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Drawing inspiration from the recent trend of Sauce-Flavored Latte, this paper ingeniously explores the dual narrative of "wine meets coffee", unraveling the anthropomorphic tale of ethanol and caffeine. Delving into their chemical properties, physiological mechanisms, and metabolic pathways, the narrative aims to enlighten readers about the underlying chemistry and health implications, enabling a more informed and moderate consumption of beverages. [ABSTRACT FROM AUTHOR]

[Purpose/Significance] This study aims to analyze the mechanism of collaborative knowledge management capability on the innovation of new think tank smart services, clarify the internal driving force and main methods of providing innovative new think tank smart services, and uncover the internal role "black box" of innovation in new think tank smart services from the perspective of collaborative knowledge management, in order to enhance the innovative new think tank smart services. The contribution of the article lies in the construction of a model for understanding the role of collaborative knowledge management capability in providing the innovative new think tank smart services. The impact of collaborative knowledge management capability on the innovation of new think tank smart services is a complex dynamic process that requires continuous investment of multiple forces and energy. Through system dynamics simulation, it is possible to observe which key factors should be emphasized in long-term development, providing reference basis for organizational development. [Method/Process] This article takes knowledge ecology as the theoretical support, analyzes the composition of collaborative knowledge management capability and its mechanism of action on innovative smart services in new think tanks, and uses system dynamics methods to construct a model of the effect of collaborative knowledge management capability on innovative smart services in new think tanks. It simulates and analyzes the dynamic changes in the impact of each capability on innovative smart services, providing reference for the development of innovative smart services in new think tanks, simultaneously expanding the research perspective of new think tank smart services. [Results/Conclusions] The results show that collaborative knowledge ability, collaborative supporting ability and collaborative management ability have different effects on the smart service innovation of new think tanks, and collaborative knowledge ability is the key factor affecting the smart service innovation level of new think tanks. This article cannot cover all collaborative knowledge management capabilities in the classification of collaborative knowledge management capabilities. In the future research, it is necessary to explore their impact on the innovation of new think tank smart services from a more comprehensive and representative perspective. [ABSTRACT FROM AUTHOR]

With the deepening of the research on emotion labor in the world, teachers' emotion labor has gained more and more researchers' attention. From the perspective of the mechanism of emotion labor, most of the research themes focus on the influencing factors, effects and regulation strategies of teachers' emotion labor. From the perspective of theory, the research on teachers' emotions has undergone the transformation from psychology to sociology and then to pluralism, and the research methods have gradually transited from the initial quantitative measurement to the qualitative analysis and finally to the hybrid research method. In general, the development of the research on teachers' emotion labor presents a trend of constantly enriching theoretical perspectives, expanding research scope, extending research content and integrating research methods, which researchers should pay more attention to. [ABSTRACT FROM AUTHOR]

Objective · To investigate the prospective value of early postoperative PI-APD in children with hydronephrosis. Methods · Data of children with hydronephrosis who underwent pyeloplasty in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine between Jan 2012 to Nov 2015 was collected. PI-APD was divided into 3 categories (≤ 19%, 19%

Aiming at the problem that machine adjustment time was ignored in green workshop scheduling, the energy consumption and makes-pan of machine were studied in the adjustment mode and processing mode. The characteristics of energy consumption and completion time of machine were summarized in different modes . A green and flexible workshop scheduling with adjustment time was established, and the weighted normalization method was used to unify the multi-objective dimensions of this mode. The multi-layer coding method was adopted to optimize the machine selection and process sequencing problems; the iterative method of generating new solutions on the basis of the old solutions and filtering the better solutions with data analysis methods was introduced to enhance the local and global search capabilities. The benchmark cases and production examples were tested on the MATLAB simulation platform. The research results show that the scheduling scheme based on the improved brainstorming optimization algorithm is feasible and effective, the algorithm has higher convergence accuracy and faster convergence speed. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical value of continuous bispectral index monitoring (BIS) for the diagnosis and evaluation of disease severity of sepsis-related encephalopathy. Methods: Ninety-eight patients with sepsis treated in the ICU ward from January 2015 to June 2018 were selected, including 38 patients with sepsis-related encephalopathy (encephalopathy group) and 52 patients with related encephalopathy (Non-encephalopathy group). All the patients underwent continuous BIS monitoring for 24 hours after admission to the ICU, and the serum PCT and S100β levels of the two groups were compared between and after treatment, the correlation between BIS and Glasgow Coma Scale (GCS) and APACHE-II were also analyzed. Results: The levels of PCT and S100β in serum and the acute physiology and chronic health evaluation II score (APACHE-II) in patients with encephalopathy group were significantly higher than those in the non-encephalopathy group (P<0.05). The BIS and GCS scores in the encephalopathy group were significantly lower than those in the non-encephalopathy group (P<0.05). The BIS value of the patients with sepsis encephalopathy was positively correlated with the GCS score (r=0.487, P=0.013); the BIS value was negatively correlated with the APACHE-II score. (r=-0. 682, P=0.027). Conclusion: BIS monitoring is helpful for the early diagnosis of sepsis-related encephalopathy. Combined with the detection of serum PCT and S100 βlevels may be helpful to evaluate the disease severity. [ABSTRACT FROM AUTHOR]

The standardized training of residents in the Department of Ultrasound Medicine plays a key role in the continuing education of medical students and specialists after graduation. In recent years, as graduate students, the students who have just graduated and also social people are included in the standardized training of residents in the Department of Ultrasound Medicine, they have encountered some problems, such as uneven quality of trainees, lack of individualization of training Objectives, insufficient methodology for implementation and management, etc. This paper discusses the specific contents of the construction of standardized training system in the Department of Ultrasound Medicine, including cultural construction, curriculum construction, process assessment, and faculty development and so on. We can create our own characteristics in the standardized training of residents in the Department of Ultrasound Medicine through measures such as integrating curriculum and other resources, optimizing the application, perfecting and strictly implementing the training and assessment system, paying more attention to the capacity building of teachers, good working environment in the department and humanistic care, so as to lay the foundation and provide experience for the construction of a standardized training management system for ultrasound doctors in the future. [ABSTRACT FROM AUTHOR]

The theory of traditional Chinese medicine believes that children’ s shaoyang constitution affects the evolution of disease. “Shaoyang dominating bone” highly summarizes the pathogenesis of bone disease, and children’ s bone tumor presents typical shaoyang pathogenesis characteristics in many aspects. Therefore, this paper combined the theory of “shaoyang dominating bone” with shaoyang as the pivot, shaoyang meridians circulation, the gallbladder having the nature of stiff, shaoyang’s qi being fire in nature and manifested as yang, corresponding to a high incidence in joints, bone marrow, soft tissue, or a wide range in children’s bone tumor, explained the mechanism of shaoyang effects bone strength, cold or heat syndrome, pathological type and metastasis, and elucidated the guiding significance of shaoyang in the pathogenesis of children bone tumor preliminarily. [ABSTRACT FROM AUTHOR]

Objective To compare swab sampling method with tissue sampling method to determine whether diabetic foot (DF) were infected pathogenic bacteria and to determine the consistency of pathogenic microorganism by using Meta-analysis method. Methods Relevant literatures were retrieved from PubMed, Embase, The Cochrane Library, CBM, CNKI, VIP and Wanfang Data until March 25, 2021. Two independent researchers evaluated the included literatures and extracted the data to analysis, RevMan5.3 and STATA13 software were used to calculate the sensitivity (Sen) and specificity (Spe) of the swab sampling methods to determine whether DF were winfected pathogenic bacteria and the consistence of the pathogenic microorganisms, and subgroup analysis was conducted according to the depth of infection. To compare the difference between the two methods, t test was used to analyze the number of pathogens and Chi-square test was used to analyze the classification of Gram stain typing. Results A total of 725 samples from 6 studies were included. In the evaluation of swab sampling method to determine whether DF infected pathogenic bacteria, the combined SEN=0.94 [95%CI (0.82-0.98)], the combined SPE=0.59 [95%CI(0.33-0.81)]. While the combined SEN=0.71 [95%CI (0.46-0.87)], the combined SPE=0.28 [95%CI (0.14-0.49)], AUC=0.45 [95%CI (0.41-0.60)], when swab sampling method was used to determine pathogenic microorganisms. In the subgroup analysis, the sensitivity of the shallow infection group was higher than that of the deep infection group. There was no significant difference between the two sampling methods in the number of pathogens obtained by Gram stain typing. Conclusions Swab sampling is of high diagnostic value in determining whether pathogenic bacteria are infected, but its accuracy in identifying DF infection of pathogenic microorganisms is poor. Swab sampling method cannot completely replace tissue sampling method. [ABSTRACT FROM AUTHOR]

Complex fracture technology is one of the keys to the successful development of unconventional oil and gas reservoirs such as shale. At present, most studies focus on how to improve the complexity of fracture network. It is still unclear whether proppant can enter branch fractures at all levels after the complex fractures are formed. Numerical simulation and indoor experiments provide some qualitative results, but there are still lack of quantitative models. Thus, the liquid distribution model and the proppant turning law were proposed to predict the proppant transportation behavior in the complex fractures. The results show that the prediction accuracy of this model is higher than that of previous ones. In addition, the influence of branch fracture angle on the liquid distribution is discussed. Finally, an engineering case is studied with this model, and some suggestions are provided for the fracturing parameter optimization. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect on renal autophagy activity of cystinuria rat models. Methods: 24-hour urine was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS) to confirm high content of cystine in urine. IHC was con- ducted to make sure no stone formatted and no obvious organizational changes. Masson staining of kidney tissue sections was done to detect renal fibrosis level and to evaluate degree of kidney damage. Expression of autophagy marker, LC3-I, LC3-II, p62 and mTOR protein was, measured by Western blotting to detect changes in the pathway of autophagy and the reason of variations. Results: The urinary cystine of 10 cystinuria rats obtained was significantly higher than those of the wild type group rats, and the generation of cystine stones was not detected. Masson staining suggested that mild renal fibrosis was found in cystinuria rats. The relative expression of LC3-I, LC3-II and p62 proteins and the LC3-II/LC3-I ratio in the kidney tissues of stone-free cystinuria rats were significantly lower than those of the wild type group rats. Expression of mTOR raised significantly. All those differences were statistically significant (P<0.05). Conclusions: Cystinuria rats inhibited renal autophagy activity significantly by upregulating mTOR level, and hence lead decreasing of self-protection to the kidney, even without stone formation. And inhibited autophagy activity may involve in the process of kidney damage in cystinuria. [ABSTRACT FROM AUTHOR]