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Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Nov 15; Vol. 18 (22), pp. 7997-8004. Date of Electronic Publication: 2010 Sep 18. - Publication Year :
- 2010
-
Abstract
- Lipidic α-amino acids (LAAs) have been described as non-natural amino acids with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we have obtained a mixture of two cytotoxic LAAs (1a and 1b) from the zoanthid Protopalythoa variabilis. The anti-proliferative potential of 14 synthetic LAAs and 1a/1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, and HL-60). Five of the synthetic LAAs showed high percentage of tumor cell inhibition, while 1a/1b completely inhibited tumor cell growth. Additionally, apoptotic effects of 1a/1b were studied on HL-60 cell line. 1a/1b-treated cells showed apoptosis morphology, loss of mitochondrial potential, and DNA fragmentation.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Amino Acids, Neutral chemistry
Amino Acids, Neutral isolation & purification
Animals
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Apoptosis drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
Erythrocytes drug effects
Hemolysis
Humans
Membrane Potential, Mitochondrial drug effects
Mice
Amino Acids, Neutral pharmacology
Anthozoa metabolism
Antineoplastic Agents chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 18
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20943402
- Full Text :
- https://doi.org/10.1016/j.bmc.2010.09.027