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Characterization of a polyurethane-based controlled release system for local delivery of chlorhexidine diacetate.
- Source :
-
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2010 Feb; Vol. 74 (2), pp. 255-64. Date of Electronic Publication: 2009 Nov 10. - Publication Year :
- 2010
-
Abstract
- Conventional formulations of chlorhexidine usually provide short-term efficiency, requiring repeated applications to maintain antibacterial activity. Therefore, appropriate release system of chlorhexidine controlling local drug delivery would reduce the number of applications and enhance patient compliance. The aim of this study was to develop a controlled release system based on medical polyurethane for the local delivery of chlorhexidine diacetate (CDA). CDA-loaded polyurethane films (CDA-Films) and CDA-loaded polyurethane sandwiches (CDA-Sandwiches) were obtained by casting and solvent evaporation. The physico-chemical aspects of CDA-loaded polyurethane systems were investigated, and the crystalline state of CDA in the polymeric system was highlighted. CDA-Films exhibited appropriate mechanical properties for further applications. Drug release was measured in two different media: (i) distilled water and (ii) physiological saline solution to mimic in vivo conditions. Drug release studies were performed up to 11days on CDA-Films and 29days for CDA-Sandwiches. Release of CDA depended on drug loading and the structure of the system. In particular, release of CDA from the sandwich system followed zero-order kinetic. The release rate was significantly lower in physiological solution. Antibacterial studies were carried out on CDA-Films against Staphylococcus aureus and Staphylococcus epidermidis showing 35days persisting antibacterial activity. In conclusion, the polyurethane-based system developed in this study is potentially useful as a local delivery system for CDA and could be used not only in surgery but also in dental and clinical applications.<br /> (Copyright (c) 2009 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Topical
Anti-Infective Agents, Local chemistry
Anti-Infective Agents, Local pharmacokinetics
Chemical Phenomena
Chlorhexidine chemistry
Chlorhexidine pharmacokinetics
Crystallization
Drug Carriers administration & dosage
Drug Carriers chemical synthesis
Drug Carriers pharmacokinetics
In Vitro Techniques
Kinetics
Mechanical Phenomena
Microbial Sensitivity Tests
Polymers administration & dosage
Polymers chemical synthesis
Polymers pharmacokinetics
Sodium Chloride analysis
Water analysis
Anti-Infective Agents, Local administration & dosage
Chlorhexidine administration & dosage
Delayed-Action Preparations administration & dosage
Delayed-Action Preparations chemical synthesis
Delayed-Action Preparations chemistry
Delayed-Action Preparations pharmacokinetics
Drug Compounding methods
Polyurethanes administration & dosage
Polyurethanes chemistry
Polyurethanes pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3441
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
- Publication Type :
- Academic Journal
- Accession number :
- 19909814
- Full Text :
- https://doi.org/10.1016/j.ejpb.2009.11.002