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An intrinsically disordered region in MED13 turns Mediator on/off on cue.
- Source :
-
Molecular cell [Mol Cell] 2024 Aug 22; Vol. 84 (16), pp. 3005-3007. - Publication Year :
- 2024
-
Abstract
- Complementary studies by Zhao et al. <superscript>1</superscript> and Chen et al. <superscript>2</superscript> reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching Mediator and transcription activation on and off.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Intrinsically Disordered Proteins metabolism
Intrinsically Disordered Proteins chemistry
Intrinsically Disordered Proteins genetics
Protein Binding
Transcriptional Activation
Mediator Complex metabolism
Mediator Complex genetics
Mediator Complex chemistry
Cyclin-Dependent Kinase 8 metabolism
Cyclin-Dependent Kinase 8 genetics
RNA Polymerase II metabolism
RNA Polymerase II genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4164
- Volume :
- 84
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Molecular cell
- Publication Type :
- Academic Journal
- Accession number :
- 39178836
- Full Text :
- https://doi.org/10.1016/j.molcel.2024.07.027