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Background: Pregnant women are a vulnerable population to COVID-19 given an increased susceptibility to severe SARS-CoV-2 infection and pregnancy complications. However, few SARS-CoV-2 serological surveys have been performed among this population to assess the extent of the infection in sub-Saharan countries. The objectives of this study were to determine SARS-CoV-2 seroprevalence among Beninese pregnant women, to identify spatial seropositivity clusters and to analyse factors associated with the infection. Methods: A cross-sectional study including women in their third trimester of pregnancy attending the antenatal care (ANC) clinics at Allada (south Benin) and Natitingou (north Benin) was conducted. Rapid diagnostic tests (RDT) for detection of IgG/IgM against the SARS-CoV-2 spike protein were performed using capillary blood. Seroprevalence of SARS-CoV-2 antibodies and associations between SARS-CoV-2 serostatus and maternal characteristics were analyzed by multivariate logistic regression. Spatial analyses were performed using the spatial scan statistics to identify spatial clusters of SARS-CoV-2 infection. Results: A total of 861 pregnant women were enrolled between May 4 and June 29, 2022. 58/861 (6.7%) participants reported having received COVID-19 vaccine. None of the participants had been diagnosed with COVID-19 during their pregnancy. SARS-CoV-2 antibodies were detected in 607/802 (75.7%; 95% CI 72.56%–78.62%) of unvaccinated participants. Several urban and rural spatial clusters of SARS-CoV-2 cases were identified in Allada and one urban spatial cluster was identified in Natitingou. Unvaccinated participants from Allada with at least one previous morbidity were at a three-times higher risk of presenting SARS-CoV-2 antibodies (OR = 2.89; 95%CI 1.19%-7.00%). Conclusion: Three out of four pregnant women had SARS-CoV-2 antibodies, suggesting a high virus circulation among pregnant women in Benin, while COVID-19 vaccination coverage was low. Pregnant women with comorbidities may be at increased risk of SARS-CoV-2 infection. This population should be prioritized for COVID-19 diagnosis and vaccination in order to prevent its deleterious effects. Trial registration: NCT06170320 (retrospectively registered on December 21, 2023). [ABSTRACT FROM AUTHOR]

Purpose: Group B Streptococcus (GBS) is the leading cause of invasive infections in newborns. The prevention of GBS neonatal disease relies on the administration of an intrapartum antibiotic prophylaxis to GBS-colonized women. In recent years, rapid intrapartum detection of GBS vaginal colonization using real-time nucleic acid amplification tests (NAATs) emerged as an alternative to antenatal culture screening methods. Methods: We compared the performances of two loop-mediated isothermal amplification (LAMP) tests, the Ampliflash® GBS and the PlusLife® GBS tests, to standard culture for GBS detection in vaginal specimens from pregnant women. The study was conducted from April to July 2023 in a French hospital of the Paris area. Results: A total of 303 samples were analyzed, including 85 culture-positive samples (28.1%). The Ampliflash® GBS test and the PlusLife® GBS tests gave a result for 100% and 96.3% tests, respectively. The performances of the tests were as follows: sensitivity 87.1% (95% confidence interval (CI) 78.3–92.6) and 98.7% (95% CI 93.0-99.8), specificity 99.1% (95% CI 96.7–99.8), and 91.9% (95% CI 87.3–95.0), respectively. False negative results of the Ampliflash® GBS test correlated with low-density GBS cultures. Time-to-results correlated with GBS culture density only for the PlusLife® GBS test (p < 0.001). Conclusion: Both techniques provide excellent analytical performances with high sensitivity and specificity together with a short turnaround time and results available in 10 to 35 min. Their potential to further reduce the burden of GBS neonatal disease compared with antenatal culture screening needs to be assessed in future clinical studies. [ABSTRACT FROM AUTHOR]

A correction is presented to the article "Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health?"

In epidemiological studies, dairy food consumption has been associated with minimal effect or decreased risk of some cardiometabolic diseases (CMD). However, current methods of dietary assessment do not provide objective and accurate measures of food intakes. Thus, the identification of valid and reliable biomarkers of dairy product intake is an important challenge to best determine the relationship between dairy consumption and health status. This review investigated potential biomarkers of dairy fat consumption, such as odd-chain, trans- and branched-chain fatty acids (FA), which may improve the assessment of full-fat dairy product consumption. Overall, the current use of serum/plasma FA as biomarkers of dairy fat consumption is mostly based on observational evidence, with a lack of well-controlled, dose–response intervention studies to accurately assess the strength of the relationship. Circulating odd-chain SFA and trans-palmitoleic acid are increasingly studied in relation to CMD risk and seem to be consistently associated with a reduced risk of type 2 diabetes in prospective cohort studies. However, associations with CVD are less clear. Overall, adding less studied FA such as vaccenic and phytanic acids to the current available evidence may provide a more complete assessment of dairy fat intake and minimise potential confounding from endogenous synthesis. Finally, the current evidence base on the direct effect of dairy fatty acids on established biomarkers of CMD risk (e.g. fasting lipid profiles and markers of glycaemic control) mostly derives from cross-sectional, animal and in vitro studies and should be strengthened by well-controlled human intervention studies. [ABSTRACT FROM AUTHOR]

Salvinia minima Baker (Salviniaceae) has been recorded for the first time in Africa. This South American native macrophyte is highly invasive and damaging, costing millions of dollars to control in the USA, and has the potential to invade many of southern Africa's waterbodies. Field surveys have confirmed the presence of S. minima from four sites in South Africa, with the largest invasion occurring on the highly polluted Hartbeespoort Dam, north east of the country's capital. Salvinia minima has been targeted for biological control in South Africa, using the weevil, Cyrtobagous salviniae, which is undergoing host specificity testing under quarantine conditions. [ABSTRACT FROM AUTHOR]

Glucosylceramides (GlcCer), glucose-conjugated sphingolipids, are major components of the endomembrane system and plasma membrane in most eukaryotic cells. Yet the quantitative significance and cellular functions of GlcCer are not well characterized in plants and other multi-organ eukaryotes. To address this, we examined Arabidopsis lines that were lacking or deficient in GlcCer by insertional disruption or by RNA interference ( RNAi) suppression of the single gene for GlcCer synthase ( GCS, At2g19880), the enzyme that catalyzes GlcCer synthesis. Null mutants for GCS (designated ' gcs-1') were viable as seedlings, albeit strongly reduced in size, and failed to develop beyond the seedling stage. Heterozygous plants harboring the insertion allele exhibited reduced transmission through the male gametophyte. Undifferentiated calli generated from gcs-1 seedlings and lacking GlcCer proliferated in a manner similar to calli from wild-type plants. However, gcs-1 calli, in contrast to wild-type calli, were unable to develop organs on differentiation media. Consistent with a role for GlcCer in organ-specific cell differentiation, calli from gcs-1 mutants formed roots and leaves on media supplemented with the glucosylated sphingosine glucopsychosine, which was readily converted to GlcCer independent of GCS. Underlying these phenotypes, gcs-1 cells had altered Golgi morphology and fewer cisternae per Golgi apparatus relative to wild-type cells, indicative of protein trafficking defects. Despite seedling lethality in the null mutant, GCS RNAi suppression lines with ≤2% of wild-type GlcCer levels were viable and fertile. Collectively, these results indicate that GlcCer are essential for cell-type differentiation and organogenesis, and plant cells produce amounts of GlcCer in excess of that required for normal development. [ABSTRACT FROM AUTHOR]

The class IV homeodomain leucine zipper transcription factor GLABRA2 (GL2) acts in a complex regulatory circuit that regulates the differentiation of trichomes in Arabidopsis thaliana. We describe a genetic interaction with HOMEODOMAIN GLABROUS11 (HDG11), previously identified as a negative regulator of trichome branching. gl2 hdg11 double mutants display enhanced trichome cell-type differentiation defects. Transgenic expression of HDG11 using the GL2 promoter partially suppresses gl2 trichome phenotypes. Vice versa, expression of GL2 under the control of its native promoter partially complements hdg11 ectopic branching. Since gl2 hdg11 and gl2 myb23 double mutants and the triple mutant display similar trichome differentiation defects, we investigated a connection to the R2R3-MYB transcription factor MYB23. We show that MYB23 transcript levels are significantly reduced in shoots from gl2 mutants and that GL2 can drive the expression of a MYB23 -promoter fusion to green fluorescent protein. Yeast one-hybrid, chromatin immunoprecipitation, and in planta reporter gene experiments indicate that an L1-box in the MYB23 promoter acts as a GL2 binding site. Taken together, our findings reveal a functional redundancy between GL2 and HDG11, two homeodomain leucine zipper transcription factors previously thought to mediate opposing functions in trichome morphogenesis. A model is proposed in which GL2 transcript levels are maintained through a positive feedback loop involving GL2 activation of MYB23. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this study is to explore the attitudes and beliefs of front-line employees regarding how customer-company interactions might be improved. Since front-line employees are closely connected to customers, the resultant experiences and relationships with customers are highly dependent on their actions. However, little is written from the perspective of front-line employees. Design/methodology/approach – Using a qualitative approach and employing an adaptation of the grounded theory method, this study uses front-line employee participants with data collection occurring over a six-month period. A variety of data sources were used including open-ended reciprocal interviews, member-checking interviews, observation, and collection of participant and researcher artifacts. Findings – Findings suggest that organizational changes initiated by management create strategically constructed silos that force implementation through people and systems to control and standardize the service interface and resultant customer experience(s). This reactive and inwardly focused construction of silos often serves company rather than customer needs and can result in deteriorating service levels based on the type of customer-company interaction occurring. Originality/value – Contrary to how most customer service processes are designed by management, not all customer-company interactions are alike and vary both in regard to the degree of knowledge needed by front-line employees to fully serve customers, and the routine or non-routine nature of the interaction. A two-by-two matrix is presented to highlight the impacts of silos occurring for various interaction types. [ABSTRACT FROM AUTHOR]

A preface to the journal "Information Resources Management Journal" is presented.

The high requirement of the gut for threonine has often been ascribed to the synthesis of mucins, secreted threonine-rich glycoproteins protecting the intestinal epithelium from injury. This requirement could be even greater during intestinal inflammation, when mucin synthesis is enhanced. In this study, we used an animal model to investigate the effects of an acute ileitis on threonine splanchnic fluxes. Eight adult multi-catheterized minipigs were fed with an enteral solution. Four of them were subjected to experimental ileitis involving direct administration of trinitrobenzene sulfonic acid (TNBS) into the ileum (TNBS-treated group) and the other 4 were not treated (control group). Threonine fluxes across the portal-drained viscera (PDV) were quantified with the use of simultaneous i.g. L-[15Nithreonine and iv. L-[U-13C]threonine infusions. Ileal mucosa was sampled for mucin fractional synthesis rate measurement, which was greater in the TNBS-treated group (114 ± 15%/d) than in the control group (61 ± 8%/d) (P= 0.021). The first-pass extraction of dietary threonine by the PDV and liver did not differ between groups and accounted for ∼27 and 10% of the intragastric delivery, respectively. PDV uptake of arterial threonine increased from 25 ± 14 μmol·kg-1· h-1 in the control group to 171 ± 35 μmoI·kg-1· h-1 in the TNBS-treated group (P < 0.001). In conclusion, ileitis increased intestinal mucin synthesis and PDV utilization of threonine from arterial but not luminal supply. This leads to the mobilization of endogenous proteins to meet the increased threonine demand associated with acute intestinal inflammation. [ABSTRACT FROM AUTHOR]

Recently we demonstrated that in inflammatory bowel disease (IBD) macrophage-oxidative burst activity is increased and NADPH oxidase mRNA is induced. The herbal phenylethanoid acteoside isolated from Plantago lanceolata L. was shown to exhibit anti-oxidative potential. Using the dextran sulphate sodium (DSS)-induced colitis model, in this study we have assessed whether systemic application of acteoside affects colitis. Colitis was induced by DSS in Balb/c mice. Treatment with acteoside (120, 600 µg/mouse/day) was performed intraperitoneally. The colon lengths were determined. Colonic tissue was scored histologically (max. score 8) by a blinded investigator. T cells isolated from mesenteric lymph nodes (MLN) were stimulated with anti-CD3 antibody in the presence of interleukin (IL)-2 (final concentration 10 U/ml). After incubation for 24 h, IL-1β, IL-6, IL-12 tumour necrosis factor (TNF)-α and interferon (IFN)-γ levels in supernatants were analysed by the beadlyte® cytokine detection system. Histological scoring of colonic tissue revealed that application of acteoside was followed by a significantly improved histological score. In acute colitis the histological score was 3·2 with acteoside versus 5·2 with phosphate-buffered saline (PBS) ( P < 0·02). In chronic colitis both 120 µg (3·3 versus 5·2) or 600 µg acteoside (3·0 versus 5·2) significantly ameliorated colitis (both P < 0·02). Stimulated MLN from mice with chronic DSS-induced colitis treated with acteoside showed a significant down-regulation of IFN-γ secretion (195 pg/ml with 600 µg acteoside versus 612 pg/ml with PBS, P < 0·02). Inhibition of oxidative burst activity with acteoside reduced mucosal tissue damage in DSS colitis and could be a therapeutic alternative for IBD treatment. Further studies of this agent are warranted. [ABSTRACT FROM AUTHOR]

Voice recognition technology-enabled devices possess extraordinary growth potential, yet some research indicates that organizations and consumers are resisting their adoption. This study investigates the implementation of a voice recognition device in the United States Navy. Grounded in the social psychology and information systems literature, the researchers adapted instruments and developed a tool to explain technology adoption in this' environment. Using factor analysis and structural equation modeling, analysis of data from the 270 participants explained almost 90% of the variance in the model. This research adapts the technology acceptance model by adding elements of the theory of planned behavior, providing researchers and practitioners with a valuable instrument to predict technology adoption. [ABSTRACT FROM AUTHOR]

The article informs that organizational change is ubiquitous and continuous process. It permeates organizational processes and life. Many organizations invest significant sums of resources into external consulting. Some organizations even embrace change and attempt to integrate it into their strategic planning. In the MIS academic arena, the most prevalent research topic associated with change over the past decade has focused on a change methodology, namely, business process reengineering (BPR). In the management academic arena, the focus has been on change management as a research construct. MIS research on change tends to be oriented toward applied research, while management research tends to be oriented more toward conceptual research. Quality research, regardless of orientation, must adhere to rigorous academic standards, while being grounded in business practice. Beginning around 1990, BPR came onto the business scene as the savior of under performing organizations. Early advocates of BPR touted it as the next revolution in obtaining breakthrough performance via process improvement and process change.

The failure of dot-coms is a staggering 75% in the first two years. Many of these failures were small and medium-sized enterprises (SMEs). One of the most commonly cited reasons for failure has been lack of a workable strategic business model to guide e-commerce (electronic commerce) efforts. We began this study because we wanted to explore if successful e-commerce SMEs use a guiding strategic process model, and if they do, ask them to articulate the model components. We chose a qualitative research method to obtain a rich description of the e-commerce process. The interview pool consisted of 15 interviews with established SME e-commerce entrepreneurs. From deep analysis of the data, a set of e-commerce process components and interrelationships between those components emerged from the data. We then synthesized (from the rich description) a model of the e-commerce process. [ABSTRACT FROM AUTHOR]

Discusses the information technology revolution. Background on the business process reengineering (BPR) phenomenon; Reasons for BPR failure; Implications of the customer revolution for the management information system field; Details on the four industry models of information technology.

Focuses on the use of the Harel statecharts in modeling business workflows. Importance of statechart mapping in identifying potential workflow problems; Analysis of the specific properties inherent in actual business workflows; Properties of active database systems.

Discusses how the understanding of one culture can be expressed in such a way as to be meaningful to persons of another culture. Information on the inductive method of teaching a language; Details on the relationship between Euroamerican and Native cultures.

Presents various information which deals with subjects on linguistics. Growth of the term mobile as a suffix; Presence of logograms within the English writing system; Use of the heart symbol.

Analyzes the means by which high god concepts developed in native U.S. citizen religions following contact with and eventual domination by European culture. Reason for the Algonkin religion being propounded as a model for precontact religion; Comparison between the lack of a high-god concept among the Odawa with Algonkin cultures to the south; Information on the ideological changes in Algonkin cultures that contributed to the development of the concept of manito.

Presents excerpts from the book 'Brandeis,' by Lewis Paper.

ABSTRACT "What's right with unemployment insurance" by far outweighs "What's wrong." There are, nevertheless, many flaws in the program--in philosophy, in benefits, in taxes, in administration. Most important is the need for consensus concerning primary goals. There is still no generally-accepted philosophy concerning the proper place and purpose of unemployment insurance in our economic system. Many workers currently exempt from coverage should be protected. Qualifying requirements for benefit eligibility, as well as disqualifying provisions, should be reexamined. Minimum and maximum weekly benefit amounts and potential duration provisions indicate inherent philosophies which are inconsistent and inequitable, which yield more generous benefits to unemployed secondary workers than to unemployed heads of families. Changes should relate qualifying employment and earnings, by sex, to minimum and maximum benefits and duration, in fixed proportions rather than in fixed amounts. Payroll tax bases vary considerably. Their impact among different industries is widely divergent. A supplemental flat-rate employee tax should help finance more adequate benefits. Pending agreement on primary goals, no practical solution to federal-state administrative problems can be suggested. Thereafter, however, authority and responsibility and costs should be fairly and dearly allocated between the federal government and the states. This would contribute to a much better partnership, program, and public image. [ABSTRACT FROM AUTHOR]

The article focuses on the translations of Judeo-Persian Bible Translations. It mentions the Persian language in its judeo-persian form has been long neglected by scholars in Iranian studies and also highlights the bibliographical references to Judeo-Persian in the historical overview of the Persian language.

The goal of the SunPy project is to facilitate and promote the use and development of community-led, free, and open source data analysis software for solar physics based on the scientific Python environment. The project achieves this goal by developing and maintaining the sunpy core package and supporting an ecosystem of affiliated packages. This paper describes the first official stable release (version 1.0) of the core package, as well as the project organization and infrastructure. This paper concludes with a discussion of the future of the SunPy project. [ABSTRACT FROM AUTHOR]

The article presents an interview with Dean Garlick, director of professional services, Silicon Graphics Inc. In response to a query about the critical success factors that drive the organization, Garlick replied that the quality of the staff is most important. Good people are more important than good technology. Clear direction and expectations of the team is critical. Hire stellar performers, provide them with the right tools, give them clear guidance and then get out of the way. In response to another query about how does he effectively manage his project teams, he answered that it is not difficult. Many people believe that to be successful in technology development and project delivery, one must work in the same office. In fact, most computer scientists and engineers would rather close the door and only talk through email or microsoft network messenger anyway. Often meetings are held too frequently and nearly all meetings can be conducted via teleconference. It is nice to put a name with a face, but that only needs to really occur once. With the advent of the ubiquitous high speed networks and the utilization of virtual private network for security, a virtual team can be assembled in multiple locations across the country.

Background: Phospholipids are important structural and signaling molecules in plant membranes. Some fluorescent dyes can stain general lipids of membranes, but labeling and visualization of specific lipid classes have yet to be developed for most components of the membrane. New techniques for visualizing membrane lipids are needed to further delineate their dynamic structural and signaling roles in plant cells. In this study we examined whether propargylcholine, a bioortholog of choline, can be used to label the major membrane lipid, phosphatidylcholine, and other choline phospholipids in plants. We established that propargylcholine is readily taken up by roots, and that its incorporation is not detrimental to plant growth. After plant tissue is harvested and fixed, a click-chemistry reaction covalently links the alkyne group of propargylcholine to a fluorescently-tagged azide, resulting in specific labeling of choline phospholipids. Results: Uptake of propargylcholine, followed by click chemistry with fluorescein or Alexa Fluor 594 azide was used to visualize choline phospholipids in cells of root, leaf, stem, silique and seed tissues from Arabidopsis thaliana. Co-localization with various subcellular markers indicated coinciding fluorescent signals in cell membranes, such as the tonoplast and the ER. Among different cell types in the leaf epidermis, guard cells displayed strong labeling. Mass spectrometry-based lipidomic analysis of the various plant tissues revealed that incorporation of propargylcholine was strongest in roots with approximately 50% of total choline phospholipids being labeled, but it was also incorporated in the other tissues including seeds. Phospholipid profiling confirmed that, in each tissue analyzed, incorporation of the bioortholog had little impact on the pool of choline plus choline-like phospholipids or other lipid species. Conclusion: We developed and validated a click-chemistry based method for fluorescence imaging of choline phospholipids using a bioortholog of choline, propargylcholine, in various cell-types and tissues from Arabidopsis. This click-chemistry method provides a direct way to metabolically tag and visualize specific lipid molecules in plant cells. This work paves the way for future studies addressing in situ localization of specific lipids in plants. [ABSTRACT FROM AUTHOR]

Discusses the use of infixation and interposition in American English. Examples of infixed and interposed forms of words.