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Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis.

Authors :
Wilke DV
Jimenez PC
Araújo RM
da Silva WM
Pessoa OD
Silveira ER
Pessoa C
de Moraes MO
Skwarczynski M
Simerska P
Toth I
Costa-Lotufo LV
Source :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Nov 15; Vol. 18 (22), pp. 7997-8004. Date of Electronic Publication: 2010 Sep 18.
Publication Year :
2010

Abstract

Lipidic α-amino acids (LAAs) have been described as non-natural amino acids with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we have obtained a mixture of two cytotoxic LAAs (1a and 1b) from the zoanthid Protopalythoa variabilis. The anti-proliferative potential of 14 synthetic LAAs and 1a/1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, and HL-60). Five of the synthetic LAAs showed high percentage of tumor cell inhibition, while 1a/1b completely inhibited tumor cell growth. Additionally, apoptotic effects of 1a/1b were studied on HL-60 cell line. 1a/1b-treated cells showed apoptosis morphology, loss of mitochondrial potential, and DNA fragmentation.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1464-3391
Volume :
18
Issue :
22
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry
Publication Type :
Academic Journal
Accession number :
20943402
Full Text :
https://doi.org/10.1016/j.bmc.2010.09.027