10 results
Search Results
2. SARS-CoV-2 seroprevalence among Beninese pregnant women in the third year of the pandemic.
- Author
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Figueroa-Romero, Antía, Atchadé, Aurore, Yadouleton, Anges, Fiogbe, Marc, Bonnet, Emmanuel, Yovo, Emmanuel, Accrombessi, Manfred, Hounsa, Sandrine, Paper, Thierry, Dupont, Raphael, Gaudart, Jean, Le Hesran, Jean-Yves, Massougbodji, Achille, Cottrell, Gilles, and González, Raquel
- Subjects
PREGNANT women ,RAPID diagnostic tests ,SARS-CoV-2 ,THIRD trimester of pregnancy ,COVID-19 pandemic - Abstract
Background: Pregnant women are a vulnerable population to COVID-19 given an increased susceptibility to severe SARS-CoV-2 infection and pregnancy complications. However, few SARS-CoV-2 serological surveys have been performed among this population to assess the extent of the infection in sub-Saharan countries. The objectives of this study were to determine SARS-CoV-2 seroprevalence among Beninese pregnant women, to identify spatial seropositivity clusters and to analyse factors associated with the infection. Methods: A cross-sectional study including women in their third trimester of pregnancy attending the antenatal care (ANC) clinics at Allada (south Benin) and Natitingou (north Benin) was conducted. Rapid diagnostic tests (RDT) for detection of IgG/IgM against the SARS-CoV-2 spike protein were performed using capillary blood. Seroprevalence of SARS-CoV-2 antibodies and associations between SARS-CoV-2 serostatus and maternal characteristics were analyzed by multivariate logistic regression. Spatial analyses were performed using the spatial scan statistics to identify spatial clusters of SARS-CoV-2 infection. Results: A total of 861 pregnant women were enrolled between May 4 and June 29, 2022. 58/861 (6.7%) participants reported having received COVID-19 vaccine. None of the participants had been diagnosed with COVID-19 during their pregnancy. SARS-CoV-2 antibodies were detected in 607/802 (75.7%; 95% CI 72.56%–78.62%) of unvaccinated participants. Several urban and rural spatial clusters of SARS-CoV-2 cases were identified in Allada and one urban spatial cluster was identified in Natitingou. Unvaccinated participants from Allada with at least one previous morbidity were at a three-times higher risk of presenting SARS-CoV-2 antibodies (OR = 2.89; 95%CI 1.19%-7.00%). Conclusion: Three out of four pregnant women had SARS-CoV-2 antibodies, suggesting a high virus circulation among pregnant women in Benin, while COVID-19 vaccination coverage was low. Pregnant women with comorbidities may be at increased risk of SARS-CoV-2 infection. This population should be prioritized for COVID-19 diagnosis and vaccination in order to prevent its deleterious effects. Trial registration: NCT06170320 (retrospectively registered on December 21, 2023). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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3. Performances of two rapid LAMP-based techniques for the intrapartum detection of Group B Streptococcus vaginal colonization.
- Author
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Charfi, Rym, Guyonnet, Cécile, Untrau, Meiggie, Giacometti, Gaëlle, Paper, Thierry, Poyart, Claire, Plainvert, Céline, and Tazi, Asmaa
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STREPTOCOCCUS agalactiae ,NUCLEIC acid amplification techniques ,SONICATION ,NEONATAL diseases - Abstract
Purpose: Group B Streptococcus (GBS) is the leading cause of invasive infections in newborns. The prevention of GBS neonatal disease relies on the administration of an intrapartum antibiotic prophylaxis to GBS-colonized women. In recent years, rapid intrapartum detection of GBS vaginal colonization using real-time nucleic acid amplification tests (NAATs) emerged as an alternative to antenatal culture screening methods. Methods: We compared the performances of two loop-mediated isothermal amplification (LAMP) tests, the Ampliflash® GBS and the PlusLife® GBS tests, to standard culture for GBS detection in vaginal specimens from pregnant women. The study was conducted from April to July 2023 in a French hospital of the Paris area. Results: A total of 303 samples were analyzed, including 85 culture-positive samples (28.1%). The Ampliflash® GBS test and the PlusLife® GBS tests gave a result for 100% and 96.3% tests, respectively. The performances of the tests were as follows: sensitivity 87.1% (95% confidence interval (CI) 78.3–92.6) and 98.7% (95% CI 93.0-99.8), specificity 99.1% (95% CI 96.7–99.8), and 91.9% (95% CI 87.3–95.0), respectively. False negative results of the Ampliflash® GBS test correlated with low-density GBS cultures. Time-to-results correlated with GBS culture density only for the PlusLife® GBS test (p < 0.001). Conclusion: Both techniques provide excellent analytical performances with high sensitivity and specificity together with a short turnaround time and results available in 10 to 35 min. Their potential to further reduce the burden of GBS neonatal disease compared with antenatal culture screening needs to be assessed in future clinical studies. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Rare earth element stripping from kaolin sands via mild acid treatment.
- Author
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Koch, Max, Paper, Michael, Brück, Thomas B., and Nilges, Tom
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KAOLIN ,CLAY minerals ,SAND ,SULFURIC acid ,HYDROCHLORIC acid ,KAOLINITE - Abstract
Due to their chemical and physical properties, rare earth elements (REEs) are essential in modern applications such as energy conversion or IT technology. The increasing demand for these elements leads to strong incentives for REE recovery and induces the exploration of new, alternative sources for REEs. Accessing REEs from clay minerals, in our case kaolinite, by an elution process is a promising method. The present study investigates the potential application of REE recovery through elution with different mineral acids (HNO3, H2SO4, and HCl) in a microwave process. The material used in this study—residues from an industrial kaolin production process—contained 2.47 g/kg REEs which is a significant amount for REE recovery. The ability of various mineral acids to solubilize metals was studied to assess the REE content of this residual resource. Around 1.87 g/kg of REEs was eluted from industrial kaolinite residues in hydrochloric acid, 1.71 g/kg in sulfuric acid, and 1.13 g/kg in nitric acid. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Effects of elevated CO2 on feeding responses of biological control agents of Pontederia crassipes.
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Paper, M. K., Righetti, T., Raubenheimer, S. L., Coetzee, J. A., Sosa, A. J., and Hill, M. P.
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BIOLOGICAL weed control ,WATER hyacinth ,AQUATIC weeds ,ORTHOPTERA ,BIOLOGICAL pest control agents ,PHOTOSYNTHETIC rates ,PLANT-water relationships - Abstract
Elevated carbon dioxide (eCO2) and rising temperatures will have far‐reaching effects on global plant‐insect interactions, yet their implications for future biological control programs are not fully understood. Studies have shown that elevated CO2 will affect insect feeding guilds differently and these responses can be predicted with some confidence. Water hyacinth, Pontederia crassipes Mart. (Pontederiaceae), is a native and representative species of the Del Plata wetlands (Argentina) that invades outside of its native environment. It is considered one of the world's worst aquatic weeds and a target for biological control. In this study, water hyacinth plants were grown under two CO2 concentrations – current (400 p.p.m.) or elevated (800 p.p.m.) –, with and without two biocontrol agents representing different feeding guilds, the leaf‐chewing Cornops aquaticum Brüner (Orthoptera: Acrididae) and the phloem‐feeding Megamelus scutellaris Berg (Hemiptera: Delphacidae). Under eCO2 concentration, photosynthetic rate, total dry weight, and relative growth rate of P. crassipes acclimated to eCO2 conditions and plants showed very little CO2 fertilization response in eutrophic water. Insect herbivory varied depending on feeding guilds at eCO2; however, P. crassipes growth responses increased when exposed to insect herbivory. Chewing herbivory by C. aquaticum was consistent across CO2 conditions, whereas the feeding by M. scutellaris increased substantially at eCO2. These results indicate that successful biological control of P. crassipes under conditions of elevated CO2 might rely on phloem‐feeding insects, with chewers playing a lesser role. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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6. An Approach to Integrated Digital Requirements Engineering.
- Author
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Duprez, Jean, Paper, Pascal, Fraj, Amine, Royer, Laurent, and Petteys, Becky
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REQUIREMENTS engineering ,SYSTEMS engineering ,NATURAL languages ,SIMULATION methods & models - Abstract
Systems engineering activities in the concept and development phases have evolved continuously for decades. The deployment of digital thread, digital engineering, MBSE approaches, and modeling and simulation techniques have driven part of this evolution. Despite this trend, requirements are still largely textual and expressed in natural language, and requirements engineering activities are still often document‐based. However, model‐based requirements‐engineering approaches have emerged in recent years and have demonstrated significant benefits, including improved requirements quality, less ambiguity, and early and efficient verification and validation. The goal of this paper is to present the current outcomes and perspectives of setting up an Integrated Digital Requirements Engineering approach as developed within our company. This approach seeks to optimize usability and maximize benefits to support end‐to‐end V&V activities while fully integrating into MBSE workflows. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Cross-sectional comparisons of dietary indexes underlying nutrition labels: nutri-score, Canadian 'high in' labels and Diabetes Canada Clinical Practices (DCCP).
- Author
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Paper, Laura, Ahmed, Mavra, Lee, Jennifer J., Kesse-Guyot, Emmanuelle, Touvier, Mathilde, Hercberg, Serge, Galan, Pilar, Salanave, Benoît, Verdot, Charlotte, L'Abbé, Mary R., Deschamps, Valérie, and Julia, Chantal
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BIOMARKERS ,FOOD labeling ,NUTRITIONAL value ,CROSS-sectional method ,DIET ,NUTRITIONAL requirements ,MEDICAL protocols ,DESCRIPTIVE statistics ,DATA analysis software - Abstract
Purpose: To assess the cross-sectional association between dietary indexes (DI) that underlie, respectively, the Nutri-score (NS), the proposed Canadian 'High In' Symbol (CHIL) and the Diabetes Canada Clinical Practice Guidelines (DCCP) with food consumption, nutrient intakes and metabolic markers. Methods: 1836 adults (18–74 years) participating in the representative ESTEBAN study, conducted in mainland France in 2014–2016, were included in the analysis. Food consumption was assessed with three repeated 24 h dietary recalls. Anthropometric measurements and biomarkers of metabolic risk (cholesterol—total, LDL (Low Density Lipoprotein), HDL (High Density Lipoprotein)—triglycerides, glucose) were obtained through a clinical examination and fasting blood draw. The DI were assessed for their association with food consumption, dietary intakes and metabolic biomarkers as quintiles and continuous variables using multi-adjusted linear regression. Heathier diets were assigned to lower scores. Results: Correlations between scores ranged from + 0.62 between CHIL-DI and NS-DI to + 0.75 between NS-DI and DCCP-DI. All DIs discriminated individuals according to the nutritional quality of their diets through food consumption and nutrient intakes (healthier diets were associated with lower intakes of energy, added sugars and saturated fat; and with higher intakes of fiber, vitamins and minerals). NS-DI was associated with blood glucose (adjusted mean in Q1 = 5 vs. Q5 = 5.46 mmol/dl, p
trend = 0.001) and DCCP-DI was associated with BMI (Q1 = 24.8 kg/m2 vs. Q5 = 25.8 kg/m2 , ptrend = 0.025), while CHIL showed no significant association with any anthropometric measures or biomarkers. Conclusions: This study provides elements supporting the validity of the nutrient profiling systems underlying front-of-package nutrition labellings (FOPLs) to characterize the healthiness of diets. [ABSTRACT FROM AUTHOR]- Published
- 2023
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8. Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review—CORRIGENDUM.
- Author
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Sellem, Laury, Jackson, Kim G., Paper, Laura, Givens, Ian D., and Lovegrove, Julie A.
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CARDIOVASCULAR diseases risk factors ,BIOMARKERS ,DAIRY products ,DIETARY fats ,FATTY acids - Abstract
A correction is presented to the article "Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health?"
- Published
- 2022
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9. Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review.
- Author
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Sellem, Laury, Jackson, Kim G., Paper, Laura, Givens, Ian D., and Lovegrove, Julie A.
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CARDIOVASCULAR disease related mortality ,BIOMARKERS ,CARDIOVASCULAR diseases risk factors ,NUTRITIONAL assessment ,SERUM ,BLOOD plasma ,GLYCEMIC control ,GUT microbiome ,HEALTH status indicators ,DAIRY products ,TYPE 2 diabetes ,METABOLIC disorders ,RISK assessment ,METABOLIC syndrome ,MOLECULAR structure ,FATTY acids ,DIETARY fats ,SHORT-chain fatty acids - Abstract
In epidemiological studies, dairy food consumption has been associated with minimal effect or decreased risk of some cardiometabolic diseases (CMD). However, current methods of dietary assessment do not provide objective and accurate measures of food intakes. Thus, the identification of valid and reliable biomarkers of dairy product intake is an important challenge to best determine the relationship between dairy consumption and health status. This review investigated potential biomarkers of dairy fat consumption, such as odd-chain, trans- and branched-chain fatty acids (FA), which may improve the assessment of full-fat dairy product consumption. Overall, the current use of serum/plasma FA as biomarkers of dairy fat consumption is mostly based on observational evidence, with a lack of well-controlled, dose–response intervention studies to accurately assess the strength of the relationship. Circulating odd-chain SFA and trans-palmitoleic acid are increasingly studied in relation to CMD risk and seem to be consistently associated with a reduced risk of type 2 diabetes in prospective cohort studies. However, associations with CVD are less clear. Overall, adding less studied FA such as vaccenic and phytanic acids to the current available evidence may provide a more complete assessment of dairy fat intake and minimise potential confounding from endogenous synthesis. Finally, the current evidence base on the direct effect of dairy fatty acids on established biomarkers of CMD risk (e.g. fasting lipid profiles and markers of glycaemic control) mostly derives from cross-sectional, animal and in vitro studies and should be strengthened by well-controlled human intervention studies. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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10. Into Africa: Salvinia minima Baker (Salviniaceae) invades South Africa.
- Author
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Coetzee, Julie A., Paper, Matthew K., Miller, Benjamin E., Kinsler, David, Cilliers, Carina J., and Hill, Martin P.
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INDIGENOUS peoples of South America ,BODIES of water - Abstract
Salvinia minima Baker (Salviniaceae) has been recorded for the first time in Africa. This South American native macrophyte is highly invasive and damaging, costing millions of dollars to control in the USA, and has the potential to invade many of southern Africa's waterbodies. Field surveys have confirmed the presence of S. minima from four sites in South Africa, with the largest invasion occurring on the highly polluted Hartbeespoort Dam, north east of the country's capital. Salvinia minima has been targeted for biological control in South Africa, using the weevil, Cyrtobagous salviniae, which is undergoing host specificity testing under quarantine conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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