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An instrumental neutron activation analysis method in conjunction with Compton suppression spectrometry was developed for the simultaneous determination of nanogram levels of Cl, Br and I in salmon muscle and skin. Several non-chlorinated solvent systems were evaluated for the extraction of lipids containing organohalogens and an acetone-hexane (1:1) system was selected because it gave the highest extraction efficiency with least contamination. An extensive quality assurance program was designed. Lipid fractionation procedures were developed using size exclusion, solid phase extraction and thin layer chromatography followed by characterization using 1H, 13C and 31P nuclear magnetic resonance and mass spectrometry. Results show that both muscle and skin had high levels of triacylglycerols. [ABSTRACT FROM AUTHOR]

Background: Ocular complaints, including acute or subacute vision loss, are commonly encountered in emergency departments (ED). These potentially time-sensitive complaints are difficult to diagnose and evaluate without adequate, specialized equipment and expertise. Additionally, a thorough evaluation often requires a more extensive and specialized physical exam, imaging, and ophthalmologic consultation, all of which may not be readily available in the acute setting. Case presentation: This case report presented a patient in the emergency department with the chief complaint of vision loss. Point-of-care ultrasound (POCUS) using the 10-MHz-linear-array probe, in the ocular setting, demonstrated calcification of the lens, a finding consistent with cataract in the right eye. Conclusions: The use of POCUS can expedite the accurate identification of vision threatening pathology, such as cataracts, and streamline ED disposition and plan of care. [ABSTRACT FROM AUTHOR]

A fundamental property of place cells in the hippocampus is the anchoring of their firing fields to salient landmarks within the environment. However, it is unclear how such information reaches the hippocampus. In the current experiment, we tested the hypothesis that the stimulus control exerted by distal visual landmarks requires input from the medial entorhinal cortex (MEC). Place cells were recorded from mice with ibotenic acid lesions of the MEC (n = 7) and from sham‐lesioned mice (n = 6) following 90° rotations of either distal landmarks or proximal cues in a cue‐ controlled environment. We found that lesions of the MEC impaired the anchoring of place fields to distal landmarks, but not proximal cues. We also observed that, relative to sham‐lesioned mice, place cells in animals with MEC lesions exhibited significantly reduced spatial information and increased sparsity. These results support the view that distal landmark information reaches the hippocampus via the MEC, but that proximal cue information can do so via an alternative neural pathway. [ABSTRACT FROM AUTHOR]

[Display omitted] • Activation of Tac1PBN neurons promotes escape, not freezing. • Activation of Tac1PBN neurons does not elicit conditioned taste aversion (CTA). • Activation of Tac1PBN neurons blocks CTA generated by LiCl or CGRPPBN activation. • Activation of Tac1+;CGRP− via INTRSECT replicates Tac1PBN activation. Many threats activate parabrachial neurons expressing calcitonin gene-related peptide (CGRPPBN) which transmit alarm signals to forebrain regions. Most CGRPPBN neurons also express tachykinin 1 (Tac1), but there are also Tac1-expressing neurons in the PBN that do not express CGRP (Tac1+;CGRP− neurons). Chemogenetic or optogenetic activation of all Tac1PBN neurons in mice elicited many physiological/behavioral responses resembling the activation of CGRPPBN neurons, e.g., anorexia, jumping on a hot plate, avoidance of photostimulation; however, two key responses opposed activation of CGRPPBN neurons. Activating Tac1PBN neurons did not produce conditioned taste aversion and it elicited dynamic escape behaviors rather than freezing. Activating Tac1+;CGRP− neurons, using an intersectional genetic targeting approach, resembles activating all Tac1PBN neurons. These results reveal that activation of Tac1+;CGRP− neurons can suppress some functions attributed to the CGRPPBN neurons, which provides a mechanism to bias behavioral responses to threats. [ABSTRACT FROM AUTHOR]

Introduction: Cancer consistently remains one of the top causes of death in the United States every year, with many cancer deaths preventable if detected early. Circulating serum miRNAs are a promising, minimally invasive supplement or even an alternative to many current screening procedures. Many studies have shown that different serum miRNAs can discriminate healthy individuals from those with certain types of cancer. Although many of those miRNAs are often reported to be significant in one cancer type, they are also altered in other cancer types. Currently, very few studies have investigated serum miRNA biomarkers for multiple cancer types for general cancer screening purposes. Method: To identify serum miRNAs that would be useful in screening multiple types of cancers, microarray cancer datasets were curated, yielding 13 different types of cancer with a total of 3352 cancer samples and 2809 non-cancer samples. The samples were divided into training and validation sets. One hundred random forest models were built using the training set to select candidate miRNAs. The selected miRNAs were then used in the validation set to see how well they differentiate cancer from normal samples in an independent dataset. Furthermore, the interactions between these miRNAs and their target mRNAs were investigated. Result: The random forest models achieved an average of 97% accuracy in the training set with 95% bootstrap confidence interval of 0.9544 to 0.9778. The selected miRNAs were hsa-miR-663a, hsa-miR-6802-5p, hsa-miR-6784-5p, hsa-miR-3184-5p, and hsa-miR-8073. Each miRNA exhibited high area under the curve (AUC) value using receiver operating characteristic analysis. Moreover, the combination of four out of five miRNAs achieved the highest AUC value of 0.9815 with high sensitivity of 0.9773, indicating that these miRNAs have a high potential for cancer screening. miRNA-mRNA and protein-protein interaction analysis provided insights into how these miRNAs play a role in cancer. [ABSTRACT FROM AUTHOR]

"For the Sake of the Song: Essays on Townes Van Zandt" is a collection of essays edited by Anne Norton Holbrook and Dan Bellar-McKenna that explores the life and work of the late singer-songwriter Townes Van Zandt. The book covers a wide range of topics, including Van Zandt's recorded legacy, his influences, the role of gender in his compositions, and the musical and production aspects of his music. The collection also delves into Van Zandt's mental illness and includes episodes from Richard Dobson's memoir that offer insights into touring with Van Zandt. Overall, "For the Sake of the Song" provides a valuable addition to the existing body of Van Zandt commentaries. [Extracted from the article]

The Ames dwarf (df/df) mouse is a well-established model for delayed aging. MicroRNAs (miRNAs), the most studied small noncoding RNAs (sncRNAs), may regulate ovarian aging to maintain a younger ovarian phenotype in df/df mice. In this study, we profile other types of ovarian sncRNAs, PIWI-interacting RNAs (piRNAs) and piRNA-Like RNAs (piLRNAs) in young and aged df/df and normal mice. Half of the piRNAs derive from transfer RNA fragments (tRF-piRNAs). Aging and dwarfism alter the ovarian expression of these novel sncRNAs. Specific tRF-piRNAs that increased with age might target and decrease the expression of the breast cancer antiestrogen resistance protein 3 (BCAR3) gene in the ovaries of old df/df mice. A set of piLRNAs that decreased with age map to D10Wsu102e mRNA and may be involved in trans-regulatory functions. Other piLRNAs that decreased with age potentially target and may de-repress transposable elements (TEs), leading to a beneficial impact on ovarian aging in df/df mice. These results identify unique responses in ovarian tissues with regard to aging and dwarfism. Overall, our findings highlight the complexity of the aging effects on gene expression and suggest that, in addition to miRNAs, piRNAs, piLRNAs, tRF-piRNAs, and their potential targets, can be central players in the maintenance of a younger ovarian phenotype in df/df mice. [ABSTRACT FROM AUTHOR]

Lung cancer is one of the deadliest cancers in the world. Two of the most common subtypes, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), have drastically different biological signatures, yet they are often treated similarly and classified together as non-small cell lung cancer (NSCLC). LUAD and LUSC biomarkers are scarce, and their distinct biological mechanisms have yet to be elucidated. To detect biologically relevant markers, many studies have attempted to improve traditional machine learning algorithms or develop novel algorithms for biomarker discovery. However, few have used overlapping machine learning or feature selection methods for cancer classification, biomarker identification, or gene expression analysis. This study proposes to use overlapping traditional feature selection or feature reduction techniques for cancer classification and biomarker discovery. The genes selected by the overlapping method were then verified using random forest. The classification statistics of the overlapping method were compared to those of the traditional feature selection methods. The identified biomarkers were validated in an external dataset using AUC and ROC analysis. Gene expression analysis was then performed to further investigate biological differences between LUAD and LUSC. Overall, our method achieved classification results comparable to, if not better than, the traditional algorithms. It also identified multiple known biomarkers, and five potentially novel biomarkers with high discriminating values between LUAD and LUSC. Many of the biomarkers also exhibit significant prognostic potential, particularly in LUAD. Our study also unraveled distinct biological pathways between LUAD and LUSC. [ABSTRACT FROM AUTHOR]

• Crushing of closed-cell foam under combined axial compression and external pressure. • Stress response rises to a maximum and drops to an extended stress plateau. • Deformation localizes in a band of crushed cells that propagates with stress unchanged. • Maximum stress and plateau stress decrease as pressure increases. • Custom testing facility that allows visualization of the evolution of deformation. The crushing behavior of a polymeric closed-cell foam with a relative density of 0.077 under combined axial compression and external pressure is investigated experimentally. The foam has a nearly monodisperse polyhedral microstructure with mean cell size and wall thickness of 0.50 mm and 0.0348 mm respectively. A custom triaxial apparatus is used to compress cylindrical specimens at different levels of external pressure. A typical axial stress-displacement response exhibits a stiff elastic branch that terminates into a maximum beyond which deformation localizes into a horizontal axisymmetric band of crushed cells. The band then propagates axially with the stress remaining essentially constant. Both the initial stress maximum and the plateau stress decrease linearly as the pressure increases. Micro-computed tomography imaging of the microstructure of a specimen crushed axially at zero pressure confirmed that during the stress plateau, a highly crushed zone of cells with an average strain of about 50 % coexists with zones of essentially undeformed cells. Above a critical pressure, the mode of instability switches to predominantly lateral contraction that evolves into a neck. This is also the mechanism of failure under pure pressure. The localized crushing behavior observed is similar to that of low-density open-cell foams and the results should inform and guide further development of homogenized models for this class of materials. [ABSTRACT FROM AUTHOR]

The use of modern analog Monte Carlo software to perform space-time kinetics and probability of extinction (POE) calculations in support of nuclear design and safety studies can be hampered by appreciable execution times and code crashes attributable to lengthy finite and divergent prompt-neutron fission chains. To estimate chain behavior for modern 235U fission-multiplicity data and constant reactivity conditions, static point POE discrete-step stochastic models of unrestricted and restricted prompt-neutron fission chains are developed and solved analytically. These models are used in a simple expression which gives the estimated chain length LMAX required to calculate a POE to a prescribed accuracy. The analytical procedure entails solving a quintic polynomial, the roots of which are POE candidates. Methods including Galois theory are used to analyze the POE quintic. Analytical techniques are used to show that only a single POE exists for any state of criticality. Ingenious mathematics from the late 1800's, as updated in the early 1990's by King, are used to obtain the algebraic roots. The analytical models give valuable insights into fission chain behavior, and should be of use in providing chain control guidance for mainstream analog Monte Carlo code simulations of nuclear systems. [ABSTRACT FROM AUTHOR]

This article explores the influence of Blind Lemon Jefferson, a renowned blues musician, on various musicians and their songs. It discusses how Jefferson's songs, such as "Long Lonesome Blues," influenced artists like Lil' Son Jackson, Joel Hopkins, Hop Wilson, Albert Collins, and Johnny Copeland. The article also highlights the geographical confusion in some of the songs, where artists mention walking from Dallas to Wichita Falls, despite the two cities being in different directions. Additionally, the article discusses the impact of Texas and the cities of Dallas and Wichita Falls on various musicians and their songs, including the influence of Bob Wills and his Western swing music on Merle Haggard. It explores the cultural significance of these songs and their ties to Texas music traditions. [Extracted from the article]

Background: The winter pressure often experienced by NHS hospitals in England is considerably contributed to by severe cases of seasonal influenza resulting in hospitalisation. The prevention planning and commissioning of the influenza vaccination programme in the UK does not always involve those who control the hospital budget. The objective of this study was to describe the direct medical costs of secondary care influenza-related hospital admissions across different age groups in England during two consecutive influenza seasons.Methods: The number of hospital admissions, length of stay, and associated costs were quantified as well as determining the primary costs of influenza-related hospitalisations. Data were extracted from the Hospital Episode Statistics (HES) database between September 2017 to March 2018 and September 2018 to March 2019 in order to incorporate the annual influenza seasons. The use of international classification of disease (ICD)-10 codes were used to identify relevant influenza hospitalisations. Healthcare Resource Group (HRG) codes were used to determine the costs of influenza-related hospitalisations.Results: During the 2017/18 and 2018/19 seasons there were 46,215 and 39,670 influenza-related hospital admissions respectively. This resulted in a hospital cost of £128,153,810 and £99,565,310 across both seasons. Results showed that those in the 65+ year group were associated with the highest hospitalisation costs and proportion of in-hospital deaths. In both influenza seasons, the HRG code WJ06 (Sepsis without Interventions) was found to be associated with the longest average length of stay and cost per admission, whereas PD14 (Paediatric Lower Respiratory Tract Disorders without Acute Bronchiolitis) had the shortest length of stay.Conclusion: This study has shown that influenza-related hospital admissions had a considerable impact on the secondary healthcare system during the 2017/18 and 2018/19 influenza seasons, before taking into account its impact on primary health care. [ABSTRACT FROM AUTHOR]

Influenza contributes significantly to the burden of disease worldwide; the United Kingdom has a policy of vaccination across all ages. Influenza vaccinations are known to be associated with common minor adverse events of interest (AEIs). The European Medicines Agency (EMA) recommends ongoing surveillance of AEIs following influenza vaccination to monitor common and detect infrequent but important AEIs. A retrospective cohort study using computerised medical record data from the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) sentinel network database 2010–2018 (N = 848,375). We extracted data about vaccine exposure (n = 3,121,334) and consultations for AEIs within seven days of receiving vaccinations specified by the EMA (1,488,870 consultations by 430,029 unique individuals). We used a self-case series design which employs a likelihood estimation method using conditioning of observed adverse events. Such a model assumes non-homogenous Poisson intensity processes for each exposure period and age interval. We compared AEI between QIV and TIV reporting relative incidence (RI) of AEIs. A RI < 1 signified lower AEI rate compared to TIV. QIV was associated with a RI of AEIs of 1.14 (95%CI, 1.10–1.18, p < 0.01), though the number of years exposure was limited. By way of contrast, LAIV had a lower rate 0.60 (95%CI 0.63–0.68, p < 0.001). Cellular manufacture was also associated with a lower rate 0.78 (95%CI 0.61–0.99, p = 0.04). AEIs varied by season: Rash and musculoskeletal conditions are particularly pronounced in the 2014/15 season and respiratory conditions in 2016/17. In an analysis of all seasons, we found an elevated relative incidence of AEIs of 1.78 (95%CI, 1.62–1.95) in pregnant women and 1.76 (95%CI, 1.56 – 1.99) in children under 5 years. Routine sentinel network data can be used to contrast AEIs between vaccine types and may provide a consistent method of observation of vaccine benefit-risk over time. [ABSTRACT FROM AUTHOR]

Volcanic emissions are known to be a serious source of pollution to humans and animals. This study aimed to examine the possible health burden of fluoride (F) exposure from volcanic eruptions in the past. Osteological analyses were performed on 186 skeletons from seven sites across Iceland with the aim of identifying skeletal changes potentially associated with osteofluorosis. Additionally, ion selective electrode (ISE) was used to investigate possible correlations between skeletal lesions and bone fluoride concentrations in a subset of skeletons (n = 50) from two of these sites, Skriðuklaustur in Fljótsdalur and Skeljastaðir in Þjórsárdalur. The results showed that pathological markers or skeletal changes increased according to age across all investigated time periods and geographical regions but likely not due to significant fluoride exposure. The fluoride concentration range was 223–4370 ppm (mean = 2324 ± 1067 ppm) at Skriðuklaustur (n = 36) while at Skeljastaðir (n = 14), the range was 223–3030 ppm (mean = 1366 ± 937 ppm). The pathological changes noted in this study are thus more likely to relate to the environment, population dynamics, culturally mediated behaviours and increasing urbanisation than serious fluoride contamination. Therefore, volcanic emissions appear to have only substantially affected those living within the closest vicinity of actual eruption events. It may be vital to not only consider the severity of the immediate effects of volcanic pollution but also to reinforce socioeconomic circumstances and disaster preparation in regions with environmental hazards. [ABSTRACT FROM AUTHOR]

Objectives: A multi‐isotope study was conducted on individuals buried at Skriðuklaustur monastery (AD 1493–1554) to investigate their geographic origins and dietary composition. Comparative material from individuals excavated from Skeljastaðir, an inland farm site was also analyzed. Materials and methods: Bone collagen was extracted from 50 humans (Skriðuklaustur and Skeljastaðir) and 25 animals (Skriðuklaustur) and analyzed for δ13C, δ15N, and δ34S. Dental enamel samples from 31 individuals (Skriðuklaustur) were also analyzed for 87Sr/86Sr, δ18O, δ13C, and trace elements (Pb, Sr, Zn, Ba). Results: The mean value determined from individuals from Skriðuklaustur (n = 36) was δ13C = −18.7 ± 0.8‰, δ15N = 12.8 ± 1.1‰, and δ34S = 9.0 ± 1.6‰, whereas at Skeljastaðir (n = 14), it was δ13C = −20.5 ± 0.8‰, δ15N = 7.8 ± 0.9‰, and δ34S = 9.4 ± 1.6‰. At Skriðuklaustur, human dental enamel samples (n = 31) provided a 87Sr/86Sr range of 0.7060–0.7088, δ18Ophosphate from 13.9 to 16.1‰ and δ13Ccarbonate from −16.6 to −12.9‰. Inferred drinking water (δ18Odw) values range from −12.3 to −8.9‰. Sr concentrations range from 25.8 to 156.7 ppm, Ba from 0.11 to 0.81 ppm, Zn from 43.8 to 145.8 ppm, and Pb from 0.13 to 9.40 ppm. Discussion: A combination of results indicates that the people from Skriðuklaustur were born in Iceland, but some lived inland during childhood while others lived closer to the coast. Since Skriðuklaustur was a hospital, these individuals may have sought medical treatment at the monastery. The δ13C and δ15N values determined from bone collagen indicate that the people residing at Skriðuklaustur consumed a diet high in marine protein, while those residing at Skeljastaðir exhibit values more consistent with terrestrial resources. [ABSTRACT FROM AUTHOR]

Background and Aims: Symptom control for atrial fibrillation can be achieved by catheter ablation or drug therapy. We assessed the cost effectiveness of a novel streamlined atrial fibrillation cryoballoon ablation protocol (AVATAR) compared with optimised antiarrhythmic drug (AAD) therapy and a conventional catheter ablation protocol, from a UK National Health Service (NHS) perspective.Data from the AVATAR study were assessed to determine the cost effectiveness of the three protocols in a two-step process. In the first stage, statistical analysis of clinical efficacy outcomes was conducted considering either a three-way comparison (AVATAR vs. conventional ablation vs. optimised AAD therapies) or a two-way comparison (pooled ablation protocol data vs. optimised AAD therapies). In the second stage, models assessed the cost effectiveness of the protocols. Costs and some of the clinical inputs in the models were derived from within-trial cost analysis and published literature. The remaining inputs were derived from clinical experts.No significant differences between the ablation protocols were found for any of the clinical outcomes used in the model. Results of a within-trial cost analysis show that AVATAR is cost-saving (£1279 per patient) compared with the conventional ablation protocol. When compared with optimised AAD therapies, AVATAR (pooled conventional and AVATAR ablation protocols efficacy) was found to be more costly while offering improved clinical benefits. Over a lifetime time horizon, the incremental cost-effectiveness ratio of AVATAR was estimated as £21,046 per quality-adjusted life-year gained (95% credible interval £7086–£71,718).The AVATAR streamlined protocol is likely to be a cost-effective option versus both conventional ablation and optimised AAD therapy in the UK NHS healthcare setting.Methods: Symptom control for atrial fibrillation can be achieved by catheter ablation or drug therapy. We assessed the cost effectiveness of a novel streamlined atrial fibrillation cryoballoon ablation protocol (AVATAR) compared with optimised antiarrhythmic drug (AAD) therapy and a conventional catheter ablation protocol, from a UK National Health Service (NHS) perspective.Data from the AVATAR study were assessed to determine the cost effectiveness of the three protocols in a two-step process. In the first stage, statistical analysis of clinical efficacy outcomes was conducted considering either a three-way comparison (AVATAR vs. conventional ablation vs. optimised AAD therapies) or a two-way comparison (pooled ablation protocol data vs. optimised AAD therapies). In the second stage, models assessed the cost effectiveness of the protocols. Costs and some of the clinical inputs in the models were derived from within-trial cost analysis and published literature. The remaining inputs were derived from clinical experts.No significant differences between the ablation protocols were found for any of the clinical outcomes used in the model. Results of a within-trial cost analysis show that AVATAR is cost-saving (£1279 per patient) compared with the conventional ablation protocol. When compared with optimised AAD therapies, AVATAR (pooled conventional and AVATAR ablation protocols efficacy) was found to be more costly while offering improved clinical benefits. Over a lifetime time horizon, the incremental cost-effectiveness ratio of AVATAR was estimated as £21,046 per quality-adjusted life-year gained (95% credible interval £7086–£71,718).The AVATAR streamlined protocol is likely to be a cost-effective option versus both conventional ablation and optimised AAD therapy in the UK NHS healthcare setting.Results: Symptom control for atrial fibrillation can be achieved by catheter ablation or drug therapy. We assessed the cost effectiveness of a novel streamlined atrial fibrillation cryoballoon ablation protocol (AVATAR) compared with optimised antiarrhythmic drug (AAD) therapy and a conventional catheter ablation protocol, from a UK National Health Service (NHS) perspective.Data from the AVATAR study were assessed to determine the cost effectiveness of the three protocols in a two-step process. In the first stage, statistical analysis of clinical efficacy outcomes was conducted considering either a three-way comparison (AVATAR vs. conventional ablation vs. optimised AAD therapies) or a two-way comparison (pooled ablation protocol data vs. optimised AAD therapies). In the second stage, models assessed the cost effectiveness of the protocols. Costs and some of the clinical inputs in the models were derived from within-trial cost analysis and published literature. The remaining inputs were derived from clinical experts.No significant differences between the ablation protocols were found for any of the clinical outcomes used in the model. Results of a within-trial cost analysis show that AVATAR is cost-saving (£1279 per patient) compared with the conventional ablation protocol. When compared with optimised AAD therapies, AVATAR (pooled conventional and AVATAR ablation protocols efficacy) was found to be more costly while offering improved clinical benefits. Over a lifetime time horizon, the incremental cost-effectiveness ratio of AVATAR was estimated as £21,046 per quality-adjusted life-year gained (95% credible interval £7086–£71,718).The AVATAR streamlined protocol is likely to be a cost-effective option versus both conventional ablation and optimised AAD therapy in the UK NHS healthcare setting.Conclusions: Symptom control for atrial fibrillation can be achieved by catheter ablation or drug therapy. We assessed the cost effectiveness of a novel streamlined atrial fibrillation cryoballoon ablation protocol (AVATAR) compared with optimised antiarrhythmic drug (AAD) therapy and a conventional catheter ablation protocol, from a UK National Health Service (NHS) perspective.Data from the AVATAR study were assessed to determine the cost effectiveness of the three protocols in a two-step process. In the first stage, statistical analysis of clinical efficacy outcomes was conducted considering either a three-way comparison (AVATAR vs. conventional ablation vs. optimised AAD therapies) or a two-way comparison (pooled ablation protocol data vs. optimised AAD therapies). In the second stage, models assessed the cost effectiveness of the protocols. Costs and some of the clinical inputs in the models were derived from within-trial cost analysis and published literature. The remaining inputs were derived from clinical experts.No significant differences between the ablation protocols were found for any of the clinical outcomes used in the model. Results of a within-trial cost analysis show that AVATAR is cost-saving (£1279 per patient) compared with the conventional ablation protocol. When compared with optimised AAD therapies, AVATAR (pooled conventional and AVATAR ablation protocols efficacy) was found to be more costly while offering improved clinical benefits. Over a lifetime time horizon, the incremental cost-effectiveness ratio of AVATAR was estimated as £21,046 per quality-adjusted life-year gained (95% credible interval £7086–£71,718).The AVATAR streamlined protocol is likely to be a cost-effective option versus both conventional ablation and optimised AAD therapy in the UK NHS healthcare setting. [ABSTRACT FROM AUTHOR]

Reports on the case of an 18-year-old volleyball player presented with significant left-knee-joint laxity. Occurrence of knee injuries; Implementation of cardiorespiratory-endurance training; Muscle-strength and -endurance training.

This study aimed to evaluate the possible use of mercury as a medical treatment at the medieval monastic hospital Skriðuklaustur (ad 1494–1554) in eastern Iceland. The individuals excavated from Skriðuklaustur exhibited a wide range of pathological conditions, including the only skeletal evidence of venereal syphilis in Iceland. Skeletal remains from the Skeljastaðir cemetery (ca. ad 1000–1104) in southern Iceland were also analysed in light of the site's proximity to the mercury emitting volcano Hekla. The eruption produced a severe toxic fallout resulting in the mass mortality of livestock and is believed to have caused the abandonment of Skeljastaðir and the other farms in the region. The skeletal analyses and sampling were conducted according to standard anthropological methods. Mercury concentrations were determined in human (n = 50), faunal (n = 23), and soil (n = 22) samples using inductively coupled plasma mass spectrometry. Individuals from both sites exhibited elevated mercury concentrations. At Skriðuklaustur, some individuals showed normal concentrations, but those with pathological conditions (e.g., hydatidosis, syphilis, tuberculosis, and other non‐specific infections) had the highest concentrations overall. On the other hand, all the individuals analysed from Skeljastaðir exhibited elevated mercury concentrations, some of which were remarkably high. A few of the individuals buried at Skeljastaðir post‐date the eruption, possibly indicating that some of them experienced heavy exposure to volcanic emissions. The less extreme concentrations at Skriðuklaustur may be a result of attention to dosage and the temporary nature of mercurial treatments. None of the faunal and soil samples presented with concentrations exceeding the normal limit, implying that diagenesis was not a concern in this research. The conclusion is that a variety of factors from medical treatment to scholarly work lead to mercury exposure at Skriðuklaustur, whereas at Skeljastaðir, volcanogenic emissions are implicated. [ABSTRACT FROM AUTHOR]

Four studies were conducted to better understand the relationship between arousal, conformity, and the influence of arbitrary and genuine social information. Experiment 1 found that conforming to an apparently genuine majority led to lower levels of autonomic arousal than did independence. Experiment 2 replicated the same findings under nonrealistic conditions in which the experimenter, in front of the participant, told the majority which response to give, thus removing social information from the response. Experiment 3 used arousal-based reasoning to predict that if disagreeing with a majority leads to higher arousal than conformity, even when majority responses contain no social information, participants will conform to majority responses under those same conditions, which was supported. Experiment 4 attempted to broaden our understanding of how arbitrary and real majority responses affect conformity by varying the size of the majority and whether majority responses were arbitrary or genuine. Responses were significantly influenced in all experimental conditions, thus replicating Experiment 3, but more influence occurred with a larger majority that appeared to be giving genuine responses. Our findings expand our understanding of the factors involved in the typical conformity situation by showing that the responses given by the majority affect conformity, whether or not they are genuine, though genuineness adds to the effect with a group size of 3. Also, we argue that taking an arousal-based view provides a way of viewing these results as part of a broader homeostatic behavioral system, although the compatibility of the results with other approaches is acknowledged. [ABSTRACT FROM AUTHOR]

Though Bayesian methods are being used more frequently, many still struggle with the best method for setting priors with novel measures or task environments. We propose a method for setting priors by eliciting continuous probability distributions from naive participants. This allows us to include any relevant information participants have for a given effect. Even when prior means are near-zero, this method provides a principle way to estimate dispersion and produce shrinkage, reducing the occurrence of overestimated effect sizes. We demonstrate this method with a number of published studies and compare the effect of different prior estimation and aggregation methods. [ABSTRACT FROM AUTHOR]

Despite the fact that data and theories in the social, behavioural, and health sciences are often represented on an ordinal scale, there has been relatively little emphasis on modelling ordinal properties. The most common analytic framework used in psychological science is the general linear model, whose variants include ANOVA, MANOVA, and ordinary linear regression. While these methods are designed to provide the best fit to the metric properties of the data, they are not designed to maximally model ordinal properties. In this paper, we develop an order-constrained linear least-squares (OCLO) optimization algorithm that maximizes the linear least-squares fit to the data conditional on maximizing the ordinal fit based on Kendall's τ. The algorithm builds on the maximum rank correlation estimator (Han, 1987, Journal of Econometrics, 35, 303) and the general monotone model (Dougherty & Thomas, 2012, Psychological Review, 119, 321). Analyses of simulated data indicate that when modelling data that adhere to the assumptions of ordinary least squares, OCLO shows minimal bias, little increase in variance, and almost no loss in out-of-sample predictive accuracy. In contrast, under conditions in which data include a small number of extreme scores (fat-tailed distributions), OCLO shows less bias and variance, and substantially better out-of-sample predictive accuracy, even when the outliers are removed. We show that the advantages of OCLO over ordinary least squares in predicting new observations hold across a variety of scenarios in which researchers must decide to retain or eliminate extreme scores when fitting data. [ABSTRACT FROM AUTHOR]

In this communication we outline how the bespoke arrangements and design of micron-sized superparamagnetic shapes provide levers to modulate their assembly under homogeneous magnetic fields. We label this new approach, 'assembly modulated by particle position and shape' (APPS). Specifically, using rectangular lattices of superparamagnetic micron-sized cuboids, we construct distinct microstructures by adjusting lattice pitch and angle of array with respect to a magnetic field. Broadly, we find two modes of assembly: (1) immediate 2D jamming of the cuboids as they rotate to align with the applied field (rotation-induced jamming) and (2) aggregation via translation after their full alignment (dipole-dipole assembly). The boundary between these two assembly pathways is independent on field strength being solely a function of the cuboid's dimensions, lattice pitch, and array angle with respect to field--a relationship which we capture, along with other features of the assembly process, in a 'phase diagram'. In doing so, we set out initial design rules to build custom made assemblies. Moreover, these assemblies can be made flexible thanks to the hinged contacts of their particle building blocks. This flexibility, combined with the superparamagnetic nature of the architectures, renders our assembly method particularly appropriate for the construction of complex actuators at a scale hitherto not possible. [ABSTRACT FROM AUTHOR]

The gin stand power is measurable using common tools; however, such tools typically do not detect active ginning. Detecting active ginning is important when trying to separate out the energy going to the moving parts of the gin stand (i.e., the baseline energy) versus the active energy doing work to remove the cotton fibers from the seed. Studies have shown that the gin stand is the second largest consumer of electricity in the ginning operation, while electricity accounts for nearly 17% of the average expense per bale. If active energy differences exist between cotton cultivars, there may be room to optimize and lower these expenses. The goal of the current work is to provide a method (and software tool) to analyze typical power logger data, and extract periods of active ginning, along with the energy consumed and ginning times, in a semi-automated way. The new method presented allows multiple periods of active ginning in a single file, and can separate the total energy into the active and baseline components. Other metrics of interest that the software calculates include the ginning time, and average power. Software validation using a simulated test signal showed that a 2%-or-lower error is possible with a noisy signal. [ABSTRACT FROM AUTHOR]

Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). Although the development of pharmacotherapies to treat CVD has contributed to a decline in cardiac mortality in the past few decades, CVD is estimated to be the cause of one-third of deaths globally. Nutraceuticals are natural nutritional compounds that are beneficial for the prevention or treatment of disease and, therefore, are a possible therapeutic avenue for the treatment of atherosclerosis. The purpose of this Review is to highlight potential nutraceuticals for use as antiatherogenic therapies with evidence from in vitro and in vivo studies. Furthermore, the current evidence from observational and randomized clinical studies into the role of nutraceuticals in preventing atherosclerosis in humans will also be discussed. [ABSTRACT FROM AUTHOR]

Introduction: Atherosclerosis is the underlying cause of cardiovascular disease that leads to more global mortalities each year than any other ailment. Consumption of active food ingredients such as phytosterols, omega-3 polyunsaturated fatty acids and flavanols are known to impart beneficial effects on cardiovascular disease although the combined actions of such agents in atherosclerosis is poorly understood. The aim of this study was to screen a nutritional supplement containing each of these active components for its anti-atherosclerotic effect on macrophages in vitro. Results: The supplement attenuated the expression of intercellular adhesion molecule-1 and macrophage chemoattractant protein-1 in human and murine macrophages at physiologically relevant doses. The migratory capacity of human monocytes was also hindered, possibly mediated by eicosapentaenoic acid and catechin, while the ability of foam cells to efflux cholesterol was improved. The polarisation of murine macrophages towards a pro-inflammatory phenotype was also attenuated by the supplement. Conclusion: The formulation was able to hinder multiple key steps of atherosclerosis development in vitro by inhibiting monocyte recruitment, foam cell formation and macrophage polarisation towards an inflammatory phenotype. This is the first time a combination these ingredients has been shown to elicit such effects and supports its further study in preclinical in vivo models. [ABSTRACT FROM AUTHOR]

Various radiation transport simulations pertaining to active and passive interrogation, medical physics, space applications, and other disciplines involve the motion of objects. In some instances radiation is emitted from within an object, while in other cases radiation is incident on an object. In our latest innovation for MCNP6, we introduce the capability to perform self-contained radiation-transport simulations involving moving objects. Object motion is treated using rigid-body kinematics as characterized by rectilinear translation, curvilinear translation, and curvilinear rotation along motion segments. Individual motion segments can be linked together to create complicated paths. Simulations can accommodate the simultaneous motion of up to 1000 moving objects. The moving-objects feature is designed for source-mode (“SDEF”) simulations, and includes the capacity to model moving sources comprised of prompt particles as well as delayed neutrons and gammas. The motion of objects and sources can be simulated by constant velocity, acceleration or deceleration, or simple relocation. In addition, the MCNP6 plot utility has been upgraded to permit animated plots of geometry as it evolves in time. The moving-objects feature may be executed in either serial mode or parallel mode using MPI. In this article we delineate the formulations and code modifications required in MCNP6 to implement the new moving-objects capability. In the companion article we illustrate the capability using several simulations. The moving-objects innovation will bring enhanced realism to simulations that exhibit motion. [ABSTRACT FROM AUTHOR]

In Part I we presented the theory and code-development upgrades for the new MCNP6 moving-objects feature. This feature facilitates automated execution of radiation transport simulations in which motion is characterized by rigid-body kinematics for three types of continuous motion: rectilinear translation, curvilinear translation, and curvilinear rotation. Models that have complicated motion paths can be simulated using motion-segment linking. Models containing up to 1000 moving objects can be executed. In addition, moving sources and delayed-neutron and delayed-gamma emission due to fission and activation reactions can be modeled. To illustrate this new capability, we present results for two sets of test models. The objective of the first set is to demonstrate object motion for a variety of dynamics conditions. These test models are executed without particle emission or transport. The updated MCNP6 geometry plotting utility is used to provide numerous plots of model geometries as they evolve with time. The second set is used to demonstrate object motion with particle emission and transport. These models examine delayed-gamma emission induced by thermal neutron irradiation of moving versions of the highly enriched uranium (HEU) and plutonium (Pu) targets used by Beddingfield and Cecil (1998) in experimental work. Our calculated results show good agreement with the measured delayed-gamma spectra. This new MCNP6 feature allows realistic simulations of object and/or source motion, which will enhance modeling realism for a variety of radiation-transport applications. [ABSTRACT FROM AUTHOR]

Background We consider the problem of reconstructing a gene regulatory network structure from limited time series gene expression data, without any a priori knowledge of connectivity. We assume that the network is sparse, meaning the connectivity among genes is much less than full connectivity. We develop a method for network reconstruction based on compressive sensing, which takes advantage of the network's sparseness. Results For the case in which all genes are accessible for measurement, and there is no measurement noise, we show that our method can be used to exactly reconstruct the network. For the more general problem, in which hidden genes exist and all measurements are contaminated by noise, we show that our method leads to reliable reconstruction. In both cases, coherence of the model is used to assess the ability to reconstruct the network and to design new experiments. We demonstrate that it is possible to use the coherence distribution to guide biological experiment design effectively. By collecting a more informative dataset, the proposed method helps reduce the cost of experiments. For each problem, a set of numerical examples is presented. Conclusions The method provides a guarantee on how well the inferred graph structure represents the underlying system, reveals deficiencies in the data and model, and suggests experimental directions to remedy the deficiencies. [ABSTRACT FROM AUTHOR]

This paper presents results of analyses of body burdens of metals and hydrocarbons, and taste tests for taint, in Iceland scallop and American plaice performed as part of the Environmental Effects Monitoring (EEM) program for the Terra Nova offshore oil development (Grand Banks of Newfoundland, Canada). Scallop and plaice were collected in a Study Area located within approximately 1 km of drill centres at Terra Nova and in a Reference Area located approximately 20 km from the development. Samples were collected in 1997 to establish a baseline, and from 2000 to 2010, during drilling periods. Scallop adductor muscle tissue was contaminated with >C 10 –C 21 aliphatic hydrocarbons resembling the drilling fluid in the synthetic drilling mud (SBM) used at Terra Nova in 2000, 2002 and 2004, but contamination of adductor muscle was not noted in 2006, 2008 and 2010. The maximum concentration in muscle was 28 mg/kg wet weight, noted in 2002. Scallop viscera was contaminated with hydrocarbons resembling drilling fluid in SBMs near drill centres in all EEM years except 2010. Viscera contamination with >C 10 –C 21 hydrocarbons gradually decreased from a maximum of 150 mg/kg in 2000, to a maximum of 27 mg/kg in 2008; all values were below the laboratory reporting detection limit of 15 mg/kg in 2010. Therefore, evidence from both muscle and viscera indicates a decrease in tissue hydrocarbon contamination in recent years. Barium, another major constituent in drilling muds, has not been noted in scallop adductor muscles at concentrations above the reporting detection limit, but barium was detected in viscera in baseline and EEM years. The maximum concentration of barium in viscera during baseline sampling was 8 mg/kg. The maximum concentration in EEM years (29 mg/kg) was noted in 2000. The maximum concentration in 2010 was 25 mg/kg. The concentration of metals other than barium in scallop tissues was similar between the Terra Nova Study Area and the Reference Area. Hydrocarbons resembling the fluid in SBMs were noted in one American plaice liver sample collected near drill centres in 2000. Otherwise, there has been no evidence of project-related metals or hydrocarbon contamination in plaice liver or fillet samples. There has been no evidence of taint (off-taste) for scallop adductor muscle and plaice fillet tissue in baseline or EEM years. Combined with a parallel study on fish bioindicators at Terra Nova that showed that fish health at Terra Nova was similar to that at the Reference Area ( Mathieu et al., 2011 ), these results indicate little to no detectable biological effects on Iceland scallop and American plaice as a result of Terra Nova activities. [ABSTRACT FROM AUTHOR]

The article discusses gun rights, schools, and the constitutionality of the private universities' exemption from Nebraska's Concealed Handgun Permit Act. The U.S. Supreme Court case McDonald v. City of Chicago, which deals with guarantees of liberty under the Second Amendment to the nation's Constitution and state and federal regulations in America, is mentioned. State gun laws and decisions by U.S. federal courts are examined, along with the handgun-related case District of Columbia v. Heller.

Metastasis, the spreading of cancer cells from a primary tumor to secondary sites throughout the body, is the primary cause of death for patients with cancer. New therapies that prevent invasion and metastasis in combination with current treatments could therefore significantly reduce cancer recurrence and morbidity. Metastasis is driven by altered signaling pathways that induce changes in cell-cell adhesion, the cytoskeleton, integrin function, protease expression, epithelial-to-mesenchymal transition and cell survival. The ribosomal S6 kinase (RSK) family of kinases is a group of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) effectors that can regulate these steps of metastasis by phosphorylating both nuclear and cytoplasmic targets. However, our understanding of RSK function in metastasis remains incomplete and is complicated by the fact that the four RSK isoforms perform nonredundant, sometimes opposing functions. Although some isoforms promote cell motility and invasion by altering transcription and integrin activity, others impair cell motility and invasion through effects on the actin cytoskeleton. The mechanism of RSK action depends both on the isoform and the cancer type. However, despite the variance in RSK-mediated outcomes, chemical inhibition of this group of kinases has proven effective in blocking invasion and metastasis of several solid tumors in preclinical models. RSKs are therefore a promising drug target for antimetastatic cancer treatments that could supplement and improve current therapeutic approaches. This review highlights contradiction and agreement in the current data on the function of RSK isoforms in metastasis and suggests ways forward in developing RSK inhibitors as new antimetastasis drugs. [ABSTRACT FROM AUTHOR]

The article looks at the effect of various athletic footwear types on vertical jump and landing performance in male and female athletes. Subjects were evaluated for relative peak power in vertical, depth, and Bosco test jumps while wearing tennis shoes, minimalist footwear, or bare feet. The results indicated higher jump performance in bare feet or minimalist footwear without changes in impact forces.

The interaction of radiation with matter can cause activation or fission reactions producing unstable residuals that decay with the emission of delayed-neutron and/or delayed-gamma radiation. This delayed radiation can be exploited for a variety of purposes, including homeland security, health physics, instrumentation and equipment design, and nuclear forensics. Here we report on capability that has been developed to provide automated simulations of delayed-neutron and/or delayed-gamma radiation using MCNP6. We present new high-fidelity delayed-gamma simulation results for models based on the neutron-fission experiments conducted by Beddingfield and Cecil to illustrate and validate this powerful feature. [ABSTRACT FROM AUTHOR]

Abstract: The MCNP Monte Carlo radiation-transport code contains versatile capabilities to develop and plot geometries used in simulations. Although these capabilities have been available in MCNP since the late 1970s, many of the derivational details underpinning these capabilities are not contained in the MCNP manual and do not appear to have been documented in Los Alamos reports or the published literature. Derivations of many of the equations underlying the MCNP geometry transformation and geometry plot utility are presented here. Although this document does not include derivations of all of the expressions contained in MCNP, its contents should nevertheless provide the reader with a deeper understanding of the geometry transformation and plotting features than can be obtained using only the MCNP theory manual. [Copyright &y& Elsevier]

Incense burning is a common ritual in Asian communities both indoors in residential homes and outdoors in temple premises. Organic particles from burning of incense sticks, incense coils, and mosquito coils after extensive dilution (>1000×) were characterized by the Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS). The obtained mass spectra in general resemble those reported for biomass burning aerosols. Ion peaks with m/z values higher than 100 accounted for 15%–25% of the organic signals in the unit-mass-resolution (UMR) mass spectra. In the high-resolution (HR) mass spectra, the ion peaks at m/z 60 and 73 are found to be related to the sugar anhydrides as in particles from other biomass burning processes. In addition, the ion peaks at m/z 107, 121, 137, 151, 167, and 181, some of which (e.g., m/z 137 and 167) have been observed in particles from biomass burning but not yet assigned, were assigned to lignin-related components. Elemental analysis from the HR data reveals that a large portion of particulate organics from incense burning are oxygenated (O/C between 0.3 and 0.5) and unsaturated (and/or cyclic) in nature. Results from this study also highlight that mass spectra from HR-ToF-AMS measurements concerning primary emissions such as incense burning contain very useful information in the high m/z (>100) region about the chemical characteristics of those primary organic particles. Copyright 2012 American Association for Aerosol Research [ABSTRACT FROM PUBLISHER]

Abstract: A founding premise of the human genome project was that knowledge of the spectrum of abnormalities that comprise cancers and other human diseases would lead to improved disease management by identifying molecular abnormalities that could guide disease detection and diagnosis, suggest new therapeutic strategies and be developed as markers to predict response to therapy. This project led to elucidation of a reference normal human genome sequence and normal polymorphisms therein against which sequences from diseased tissues can be compared to enable identification of causal abnormalities. It also stimulated development of an array of computational tools for genomic analysis and catalyzed public and private sector development of revolutionary tools for genome analysis that transformed analysis of whole genomes from an enterprise that required international teams and hundreds of millions of dollars to a process that can be carried out in core facilities for only a few thousand dollars per sample. Indeed, the $1000 genome is nearly upon us. Applications of these technologies to human cancers in international cancer genome projects are now revealing the spectra of abnormalities that comprise thousands of individual cancers. Analyses of these data are leading to the promised improvements in disease management. We review several aspects of cancer genomics with emphasis on aspects that are relevant to improving cancer therapy. [Copyright &y& Elsevier]

The specification of the skeletal muscle lineage during craniofacial development is dependent on the activity of MYF5 and MYOD, two members of the myogenic regulatory factor family. In the absence of MYF5 or MYOD there is not an overt muscle phenotype, whereas in the double Myf5;MyoD knockout branchiomeric myogenic precursors fail to be specified and skeletal muscle is not formed. The transcriptional regulation of Myf5 is controlled by a multitude of regulatory elements acting at different times and anatomical locations, with at least five operating in the branchial arches. By contrast, only two enhancers have been implicated in the regulation of MyoD. In this work, we characterize an enhancer element that drives Myf5 expression in the branchial arches from 9.5 days post-coitum and show that its activity in the context of the entire locus is dependent on two highly conserved E-boxes. These binding sites are required in a subset of Myf5-expressing cells including both progenitors and those which have entered the myogenic pathway. The correct levels of expression of Myf5 and MyoD result from activation by musculin and TCF21 through direct binding to specific enhancers. Consistent with this, we show that in the absence of musculin the timing of activation of Myf5 and MyoD is not affected but the expression levels are significantly reduced. Importantly, normal levels of Myf5 expression are restored at later stages, which might explain the absence of particular muscles in the Msc;Tcf21 double-knockout mice. [ABSTRACT FROM AUTHOR]

A new palladium(II) catalyzed methodology for the direct synthesis of alkylidene isoindolinones from N-alkoxybenzamides is presented. Isoindolinone formation proceeds through a highly efficient and E-selective C–H activation/Heck/Aza-Wacker sequence. Substoichiometric amounts of benzoquinone can be employed in a cooperative oxidation system with O2, leading to facile purification of products. Modification of the reaction conditions provides a general route to substituted phthalimides by carbonylation with CO. Both systems were found to tolerate a wide range of functionality. [ABSTRACT FROM AUTHOR]

The following study was conducted in order to compare the modified single-seed descent method of selection used in soybean breeding at the Institute of Field and Vegetable Crops in Novi Sad, Serbia, with the standard bulk method and the pedigree method. The source materials for the development of hybrid populations were 15 genotypes, and a total of 10 cross combinations were made. Comparison of the lines developed by the different breeding methods was done in the F6 generation. Genetic gain from selection was taken as the main indicator of efficiency of the tested methods. The modified single-seed descent method produced the best results. In most cases, the mean values for seed yield of the populations developed by that method were significantly higher than the values shown in the populations developed by the other 2 methods. The advantages of using genetic gain as the indicator of breeding efficiency were clearly demonstrated when interpreting the results for seed yield and yield components. Populations possessing desirable traits were easier to perceive, which is exceedingly useful when breeding for a complex trait such as yield. [ABSTRACT FROM AUTHOR]

Priest, JW, Jones, JN, Conger, B, and Marble, DK. Performance measures of NCAA baseball tryouts obtained from the new 60-yd run-shuttle. J Strength Cond Res 25(10): 2872-2878, 2011-The ability to accelerate, decelerate, and change directions quickly is a well-known asset to athletic performance. Determination of basic movement skills may be accomplished by timing the athlete's ability to move through a prescribed course. The purpose of this investigation was (a) to describe and compare 4 distinct segments of a new agility test called 'JJ Shuttle,' and (b) to describe the agility and kinetic factors obtained from young men (age 18-22 years) who were competing for a limited number of positions on the National Collegiate Athletic Association Division II team. Speed calculations allowed for comparisons between and among shuttle segments and, when considered with body mass, permitted calculation of an energy of motion represented by the kinetic factor (K-factor). Sorting of shuttle times identified the fastest athletes and revealed that they do not necessarily have the highest K-factor. Similarly, highlighting performances by K-factors identified athletes who may be able to contribute more by a particular combination of speed and size. Furthermore, rare individuals who might have both attributes stand out to the coach by employing sorting and ranking, all within the capabilities of Microsoft Office Excel(R) 2007. These performance measures and calculations obtained from the agility test may provide the coach or trainer with valuable insight into movement skills and potential contribution of the individual athlete to the success of the team. This information is critical in preseason assessments to help decide who makes the team and to evaluate progress within and between competitive seasons. [ABSTRACT FROM AUTHOR]

The article presents the results of a study which investigated the usefulness of a 60-yard run-shuttle test in determining the kinetic abilities and agility of young men competing for positions on the National Collegiate Athletic Association Division II baseball team. An overview of related evaluation methods is provided, along with details of the test.

Fish recruitment can vary by an order of magnitude between years, and the larval stage is a key determining factor. Zooplankton, the main source of larval food, are temporally and spatially heterogeneous, and this could contribute to recruitment variability and ultimately stock sustainability. Here we use simple stochastic models of larval growth and zooplankton dynamics, together with an evolutionary algorithm, to investigate the role of transient peaks in zooplankton abundance and the match/mismatch hypothesis in recruitment success and variability. We draw four main conclusions. (i) Stochasticity in individual growth is more beneficial to recruitment when larvae experience high food availability early on in their growth. (ii) When the timing of peak prey abundance is stochastic, recruitment probabilities are greatest for hatching days just before the expected timing of peak prey abundance. (iii) When the timing of periods of high prey density is held fixed, the evolved optimum hatching day becomes earlier as the length of the high density period increases. (iv) When both the timing and length of the periods of high density are allowed to (co-)vary, we find no evidence of strong selection pressure for specific hatching days, only for a hatching “window” around the expected prey peak. [ABSTRACT FROM AUTHOR]

Abstract: The neuropeptide Y family of peptides is implicated in the regulation of feeding across a broad range of animals, including insects. Among vertebrates, neuropeptide Y exerts its actions mainly centrally, whereas peptide YY and pancreatic polypeptide arise from digestive tissues. Among invertebrates, neuropeptide F (NPF) is the sole counterpart of the NPY family. Shared features of NPF sequences derived for Lepidoptera indicate that the midgut peptide (Hez-MP-I) of the corn earworm, Helicoverpa zea, characterized more than a decade ago, is a carboxyl fragment of a full-length NPF. An antibody to Hez-MP-I was used to characterize the peptide''s distribution in tissues of larvae, pupae, and adults. Immunostaining demonstrated NPF-related material both in nervous tissues and in abundant endocrine cells of the midgut. Radioimmunoassay of Hez-MP-I in the head, midgut and hemolymph of fifth instar larvae revealed concentration changes corresponding to development and feeding state. As with the vertebrate homologs, NPF may arise both centrally and peripherally to modulate the physiology of feeding and digestion of Lepidoptera. [Copyright &y& Elsevier]

The article presents an exploration into the history of African American Blues music in Texas, focusing on the development of the oil patch song genre. Accounts are given describing the employment opportunities which existed for African Americans in the oil fields of Texas at the beginning of the 20th century and the development of the music tradition which grew out from it. Analysis of the common features and tropes seen in the songs is provided. Notable figures in the genre are also profiled, including Blind Lemon Jefferson, Walter Davis, and Amédé Ardoin.

N-Ts and N-Boc derivatives of 1,2-diamines and 1,2-amino alcohols are shown to undergo efficient Pd(II)-catalyzed aza-Wacker reactions with a large range of electron-deficient alkenes. The resulting enamine intermediate generally undergoes cyclization with the second heteroatom to form 1,3-heterocycles. The sequence facilitates the rapid synthesis of saturated oxazolidines, imidazolidines, and their derivatives. Use of N-l-valinol derivatives results in highly diastereoselective reactions, where the net stereochemical outcome diverges between N-Ts and N-Boc. [ABSTRACT FROM AUTHOR]

This paper analyses the Indian National Family Health Survey (2005-2006) data to present certain broad descriptive features of child health inequalities in India and their distribution across well-defined socio-economic groups classified by gender and sector-of-origin, and their dispersal across space. This study finds that poorer sections of the population are beleaguered with ill health whether in the quest for child survival or due to anxieties pertaining to child nutrition. The concentration index value for the indicators of under-five mortality, full immunisation and underweight outcomes at the national level is calculated to be -0.159, 0.204 and -0.158, respectively. The other disturbing finding here is that there are reigning regional and gender disadvantages irrespective of the developmental status of the State. This study would not only help policymakers to recognise these persistent inequalities but also would help understand health performance at the state and regional levels thus facilitating targeting intervention. [ABSTRACT FROM AUTHOR]