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Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line.
- Source :
-
FEBS letters [FEBS Lett] 2005 Jan 03; Vol. 579 (1), pp. 66-70. - Publication Year :
- 2005
-
Abstract
- Erm, a member of the PEA3 group within the Ets family of transcription factors, is expressed in murine and human lymphocytes. Here, we show that in the human Molt4 lymphoblastic cell line, the erm gene expression is regulated by the conventional PKC (cPKC) pathway. To better characterize the molecular mechanism by which cPKC regulates Erm transcription in Molt4 cells, we tested proximal promoter deletions of the human gene, and identified a specific cPKC-regulated region between positions -420 and -115 upstream of the first exon.
- Subjects :
- Cell Line, Tumor
DNA-Binding Proteins metabolism
Dactinomycin pharmacology
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein Kinase C antagonists & inhibitors
RNA, Messenger analysis
RNA, Messenger metabolism
Sequence Deletion genetics
Tetradecanoylphorbol Acetate pharmacology
Transcription Factors metabolism
Transcription, Genetic drug effects
Transcription, Genetic physiology
Up-Regulation
DNA-Binding Proteins genetics
Gene Expression Regulation physiology
Promoter Regions, Genetic genetics
Protein Kinase C physiology
Signal Transduction physiology
T-Lymphocytes metabolism
Tetradecanoylphorbol Acetate analogs & derivatives
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 579
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 15620692
- Full Text :
- https://doi.org/10.1016/j.febslet.2004.11.052