promising natural product for preventing bacterial biofilm infections., (© 2022 Wiley-VHCA AG, Zurich, Switzerland.)
- Published
- 2023
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