Isolation and Characterization of a New Streptomyces Strain d15 with Antimicrobial Activity from an Algerian Steppe Soil.

This study explores the isolation and characterization of Streptomyces strain D15 from the Algerian steppes, with a focus on combating antibiotic-resistant microbial strains. In response to the global health threat posed by antimicrobial resistance, the research delves into the unique ecological niche of Algerian steppes. The isolated strain, identified as belonging to the genus Streptomyces, exhibits typical morphological and cultural traits, supported by chemical and genomic analyses. Phylogenetic analysis establishes the genetic closeness of D15 to Streptomyces lavendofoliae. The strain demonstrates potent antagonistic activity against various microorganisms, showcasing significant antimicrobial effects, particularly against Micrococcus luteus, Enterococcus faecalis, and Candida albicans. Genomic analysis unveils a rich repertoire of biosynthetic gene clusters, emphasizing the strain's potential to produce diverse secondary metabolites, essential for combating antibiotic resistance. Streptomyces strain D15 emerges as a promising candidate for novel antimicrobial agents, with its broad-spectrum activity and genomic potential. The study underscores the importance of exploring untapped environments, like Algerian steppes, to discover new strains capable of addressing the challenges posed by antibiotic-resistant microbial strains. This research contributes to the ongoing global efforts to find innovative solutions and underscores the pivotal role Streptomyces plays in the search for effective antibiotics. [ABSTRACT FROM AUTHOR]