1. The dietary sweetener sucralose is a negative modulator of T cell-mediated responses.
- Author
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Zani F, Blagih J, Gruber T, Buck MD, Jones N, Hennequart M, Newell CL, Pilley SE, Soro-Barrio P, Kelly G, Legrave NM, Cheung EC, Gilmore IS, Gould AP, Garcia-Caceres C, and Vousden KH
- Subjects
- Animals, Mice, Food Safety, Calcium Signaling drug effects, Receptors, Antigen, T-Cell drug effects, Receptors, Antigen, T-Cell immunology, Bacterial Infections immunology, Neoplasms immunology, Autoimmunity drug effects, Autoimmunity immunology, CD8-Positive T-Lymphocytes drug effects, CD8-Positive T-Lymphocytes immunology, Sucrose analogs & derivatives, Sweetening Agents administration & dosage, Sweetening Agents adverse effects, Sweetening Agents pharmacology, Sweetening Agents therapeutic use, T-Lymphocytes drug effects, T-Lymphocytes immunology, T-Lymphocytes pathology
- Abstract
Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years
1 . Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners2-5 . In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation. Mechanistically, sucralose affects the membrane order of T cells, accompanied by a reduced efficiency of T cell receptor signalling and intracellular calcium mobilization. Mice given sucralose show decreased CD8+ T cell antigen-specific responses in subcutaneous cancer models and bacterial infection models, and reduced T cell function in models of T cell-mediated autoimmunity. Overall, these findings suggest that a high intake of sucralose can dampen T cell-mediated responses, an effect that could be used in therapy to mitigate T cell-dependent autoimmune disorders., (© 2023. The Author(s).)- Published
- 2023
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