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New Heteroannulation Reactions of N-Alkoxybenzamides by Pd(II) Catalyzed CâH Activation.
- Source :
-
Organic Letters . Oct2011, Vol. 13 Issue 19, p5326-5329. 4p. - Publication Year :
- 2011
-
Abstract
- A new palladium(II) catalyzed methodology for the direct synthesis of alkylidene isoindolinones from N-alkoxybenzamides is presented. Isoindolinone formation proceeds through a highly efficient and E-selective CâH activation/Heck/Aza-Wacker sequence. Substoichiometric amounts of benzoquinone can be employed in a cooperative oxidation system with O2, leading to facile purification of products. Modification of the reaction conditions provides a general route to substituted phthalimides by carbonylation with CO. Both systems were found to tolerate a wide range of functionality. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 13
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 66287263
- Full Text :
- https://doi.org/10.1021/ol202187h