Search

Researchers at Pondicherry University in India have conducted a study on the use of electrospun nanofibers in various biological applications. The study highlights the unique characteristics of nanofibers, such as small diameters, high porosity, and a high specific surface area, making them suitable for tissue regeneration, antibacterial activity, drug delivery, and antioxidant activity. The research, supported by the Science and Engineering Research Board in New Delhi, focuses on the potential of nanofiber materials-based supramolecular assembly in biological fields. The study has been peer-reviewed and provides valuable insights into the applications of nanofibers in biomedical research. [Extracted from the article]

A recent study conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, focused on comparing the management and outcomes of pulmonary artery hypertension (PAH) and Eisenmenger syndrome during pregnancy. The study found that maternal mortality was lower in the PAH group compared to the Eisenmenger syndrome group, with higher incidences of heart failure and hypoxemia in the latter. The research concluded that outcomes in Eisenmenger syndrome were inferior to PAH and comparable to those in developed nations. [Extracted from the article]

Researchers from the Department of Chemical Engineering in Pondicherry, India, have developed new thermodynamic correlations for the solubility of pharmaceutical compounds in supercritical carbon dioxide. The study utilized Universal quasi-chemical Functional Group Activity Coefficient and Wilson models to propose activity coefficient models. The research focused on pharmaceutical compounds such as anticancer, antibiotics, and anti-inflammatory drugs, comparing the newly proposed models with existing solid-fluid equilibrium models. The findings suggest that the new models show promise in correlating the solubility of pharmaceutical compounds in supercritical carbon dioxide. [Extracted from the article]

A study conducted at Pondicherry University in India focused on developing a curcumin-fused lipogel for wound healing applications. The research aimed to enhance wound healing ability through sustained drug release and antibacterial efficacy. Results showed improved solubility of curcumin in liposome formulation, prolonged drug release, and better antibacterial efficacy against tested bacterial strains. The study concluded that the developed hydrogel displayed good adhesion and water retention, essential for effective wound healing. [Extracted from the article]

A recent study conducted in Pondicherry, India, focused on treating moderate iron deficiency anemia in children aged 6-11 years. The research involved an open-labeled randomized controlled trial where children received sesame jaggery balls in addition to oral iron syrup. Results showed that the group receiving sesame jaggery balls had more significant increases in hemoglobin levels, serum ferritin levels, and body weight compared to the control group. The study concluded that daily supplementation of sesame jaggery balls alongside routine oral iron syrup can improve the iron status of children with moderate iron deficiency anemia. [Extracted from the article]

Recent research conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, focused on characterizing beta-thalassemia mutations in a tertiary care hospital in Southern India. The study identified common mutations such as IVS I-5(G > C) and Cd 15(G > A) among patients and their families, highlighting the importance of mutation screening for genetic counseling and prenatal diagnosis. This research, supported by the Indian Council of Medical Research, sheds light on regional variations in beta-thalassemia mutations and emphasizes the significance of understanding genetic patterns in diverse populations. [Extracted from the article]

A study conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, focused on the prevalence of functional vitamin B12 deficiency and elevated serum vitamin B12 levels among Indian patients with myeloproliferative neoplasms (MPNs). The research found that despite elevated serum vitamin B12 levels, a significant proportion of MPN patients had functional vitamin B12 deficiency. The study recommended evaluating for functional deficiency regardless of serum vitamin B12 levels and suggested further research on the potential benefits of vitamin B12 replacement in MPN patients with functional deficiency. [Extracted from the article]

A recent study conducted at Pondicherry University in India focused on the degradation of Methylene blue dye by Bacillus cereus strains. The researchers isolated microbes from industrial wastewater and identified two strains of Bacillus cereus. They optimized various parameters and found that high levels of degradation could be achieved within 7 days, but the presence of surfactants reduced the degradation time to 72 hours. The study concluded that Bacillus cereus strains are capable of completely mineralizing Methylene blue dye, but further research is needed to remove the remaining surfactants in the degraded products. [Extracted from the article]

Researchers at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India have conducted a study on the clinical and radiological features of superior mesenteric artery occlusion (SMAO), a condition that can present as acute mesenteric ischemia (AMI) or chronic mesenteric ischemia (CMI). The study included 39 patients with SMAO and found that acute SMAO had proximal and distal occlusions with bowel gangrene changes but without collaterals, while chronic SMAO had mainly proximal stenosis/occlusion with well-formed collaterals and no bowel changes. The researchers also noted that Takayasu arteritis may be a subset of chronic SMAO. Early surgery in the acute group was associated with a better prognosis. [Extracted from the article]

A recent study conducted in Pondicherry, India, by researchers from the Jawaharlal Institute of Postgraduate Medical Education and Research focuses on the surgical treatment of esophageal cancer. The study highlights the importance of radical lymphadenectomy in esophageal cancer surgery but acknowledges the associated postoperative complications. The researchers propose a function-preserving mediastinal lymphadenectomy approach that aims to balance radicality and functional outcomes by preserving vital structures such as the thoracic duct, tracheobronchial vascularity, and branches of the vagus nerve. The study suggests that this approach has the potential to improve short- and long-term outcomes after esophagectomy for esophageal cancer. [Extracted from the article]

A study conducted by the Department of Chemical Engineering in Pondicherry, India, focused on developing new solubility models for drugs in supercritical carbon dioxide (SC-CO2). The researchers aimed to predict solubility data at desired experimental conditions, which is crucial for micronizing drug particles with SC-CO2. The study compared the proposed models with existing density models and also calculated thermodynamic quantities of the compounds. The research concluded with a statistical comparison of the models. For more information, readers can contact Chandrasekhar Garlapati at Puducherry Technol Univ, Dept. of Chemical Engineering in Pondicherry, India. [Extracted from the article]

A recent report from the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, discusses the occurrence of cutaneous myiasis, which is an infestation of fly larvae in the tissues and organs of living vertebrates and humans. The research highlights that pre-existing dermatological conditions and poor hygiene are contributing factors to this condition, particularly among neglected patients. The report presents a case series of eight patients with autoimmune bullous disorders (AIBDs) who also had cutaneous myiasis. This research emphasizes the importance of proper hygiene practices and accurate diagnosis and treatment of AIBDs to prevent the occurrence of cutaneous myiasis. [Extracted from the article]

A recent study conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, aimed to evaluate the laboratory profile of lupus anticoagulant (LA)-positive cases and its association with various clinical presentations. The study found that the sensitivity of tests for LA positivity was around 78-79%. The thrombotic group showed a significantly higher rate of LA positivity, indicating an increased risk of thrombosis. Additionally, persistent LA positivity was more frequently observed in cases that were initially dual, double, or triple LA positive. This research provides valuable insights into the laboratory profile of LA-positive cases and their clinical implications. [Extracted from the article]

A recent study conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) in Pondicherry, India, focused on characterizing the human respiratory syncytial virus (RSV) among children admitted with acute respiratory tract infections. The study found that RSV is a major cause of lower respiratory tract infections in children, particularly infants, with significant morbidity and mortality implications. The virus undergoes continuous evolution, necessitating ongoing surveillance to inform public health strategies and vaccine development efforts. The study identified specific strains of RSV and highlighted the importance of vigilant surveillance in combating the virus. [Extracted from the article]

A recent report from the Jawaharlal Institute of Post Graduate Medical Education and Research in Pondicherry, India, discusses the diagnostic challenges and treatment delays associated with cancer-related microangiopathic hemolytic anemia. The study focuses on seven young patients who presented with unexplained anemia and peripheral blood findings consistent with microangiopathic hemolytic anemia. Subsequent bone marrow examinations revealed metastatic adenocarcinoma, with the primary site identified in five of the seven patients. The research emphasizes the importance of careful observation of peripheral blood smears in detecting underlying malignancies. [Extracted from the article]

A recent study conducted by researchers at the Department of Chemical Engineering in Pondicherry, India, has proposed a new model for correlating the solubility of anticancer drugs in supercritical carbon dioxide. The study highlights the importance of supercritical fluid technology in the production of anticancer drugs and the need for an efficient model to determine drug solubility. The researchers evaluated the performance of the proposed model using statistical parameters and the Kruskal-Wallis test. This research provides valuable insights into the development of sustainable and eco-friendly technologies for cancer therapy. [Extracted from the article]

The article focuses on new research from Pondicherry University examining the green synthesis and evaluation of quercetin-loaded magneto-liposomes for cancer therapy. Topics include the antioxidant properties of these magneto-liposomes, their effectiveness in magnetic hyperthermia, and their MRI contrast capabilities, alongside their impact on cancer cell viability and minimal cytotoxicity to non-cancerous cells.

The article from Jawaharlal Institute of Post Graduate Medical Education and Research focuses on new findings related to surgical site infections (SSI) in gastrointestinal surgeries. Topics include the effectiveness of a customized care bundle in reducing SSI rates, the implementation of pre-operative, intraoperative, and post-operative care components, and the impact of adherence to the care bundle on SSI risk and overall compliance.

A recent study conducted in India examined the clinical characteristics and genetic profiles of children with WDR72-associated distal renal tubular acidosis (dRTA). The study included 22 patients, the majority of whom were female, with a median age of diagnosis at 5.3 years. Common symptoms included polyuria, poor growth, rickets, and amelogenesis imperfecta. Genetic analysis revealed biallelic nonsense variants in the majority of patients. While most patients responded well to treatment, long-term follow-up showed a decline in estimated glomerular filtration rate (eGFR) in some cases. The study highlights the importance of considering WDR72-dRTA in children with amelogenesis imperfecta and dRTA symptoms. [Extracted from the article]

A recent study conducted at Pondicherry University in India explored the potential of 26 hybrid compounds containing sulfonamide, chalcone, and nitro group scaffolds as anti-malarial agents. The compounds were tested against the human malarial parasite Plasmodium falciparum, and two compounds showed significant inhibitory activity. These compounds did not exhibit toxic effects on host red blood cells or human and murine cells. The study suggests that the hybrid scaffold, 4-nitrobenzenesulfonamide chalcones, has potential as an anti-plasmodial agent. [Extracted from the article]

A recent study conducted in Pondicherry, India, examined the efficacy and tolerability of different oral iron replacement regimens for women with iron-deficiency anemia (IDA). The study compared a daily arm (DA) with a regimen of 60 mg elemental iron administered daily, and an alternate-day arm (ADA) with a regimen of 120 mg elemental iron administered as a single dose on alternate days. The primary outcome measured was the change in hemoglobin levels on Day 28. The study found that the ADA resulted in a significantly higher increase in hemoglobin levels compared to the DA, with fewer adverse effects. The researchers suggest that larger trials should be conducted to further evaluate the benefits of alternate-day iron replacement. [Extracted from the article]

A study conducted at the Jawaharlal Institute of Post Graduate Medical Education and Research in Pondicherry, India, examined the response to immunosuppressive therapy (IST) in patients with aplastic anemia. The study included 158 patients and found that the overall response rate to IST was 66% at 6 months post-treatment. The mortality rate was 13%, and the response rates at 12 and 24 months were 64% and 61% respectively. The study concluded that age, gender, and severity at presentation did not influence response rates. This research provides valuable insights into the effectiveness of IST in treating aplastic anemia. [Extracted from the article]

A new report discusses research findings on Ankylosing Spondylitis (AS), a type of musculoskeletal disease. The study compared clinical features, disease activity, and functional outcomes among different age groups of AS patients. The researchers found that there were no significant differences in clinical presentation or disease activity between juvenile-onset AS, adult-onset AS, and late-onset AS. However, a majority of patients in all groups had poor functional outcomes, which may be due to limited access to TNF inhibitors. This study provides insights into the characteristics and outcomes of AS in a specific population. [Extracted from the article]

A study conducted at the Jawaharlal Institute of Post Graduate Medical Education and Research in Pondicherry, India, explored the gene expression patterns of regulatory T cells (Tregs) in individuals with rheumatoid arthritis (RA), osteoarthritis (OA), and healthy controls (HC). The researchers found that Tregs in individuals with RA exhibited higher percentages of Th1 and Th17-like Tregs compared to those with OA and HC. Additionally, the study revealed altered gene regulation in RA Tregs, particularly in pathways related to TCR signaling, cytokine signaling, and chemokine signaling. The findings suggest a possible metabolic re-programming of Tregs towards an inflammatory phenotype in RA. [Extracted from the article]

A study conducted at the Jawaharlal Institute of Post Graduate Medical Education and Research in Pondicherry, India, aimed to understand the mechanisms contributing to non-response in lupus nephritis (LN). The researchers used peripheral blood mononuclear cells (PBMCs) as an alternative to kidney biopsy to monitor treatment response. They identified changes in functional pathways in PBMCs and renal tissues after cyclophosphamide treatment and identified baseline genes that predict treatment response. The study found that certain genes and pathways were upregulated or downregulated in different groups of patients, and specific genes in PBMCs and renal tissue predicted non-response and renal flare. [Extracted from the article]

A recent study conducted in Pondicherry, India, examined the clinical outcomes and predictors of difficult-to-treat lupus nephritis (LN). LN is a serious manifestation of systemic lupus erythematosus (SLE), and a significant percentage of patients fail to respond to standard treatment. The study found that the presence of active sediments at initial diagnosis and the co-existence of antiphospholipid antibodies (aPLs) were independent predictors of difficult-to-treat LN. The research highlights the challenges in managing LN and provides valuable insights for improving treatment outcomes. [Extracted from the article]

A recent study conducted in Pondicherry, India, examined the effects of Naga Parpam (NP), a zinc-containing drug used in Siddha medicine, on lipid peroxidation, antioxidant enzymes, and liver tissues in Wistar rats. The drug was administered orally to the rats in different doses for 28 days, and on day 29, their livers were analyzed. The study found that NP exhibited potential antioxidant activity, as it decreased lipid peroxidation and increased the activity of antioxidant enzymes. Additionally, there were no significant changes in the liver tissue architecture, suggesting the drug's potential in treating diseases. [Extracted from the article]

A study conducted at Pondicherry University in India has focused on the development of superparamagnetic hydrogels for use in tissue engineering. The researchers aimed to integrate iron into polyvinyl alcohol (PVA) hydrogels using a freeze-thawing technique. The physiochemical properties of the hydrogels were evaluated, confirming their superparamagnetic nature. The study also examined the release profiles of a drug loaded into the hydrogels. The research concluded by discussing the tensile and compression strength of the hydrogels. This study provides valuable insights into the potential applications of superparamagnetic hydrogels in tissue engineering, drug delivery, and bioimaging. [Extracted from the article]

Researchers from the Jawaharlal Institute of Post Graduate Medical Education and Research in Pondicherry, India, conducted a cross-sectional study to evaluate the correlation between medial plantar nerve (MPL) sensory nerve action potentials (SNAPs) and the severity of diabetic peripheral neuropathy (DPN). The study included 51 diabetic subjects referred for suspected DPN, and the results showed a correlation between MPL SNAP and the Toronto Clinical Neuropathy Score (TCNS). The researchers concluded that MPL SNAP has a moderate correlation with the clinical score and can identify more cases of diabetic neuropathy than sural nerve conduction studies. [Extracted from the article]

A study conducted at Pondicherry University in India has found that the natural compound fisetin has potential anti-cancer properties. However, its low solubility prevents effective delivery through intravenous administration. To address this issue, researchers formulated fisetin-loaded polymannose nanoparticles (FIS-PM NPs) and nanotized fisetin (Nano FIS) to increase solubility and therapeutic efficacy. The nanoformulations showed improved anticancer potential in breast cancer cell lines compared to raw fisetin, attributed to enhanced solubility. This research provides insights into potential strategies for enhancing the efficacy of fisetin as an anticancer therapy. [Extracted from the article]

A study conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, explored the role of T-cells and macrophages in the prognosis of lymphomas. The researchers collected data from 83 patients with nodal diffuse large B-cell lymphoma (DLBCL) and analyzed the association of these immune cells with clinicopathological factors, treatment response, and survival. The study found that a higher percentage of CD3 positive T-cells and CD8 positive cytotoxic T-cells were associated with a better response to treatment. Additionally, a higher number of macrophages in the tumor microenvironment correlated with better overall survival. This research provides insights into potential prognostic markers for DLBCL. [Extracted from the article]

A recent study conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, examined the clinical course and outcomes of children with primary focal segmental glomerulosclerosis (FSGS) from low- and middle-income countries. The study followed 73 children aged 1-18 years with biopsy-proven primary FSGS over a period of 13 years. The most common histological subtype was FSGS-not otherwise specified (NOS), and calcineurin inhibitors were found to be effective in achieving remission. However, 28.7% of the children progressed to chronic kidney disease (CKD) stage 2-5, with collapsing variant and segmental sclerosis > 25% predicting kidney disease progression. The study highlights the importance of immunosuppression in predicting kidney survival in children with FSGS. [Extracted from the article]

A study conducted at the Jawaharlal Institute of Post Graduate Medical Education and Research in Pondicherry, India, aimed to develop a prognostic-scoring model for predicting mortality among newly diagnosed drug-sensitive pulmonary tuberculosis (TB) patients in South India. The researchers analyzed cohort data and identified eight variables (age, gender, functional limitation, anemia, leukopenia, thrombocytopenia, diabetes, neutrophil-lymphocyte ratio) that were used to build a nomogram-scoring system. The model showed a discriminatory power of 0.81 and was well-calibrated. The researchers concluded that this scoring system could help clinicians and policymakers devise targeted interventions to reduce TB mortality in India. [Extracted from the article]

A study conducted at Pondicherry University in India explored the impact of combining the natural compound mangiferin with the oral hypoglycemic drugs metformin and gliclazide on diabetic neuropathy. Diabetic neuropathy is a complication of diabetes characterized by neuronal damage and neuropathic pain. The study found that the combination of mangiferin with metformin and gliclazide delayed pain perception in rats and showed a synergistic effect on antioxidant enzyme levels in the brain tissue. These findings suggest that the combination of mangiferin with these commonly used drugs may help alleviate the symptoms of diabetic complications. [Extracted from the article]

A recent report from the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India discusses the diagnosis of Langerhans-Cell Histiocytosis (LCH) in the thyroid and bilateral parotid using fine needle aspiration cytology (FNAC). The researchers highlight that LCH can present diagnostic challenges in unusual sites or with deviated cytomorphology, and FNAC is a minimally invasive procedure that can aid in diagnosis. The study concludes that FNAC sampling can also facilitate further immunohistochemistry and molecular studies if needed. This research has been peer-reviewed and provides valuable insights into the diagnosis of LCH. [Extracted from the article]

A recent study conducted in Pondicherry, India, explored the barriers and potential solutions for improving the utilization of Facility-based Integrated Counseling and Testing Center (F-ICTC) counseling services. The study found that certain populations, such as antenatal checkup mothers and their spouses, surgery patients, and individuals attending STI clinics, were reluctant to undergo pretest counseling. Barriers identified by stakeholders included fear of the disease, violation of privacy, unacceptance, gender bias, fear of social stigma and discrimination, and neglect associated with the disease. The study proposed several potential solutions, including asking individuals who refuse pretest counseling to answer a set of questions, creating a conducive hospital environment, implementing a zero discrimination policy, providing group counseling for specific populations, offering phone counseling for unwilling patients, and relocating the testing center. The researchers concluded that context-specific evidence-based interventions could help improve the utilization of F-ICTC services. [Extracted from the article]

A new report from the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry, India, presents findings from a retrospective cohort study on the etiology and outcomes of rapidly progressive glomerulonephritis (RPGN) in children. The study evaluated patients under 18 years old with RPGN over an 8-year period and found that the most common etiology of RPGN in children was lupus nephritis. The study also identified factors that predicted kidney survival, such as the duration of symptoms prior to presentation and the presence of certain types of crescents. The research concluded that renal outcomes were determined by pre-admission symptoms and the percentage and stage of crescents. [Extracted from the article]

A recent article in Drug Week discusses new findings in the field of Chemicals and Chemistry. Researchers from the Department of Chemistry in Pondicherry, India, have focused on the Thia-Michael addition reactions, which are important for the synthesis of organic compounds. These reactions play a significant role in medicinal and material science, and have applications in the production of bioactive molecules, insect sprays, and polymer substances. The research highlights the development of novel methods for C-S bond formation that are more convenient and environmentally friendly. For more information, readers can refer to the article "Thia-michael Addition In Diverse Organic Synthesis" published in Croatica Chemica Acta. [Extracted from the article]