Search

CTNNB1, encoding the ß-catenin protein, is a key oncogene contributing to liver carcinogenesis. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer in adult, representing the third leading cause of cancer-related death. Aberrant activation of the Wnt/ß-catenin pathway, mainly due to mutations of the CTNNB1 gene, is observed in a significant subset of HCC. In this review, we first resume the major recent advances in HCC classification with a focus on CTNNB1-mutated HCC subclass. We present the regulatory mechanisms involved in β-catenin stabilisation, transcriptional activity and binding to partner proteins. We then describe specific phenotypic characteristics of CTNNB1-mutated HCC thanks to their unique gene expression patterns. CTNNB1-mutated HCC constitute a full-fledged subclass of HCC with distinct pathological features such as well-differentiated cells with low proliferation rate, association to cholestasis, metabolic alterations, immune exclusion and invasion. Finally, we discuss therapeutic approaches to target ß-catenin-mutated liver tumours and innovative perspectives for future drug developments. [ABSTRACT FROM AUTHOR]

This study revisits the taxonomic classification of the genus Nocardiopsis through the application of advanced genome-based methodologies, representing a notable advancement beyond traditional approaches that primarily rely on 16S rRNA gene sequences and phenotypic traits. The advent of Next-Generation Sequencing (NGS) and sophisticated bioinformatic tools has enabled a more precise framework for prokaryotic classification. However, many recognized species still lack complete genome sequences. In this study, we employed overall genome-related indices (OGRI), particularly Average Nucleotide Identity (ANI) and digital DNA-DNA hybridization (dDDH), to reassess the phylogenetic relationships within the genus. Comparative analyses of complete 16S rRNA sequences demonstrated high genetic similarity between N. umidischolae 66/93 T and N. tropica VKMAc-1457 T (99.61% similarity), as well as between N. rhodophaea JCM15313T and N. rosea JCM15314T (100% identity). The dDDH, ANI%, FastANI%, ANIm, and ANIb values further supported these results, with 73.2%, 96.94%, 96.15%, 97.19%, and 96.74% for the former pair, and 93.6%, 99.13%, 99.97%, 99.98%, and 99.27% for the latter pair, respectively. All values surpassed the species delineation thresholds of 70% for dDDH and 95–96% for ANI. Consequently, we propose reclassifying N. umidischolae as a heterotypic synonym of N. tropica, and N. rosea as a heterotypic synonym of N. rhodophaea, in accordance with the International Code of Nomenclature of Prokaryotes (ICNP). [ABSTRACT FROM AUTHOR]

This study explores the isolation and characterization of Streptomyces strain D15 from the Algerian steppes, with a focus on combating antibiotic-resistant microbial strains. In response to the global health threat posed by antimicrobial resistance, the research delves into the unique ecological niche of Algerian steppes. The isolated strain, identified as belonging to the genus Streptomyces, exhibits typical morphological and cultural traits, supported by chemical and genomic analyses. Phylogenetic analysis establishes the genetic closeness of D15 to Streptomyces lavendofoliae. The strain demonstrates potent antagonistic activity against various microorganisms, showcasing significant antimicrobial effects, particularly against Micrococcus luteus, Enterococcus faecalis, and Candida albicans. Genomic analysis unveils a rich repertoire of biosynthetic gene clusters, emphasizing the strain's potential to produce diverse secondary metabolites, essential for combating antibiotic resistance. Streptomyces strain D15 emerges as a promising candidate for novel antimicrobial agents, with its broad-spectrum activity and genomic potential. The study underscores the importance of exploring untapped environments, like Algerian steppes, to discover new strains capable of addressing the challenges posed by antibiotic-resistant microbial strains. This research contributes to the ongoing global efforts to find innovative solutions and underscores the pivotal role Streptomyces plays in the search for effective antibiotics. [ABSTRACT FROM AUTHOR]

This study aims to evaluate the in silico genomic characteristics of five species of the genus Planotetraspora: P. kaengkrachanensis, P. mira, P. phitsanulokensis, P. silvatica, and P. thailandica, with a view to their application in therapeutic research. The 16S rRNA comparison indicated that these species were phylogenetically distinct. Pairwise comparisons of digital DNA-DNA hybridization (dDDH) and OrthoANI values between these studied type strains indicated that dDDH values were below 62.5%, while OrthoANI values were lower than 95.3%, suggesting that the five species represent distinct genomospecies. These results were consistent with the phylogenomic study based on core genes and the pangenome analysis of these five species within the genus Planotetraspora. However, the genome annotation showed some differences between these species, such as variations in the number of subsystem category distributions across whole genomes (ranging between 1979 and 2024). Additionally, the number of CAZYme (Carbohydrate-Active enZYme) genes ranged between 298 and 325, highlighting the potential of these bacteria for therapeutic research applications. The in silico physico-chemical characteristics of cellulases from Planotetraspora species were analyzed. Their 3D structure was modeled, refined, and validated. A molecular docking analysis of this cellulase protein structural model was conducted with cellobiose, cellotetraose, laminaribiose, carboxymethyl cellulose, glucose, and xylose ligand. Our study revealed significant interaction between the Planotetraspora cellulase and cellotetraose substrate, evidenced by stable binding energies. This suggests that this bacterial enzyme holds great potential for utilizing cellotetraose as a substrate in various applications. This study enriches our understanding of the potential applications of Planotetraspora species in therapeutic research. [ABSTRACT FROM AUTHOR]

The objective of this study is to gather additional on the impact of perlite on both the mechanical properties and resistance to chemical attacks of materials. Various combinations,incorporating perlite in the form of cement additions, were examined. Five different substitution rates of 10 %, 15 %, 20 %, 25 %,and 30 % of cement with powder perlite were utilized for comparison with plain cement. The findings indicate that the interaction between lime,silica,and alumina in powder perlite results in the formation of several hydrates, such as calcium silicate hydrate, hydrated calcium aluminates,and hydrated gelhenite.Our research focuses on the development of natural perlite from maghnia as a potentially pozzolanic supplementary cementing material. In evaluating the pozzolanicity of this material, it was observed that external aggressions, such as chlorides, CO2, and chemical attacks, can compromise the physical and mechanical properties of concrete, affecting its long-term durability. However, natural pozzolans like pelite exhibit a positive influence on the durability of mortars against sulphate attacks. Test results revealed specimens with no apparent degradation, indicating that sulphate ions in the solution did not adversely affect perlite-based mortars. There is a growing preference for mineral additives with lower production costs than cement. Consequently, the optimal mixture was determined to be one containing 25 % perlite. However, cement pastes and mortars incorporating up to 20 % perlite demonstrated satisfactory physical and mechanical properties, comparable to materials without perlite. The investigation into the perlite materials used in conjunction with cement suggests the potential for sustainable concrete. Experimental results indicate that natural perlite powder from Maghnia can be considered a good pozzolanic material, suitable as a mineral admixture in cement production. [ABSTRACT FROM AUTHOR]

Chest x-rays (CXRs) are broadly used in clinical practice to diagnose pulmonary diseases. Developing reliable computer-aided diagnosis (CAD) systems to automate the interpretation of CXRs can save medical practitioners time and improve diagnosis accuracy. Besides, segmenting lungs accurately plays a vital role in CAD systems. However, several challenges hamper the generalizability of current automatic lung segmentation approaches. These include the high varied shape and scale of lungs, the device-specific artifacts in CXRs, and the false positive generation. This study aims to address these issues by proposing a new attention-gated residual deep convolutional network based on an enhanced DeepLabV3 + network. The novel sophistications proposed promote the effective learning of intrinsic lung-related features to improve the network robustness against device-specific artifacts and false positive generation. In the encoder, the proposed framework leverages the attention gate mechanism to selectively filter irrelevant lower-level features using high-level multiscale features learned by the Atrous Spatial Pyramid Pooling (ASPP) module. This improves the network adaptability to different scale and shape lungs and reduces its bias to device-specific artifacts. In the decoder, residual convolutions are used to prevent significant information loss during the segmentation map composition. Several models based on the proposed approach are built by employing the EfficientNetB4 and ResNet50 pretrained models as feature extractors and using different public datasets for training and evaluation. Empirical results demonstrated the proposed framework superiority over many state-of-the-art models by achieving 98.03% for the dice coefficient and 96.14% for the Jaccard index without applying any preprocessing or post-processing. [ABSTRACT FROM AUTHOR]

A several diagnostic methods used to evaluate and detect any potential issues or faults in the transformer before they cause significant problems. The research proposal focuses on employing the SFRA (Sweep Frequency Response Analysis) technique, renowned for its exceptional sensitivity and diagnostic capabilities. This method serves to identify the mechanical integrity of the transformer's core, winding distortion, and clamping structures by analyzing their electrical transfer functions across a broad frequency spectrum. By utilizing SFRA, the study aims to accurately predict the internal physical condition of the transformer, making it a highly effective and reliable indicator for assessing its overall health. The motivation of this present work is using all experiments of SFRA were conducted and validated on a three-phase 30kV/0.4KV voltage transformer with 50kVA at the laboratory of Msila university. The result of these experiments is presented and discussed in terms of interpretation the analyses based on different standards. [ABSTRACT FROM AUTHOR]

This study aims to determine the knowledge of the role of knowledge management in improving the internal work environment; and to stop at the extent to which the technological developments used to improve the performance of employees of the sports institution, by facilitating and simplifying work procedures, achieving effectiveness and acquiring knowledge and skills; and also aims to know the contribution of knowledge management to decisionmaking work by making changes in the direction of decisions, re-studying them and the speed of data acquisition. To achieve the objectives of this study, we used the appropriate descriptive analytical approach to the subject of the research by highlighting the role of knowledge management in improving the internal work environment of the sports organization in Algeria. The sample of the study was from a sample of those in charge of running the Directorate of Youth and Sports Foundation for the state of Tebessa from heads and subordinates of various interests, where their number reached (75) framework and worker in the institution and we took a sample of 25 workers and to collect data we used the questionnaire and analyzed it through the statistical program SPSS, and we got the results that interest in knowledge management has become an urgent necessity to keep pace with the rapid development in various sciences, which is the permanent and specific source that works to achieve the internal work environment and successful and effective in sports institutions. [ABSTRACT FROM AUTHOR]

This study is motivated by experiments on Tore Supra and WEST tokamaks where a deepening of the E × B velocity—governed by the radial electric field Er —near the edge is observed when the safety factor decreases in L-mode plasmas. Flux-driven global simulations of ion temperature gradient turbulence recover qualitatively the trend observed in the experiments, i.e. the E × B velocity increases when decreasing the safety factor. From these simulations, multiple clues point out the role of turbulence in the establishment of the radial electric field even though the turbulent intensity increases with the safety factor. The proposed mechanism to elucidate this phenomenon, backed up by a reduced model, is that the damping of the poloidal flow, governed by the neoclassical friction, increases more strongly with the safety factor than the turbulent drive for Er, due to the (r , θ) component of the Reynolds stress. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the effect of indole-3-acetic acid (IAA)-producing endophytes from saline environments on survival and growth of tomato under salt stress, using different treatment times. Twenty-five endophytic bacteria were isolated from halophytes (Atriplex halimus L., Tamarix aphylla L.) issued from saline regions (Algeria). Five strains were selected based on tolerance to NaCl. A polyphasic taxonomic study was conducted. The selected strains were assigned to the Bacillus cereus group. Quantification of IAA production was done by high-performance liquid chromatography (HPLC). An in vitro test of growth promotion/protection of tomato 'Aicha' was conducted under saline conditions (50 mM, 75 mM, 100 mM, and 125 mM), for different durations of seed biopriming (1h, 3h, and 12h). Endophytes led to a significant amelioration of salt stress in tomato 'Aicha' at all salinity levels, depending on treatment times, indicating the necessity of optimizing this crucial factor. [ABSTRACT FROM AUTHOR]

This research studied the effect of recycled steel fibers extracted from twisted cable waste on the fresh and hardened states of high-performance concretes. Accordingly, slump, water absorption (WA), compressive strength (CS), flexural strength (FS), and split tensile strength (STS) were measured in the laboratory using mixtures generated by the response surface methodology (RSM). The RSM-based central composite design (CCD) was used to assess the influence of water-to-binder (W/B) ratios from 0.27 to 0.31, length-to-diameter (L/d = 46 to 80) and steel fiber content (SFC) in the range of 19 to 29 kg/m3 on the behavior of high-performance fiber-reinforced concrete (HPFRC). The accuracy and validation of the generated models were evaluated by employing analysis of variance (ANOVA) and optimal parameters. The experimental findings revealed that the use of an L/d ratio of 63, a W/B ratio of approximately 0.28, and an SFC of around 22 kg/m3 resulted in high workability in terms of slump. While a notable increase in compressive strength was observed when employing an L/d ratio of approximately 70, a W/B ratio of around 0.28, and the maximum SFC of 29 kg/m3, as confirmed by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis. [ABSTRACT FROM AUTHOR]

This work is devoted for the floral richness and seasonality evaluation of the plant communities of the Tessala Mountains in Western Algeria. The floristic inventory of the 30 surveys carried out on 10 selected stations has resulted in 152 species under 125 genera and 48 families. Seasonal floral richness is concentrated in both spring and summer seasons, while the monthly richness is significant between March to August. Vegetations formations are represented physiognomically by four strata, taken into consideration in descending order of importance: Herbaceous (68%), shrubby (12%), arbustive (11%), and arborescent (10%). The overall and seasonal distributions of biological types almost follow the diagrams: Therophytes (The) > Hemicryptophytes (Hem) > Phanerophytes (Pha) > Chamephytes (Cha) > Geophytes (Geo). During the two season: the winter and the spring, the annual herbaceous dominate the bio-morphological spectrum with perennial herbs. During the summer and autumn, perennial herbaceous plants dominate the bio-morphological spectrum. The families that are most existing overall and during the four seasons are Asteraceae, Poaceae, Lamiaceae and Fabaceae. [ABSTRACT FROM AUTHOR]

The advances of deep learning in histopathology show the ability to assist pathologists in reducing workload and avoiding subjective decisions. Such algorithms lead to a more reliable diagnosis because they give computer-based second opinions to the clinician. However, in histopathology cancer image analysis, pathologists mostly diagnose the pathology as positive if a small part of it is considered cancer tissue. These small parts are called regions of interest or patches. Finding the relevant patches is crucial as it can save computation time and memory. Also, deep learning systems can receive only small inputs, and these patches represent the best input. This paper proposes a new clustering algorithm for the patch selection based on subspace clustering. This technique discovers clusters embedded in multiple, overlapping subspaces of high-dimensional data. The proposed algorithm manages to find the data's best partitioning and the images' relevant patches. [ABSTRACT FROM AUTHOR]

Two time slices in linear and saturated Ohmic confinement (LOC and SOC) regimes in a Tore Supra Ohmic L-mode discharge are analyzed using nonlinear global full-f gyrokinetic simulations, and qualitative features of the LOC–SOC transition are reproduced. The exhaust of carbon impurity ions is caused by ion mixing, which is driven by the toroidal field stress. The intrinsic rotation develops in the opposite direction between the LOC and SOC phases, which is characterized by different features of the mode asymmetry between trapped electron modes (TEMs) in the LOC phase and ion temperature gradient-driven modes in the SOC phase, leading to the change of the profile shear stress. Here, the mode asymmetry or the ballooning angle depends not only on the profile shear and the Er shear but also on the radial electric field Er itself. The energy fluxes of electrons and deuterium ions are dominant in the LOC and SOC phases, respectively, and the ratio of the energy confinement time between the two phases agree with the experimental value. Turbulent frequency spectra are characterized by quasi-coherent modes (QCMs) and broad-band spectra in the LOC and SOC phases, respectively. The QCMs are produced by a split of the toroidal mode number spectra of TEMs induced by the Doppler shift of poloidal E × B rotation due to Er, which is sustained in the electron diamagnetic direction by the ripple induced counter-current rotation, and enhanced by higher temperature in the LOC phase. [ABSTRACT FROM AUTHOR]

This research aims to propose a training program using the integrated training method to develop certain physical attributes (endurance, speed, strength) for football players U21 during the competition based on scientific bases. The research staff hypothesized the influence of the combined training method positively on the development of certain physical qualities (endurance, speed, strength), and taking into account the nature of the research and the method used. the two samples were chosen by the intentional method, where the control and experimental samples were from the same team, where the training program was applied to the experimental sample, which contains 22 training units at a rate of four units per week for a period of six weeks. and the time of the training unit lasted on average 90 minutes. after emptying the data and statistical processing, the proposed training program using the integrated training method obtained a positive evolution between the pre and post tests in favor of the experimental group. the proposed training program using the integrated training method obtained a positive evolution in the results of the posttests between the two control and experimental groups and in favor of the experimental sample. This indicates the effect of the training program on the development of the level of certain physical attributes (endurance, speed, strength) among the research sample based on the results of the study, the researchers suggested the need to use the integrated training method within the training program due to its positive impact on the development of physical qualities in football, and emphasizing the scientific foundations when developing the training program. [ABSTRACT FROM AUTHOR]

The study aims to identify the type of interval exercises that have an effective impact on developing some aerobic capacities (maximum airspeed - VMA, maximum oxygen consumption - VO2MAX) for football players U21. The researchers proposed two training programs for a sample of 16 players from the youth team of JSMTairet activity in the amateur second division of the Algerian championship center-west for the season 2021/2022. The sample was divided into two groups, where the first group applied the proposed training program using long-term interval training method of 3'/3', while the second group applied the program using short-term interval training method of 15" /15". The proposed training program lasted for 8 weeks, with two sessions per week, under the supervision of the research team. The Intermittent Fitness Test 30/15 IFT was used to measure the rate of aerobic capacities VMA/VO2MAX. After obtaining, processing, analyzing, and interpreting the results, it was found that there were statistically significant differences between the post-tests of the two groups. This suggests that training with short-term interval exercises improves the level of aerobic capacities VMA/VO2MAX for football players. Therefore, the researchers recommend using short-term interval exercises during planning and preparation of training programs in different preparation and competition periods to develop physical fitness for players and achieve the highest levels of sports achievement. [ABSTRACT FROM AUTHOR]

The steppe areas of El Bayadh are characterized by a great diversity of medicinal plants (South-West Algeria). This work aims to determine the traditional uses of medicinal plants in the Wilaya (Province) of El Bayadh and evaluate their sensibility. The ethnobotanical surveys carried out using 400 questionnaire sheets made it possible to inventory 40 medicinal species belonging to 23 botanical families the most important family is that of the Lamiaceae and the Fabaceae. The leaves are the most used part of the plant, and the majority of treated illnesses are those of the respiratory system (the flu). The result of the index invented to indicate the state of the sensibility of the plants is important to develop a conservation strategy for these medicinal plants in the context of sustainable development. [ABSTRACT FROM AUTHOR]

Magnetic confinement fusion offers the promise of sustainable and safe energy production on Earth. Advanced experimental scenarios exploit the fascinating yet uncommon ability of confined plasmas to bifurcate into states of enhanced performance upon application of additional free energy sources. Self-regulation of small-scale turbulent eddies is essential to accessing these improved regimes. However, after several decades, basic principles for these bifurcations are still largely debated and clarifications from first principles lacking. We show here, computed from the primitive kinetic equations, establishment of a state of improved confinement through self-organisation of plasma microturbulence. Our results highlight the critical role of the interface between plasma and material boundaries and demonstrate the importance of propagation of turbulence activity beyond regions of convective drive. These observations strongly suggest a paradigm shift where the magnetised plasma at the onset of enhanced performance self-organises into a globally critical state, 'nonlocally' controlled by fluxes of turbulence activity. A central problem in magnetized fusion plasmas is to understand whether the plasma edge sustains a turbulent state and transitions to improved confinement. The authors simulate the detailed organization of turbulence from the primitive flux-driven kinetic equations including plasma-solid interaction and identify basic mechanisms which allow to cure the oft-reported shortfall of turbulence power in the plasma edge and to describe spontaneous onset of a transport barrier. [ABSTRACT FROM AUTHOR]

The current study was conducted to evaluate the protective effect of the ethanolic extract of Anacyclus valentinus (EEA) against hepatotoxicity resulting from exposure to cisplatin (CP) in male rats. In this study, a total of twenty four adult male Wistar rats were used and divided into four groups. The first group (G1) was the control group, the second group (G2) was exposed to CP (three doses of 7 mg/Kg body weight for 6 days; by intravenous injection), the third group (G3) received 200 mg/Kg EEA orally per day for a period of 28 days and the last group (G4) was exposed to CP and treated with 200 mg/Kg EEA. Thus, the levels of γ-GT, ALP, AST and ALT were significantly increased (p <0.01) due to exposure to CP and these enzymes levels were reversed in the CP group receiving EEA. Further, CP caused a significant decrease (p <0.001) in the activity of antioxidant enzymes (SOD, CAT and GSH-PX) with an increase in the level of MDA and NO. Besides, administration of EEA to rats (G4) restored the impaired activity of the antioxidant system with a decrease in MDA and NO. A significant increase (p <0.001) in markers of inflammation (TNF-α and PGE2) was observed in animals treated with CP; while the effect was diminished by EEA. In addition, histological study of the liver indicated that injection of CP to rats caused vascular congestion, microvacuolar steatosis, inflammatory reaction and chronic hepatitis; these changes were resolved by administration of EEA. In conclusion, EEA possessed a therapeutic effect against CP-induced hepatotoxicity in rats. [ABSTRACT FROM AUTHOR]

Copyright of Al Bashaer Economic Journal is the property of Al Bashaer Economic Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Sheared flows are known to reduce turbulent transport by decreasing the correlation length and/or intensity of turbulent structures. The transport barrier that takes place at the edge during improved regimes such as H mode, corresponds to the establishment of a large shear of the radial electric field. In this context, the radial shape of the radial electric field or more exactly of the perpendicular E Ă— B velocity appears as a key element in accessing improved confinement regimes. In this paper, we present the radial profile of the perpendicular velocity measured using Doppler back-scattering system at the edge of the plasma, dominated by the E Ă— B velocity, during the first campaigns of the WEST tokamak. It is found that the radial velocity profile is clearly more sheared in lower single null configuration (with the B Ă— ∇ B magnetic drift pointing toward the active X -point) than in upper single null configuration for ohmic and low current plasmas (B = 3.7 T and q 95 = 4.7), consistently with the expectation comparing respectively ‘favourable’ versus ‘unfavourable’ configuration. Interestingly, this tendency is sensitive to the plasma current and to the amount of additional heating power leading to plasma conditions in which the E Ă— B velocity exhibits a deeper well in USN configuration. For example, while the velocity profile exhibits a clear and deep well just inside the separatrix concomitant with the formation of a density pedestal during Lâ€"H transitions observed in LSN configuration, deeper E r wells are observed in USN configuration during similar transitions with less pronounced density pedestal. [ABSTRACT FROM AUTHOR]

This study introduces a new strategy that combines unsupervised learning (clustering) and transfer learning. Clustering methods are employed to generate synthetic labels for the source dataset (ICAR-2018). The generated dataset is then used for transfer learning to other histopathological datasets (KimiaPath960, CRC, Biomaging− 2015, Breakhis, and Lymphoma). The comparative study based on two clustering algorithms (K-means and multi-objective clustering stream) demonstrates the efficiency of MOC-Stream. The generated synthetic histopathological dataset by this clustering algorithm outperformed the original labeled dataset and the imageNet models in transfer learning. [ABSTRACT FROM AUTHOR]

Algerian arid zone presents a rich diversity of medicinal plants and ethnoecological knowledge. Ethnobotanical study of medicinal plants was carried out in the Wilaya of el bayadh (Laguermi Zone). The purpose of this study is to compile a catalog of medicinal plants, to gather all the information concerning the therapeutic uses practiced by the local population in the region studied. A survey was carried out among the elderly in homes, and the annex of the National Biological Resource Development Center of Laguermi, one hundred (100) questionnaire sheets for two months. The results helped to identify medicinal plants divided into twenty-eight 28 families among which the Lamiaceae and the Asteraceae are the most for the majority of remedies. The results are a valuable source of information for both the study area and the national medicinal flora; it could be a database for further research in phytochemistry and pharmacology fields to search for new natural substances. [ABSTRACT FROM AUTHOR]

Asparagus albus L is a medicinal plant that grows spontaneously in the region of Brezina wilaya of El Bayadh. In this work, we made the extraction of flavonoids and alkaloids from the different organs (twigs, bark and roots) plant Asparagus albus to test its antioxidant, and antifungal activities. The antifungal activity is evaluated by the estimated growth is also expressed as a percentage (%) relative to the growth of control. The antioxidant activity of the various extracts of Asparagus albus L using DPPH was evaluated by the spectrophotometric method. Results show that the yield of flavonoids is 9.5% and those of alkaloids is 8.1% The study of the antioxidant power by the method of DPPH radical trapping, reveals the presence of antioxidant properties for the extract studied. The percentage of inhibition most striking was 40.11% of tannins and 55.52% of alkaloids. The evaluation of the antifungal power on Fusarium oxysporum f. sp shows an effect of the extracts on fungi which can be valorised as a fungicide. This result makes Asparagus albus a very promising natural source of antioxidants. [ABSTRACT FROM AUTHOR]

The use of halotolerant beneficial plant-growth-promoting (PGP) bacteria is considered as a promising eco-friendly approach to improve the salt tolerance of cash crops. One strategy to enhance the possibility of obtaining stress-alleviating bacteria is to screen salt impacted soils. In this study, amongst the 40 endophytic bacteria isolated from the roots of Sahara-inhabiting halophytes Atriplex halimus L. and Lygeum spartum L., 8 showed interesting NaCl tolerance in vitro. Their evaluation, through different tomato plant trials, permitted the isolate IS26 to be distinguished as the most effective seed inoculum for both plant growth promotion and mitigation of salt stress. On the basis of 16S rRNA gene sequence, the isolate was closely related to Stenotrophomonas rhizophila. It was then screened in vitro for multiple PGP traits and the strain-complete genome was sequenced and analysed to further decipher the genomic basis of the putative mechanisms underlying its osmoprotective and plant growth abilities. A remarkable number of genes putatively involved in mechanisms responsible for rhizosphere colonization, plant association, strong competition for nutrients, and the production of important plant growth regulator compounds, such as AIA and spermidine, were highlighted, as were substances protecting against stress, including different osmolytes like trehalose, glucosylglycerol, proline, and glycine betaine. By having genes related to complementary mechanisms of osmosensing, osmoregulation and osmoprotection, the strain confirmed its great capacity to adapt to highly saline environments. Moreover, the presence of various genes potentially related to multiple enzymatic antioxidant processes, able to reduce salt-induced overproduction of ROS, was also detected. [ABSTRACT FROM AUTHOR]

Our contribution is to value the contribution of co-creation in the field of entrepreneurship education as a pedagogical innovation and a perspective of devlopement of the student-teacher relationship.The study focuses on a qualitative analysis of students who participated in the experience of co-teaching during the webdays. [ABSTRACT FROM AUTHOR]

Land surface temperature can reflect environmental interactions and exchanges between soil, land cover and atmosphere, which is important for studying environmental changes. Nevertheless, research on surface temperature in ecologically fragile saline areas is rare. Thus, in most previous research articles, the main study areas were large agglomerations and other areas characterized by natural phenomena such as erosion. In fact, the study of this parameter is difficult at the local scale because it is influenced by climatic variations and anthropogenic practices that determine land use. In summary, the Atmospheric Correction Model from Landsat data can easily extract surface temperature and explore its relationship with land use and NDVI. Indeed, the variation of the surface temperature is according to the type of land use. This study provides a reference for land use planning, restoration of the ecological environment in round of saline areas. The days of 03/31/1987, 03/26/2000 and 03/28/2015 were chosen mainly for the quality and availability of the images and that the vegetation is ripe at this time of the year. [ABSTRACT FROM AUTHOR]

Reynolds stress is a key facet of turbulence self-organization. In the magnetized plasmas of controlled fusion devices, the zonal flows that are driven by the averaged Reynolds stress modify the confinement performance. We address this problem with full-f gyrokinetic simulations of ion temperature gradient-driven turbulence. From the detailed analysis of the three-dimensional electric potential and transverse pressure fields, we show that the diamagnetic contribution to the Reynolds stress—stemming from finite Larmor radius effects—exceeds the electrostatic contribution by a factor of about two. Both contributions are in phase, indicating that pressure does not behave as a passive scalar. In addition, the Reynolds stress induced by the electric drift velocity is found to be mainly governed by the gradient of the phase of the electric potential modes rather than by their magnitude. By decoupling Reynolds stress drive and turbulence intensity, this property indicates that a careful analysis of phase dynamics is crucial in the interpretation of experiments and simulations. [ABSTRACT FROM AUTHOR]

Inula viscosa is a medicinal plant belonging to the Asteraceae family. This species is known under the name of Magramen. It is widespread in the Mediterranean region. An ethnobotanical survey was carried out in the city of Sidi Bel Abbes where this plant abounds. On the other hand, a phytochemical study of Inula viscosa is carried out. The determination of total phenols was carried out by using the Folin-Ciocalteu reagent, the quantification of flavonoids by the method with aluminum trichloride and sodium hydroxide, and that of the tannins condensed by the vanillin method under acidic conditions. Antioxidant activity was assessed using the free radical reduction method (DPPH). Thus, a toxicity test was carried out according to line 420 of the OECD. The results showed that this plant is involved in: the treatment of osteoarticular or rheumatic diseases (33%), dermatological infections (33%), nervous system (11%), digestive disorders (11%), and cardiovascular diseases (6%). The phytochemical screening allowed us to highlight the presence of secondary metabolites in the leaves of our plant; such as flavonoids, terpenoids, tannins, glycosides, and carotenoids. The content of the leaves in total phenols (31.46 mg AGE / g) is higher than that of the twigs (30.28 mg GAE / g). The amount of flavonoids is slightly higher in the leaves (133.93 mg EC / g) than in the twigs (37.12 mg EC / g). The prepared extracts have very significant antifree radical activities since they recorded very remarkable IC50 values of 0.1 to 4.1 mg/ml. Inula viscosa is non-toxic for a dose of 2000 mg/ml or less. [ABSTRACT FROM AUTHOR]

Recently, Environmental Customer collaboration has gained a considerable attention among researchers and Industrial enterprises. Many studies highlight that organizations can achieve a good performance level while considering customer collaboration and environmental regulation. However, the literature in the Green Supply Chain Management (GSCM) suggests having a more structured collaboration and information exchange process based between Supply Chain partners on new technologies. Towards this end, a hybrid approach based on Multi Agent Systems and Multi Objective Linear Programming is proposed as mean of automating and facilitating the environmental customer collaboration process. This research shows that MAS can be utilized to reduce the complexity and facilitate communication in the GSCM context. The applicability of the developed MAS approach is demonstrated using an industrial case study in the automotive spare parts sector. [ABSTRACT FROM AUTHOR]

A model of E × B staircases is proposed based on a wave kinetic equation coupled to a poloidal momentum equation. A staircase pattern is idealized as a periodic radial structure of zonal shear layers that bound regions of propagating wave packets, viewed as avalanches. Wave packets are trapped in shear flow layers due to refraction. In this model, an E × B staircase motif emerges due to the interaction between propagating wave packets (avalanches) and trapped waves in the presence of an instability drive. Amplitude, shape, and spatial period of the staircase E × B flow are predicted as functions of the background fluctuation spectrum and the growth rate of drift waves. The zonal flow velocity radial profile is found to peak near its maxima and to flatten near its minima. The optimum configuration for staircase formation is a growth rate, that is, maximum at zero radial wave number. A mean shear flow is responsible for a preferential propagation speed of avalanches. It is not a mandatory condition for the existence of staircase solutions, but has an impact on their spatial period. [ABSTRACT FROM AUTHOR]

The problem of the fluid closure for the collisionless linear Vlasov system is investigated using a perspective from control theory and model order reduction. The balanced truncation method is applied to the 1D–1V Vlasov system. The first few reduction singular values are well-separated, indicating potentially low-dimensional dynamics. To avoid large-dimensional numerical work, a reduced model is formulated using rational interpolation, generalizing the seminal work from Hammett and Perkins. The resulting models are found to outperform the state-of-the-art models for thermal phase velocities. Thanks to the versatility of this formulation, an application to toroidal gyrokinetic dynamics is discussed. [ABSTRACT FROM AUTHOR]

Phase space structures are extracted from the time series of five dimensional distribution function data computed by the flux-driven full-f gyrokinetic code GT5D. Principal component analysis (PCA) is applied to reduce the dimensionality and the size of the data. Phase space bases in (φ , v ∥ , w) and the corresponding spatial coefficients (poloidal cross section) are constructed by PCA, where φ , v ∥ , and w, respectively, mean the toroidal angle, the parallel velocity, and the perpendicular velocity. It is shown that 83% of the variance of the original five dimensional distribution function can be expressed with 64 principal components, i.e., the compression of the degrees of freedom from 1.3 × 1 0 12 to 1.4 × 10 9 . One of the important findings—resulting from the detailed analysis of the contribution of each principal component to the energy flux—deals with avalanche events, which are found to be mostly driven by coherent structures in the phase space, indicating the key role of resonant particles. Another advantage of the proposed analysis is the decoupling of 6D (1D time and 5D phase space) data into the combinations of 3D data which are visible to the human eye. [ABSTRACT FROM AUTHOR]

We focus on the effect of site parameters, also called site proxies, on the variation of the amplification factor. This latter, named Fourier Amplification Factor (FAF) is defined as the ratio of the Fourier transform of the seismic motion at surface and at bedrock. For this study, the wave propagation theory is used limited to 1D linear viscoelastic domain. At this effect, a set of FAF, is established for a set of 858 real profiles. From there, the site parameters are also derived, it is necessary to mention that the FAF can be computed in independent manner of seismic signals which it is applicable only on linear domain. In Nuclear Power Industry application, the FAF is mostly used and can be approximated by limited number of site proxies. As the usual code practice implies a lower number of site proxies (generally 1, sometimes 2) as UBC97 or EC8, a sensitivity analysis is conducted to identify the "best performing" site parameters. The results show that by far, using the six site proxies lead to a better prediction of FAF. However if we have to use one single site parameter, results show that the best one is the overall resonance frequency (f0). In the case when we intend to use two site parameters built from the average shear wave velocity over the upper 30 m (Vs30) and the resonance frequency (f0) which are preferred and give an important variance reduction superior than 61%. In the result, a new formula has been established. [ABSTRACT FROM AUTHOR]

This paper deals with the simulation, and design of a trajectory-tracking control law for a physical system under parameter uncertainty modeled by a bond graph. This control strategy is based on the inversion of the system through their causal Input/Output (I/O) path using the principle of bicausality to track the desired trajectory. The proposed control strategy is validated with the use of a simple mechanical mass-springdamper system. The results show that the bond graph is a very helpful methodology for the design of control laws in the presence of uncertainties. This proposed control can be applied in several applications and can be improved to ensure robust control. [ABSTRACT FROM AUTHOR]