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34 results on '"Hoffman, Lee"'

1. Design and Fabrication of Highly Stretchable and Tough Hydrogels.

Author

Qiao, Zhen, Cao, Meijuan, Michels, Kathryn, Hoffman, Lee, and Ji, Hai-Feng

Subjects
HYDROGELS, ARTIFICIAL skin, ELECTRONIC equipment, TISSUE culture, WOUND healing, WEARABLE technology
Abstract

Stretchable and tough hydrogels have attracted a lot of attention due to their great potential in applications such as wound healing, drug delivery, tissue culture, etc. They can also be paired with electronic components to create artificial skin, wearable electronics, and patches. To promote the development of more hydrogels, we will summarize methods and materials that have been used to develop these gels, and then we will compare the performance of these gels in an aim to guide the future development of gels for superior performance, especially for specific applications. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Hyperbranched lysine−arginine copolymer for gene delivery.

Author

Peng, Qi, Zhu, Jianjun, Yu, Yongsheng, Hoffman, Lee, and Yang, Xingkun

Subjects
LYSINE, ARGININE, COPOLYMERS, GENE delivery techniques, CARBOXYL group, AMINES
Abstract

Based on the reactivity of amine groups and carboxyl groups ofL-lysine andL-arginine, thermal polymerization of these two natural amino acids results in hyperbranched lysine–arginine copolymers (P-lys-argX, whereXrefers to the relevant molar ratio of arginine to lysine). Hyperbranched polylysine (P-lys) and two derivatives (P-lys-arg0.10and P-lys-arg0.20) have been prepared. The arginine-rich hyperbranched polymers can interact with plasmid DNA to form nano-sized particles. The polyplexes were physicochemically analyzed by agarose gel electrophoresis, dynamic light scattering, and zeta potential measurements. Furthermore, their transfection efficiency was assessed, employing COS-7, 293T, and HeLa cell lines. It was found that P-lys showed poorly in its ability of condensation with DNA and transfection efficiency. On the other hand, arginine-rich products resulted to significant enhancement of its transfection efficiency, which is dependent on the content of arginine in the polymers, and the cell line used. P-lys-arg0.20exhibited better transfection efficiency under all the condition studied. Besides, P-lys-arg0.20showed lower toxicity in COS-7 cells. [ABSTRACT FROM AUTHOR]

Published
2015
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3. Non-viral gene therapy that targets motor neurons in vivo.

Author

Rogers, Mary-Louise, Smith, Kevin S., Matusica, Dusan, Fenech, Matthew, Hoffman, Lee, Rush, Robert A., and Voelcker, Nicolas H.

Subjects
NEURONS, MICROBIAL genes, NERVE cell culture, GENE therapy, GENETIC engineering
Abstract

A major challenge in neurological gene therapy is safe delivery of transgenes to sufficient cell numbers from the circulation or periphery. This is particularly difficult for diseases involving spinal cord motor neurons such as amyotrophic lateral sclerosis (ALS). We have examined the feasibility of non-viral gene delivery to spinal motor neurons from intraperitoneal injections of plasmids carried by "immunogene" nanoparticles targeted for axonal retrograde transport using antibodies. PEGylated polyethylenimine (PEI-PEG12) as DNA carrier was conjugated to an antibody (MLR2) to the neurotrophin receptor p75 (p75NTR). We used a plasmid (pVIVO2) designed for in vivo gene delivery that produces minimal immune responses, has improved nuclear entry into post mitotic cells and also expresses green fluorescent protein (GFP). MLR2-PEI-PEG12 carried pVIVO2 and was specific for mouse motor neurons in mixed cultures containing astrocytes. While only 8% of motor neurons expressed GFP 72 h post transfection in vitro, when the immunogene was given intraperitonealy to neonatal C57BL/6J mice, GFP specific motor neuron expression was observed in 25.4% of lumbar, 18.3% of thoracic and 17.0% of cervical motor neurons, 72 h post transfection. PEI-PEG12 carrying pVIVO2 by itself did not transfect motor neurons in vivo, demonstrating the need for specificity via the p75NTR antibody MLR2. This is the first time that specific transfection of spinal motor neurons has been achieved from peripheral delivery of plasmid DNA as part of a non-viral gene delivery agent. These results stress the specificity and feasibility of immunogene delivery targeted for p75NTR expressing motor neurons, but suggests that further improvements are required to increase the transfection efficiency of motor neurons in vivo. [ABSTRACT FROM AUTHOR]

Published
2014
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5. Novel Grafting onto Silica via Aldehyde Functionality.

Author

Congiusta, Carlo, Granleese, Justin, Graiver, Daniel, Hoffman, Lee, Mathew, Simon, Clarke, Dave, Johnston, Martin, and Clarke, Stephen

Abstract

Silica-bound aldehyde functional silane was used as a versatile bridge to attach porphyrin to the surface of silica and as a surface-bound free radical initiator to yield PMMA brushes. The aldehyde functionality is obtained by a simple ozonolysis of the surface-bound allylsilane, whereby the double bonds are oxidized in high yield to the desired aldehyde. Mono-amino porphyrin was attached to the silica surface under mild conditions via Schiff-base linkages, whilst anchored PMMA was obtained by free radical initiation using an aldehyde/redox free radical polymerization. FTIR and TGA data were used to determine and characterize the attachment to the silica surface. [ABSTRACT FROM AUTHOR]

Published
2009
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6. Chapter 3. SCED Subject Areas.

Author

Bradby, Denise, Pedroso, Rosio, Rogers, Andy, and Hoffman, Lee

Subjects
CURRICULUM, INSTRUCTIONAL systems, EDUCATIONAL standards, SCHOOLS
Abstract

Chapter 3 of the book "Secondary School Course Classification System: School Codes for the Exchange of Data (SCED)" is presented. It lists 22 subject areas and codes in the SCED. Each subject area has a list of courses with 3-digit identifiers to distinguish them from others in the same subject area. Examples of subject areas are English Language and Literature, Mathematics, Life and Physical Sciences, and Social Science and History.

Published
2007

7. Chapter 2. Framework of SCED.

Author

Bradby, Denise, Pedroso, Rosio, Rogers, Andy, and Hoffman, Lee

Subjects
SECONDARY education, EDUCATION, STUDENTS, SCHOOLS
Abstract

Chapter 2 of the book "Secondary School Course Classification System: School Codes for the Exchange of Data (SCED)" is presented. It discusses a unique identification code for any secondary course. The code has four component elements which include course description, course level, available credit and sequence. Each of these elements constitutes a descriptor in the identification code like subject area, course identifier, course level, credit available for a student to earn and sequence. Also noted are the content and structure of SCED.

Published
2007

8. Chapter 1. Introduction.

Author

Bradby, Denise, Pedroso, Rosio, Rogers, Andy, and Hoffman, Lee

Subjects
STUDENT records, SCHOOL records, CURRICULUM, INSTRUCTIONAL systems
Abstract

Chapter 1 of the book "Secondary School Course Classification System: School Codes for the Exchange of Data (SCED)" is presented. It describes the SCED system which makes it easier to electronically maintain student records. SCED is also use to transmit coursetaking information to other information systems, school districts and the state department of education. The SCED was developed by the National Center for Education Studies (NCES) and is part of the NCES Handbook Series, which also include the usage of the Course Coding and Classification Systems.

Published
2007

9. Appendix D--Supplementary Tables.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts
Abstract

A list of supplementary tables that relate to articles in the book "Characteristics of the 100 Largest Public Elementary & Secondary School Districts in the U.S. and Its Jurisdictions" is presented.

Published
2006

10. Appendix C--Glossary.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
GLOSSES & glossaries, SCHOOL districts
Abstract

A glossary of terms used in the book "Characteristics of the 100 Largest Public Elementary & Secondary School Districts in the U.S. and Its Jurisdictions" is presented.

Published
2006

11. Appendix A--Basic Tables.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts, STATISTICAL tables
Abstract

A list of tables representing characteristics and statistics that relate to articles in the book "Characteristics of the 100 Largest Public Elementary & Scondary School Districts in the U.S. and Its Jurisdictions" is presented.

Published
2006

12. How Did the 100 Largest School Districts Compare With All School Districts?

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts, PUBLIC institutions, SCHOOL year, STUDENTS, SCHOOL schedules
Abstract

A chapter from the book "Characteristics of the 100 Largest Public Elementary and Secondary School Districts in the U.S. and Its Jurisdictions" is presented. It reports that a school belonging to the 100 largest had at least 46,594 students while 73 percent of regular districts had less than 2,500 students. It shows that there was an average of 161.8 schools per district for the 100 largest while average number for the rest was 5.6 schools. It also notes that the 100 largest had more students per school compared to the average school district.

Published
2006

23. 24-Hour Posture Care Management: Supporting People Night and Day.

Author

Kittelson-Aldred, Tamara and Hoffman, Lee Ann

Abstract

The article offers information about the use of 24-hour posture care management, a systematic approach, in the prevention of asymmetrical deformities in children with cerebral palsy and disabilities. Other details are presented about body shape distortion prevention and the relationship between lying posture and function in sitting and standing.

Published
2017

24. Appendix B--Methodology.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts, SECONDARY education
Abstract

A list of Common Core Data (CCD) used in the book "Characteristics of the 100 Largest Public Elementary & Secondary School Districts in the U.S. and Its Jurisdictions" is presented.

Published
2006

25. LETTERS.

Author

Petty, David, Sessions, Spencer, Myers, Kenny, Fritz, Larry, Hoffman, Lee, Cornman, Ronald, Bradford, Thomas, Ackeret, Scott, Roof, George, and McKean, Andrew

Subjects
BOWHUNTING, HUNTING ethics
Published
2019

26. Acknowledgments.

Author

Bradby, Denise, Pedroso, Rosio, Rogers, Andy, and Hoffman, Lee

Subjects
ADELMAN, Nancy, INGELS, Steven
Abstract

People that the author would like to thank for their assistance in the creation of his book is offered who include Nancy Adelman of SRI International and Steven Ingels of RTI International.

Published
2007

27. Where Were the 100 Largest School Districts?

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts, SCHOOL schedules, SCHOOL administration, PUBLIC schools
Abstract

A chapter from the book "Characteristics of the 100 Largest Public Elementary and Secondary School Districts in the U.S. and Its Jurisdictions" is presented. It reports on the 100 largest school districts for the school year 2003-2004. It says that Texas had 15 districts while California and Florida had 13 each. It shows other states had more than one district in the 100 largest including Georgia, Maryland and North Carolina. It reveals that the 100 largest were in coastal and Gulf Coast areas with big populations.

Published
2006

28. Overview of the 100 Largest School Districts.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts, EDUCATION, PUBLIC schools, SCHOOL administration
Abstract

A chapter from the book "Characteristics of the 100 largest Public Elementary and Secondary School Districts in the U.S. and its Jurisdictions" is presented. It explores public schools in the U.S. and its jurisdictions during the school year 2003-2004. According to Common Core of Data (CCD), there were 98,213 public schools, 17,512 public school districts and over 49.3 million students. The public school districts vary in size from 46,594 to 1,023,674 students in 2003-2004. Information on enrollment of students and employment of teachers is provided.

Published
2006

29. Introduction.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts
Abstract

The article presents an introduction to the book "Characteristics of the 100 Largest Public Elementary and Secondary School Districts in the U.S. and Its Jurisdictions."

Published
2006

30. Foreword.

Author

Bradby, Denise, Pedroso, Rosio, Rogers, Andy, and Hoffman, Lee

Subjects
PREFACES & forewords, SECONDARY education
Abstract

A foreword to "Secondary School Course Classification System: School Codes for the Exchange of Data (SCED)" is presented.

Published
2007

31. Acknowledgments.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts
Abstract

People that the author would like to thank for their assistance in the creation of the book "Characteristics of the 100 Largest Public Elementary and Secondary School Districts in the U.S. and Its Jurisdictions" are mentioned, which include Jason Hill and Martin Hahn.

Published
2006

32. Reference and Related Data Source.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
BIBLIOGRAPHICAL citations, SCHOOL districts
Abstract

References for the articles published in the book "Characteristics of the 100 Largest Public Elementary & Secondary School Districts in the U.S. and Its Jurisdictions" are presented.

Published
2006

33. Changes in the 100 Largest School Districts Between 1993 and 2003.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts, SCHOOL district size, STUDENTS, TEACHERS
Abstract

A chapter from the book "Characteristics of the 100 Largest Public Elementary and Secondary School Districts in the U.S. and Its Jurisdictions" is presented. It reports on the changes in ranking among the 100 largest school districts in the years 1993 to 2003. It is said that in the period 1993-94 to 2003-2004, students in the 100 largest increased by 11% while teachers increased by 43% and the number of schools increased by 12%. It also notes that on the national total, however, the percentage of students was the same for 1993-1994 and 2003-2004.

Published
2006

34. Highlights.

Author

Dalton, Ben, Sable, Jennifer, and Hoffman, Lee

Subjects
SCHOOL districts
Abstract

An introduction to the book "Characteristics of the 100 Largest Public Elementary and Secondary School Districts in the U.S. and Its Jurisdictions" is presented.

Published
2006

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