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Osteoporosis is a multifactorial bone disease characterised by reduced bone mass and increased fracture risk. Family studies have made significant contribution in unravelling the genetics of osteoporosis. Yet, most of the underlying molecular and biological mechanisms remain unknown prompting the need for further studies. This review outlines the proper phenotyping and advanced genetic techniques in the form of high-throughput DNA sequencing used to identify genetic factors underlying monogenic osteoporosis in a family-based setting. The steps related to variant filtering prioritisation and curation are also described. From an evolutionary perspective, deleterious risk variants with higher penetrance tend to be rare as a result of negative selection. High-throughput sequencing (HTS) can identify rare variants with large effect sizes which are likely to be missed by candidate gene analysis or genome-wide association studies (GWAS) wherein common variants with small to moderate effect sizes are identified. We also describe the importance of replicating implicated genes, and possibly variants, identified following HTS to confirm their causality. Replication of the gene in other families, singletons or independent cohorts confirms that the shortlisted genes and/or variants are indeed causal. Furthermore, novel genes and/or variants implicated in monogenic osteoporosis require a thorough validation by means of in vitro and in vivo assessment. Therefore, analyses of families can continue to elucidate the genetic architecture of osteoporosis, paving the way for improved diagnostic and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Breast cancer (BC) is the most common malignancy affecting Western women today. It is estimated that as many as 10% of BC cases can be attributed to germline variants. However, the genetic basis of the majority of familial BC cases has yet to be identified. Discovering predisposing genes contributing to familial BC is challenging due to their presumed rarity, low penetrance, and complex biological mechanisms. Here, we focused on an analysis of rare missense variants in a cohort of 12 families of Middle Eastern origins characterized by a high incidence of BC cases. We devised a novel, high-throughput, variant analysis pipeline adapted for family studies, which aims to analyze variants at the protein level by employing state-of-the-art machine learning models and three-dimensional protein structural analysis. Using our pipeline, we analyzed 1218 rare missense variants that are shared between affected family members and classified 80 genes as candidate pathogenic. Among these genes, we found significant functional enrichment in peroxisomal and mitochondrial biological pathways which segregated across seven families in the study and covered diverse ethnic groups. We present multiple evidence that peroxisomal and mitochondrial pathways play an important, yet underappreciated, role in both germline BC predisposition and BC survival. [ABSTRACT FROM AUTHOR]

Objective: The goal was to determine whether or not there is an association between the belief that human development and family science (HDFS) is "just common sense" and academic performance in a rigorous research methods class in HDFS. Background: Naïve realism is a cognitive bias that creates a belief in common sense that is difficult to challenge. It is unknown whether student commitment to common sense impedes students' ability to learn. Method: Students (N = 112) in an HDFS research methods class were followed for a semester. Potential barriers to learning were measured through a self‐report survey before the start of the semester. The outcome variable was objective performance in the course as measured by exam scores. Results: Exam scores were positively correlated with prior academic achievement and negatively correlated with student belief that the discipline is just common sense. Conclusion: Naïve realism, expressed as the belief that HDFS is just common sense, predicts poor performance in a research methods class. Implications: Higher education faculty in HDFS must directly confront the problem that our discipline is perceived as just common sense. Naïve realism must be challenged directly in coursework if students are to learn about the science of HDFS. [ABSTRACT FROM AUTHOR]

Narcolepsy is a life‐long neurological disorder with well‐established genetic risk factors. Human leukocyte antigen‐DQB1*06:02 remains the strongest genetic predeterminant; however, polymorphisms in genes encoding the T‐cell receptor alpha chain are also strongly linked. This case report shows the inheritance pathway of these genetic markers contributing to narcolepsy onset in a 17‐year‐old female. [ABSTRACT FROM AUTHOR]

Background: Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-characterized patients and their family members have identified lithium responsive (LiR) and lithium non-responsive (LiNR) subtypes that hold promise for advancement. Method: In this narrative review, relevant observations from published longitudinal studies of well-characterized bipolar patients and their families spanning six decades are highlighted. DSM diagnoses based on SADS-L interviews were decided in blind consensus reviews by expert clinicians. Genetic, neurobiological, and psychosocial factors were investigated in subsets of well-characterized probands and adult relatives. Systematic maintenance trials of lithium, antipsychotics, and lamotrigine were carried out. Clinical profiles that included detailed histories of the clinical course, symptom sets and disorders segregating in families were documented. Offspring of LiR and LiNR families were repeatedly assessed up to 20 years using KSADS-PL format interviews and DSM diagnoses and sub-threshold symptoms were decided by expert clinicians in blind consensus reviews using all available clinical and research data. Results: A characteristic clinical profile differentiated bipolar patients who responded to lithium stabilization from those who did not. The LiR subtype was characterized by a recurrent fully remitting course predominated by depressive episodes and a positive family history of episodic remitting mood disorders, and not schizophrenia. Response to lithium clustered in families and the characteristic clinical profile predicted lithium response, with the episodic remitting course being a strong correlate. There is accumulating evidence that genetic and neurobiological markers differ between LiR and LiNR subtypes. Further, offspring of bipolar parents subdivided by lithium response differed in developmental history, clinical antecedents and early course of mood disorders. Moreover, the nature of the emergent course bred true from parent to offspring, independent of the nature of emergent psychopathology. Conclusions: Bipolar disorders are heterogeneous and response to long-term lithium is associated with a familial subtype with characteristic course, treatment response, family history and likely pathogenesis. Incorporating distinctive clinical profiles that index valid bipolar subtypes into routine practice and research will improve patient outcomes and advance the development and translation of novel treatment targets to improve prevention and early intervention. [ABSTRACT FROM AUTHOR]

Copyright of Akademik Hassasiyetler is the property of Huzeyfe Suleyman Arslan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The objective of this overview of academic programs related to Human Development and Family Science (HDFS) is to describe the current status of HDFS in the academy. Background: HDFS is an interdisciplinary nexus of family science, developmental science, and early childhood education (ECE), often coexisting in academic units. Method: Universities were identified using Classification of Instructional Programs (CIP) codes in Integrated Postsecondary Education Data System (IPEDS) data. Program information was identified by review of university websites and online catalogs. Results: Six hundred thirty‐six programs granted 28,000 HDFS‐related degrees in the United States in 2019. Universities are evenly split between public and private and are geographically diverse. Approximately half of programs self‐identify as HDFS, 30% ECE, 15% developmental science, and 5% family science. The largest number of programs (53%) were in colleges of education, but they were widely dispersed across campuses, with self‐identified HDFS programs likely to be in colleges that reflect a home economics heritage. The most common department name was Human Development and Family Studies/Science, but these were only 25% of programs. Department names and degree names reflect an interdisciplinary collaboration of developmental science with family science but were less likely to reflect early education. There was little correspondence between the name of degrees offered and the CIP codes attached to them. Conclusion: HDFS has a large and interdisciplinary presence on university campuses but an unclear identity. Implications: HDFS needs to clarify its relationship with ECE and to decide whether to standardize its complex and interdisciplinary identity. [ABSTRACT FROM AUTHOR]

The main purpose of the current study was to examine the relationship between marital satisfaction and life satisfaction through meta-analysis method. A total of 6163 studies were identified as a result of the literature scanning and accordingly examined on the basis of their titles and abstracts. Ultimately, results of 19 studies were included to analysis. The findings obtained from analyses were examined and it was determined that there is a significant difference in all subgroups regarding the relationship between marital satisfaction and life satisfaction. Output of REM analysis showed that the pooled effect size of the relationship between marital satisfaction and life satisfaction is moderate (0.46). Considering the screening process within the scope of this study, it can be concluded that there are too many poor reporting practices regarding the studies. [ABSTRACT FROM AUTHOR]

Broadly, this article details the imbrication of a Black feminist qualitative researcher's onto-epistemology and data (meta-) analysis process. I theorize Black feminist memory work, then apply this method by returning to data I collected for a completed research project and meshing those data with a curated selection of thematically connected family photographs. By revisiting and reviewing textual and visual data, I demonstrate the function of Black feminist memory work as a visual research method with which to not only describe, analyze, and interpret evocative photographs, but also excavate and make meaning of the sometimes repressed and oftentimes emotion-laden episodic and autobiographical memories that inevitably surface when conducting qualitative research. I conclude by underscoring how this tool creates opportunities for qualitative researchers to address the ontological concerns that connect qualitative inquiry to Black feminists' humanistic hopes. [ABSTRACT FROM AUTHOR]

The term "childless" is highly problematic. Attempts to split it into "voluntary" and "involuntary" may appear to give more detail on context, but the differentiation can be misleading. The condition of "-less" has negative connotations and implies "missing" something; possibly something which is "natural." The term "childfree" has been employed as an alternative expression which denotes active choice, freedom, and emancipation. Few studies, however, have explored how individuals refer to themselves, or how they interpret—or even care—about these distinctions. Such existing studies only explore the use of these English expressions among speakers of English as their primary language. This exploratory qualitative study explores how women without children define themselves in their native language in an Asian setting—Cantonese in Hong Kong. It also explores how such women interpret the various terms developed in English to describe their circumstances. Respondents refer to themselves in neutral, factual terms—literally "without children." Others make an explicit link between being unmarried and childless status. While respondents find the English expression of "childfree" positive, they do not express a strong need to either deploy it in English, nor "develop" a Cantonese equivalent. The study provides further evidence that "labels" generated and applied by academics in one context and in one language may not be universally applicable. [ABSTRACT FROM AUTHOR]

Youth with autism face challenges accessing services as they transition to adulthood. Improving parents' ability to advocate for services on behalf of their youth may be an effective way to improve service access and ultimately transition outcomes in this group. In this study, we tested whether participating in an advocacy intervention improved parents' ability to advocate for services for their transition‐aged youth with autism. One hundred and eighty‐five parents of youth with autism ages 16–26, recruited across three states in the U.S., were randomized to one of two experimental conditions. The treatment condition received the ASSIST program, a 12‐week (24‐h) group‐based intervention. The control condition received the same written materials as the treatment condition. Primary outcomes for this report—parent advocacy ability—were collected at baseline (prior to randomization) and post‐test (immediately after the treatment group finished the 12‐week program) by survey. After taking ASSIST, the treatment condition had greater gains than controls in knowledge of adult services (B = −1.62, CI = −2.33 to −0.90) and perceived advocacy skills (B = −0.19, CI = −0.33 to −0.04). Participants who had less knowledge, lower perceived advocacy skills, and less active coping styles at baseline had the greatest treatment gains. Findings suggest that ASSIST is effective in improving parent advocacy ability and may be most beneficial for parents who experience greater challenges advocating for their son/daughter with autism. Future research will examine whether gains in parent advocacy ability leads to improvements in service access and post‐school outcomes for transition‐age youth with autism. Lay Summary: Disability services can be important tools to improve the lives of autistic youth, but they are often difficult to understand and access. This study tested whether a services advocacy program improved parents' ability to advocate for services on behalf of their son or daughter with autism. The study findings suggested that parents who took the program were better prepared to pursue disability services for their transition‐aged youth. [ABSTRACT FROM AUTHOR]

Whole-exome sequencing (WES) in families with an unexplained tendency for venous thromboembolism (VTE) may favor detection of low-frequency variants in genes with known contribution to hemostasis or associated with VTE-related phenotypes. WES analysis in six family members, three of whom affected by documented VTE, filtered for MAF < 0.04 in 192 candidate genes, revealed 22 heterozygous (16 missense and six synonymous) variants in patients. Functional prediction by multi-component bioinformatics tools, implemented by a database/literature search, including ClinVar annotation and QTL analysis, prioritized 12 missense variants, three of which (CRP Leu61Pro, F2 Asn514Lys and NQO1 Arg139Trp) were present in all patients, and the frequent functional variants FGB Arg478Lys and IL1A Ala114Ser. Combinations of prioritized variants in each patient were used to infer functional protein interactions. Different interaction patterns, supported by high-quality evidence, included eight proteins intertwined in the "acute phase" (CRP, F2, SERPINA1 and IL1A) and/or in the "fibrinogen complex" (CRP, F2, PLAT, THBS1, VWF and FGB) significantly enriched terms. In a wide group of candidate genes, this approach highlighted six low-frequency variants (CRP Leu61Pro, F2 Asn514Lys, SERPINA1 Arg63Cys, THBS1 Asp901Glu, VWF Arg1399His and PLAT Arg164Trp), five of which were top ranked for predicted deleteriousness, which in different combinations may contribute to disease susceptibility in members of this family. [ABSTRACT FROM AUTHOR]

Copyright of Arab Journal of Psychiatry is the property of Arab Federation of Psychiatrists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Although much has been written to date on gender equality, on personal liberty within the family, and on the burden of family caregivers of spouses, the manner in which these different aspects intersect and impact each other has gone largely unexamined. How do relationships of power and dependency interact? How do they affect the pursuit of happiness and the ability to maintain personal liberty within the family in times of sickness and poor health? Our analysis is based on a qualitative and comparative effort of two films: The first is Paolo Virzi's The Leisure Seeker (USA, 2017). The second Zepel Yeshurun's Alaska (Israel, 2018). The findings allow to identify a model of liberty within the family at old age that consists of three aspects: first, women's freedom within an oppressive system: the ability of women in unequal conjugal relationships to retain agency, to act, to decide, and to struggle for their beliefs. Second, negative freedom: the struggle of old age couples to fend off over-involvement by concerned family members and caregiving institutions, and to assert their independence. Third, positive freedom: the desire of older couples to pursue happiness despite illness and old age. [ABSTRACT FROM AUTHOR]

Financial well-being may be an important context for daily emotional reactivity to relationship tension (e.g., arguments) whose salience varies across historical time or as a function of exposure to economic downturns. This study investigated how emotional reactivity, operationalized as daily fluctuations in negative and positive affect associated with the occurrence of daily relationship tension, varied by financial well-being among those who were and were not exposed to the Great Recession of 2008. Two matched, independent subsamples of partnered individuals from the National Study of Daily Experiences completed identical 8-day diary protocols, one before the Great Recession (n = 587) and one after (n = 351). Individuals reported higher negative affect and lower positive affect on days when relationship tension occurred. Further, results indicated that negative affect reactivity, but not positive affect reactivity, was moderated by both financial well-being and cohort status. For the pre-recession cohort, negative affect reactivity was stronger among those with lower financial well-being. However, among the post-recession cohort, financial well-being did not moderate negative affect reactivity to relationship tension. Findings highlight the utility of considering major societal events, such as economic downturns, to understand variability in emotional reactivity to day-to-day relationship tension in the context of financial well-being, as the salience of financial well-being in the ways relationship tension and negative affect are related on a daily basis appears to vary by historical context. [ABSTRACT FROM AUTHOR]

Parents of children on the autism spectrum are important members of their child's early intervention team, yet there are multiple barriers to translating evidence-based parent-mediated interventions in Mexico. We examined early intervention needs in the Mexican population and compared these needs to those of the Latinx Spanish-speaking population in the United States. A total of 242 parents in Mexico and the United States responded to our survey. Results indicate that few parents in Mexico receive parent training during early intervention, parents in Mexico are less likely than Latinx parents in the United States to report speech-language services, and most parents across both groups reported that they wished that they had more tools to support development and address challenging behavior. Responses to open-ended survey questions were coded qualitatively for themes and subthemes. We provide four recommendations for adapting early interventions in Mexico and discuss implications for future research and practice. [ABSTRACT FROM AUTHOR]

In this article, we examine changes in family climate during the first Covid‐19‐related lockdown in Germany. We compare the perspectives of mothers and adolescents to explore whether the factors of perceived changes in family climate are systematically and significantly different between these groups. We measure family climate as positive emotional climate, a sub‐dimension of the family environment scale, to capture a feeling of cohesion and emotional openness within the family. Based on family system theory and the family stress model, we expect an overall deterioration in family climate due to increased environmental adaptation in the pandemic. Furthermore, we expect family climate to deteriorate less when families have economic and social resources available. On the other hand, we assume that being employed and/or primarily responsible for family care relates to a stronger decline in the family climate. We employ longitudinal survey data (AID:A) from around 300 German families with children aged nine to 17 and apply individual fixed effects models to investigate changes in family climate from 2019 to 2020. Almost half of our respondents report a decrease in family climate. For mothers, the share of unpaid care work at home is the only significant predictor: Mothers doing more than 80% of the chores and childcare feel a greater decrease in family climate. For adolescents, however, being at risk of poverty and having less frequent family activities are important predictors of stronger decreases in family climate. In summary, our results illustrate the relevance of distinguishing between the perspective of children and parents in family studies. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study was to develop intercultural competence among Family Science undergraduate students through high‐impact experiences. Background: Service learning (SL) is a form of high‐impact experimental education that promotes learning and development by engaging students in real‐world activities that address both individual and community needs. Methods: Participants were 82 undergraduates enrolled in two similar Family Science diversity courses at a mid‐South university in the United States. Curriculum for both courses were identical, except one group of students participated in SL at one of five community agencies: boys/girls club, community center working with children, center for adults with disabilities, a primarily Hispanic middle school, or a homeless shelter. Students in both courses completed pre‐ and post‐assessments using the Intercultural Development Inventory to measure intercultural competence. Results: Students without SL opportunities did not significantly increase in intercultural competence whereas students who participated with SL increased significantly in their intercultural competence. Conclusion: It is imperative that Family Science continue to emphasize SL because meaningful interactions with community partnerships have been shown to provide culturally relevant education and deep experiential learning opportunities for students. Implications: As a result, Family Science students will more easily transition to their chosen professions and will be better prepared to increase intercultural competency and to work toward dismantling racism and promoting social justice for all. [ABSTRACT FROM AUTHOR]

This research examines maternal smoking during pregnancy and risk for poorer executive function in siblings discordant for exposure. Data (N = 173 families) were drawn from the Missouri Mothers and Their Children study, a sample, identified using birth records (years 1998–2005), in which mothers changed smoking behavior between two pregnancies (Child 1 [older sibling]: M age = 12.99; Child 2 [younger sibling]: M age = 10.19). A sibling comparison approach was used, providing a robust test for the association between maternal smoking during pregnancy and different aspects of executive function in early-mid adolescence. Results suggested within-family (i.e., potentially causal) associations between maternal smoking during pregnancy and one working memory task (visual working memory) and one response inhibition task (color-word interference), with increased exposure associated with decreased performance. Maternal smoking during pregnancy was not associated with stop-signal reaction time, cognitive flexibility/set-shifting, or auditory working memory. Initial within-family associations between maternal smoking during pregnancy and visual working memory as well as color-word interference were fully attenuated in a model including child and familial covariates. These findings indicate that exposure to maternal smoking during pregnancy may be associated with poorer performance on some, but not all skills assessed; however, familial transmission of risk for low executive function appears more important. [ABSTRACT FROM AUTHOR]

Copyright of Seminare Learned Investigations / Seminare. Poszukiwania naukowe is the property of Francis de Sales Scientific Society / Towarzystwo Naukowe Franciszka Salezego and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Focusing on rural white communities in the early twentieth century, this article examines how disability, queerness, and economic estrangement were intertwined in American eugenic assessments of the "unfit." In doing so, it attends to the knotty relations of power by which such communities were simultaneously adjudged deviant and bestowed with the privileges of whiteness. Eugenic family studies supported claims to white superiority by regulating and preventing reproduction among "unfit" rural white communities who might reveal the sham of white supremacy. Yet eugenicists were also concerned about same-sex sexuality and other nonproductive sexualities among the unfit, despite their focus on the "science of better breeding." This article first analyzes how eugenicists defined a desire for work as the counterpoint to perverse sexual desire. Next, it examines how state institutions used a legal "conduct test" to classify a person as incapable self-support — and therefore feebleminded — on the basis of same-sex sexual relationships, refusal to marry, interdependence, or failure to meet gendered labor norms. Throughout, the article details how eugenic family studies mapped disability, nonproductivity, and nonheteronormativity onto rural landscapes. It concludes by contending that rural queer studies can leverage these landscapes of marginality to think with the racialized city rather than against it. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Social Policy Studies / Sosyal Politika Çalismalari Dergisi is the property of Journal of Social Policy Studies / Sosyal Politika Calismalari Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Systemic lupus erythematosus (SLE) is propelled by pathogenic autoantibody (AutoAb) and immune pathway dysregulation. Identifying populations at risk of reaching classified SLE is essential to curtail inflammatory damage. Lupus blood relatives (Rel) have an increased risk of developing SLE. We tested factors to identify Rel at risk of developing incomplete lupus (ILE) or classified SLE vs. clinically unaffected Rel and healthy controls (HC), drawing from two unique, well characterized lupus cohorts, the lupus autoimmunity in relatives (LAUREL) follow-up cohort, consisting of Rel meeting <4 ACR criteria at baseline, and the Lupus Family Registry and Repository (LFRR), made up of SLE patients, lupus Rel, and HC. Medical record review determined ACR SLE classification criteria; study participants completed the SLE portion of the connective tissue disease questionnaire (SLE-CSQ), type 2 symptom questions, and provided samples for assessment of serum SLE-associated AutoAb specificities and 52 plasma immune mediators. Elevated SLE-CSQ scores were associated with type 2 symptoms, ACR scores, and serology in both cohorts. Fatigue at BL was associated with transition to classified SLE in the LAUREL cohort (p≤0.01). Increased levels of BLyS and decreased levels of IL-10 were associated with type 2 symptoms (p <0.05). SLE-CSQ scores, ACR scores, and accumulated AutoAb specificities correlated with levels of multiple inflammatory immune mediators (p<0.05), including BLyS, IL-2Rα, stem cell factor (SCF), soluble TNF receptors, and Th-1 type mediators and chemokines. Transition to SLE was associated with increased levels of SCF (p<0.05). ILE Rel also had increased levels of TNF-α and IFN-γ, offset by increased levels of regulatory IL-10 and TGF-β (p<0.05). Clinically unaffected Rel (vs. HC) had higher SLE-CSQ scores (p<0.001), increased serology (p<0.05), and increased inflammatory mediator levels, offset by increased IL-10 and TGF-β (p<0.01). These findings suggest that Rel at highest risk of transitioning to classified SLE have increased inflammation coupled with decreased regulatory mediators. In contrast, clinically unaffected Rel and Rel with ILE demonstrate increased inflammation offset with increased immune regulation, intimating a window of opportunity for early intervention and enrollment in prevention trials. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to analyze the impact of genetic factors on the clinical presentation of tic disorder and investigate the pathogenesis of tic disorder considering different sources of genetic influence and generations, along with the distribution characteristics of evidence from Chinese medicine. Methods: Inclusion of 474 cases of tic disorder was assembled(from October, 2020 to October, 2023), and clinical data on the children, including gender, age of onset, disease duration, initial symptoms, severity, comorbidities, and family history, and TCM patterns were collected. Firstly, the children were divided into genetic and nongenetic groups based on family history, and their clinical manifestations were observed. Secondly, the age of peak incidence of tic disorder in China(6 or 9 years) was used as the age segmentation point to explore the influence of heredity on clinical manifestations at different ages and the distribution of TCM patterns. Finally, children with genetically-related tic disorder were selected as probands to carry out family studies. The morbidity of the first-degree, second-degree and third-degree relatives of the probands were investigated to analyze the morbidity characteristics and distribution of TCM patterns of children with tic disorder under different genetic types. Results: Out of 474 children, 226 cases (47.7%) belonged to the genetic group, and 248 cases (52.3%) to the nongenetic group. Compared with the non-genetic group, the genetic group had a younger age of onset (P = 0.013), a longer duration of illness (P = 0.011), a higher degree of severity (P < 0.01), and more comorbid conditions (P = 0.016). Children in the genetic group with an age of onset under 6 years accounted for a larger proportion of the liver-hyperactive and wind-driven pattern(26.5%) and a smaller proportion of the qi depression transforming into fire pattern(17.1%), which were significantly different from those in the non-genetic group (P = 0.016).In the genetic group, 146 cases (64.6%) were inherited from the father, 80 cases (35.4%) from the mother, and there was no significant difference in the developmental characteristics of children with tic disorder from different sources of genetic influence. Furthermore, 183 cases (81.0%) were inherited from the parent-child generation, 26 cases (11.5%) from the second generation, and 17 cases (7.5%) from the third generation; the difference in initial symptoms between different genetic generations was statistically significant (P = 0.042). Conclusion: Children with genetically related tic disorder have a younger age of onset, their condition is more severe, and they are more likely to be comorbid with other psychiatric disorders. The variation in the distribution of Chinese medicine patterns among children with tic disorder of different ages of onset. [ABSTRACT FROM AUTHOR]

The article focuses on the superhero franchise "Guardians of the Galaxy" within the larger Marvel Cinematic Universe (MCU) and how it has been reimagined to represent behavioral and familial trends among millennials. The author discusses the concept of resilient placemaking and the notion of adoptive families.

The article examines how the Great Famine 1932–1933 in Ukraine (Holodomor), which took more than 3.8 million (according to other estimates—6–8 million) innocent lives, affected the lives of children, adolescents, and youth. Ukrainian families were forced to choose survival strategies in extreme conditions. These strategies rarely considered the interests of children who lost financial support as their parents were arrested, exiled, or dead. As a result, children became homeless or even fell victim to cannibalism. Nevertheless, most of the children received parental care and support as parents made every effort to keep the family together. [ABSTRACT FROM AUTHOR]

As one of the most fundamental parts of social structure, marriage significantly influences society. In Indonesia, the complexity of issues in a marriage is increased considerably by the practice of polygamy. Historically, polygamy has been a part of Indonesian society. Nonetheless, as Indonesia progresses to become more democratic society, women's rights in polygamous households has become a topic of tension among Indonesians. The effort to address women's rights in polygamy is confronted with a sensitive hurdle due to the close association of polygamy with religious beliefs, particularly within Islam. As defined by the faith, polygamy was designed to be the social welfare protection system for a widow and her children. However, the modern practice has deviated from its original intention and is at risk of harming women's rights. As such, establishing a broader perspective of polygamy with an approach that leans more towards accepting Indonesian plurality and tolerance is critical for protecting women's rights. [ABSTRACT FROM AUTHOR]

The objective of this study was to elucidate the molecular characteristics of a Chinese family with Glanzmann's thrombasthenia (GT). The proband was diagnosed with GT based on clinical manifestations, platelet aggregation, and the expression of CD41 and CD61 in platelets. Whole-exome and Sanger sequencing were used to detect genetic defects related to GT in the proband and the family of the pedigree. Whole-exome sequencing showed a c.1784–1802delinsGTCACA, p. S595Cfs*70 homozygous mutation in exon 11 of the ITGB3 gene in the proband. Heterozygous mutations were found in the proband's parents, grandmother, uncle, aunt, and younger brother. This novel p. S595Cfs*70 ITGB3 gene mutation is not present in the 1000 Genomes and ExAC databases. [ABSTRACT FROM AUTHOR]

Objective: To increase the awareness and support for family scientists' engagement in public scholarship. Background: Without appropriate dissemination efforts, important research findings may remain solely in academic journals without reaching the public. Grounded in a social justice perspective, we argue that family scientists are, and should be, on the frontlines of direct social change and activities related to broader impacts. Method: In this call to action, we articulate the utility and praxis of public scholarship, or the production and dissemination of scientific knowledge for and with communities to create social change for the public good. Results: Avenues to engaging in public scholarship as a means of disseminating family science research are presented. These avenues include collaborating with individuals who serve in complementary roles, hosting a research press conference to disseminate key findings, and writing for local outlets such as community newspapers. Mechanisms to implement (e.g., resources for developing press releases, infographics, or visual abstracts) and document (e.g., in promotion and tenure materials) these activities are outlined. Conclusion: This information can help academic family scholars achieve broader impacts of their science activities that illustrate the relevance of family science research in people's lives. Implications: By shifting academic cultures and engaging in public scholarship, family scholars can increase their reach and contribute to the enfranchisement of marginalized populations, while also enhancing the visibility of findings, building their scholarly networks, and growing public support for family science. [ABSTRACT FROM AUTHOR]

Copyright of Theological Review / Bogoslovska Smotra is the property of University of Zagreb, Catholic Faculty of Theology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Although autism spectrum disorders (ASD) are among the most heritable of all neuropsychiatric syndromes, most affected children are born to unaffected parents. Recently, we reported an average increase of 3–5% over general population risk of ASD among offspring of adults who have first-degree relatives with ASD in a large epidemiologic family sample. A next essential step is to investigate whether there are measurable characteristics of individual parents placing them at higher or lower recurrence risk, as this information could allow more personalized genetic counseling. Methods: We assembled what is to our knowledge the largest collection of data on the ability of four measurable characteristics of unaffected prospective parents to specify risk for autism among their offspring: (1) sub clinical autistic trait burden, (2) parental history of a sibling with ASD, (3) transmitted autosomal molecular genetic abnormalities, and (4) parental age. Leveraging phenotypic and genetic data in curated family cohorts, we evaluate the respective associations between these factors and child outcome when autism is present in the family in the parental generation. Results: All four characteristics were associated with elevation in offspring risk; however, the magnitude of their predictive power—with the exception of isolated rare inherited pathogenic variants —does not yet reach a threshold that would typically be considered actionable for reproductive decision-making. Conclusions: Individual specification of risk to offspring of adults in ASD-affected families is not straightforwardly improved by ascertainment of parental phenotype, and it is not yet clear whether genomic screening of prospective parents in families affected by idiopathic ASD is warranted as a clinical standard. Systematic screening of affected family members for heritable pathogenic variants, including rare sex-linked mutations, will identify a subset of families with substantially elevated transmission risk. Polygenic risk scores are only weakly predictive at this time but steadily improving and ultimately may enable more robust prediction either singly or when combined with the risk variables examined in this study. [ABSTRACT FROM AUTHOR]