持续脑电双频指数监测在脓毒症相关性脑病患者中的应用价值.

Objective: To investigate the clinical value of continuous bispectral index monitoring (BIS) for the diagnosis and evaluation of disease severity of sepsis-related encephalopathy. Methods: Ninety-eight patients with sepsis treated in the ICU ward from January 2015 to June 2018 were selected, including 38 patients with sepsis-related encephalopathy (encephalopathy group) and 52 patients with related encephalopathy (Non-encephalopathy group). All the patients underwent continuous BIS monitoring for 24 hours after admission to the ICU, and the serum PCT and S100β levels of the two groups were compared between and after treatment, the correlation between BIS and Glasgow Coma Scale (GCS) and APACHE-II were also analyzed. Results: The levels of PCT and S100β in serum and the acute physiology and chronic health evaluation II score (APACHE-II) in patients with encephalopathy group were significantly higher than those in the non-encephalopathy group (P<0.05). The BIS and GCS scores in the encephalopathy group were significantly lower than those in the non-encephalopathy group (P<0.05). The BIS value of the patients with sepsis encephalopathy was positively correlated with the GCS score (r=0.487, P=0.013); the BIS value was negatively correlated with the APACHE-II score. (r=-0. 682, P=0.027). Conclusion: BIS monitoring is helpful for the early diagnosis of sepsis-related encephalopathy. Combined with the detection of serum PCT and S100 βlevels may be helpful to evaluate the disease severity. [ABSTRACT FROM AUTHOR]