1. An intrinsically disordered region in MED13 turns Mediator on/off on cue.
- Author
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Villeret V, Monté D, and Verger A
- Subjects
- Humans, Intrinsically Disordered Proteins metabolism, Intrinsically Disordered Proteins chemistry, Intrinsically Disordered Proteins genetics, Protein Binding, Transcriptional Activation, Mediator Complex metabolism, Mediator Complex genetics, Mediator Complex chemistry, Cyclin-Dependent Kinase 8 metabolism, Cyclin-Dependent Kinase 8 genetics, RNA Polymerase II metabolism, RNA Polymerase II genetics
- Abstract
Complementary studies by Zhao et al.
1 and Chen et al.2 reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching Mediator and transcription activation on and off., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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