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Wanxiang 22S is a fragrant thermosensitive genic male sterile line that was crossbred and bred by the Rice Research Institute of Anhui Academy of Agricultural Sciences using 1892S as the female parent and Changxiang 39S, a fragrant indica rice parent introduced by Hunan Xiangsui Seed Industry Co., Ltd., as the male parent. It was approved by Anhui Provincial Technical Appraisal in August 2023. The height of Wanxiang 22S plant is 85. 0 cm, with an average total number of spikelets per spike of 193. 5 and a thousand grain weight of 24. 0 g. The plant exhibits a compact growth habit with strong tillering ability. Its leaves are upright and curly, emitting a fragrance. Fertility identification in a cold water pool is conducted under conditions of 14. 5 h, 23. 5 ℃, 6 d, with a pollen sterility of 99. 95% and a bagged self-pollination rate of 0. 25%. Wanxiang 22S was sown on May 20th in Hefei, with a sowing period of 84 days, which was about 5 days shorter than the similar variety Changxiang 39S. The main stem had 13. 2 leaves. The stigma exposure rate were outcrossing rate are relatively high,good resistance to rice blast, rice smut and bacterial blight. The rice quality was relatively good. The hybrid combination has strong heterosis, among which Wanxiang 22S / Yingyue Simiao increased yield by 9. 35% compared to Fengliangyou No. 4 in the community advantage identification in 2023, reaching a extremely significant level. [ABSTRACT FROM AUTHOR]

In ultracold Fermi gases, by adjusting the strength of spin orbit coupling to match Fermi energy, many novel quantum effec ts can be genera ted. In the pas t few decades, scholars have conducted extensive theoretical and experimental research on Fermi gases induced by one-dimensional spin orbit coupling. Compared with high-dimensional spin orbit coupling, one-dimensional spin orbit coupling, although relatively simple, is the most reliable and feasible tool for exploring basic quantum physical phenomena in experiments. This paper systematically summarizes the interesting physical phenomena of Fermi gas under one-dimensional spin orbit coupling in theoretical work. Including theoretical research on dynamic oscillation and soliton effect, topological superfluid, Majorana edge state, ferromagnetic phase transit ion, and quantum phase. How to achieve spin orbi t coupling and observe singular phenomena in exp erime nts is a hot and difficult research topic. We summarize several common experimentai schemes and detection met hods. Finally, we look forward to the research on Fermi gas induced by onedimensional spin orbit coupling. One dimensional spin orbit coupling can provide reference for abecedarians and contribute to the study of multi body system regulated by spin orbit coupling. This paper aims to provide a reference for abecedarians in cold atomic physics to gain a deeper understanding of the physical mechanisms of multi-body systems under spin orbit coupling. [ABSTRACT FROM AUTHOR]

[Objective] The aims of this study are to investigate the specific improvement effects of different additions of straw and biochar on the sloping arable land of purple soil, so as to provide theoretical references for the reasonable prevention and control of soil erosion in the Three Gorges Reservoir area. [Methods] The effects of rice straw (4, 7, 10 t/hm²) and biochar (13,39,65 t/hm²) on sediment yield and nitrogen loss in purple soil slope were studied by artificial rainfall simulation method, with bare slope as the control. [Results] (1) Under the condition of high intensity rainfall, the mixture of biochar with purple soil accelerated the process of runoff production on slope, and the application of mixed straw could prolong the initial time of runoff production and reduce the rate of runoff production. (2) The cumulative sediment yield of purple soil increased by 0.64%~66.29% compared with the control group after adding biochar, but decreased by 42.58%~70.27% after adding mixed straw. The inhibitory effect of mixed straw on sediment yield on slope was much stronger than that on runoff yield on slope. (3) The nitrogen loss process in surface runoff was dominated by NO-3-N, and the overall loss moduli of TN, NO3-N and NH+4-N were the largest under biochar treatment, and the smallest under mixed straw treatment. [Conclusion] The application of crushed straw can promote seepage and inhibit flow, effectively control soil, water and nutrient loss in purple slope farmland, while the short-term application of biochar may have negative effects. [ABSTRACT FROM AUTHOR]

BACKGROUND: Exercise is an effective method for preventing and treating osteoporosis, but it is unclear whether its effect on postmenopausal osteoporosis is related to changes in bone autophagy levels. OBJECTIVE: To observe the effects of exercise via cellular autophagy on the morphology and mechanical properties of bone tissue in ovariectomized rats, and to explore the mechanism of exercise on bone mass in ovariectomized rats from the perspective of autophagy. METHODS: A rat model of postmenopausal osteoporosis was established, and a 24-week moderate-intensity exercise was used for intervention. After the experiment, serum estradiol levels were measured by ELISA, and bone mineral density and bone microstructure of the cortical and trabecular bone were detected by micro-CT. The biomechanical indicators of the tibia were tested by a three-point bending test. Autophagosomes were observed by transmission electron microscopy. The expression of LC3 and ATG7 proteins was analyzed by western blot. RESULTS AND CONCLUSION: The serum estradiol level in the ovariectomized group was significantly lower than that of the sham-operation group and ovariectomized+exercise group (P < 0.01). The body mass of rats in each group increased, and the order was the ovariectomized group > the ovariectomized+exercise group > the sham-operation group > the sham-operation+exercise group. The bone mineral density and bone mass of rats in all groups significantly increased (P < 0.01), but the increase in the ovariectomized group was significantly lower than that of the other groups, and the increase in the ovariectomized+exercise group was significantly higher than that of the ovariectomized group. Compared with the sham-operation group, the bone mineral density of the tibial cancellous bone in the sham-operation+exercise group was significantly increased (P < 0.01), while the bone mineral density in the ovariectomized and ovariectomized+exercise groups was significantly decreased (P < 0.01). Compared with the ovariectomized+exercise group, the ovariectomized group showed significantly lower bone volume fraction, number of trabeculae, and bone mineral density of cancellous bone (P < 0.05), extremely significantly lower trabecular thickness (P < 0.01), and significantly higher mean trabecular pattern factor, trabecular separation, and structural model index (P < 0.01). Compared with the ovariectomized group, the LC3-II/LC3-I ratio and the relative expression of ATG7 protein significantly increased in the ovariectomized+exercise group (P < 0.05). Compared with the sham-operation and ovariectomized groups, the number of autophagosomes increased in the sham-operation+exercise and ovariectomized+exercise groups, respectively. To conclude, moderate-intensity treadmill exercise can improve the bone microstructure and biomechanical properties of the tibial cancellous bone and increase bone mass in ovariectomized rats by increasing serum estradiol levels and bone autophagy levels. [ABSTRACT FROM AUTHOR]

In order to screen lactic acid bacteria strains that can be applied as feed additives for fragrant pigs, this experiment isolated and screened a lactic acid bacteria strain with strong acid production ability, good stress resistance, and antibiotic sensitivity from the cecum content of fragrant pigs using 1% calcium carbonate MRS solid culture medium. After Gram staining, physiological and biochemical identification, and 16S rRNA sequencing, the lactic acid bacteria were identified as L. plantarum. Further analysis was conducted on the isolated L. from aspects such as acid production L. performance, acid resistance test, heat resistance test, bile salt resistance test, and antibiotic sensitivity test Plantarum conducts research on biological characteristics. The results indicate that L The optimal temperature for plantarum growth is 37-45 °. L. Plantarum has excellent acid production ability, with a minimum pH of 3.3. L. Plantarum can tolerate low pH and has a survival rate of 13% at a pH of 2.0. The survival rate in MRS broth containing 0.4% pig bile salt was 13%. L. Plantarum is highly sensitive to erythromycin, compound sulfamethoxazole, chloramphenicol, penicillin, ampicillin, and cefazolin. From this, it can be seen that L. Plantarum is a backup strain of probiotics derived from fragrant pigs with excellent stress resistance, an‐ tibiotic sensitivity, and acid production efficiency. [ABSTRACT FROM AUTHOR]

AIM: To evaluate the effect of astaxanthin (AST) on cognitive function of intestinal ischemia/reperfusion (I/R) injury in rats and the role of autophagy. METHODS: Eight-week-old SPF-grade male Sprague-Dawley (SD) rats were randomly divided into sham group, I/R group, AST group and AST+3-methyladenine (3-MA) group, with 12 animals in each group. The superior mesenteric artery (SMA) of the rats in sham group was only exposed without clamping. The SMA in other 3 groups was clamped for 90 min, and then the arterial clamp was released to restore blood supply and perform reperfusion, thus establishing the intestinal I/R model. The rats in AST group were intraperitoneally injected with AST (45 mg·kg−1 ·d−1 )3 d before modeling, and those in AST+3-MA group were intraperitoneally injected with AST (45 mg·kg−1 ·d−1 )+3-MA (1. 5 mg·kg−1 ·d−1 )3 d before modeling. Morris water maze was used to evaluate the cognitive function of rats 48 h after surgery. Hematoxylin-eosin (HE) staining was used to evaluate intestinal tissue damage. Nissl staining of the frontal cortex was used to evaluate neuronal damage. The levels of interleukin-6(IL-6), IL-1β and tumor necrosis factor-α(TNF-α) in the frontal cortex and hippocampus were measured by ELISA kits. The protein levels of beclin-1, microtubule-associated protein 1 light chain 3(LC3) and P62 in the frontal cortex and hippocampus were detected by Western blot. RESULTS: Compared with sham group, the swimming distance of rats in I/R group was increased, with prolonged latency, elevated Chiu's score and decreased number of neurons (P<0. 01), while the levels of IL-6, IL-1β and TNF-α in the frontal cortex and hippocampus were increased (P<0. 01). Beclin-1 expression and LC3-II/LC3-I ratio in the frontal cortex and hippocampus were increased (P<0. 05 or P<0. 01). Compared with I/R group, the swimming distance and latency of rats in AST group were shortened, with decreased Chiu's score, increased neuronal number (P<0. 01), decreased IL-6, IL-1β and TNF-α levels in the frontal cortex and hippocampus (P<0. 01), and increased beclin-1 expression and decreased of P62 expression in the frontal cortex and hippocampus (P<0. 05 or P<0. 01). Compared with AST group, the swimming distance of rats in AST+3-MA group was increased, with prolonged latency, elevated Chiu's score, decreased number of neurons (P<0. 05), increased levels of IL-6, IL-1β and TNF-α in the frontal cortex and hippocampus, and decreased beclin-1 expression and LC3-II/LC3-I ratio and increased P62 expression in the frontal cortex and hippocampus (P<0. 01). CONCLUSION: Astaxanthin alleviates intestinal I/R-induced cognitive impairment in rats by promoting autophagy and inhibiting neuroinflammation. [ABSTRACT FROM AUTHOR]

Objective To understand the relationship between different lifestyles and the formation of fatty liver, and to provide a scientific basis for the prevention of fatty liver. Methods A total of 15 858 physical examination subjects who had no history of fatty liver in the hospital in 2018 were selected as the study objects. A retrospective cohort study was adopted, questionnaire survey and physical examination data were extracted, and Chi-square and logistics regression analysis were used to statistically analyze the influence of different lifestyles on the formation of fatty liver after two years of follow-up. Results The cumulative incidence of fatty liver was 8. 1%, the incidence of male was higher than that of female, the difference was statistically significant(P <0.05), and the incidence of fatty liver increased with the increase of age. The results of univariate analysis showed that men, frequent consumption of high fat, infrequent consumption of milk and soy products, excessive intake of sugar-sweetened beverages, short or long sleep time, smoking and drinking were prone to fatty liver disease(P <0.05). logistics regression analysis shows that high-fat diet and excessive intake of sugary drinks were risk factors for fatty liver(P <0.05), and exercise was a protective factor for fatty liver(P <0.05). Conclusion Keeping a light diet, reducing the intake of sugary drinks and strengthening exercise in daily life can reduce the occurrence of fatty liver. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation between serum protein 16（CC16), soluble advanced glycation end product receptor (sRAGE) and the disease outcome in patients with acute respiratory distress syndrome（ARDS) and their predictive value. Methods A total of 127 ARDS patients admitted to the Second People′s Hospital of lingbao city from January 2021 to January 2023 were selected as the research objects, and the patients were divided into the mild group（39 cases), the moderate group（52 cases) and the severe group（36 cases) according to the severity of ARDS. The levels of serum CC16, sRAGE, oxygenation index（PaO2/FiO2), acute physiology and chronic health status Ⅱ（APACHEⅡ) scores and sequential organ failure assessment（SOFA) scores were compared between patients with different severity and patients with different disease outcomes, and the correlation between serum CC16, sRAGE levels and PaO2/FiO2, APACHEⅡ scores, SOFA scores and disease outcomes was analyzed. Logistic regression was used to analyze the risk factors of ARDS patients′ death, and ROC curve was used to analyze the predictive value of combined detection and each individual of serum CC16 and sRAGE levels for ARDS patients′ death. Results Comparison of serum CC16, sRAGE levels, and APACHEⅡ, SOFA scores of patients with different degrees of ARDS at admission: the mild group ＜ the moderate group ＜ the severe group, PaO2/FiO2 comparison: the mild group ＞ the moderate group＞ the severe group, the differences were all statistically significant（P＜0. 05); Serum CC16, sRAGE level, and APACHEⅡ, SOFA scores of the dead patients were higher than those of the surviving patients, and PaO2/FiO2 was lower than that of the surviving patients, and the differences were all statistically significant（P＜0. 05); Serum levels of CC16 and sRAGE were negatively correlated with PaO2/FiO2 on admission, and were positively correlatied with APACHEⅡ, SOFA scores, and disease outcome（P＜0. 05). Serum CC16 and sRAGE levels at admission were risk factors for mortality in ARDS patients. Moreover, the ROC area under the curve of combined detection of two index of the ARDS patients was greater than that of each individual index（P＜0. 05). Conclusion The expression of serum CC16 and sRAGE in ARDS patients is up-regulated, which is closely related to disease outcome, and can be used as an effective indicator for early clinical predictive to outcome. [ABSTRACT FROM AUTHOR]

Aiming at the problems of low model accuracy and poor noise resistance in the traditional damage identification methods for rotating machinery, a multi working condition damage identification method for rotating machinery based on composite multi-scale attention entropy (CMATE) and random forest(RF) was proposed. Firstly, a new nonlinear dynamic tool—composite multi-scale attention entropy, was proposed to measure the complexity of time series. Then, the damage characteristics of vibration signals of rotating machinery were extracted by CMATE to characterize the dynamic characteristics of rotating machinery under different working conditions. Then, the damage features were input into a multi category classifier based on random forest to identify the damage. Finally, three types of rotating machinery datasets, rolling bearings-gearboxes, gearboxes and centrifugal pumps, were used to construct multi-scale condition damage datasets for 9 working conditions and 20 working conditions respectively, and experimental research was conducted on the damage identification method. The results show that the method achieves the recognition accuracy of 95%, 97% and 100% respectively, which is superior to other nonlinear dynamics tools in accuracy and feature extraction efficiency. Moreover, it still achieves good damage recognition results under the noise interference of 0 dB, 1 dB, 2 dB and 3 dB with different signal-to-noise ratios, which proves that the model has remarkable anti-noise property. At the same time, the damage identification method can stably identify the damage of rotating machinery under different loads and speeds, with an average recognition accuracy of 97. 2 % and 93. 5 %, respectively, which has application potential. [ABSTRACT FROM AUTHOR]

The ecological stoichiometry of fine root carbon(C), nitrogen(N), and phosphorus(P)is considered to reflect the strategies whereby plants adapt to the soil environment. In order to gain an understanding of the seasonal variation in fine root C:N:P ratios in different forest types of karst ecosystem, we measured the C, N, and P contents and ratios of living and dead fine roots in shrubland and arbor forest, as well as the influence of abiotic and biotic factors. The results were as follows:(1)C, N, and P contents in the fine roots of arbor forest were higher than those of shrubland, thereby indicating that the fine roots of arbors may by characterized by a stronger absorption and storage of nutrients than those of shrubs. In addition, the contents of C in living fine roots were significantly higher than those in dead fine roots(P<0.05), but N and P contents in living fine roots were lower than those in dead fine roots.(2)It was found that the contents of C in the living and dead fine roots of the two forest types were lower during the rainy season than during the dry season. The N and P contents of living fine roots of shrubs were higher during the rainy season than those in dry season, the opposite pattern was observed for the living fine roots of arbors. During the rainy season, the C:N, C:P, and N:P ratios of living fine roots in shrubland were lower than the values obtained during the dry season. Conversely, the C:N and C:P ratios of the living and dead fine roots of arbors were higher during the rainy season than in the dry season, whereas the values for the N:P ratio were lower during the rainy season than during the dry season. The lower N:P ratios of rainy season tended to indicate that plants in shrubland and arbor forest may be less P restricted during this season.(3)It was found that for both the living and dead fine roots of the two forest types, C contents were higher in trees growing on the upper slopes than in those growing on the middle and lower slopes, whereas the contents of N and P were higher in shrubs growing on the lower slopes and in arbors growing on the middle slopes. Furthermore, the C:N, C:P, and N:P ratios of living and dead fine roots were found to be relatively higher in shrubs growing on the upper slopes. In the case of arbor forest, the C:N ratios of living and dead fine roots in trees growing on the lower slopes were higher than other slopes, however the C:P and N:P ratios in trees growing on the upper slopes were higher than those of trees growing at other slopes, indicating that trees under these two forest types were strongly influenced by P limitation in the upper slopes, but only weakly affected on the middle and lower slopes.(4)Redundancy analysis revealed that forest type, available phosphorus, and season were the main factors influencing the contents and ratios of C, N, and P nutrients in fine roots, and could explain 18.8%, 6.6%, and 6.5% of the observed variation, respectively. These findings indicate that the effects of changes in the N:P ratio associated with differences in forest type, season, and slope should be taken into consideration when vegetation restoration is promoted, which will contribute to accelerating the restoration of karst ecosystems. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical effect of Guo's Bone Setting combined with Huoluo Gukang pills in the treatment of osteoporotic distal radius fracture.Methods A total of 86 patients with osteoporotic distal radius fracture admitted to our hospital from March 2021 to February 2023 were divided into the study group (with even serial number) and the control group (with odd serial number) according to the order of treatment, with 43 cases in each group.The study group was treated with Guo's bone setting manipulative reduction combined with Huoluo Gukang pill, and the control group was treated with Guo's bone setting manipulative reduction combined with Calci D3. Imaging indexes, pain status [visual analogue scale (VAS) score], recovery time, bone mineral density and incidence of adverse reactions were compared between the two groups.Results There were no significant differences in distal radial palmar angle, ulnar deviation degree, radius height, and VAS score between two groups before treatment and on the day of reduction (P＞0.05). The distal palmar angle, ulnar angle, and radius height of the study group were significantly increased at three months after reduction, while those of the control group were significantly decreased, with statistical significance (P＜0.05). After two weeks, one, and three months after manual reduction, the distal palmar angle and ulnar deviation of the radius in the study group were significantly higher than those in the control group, and the radius height was significantly higher than that in the control group, with statistical significance (P＜0.05). Compared with the day of reduction, VAS scores of two groups were significantly decreased at two weeks and one month after reduction, and VAS scores of two weeks and one month after reduction in the study group were significantly lower than the control group, with statistical significance (P＜0.05). The disappearance time of swelling, ecchymosis, and clinical healing time of fracture in the study group were significantly shorter than those in the control group, with statistical significance (P＜0.05). There was no significant difference in bone mineral density of greater trochanteric, femoral neck and Ward triangle between two groups before treatment (P＞0.05). Bone mineral density in all parts of the study group was significantly higher than that in the control group after treatment, and the differences were statistically significant (P＜0.05). The incidence of adverse reactions in the study group was significantly lower than that in the control group, with statistical significance (P＜0.05). Conclusion Guo's Bone setting combined with Huoluo Gukang pills can effectively improve the rehabilitation effect of osteoporotic distal radius fracture, shorten the rehabilitation time and improve bone mineral density without obvious adverse reactions, and it is a safe and effective treatment [ABSTRACT FROM AUTHOR]

This paper takes the rural tourism destinations announced by the Ministry of Agricul‐ ture and Rural Affairs and the Ministry of Culture and Tourism of China as samples, and uses the methods of nearest neighbor index, kernel density and geographic detector to explore the spatial distribution law and influencing factors of rural tourism destinations in China. The results show that: (1) China's rural tourism destinations exhibit the agglomeration characteristics of "more in the east and less in the west, more in the south and less in the north", and the difference between the east and the west is more significant than that between the north and the south. The agglom‐ eration increased gradually. Except for Xinjiang and Qinghai, the nearest neighbor index values of other provinces and cities were 0. 7 to 1. 2, which tended to be evenly distributed. (2) China's rural tourism destinations form a spatial distribution pattern of "two poles-two axes-multiple cores". Of the five types of rural tourism destinations, the leisure and sightseeing type has the highest proportion (33. 06%); and the type of cultural and folk customs has the lowest proportion (8. 28%). The driving factors for the spatial differentiation of the five types of rural tourism des‐ tinations are quite different, which is closely related to the resource endowment and location characteristics of the villages. (3) The spatial differentiation of rural tourism destinations is the result of the combined effect of factors such as the natural environment of the village, the level of social development, the potential of cultural resources, the level of regional facilities, the level of tourism investment, and the scale of the tourism market. The level of social development and the scale of the tourism market are the dominant factors, with explanatory power of 0. 64, 0. 62; factors such as altitude, hydrological conditions and traffic location have a significant negative correlation with the spatial distribution of rural tourism destinations [ABSTRACT FROM AUTHOR]

目的 探讨动机性访谈联合奥瑞姆自护模式对病毒性肝炎患者自我效能感、病耻感、应对方式 的影响。方法 选取濮阳市第五人民医院 2020 年 8 月至 2022 年 7 月收治的 108 例病毒性肝炎患者,按照随机 数字表法分为常规护理组 (54 例) 和联合护理组 (54 例)。两组患者均行对症的药物治疗,常规护理组给予常规 护理,联合护理组在常规护理基础上给予动机性访谈联合奥瑞姆自护模式。干预8周后,比较两组患者治疗依 从率、自我效能感[慢性病自我效能感量表 (CSES)]、病耻感[社会影响量表 (SIS)]、应对方式[医学应对方式问 卷 (MCMQ)]。结果 干预后,联合护理组患者治疗依从率 (98. 15%) 高于常规护理组 (83. 33%),差异有统计 学意义 (P<0. 05); 联合护理组 CSES 量表中疾病共性管理与疾病症状管理 2 个维度评分高于常规护理组,SIS 量表中社会隔离、社会歧视、自我羞耻感、经济歧视 4 个维度评分均低于常规护理组 MCMQ 中回避、屈服 2 个 维度评分低于常规护理组,面对维度评分高于常规护理组,差异均有统计学意义 (P<0. 05)。结论 动机性访谈联 合奥瑞姆自护模式能提高病毒性肝炎患者治疗依从性及自我效能感,促进其积极应对疾病,从而降低病耻感。 [ABSTRACT FROM AUTHOR]

Objective To investigate sodium hydrogen sulfide(NaHS) with function of regulating glutathione(GSH) synthesis to reduce reactive oxygen species(ROS) production in type 2 diabetic cardiomyopathy (DCM). Methods Mouse cardiomyocyte cell line HL-1 was incubated with high concentration of glucose (HG:40 mmol/L) and palmitate (Pal:500 μmol/L) as a cell model of type 2 DCM. HL-1 cells were incubated with NaHS (100 μmol/L), DL-propargylglycin(PPG,1 mmol/L) and N-acetyl-l-cysteine(NAC,5 mmol/L), respectively for 72 hours. The expression of cystathionine-γ-lyase(CSE) and the key enzymes of glutathione production was tested by Western blot. Dihydroethidium(DHE) and dichlorofluoromethane(DCFH) were used to detect the content of ROS in HL-1 cells. Cell viability was detected by CCK8 kit. The content of total GSH was detected. The interaction between muscle specific ring finger protein 1(Murf1) and nuclear factor erythroid-derived 2-related factor 2(Nrf2) and Nrf2 ubiquitylation was determined by co-immunoprecipitation(co-IP). Results Compared with control group, the expression level of CSE,solute carrier family 7 members 11(SLC7A11), glutamate cysteine ligase C(GCLC), glutamate cysteine ligase M(GCLM) and glutathione synthetase(GSS) in HL-1 cells treated incubated with high glucose and palmitate was decreased, however, NaHS was found to restore it. NaHS reduced the content of ROS in HL-1 cells treated with high glucose and palmitate. The interaction between murf1 and Nrf2 was confirmed by co-immunoprecipitation(Co-IP). Compared with NaHS group, the ubiquitylation level of Nrf2 was enhanced in high glucose and palmitate group. Conclusions Sodium hydrosulfide may reduce the ubiquitylation level of Nrf2 and promote the expression of key enzymes of GSH synthesis. [ABSTRACT FROM AUTHOR]

结肠印戒细胞癌是儿童消化系统一种极为罕见的恶性肿瘤。本文回顾了在温州医科大学附属第二医院、育英儿童医院就诊的 1 例结肠印戒细胞癌患儿的临床与病理资料, 并结合国内外文献, 总结该例患儿的临床表现及诊治经验。 [ABSTRACT FROM AUTHOR]

Objective To explore the dynamic changes of anti-coronavirus antibodies in medical staff of intensive care unit after three doses of novel coronavirus inactivated vaccine, and to dynamically evaluate their immune status. Methods A total of 30 medical staff in intensive care unit who received three doses of inactivated SARS-CoV-2 vaccine in this hospital from November 2020 to November 2021 were selected as the research objects. Venous blood samples were collected at 0, 1, 3, 6 and 12 months after inoculation of novel coronavirus vaccine to detect the titer of anti-novel, coronavirus antibody immunoglobulin G, lymphocyte subsets and cytokines, and the changes were analyzed. Results Anti-coronavirus antibodies were positive in 30 medical staff one month after injection of three doses of inactivated coronavirus vaccine, and the titer increased significantly in the first month, with statistically significant difference (P＜0. 05). In the first month, the anti-neo-coronavirus antibody reached a peak and then gradually decreased. In the 12th month, the anti-neo-coronavirus antibody was still higher than that in the 0 th month, and the difference was statistically significant (P＜0. 05). There was no significant difference in lymphocyte subsets at different time points (P＞0. 05). After inoculation with the novel coronavirus inactivated vaccine, interleukin-2 (IL-2), IL-10, interferon-γ, and tumor necrosis factor-α all showed inverted U-shaped changes, IL-6 showed U-shaped changes, and IL-4 showed fluctuating changes. Conclusion The three-dose inactivated vaccine can produce a higher level of antibody and maintain a high titer for at least six months. [ABSTRACT FROM AUTHOR]

Notch信号通路在肿瘤及其微环境中的作用备受关注，该通路在调控细胞增殖、分化和凋亡等过程中发挥 重要作用，对肿瘤的发生、发展和转移起关键作用。在肿瘤微环境中，Notch信号通路影响肿瘤细胞与周围组织的相 互作用，包括血管生成、免疫调节和基质重塑等过程。最新研究显示，通过调节 Notch信号通路可有针对性地干预 肿瘤的发生发展和治疗，因此对该领域的深入研究有重要意义。 [ABSTRACT FROM AUTHOR]

By analyzing the characteristics of collaborative decision-making behavior of heterogeneous clusters, this paper introduces quantum decision-making model to solve the autonomous decision-making problem of heterogeneous clusters. First, it is triggered from the OODA loop process to clarify the control mode of heterogeneous cluster collaboration. Then, aily ming at the specific problem of heterogeneous cluster cooperative cruise, the tasks of unmanned boat cluster and UAV cluster are split, and the application models of formation optimization and autonomous detection are constructed respectively. The formation optimization algorithm is designed to dynamically generate the best communication formation structure. The quantum decision cloud and feedback scoring mechanism are designed to select the most suitable decision content among many possible detection options. Finally, the effectiveness of formation optimization model and autonomous detection model in heterogeneous cluster cooperative cruise is demonstrated by simulation experiments. Experiments show that the quantum decision model has greater applicability and mobility in decision behavior selection and optimization than the conventional decision model. [ABSTRACT FROM AUTHOR]

Objective: The predictive value and clinical significance of peripheral blood neutrophil to lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) to serum alpha-fetoprotein (AFP) detected in elderly patients with undifferentiated early gastric cancer were observed. Methods: A total of 80 patients with undifferentiated early gastric cancer, 80 patients with benign gastric diseases, and 80 healthy individuals were included. The above patients were divided into experimental group 1, experimental group 2, and control group. Serum AFP, NLR, and PLR tests were carried out, and the three groups were compared. Serum AFP, NLR, and PLR levels were used to evaluate the predictive effect and significance of serum AFP, NLR, and PLR in elderly patients with undifferentiated early gastric cancer. Results: The expression levels of NLR, PLR and AFP in the observation group 1 and observation group 2 were higher than that in the control group(P＜0.05); The levels of serum NLR, PLR and AFP in patients with lymph node metastasis were higher than those in patients without lymph node metastasis(P＜0.05); The levels of serum NLR, PLR and AFP in patients with T1bN0M0 were higher than those in patients with T1aN0M0(P＜0.05); Taking benign gastric diseases as a control, the diagnostic effects of serum NLR, PLR and AFP in patients with gastric cancer were analyzed under correlation analysis. The areas of serum AFP, NLR and PLR were 0.685, 0.755 and 0.743 respectively, with sensitivity of 65%, 69% and 75% respectively, and specificity of 72%, 74% and 59% respectively. Under the combined detection of serum AFP, NLR and PLR, the sensitivity can reach 72% and the specificity can reach 79%. Compared with a single detection, the combined detection of serum AFP, NLR and PLR has a higher specificity. Conclusion: For the elderly patients with undifferentiated early gastric cancer, the detection of serum AFP, NLR, PLR can evaluate and predict their condition, provide a certain reference basis for clinical practice, and have great clinical promotion and application value. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical efficacy of Baiyi rectal solution combined with Danbai granules in the treatment of sequelae of pelvic inflammatory disease (damp-heat stasis type). METHODS: Totally 90 patients with sequelae of pelvic inflammatory disease ( damp-heat stasis type) admitted into the hospital from Mar. 2021 to Mar. 2023 were extracted to be divided into the traditional Chinese medicine enema group, traditional Chinese medicine granule group and combined group via the random number table method, with 30 cases in each group. The traditional Chinese medicine enema group was treated with conventional treatment + Baiyi rectal solution, the traditional Chinese medicine granule group was given conventional treatment + Danbai granules, and the combined group received conventional treatment + Baiyi rectal solution + Danbai granules. After 3 menstrual cycles of treatment, the clinical efficacy, traditional Chinese medicine syndrome score, hemodynamics, inflammatory factors and treatment safety of three groups were evaluated. RESULTS: The total effective rate of combined group was 93. 33%(28 / 30), higher than 70. 00%(21 / 30) of traditional Chinese medicine enema group and 66. 67%(20 / 30) of traditional Chinese medicine granule group, with statistically significant differences (P<0. 05). After treatment, the scores of traditional Chinese medicine symptom (including lumbosacral swelling pain, poor menses, increased underband, red tongue and yellow fur) in combined group were lower than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, with statistically significant differences ( P < 0. 05). After treatment, the systolic maximum flow velocity, end-diastolic maximum flow velocity and pulsation index of uterine artery in combined group were higher than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, and the resistance index was lower than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, with statistically significant differences ( P < 0. 05 ). After treatment, the levels of inflammatory factors ( interleukin-18, prostaglandin E2 and β amyloid precursor protein) in combined group were lower than those in traditional Chinese medicine enema group and traditional Chinese medicine granule group, with statistically significant differences (P<0. 05). The incidences of adverse drug reactions in combined group, traditional Chinese medicine enema group and traditional Chinese medicine granule group were respectively 13. 33% ( 4 / 30), 10. 00%(3 / 30) and 6. 67% ( 2 / 30), with no statistically significant difference ( P > 0. 05). CONCLUSIONS: The efficacy of Baiyi rectal solution combined with Danbai granules in the treatment of sequelae of pelvic inflammatory disease ( damp-heat stasis type) is significant, which can improve the traditional Chinese medicine symptom of patients, increase the hemodynamics of patients’ pelvic uterine artery, inhibit the level of inflammatory factors with higher safety. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between Crouse Score, intima media thickness (IMT), and the degree of valve calcification in elderly patients with calcific heart valve disease. Methods A retrospective analysis was conducted on the clinical data of 106 elderly patients with calcific heart valve disease from April 2020 to March 2023 (Observation group). Additionally, 90 patients with carotid atherosclerosis without heart valve disease were selected as control group 1, and 95 non elderly patients with calcific heart valve disease were selected as control group 2. Single factor analysis of variance was used to compare Crouse Score, IMT, luminal stenosis, and Crouse Score and IMT in patients with different degrees of valve calcification in calcific heart valve disease. Pearson analysis was employed to explore the correlation between Crouse Score, IMT, and the degree of valve calcification. ROC curve analysis was performed to evaluate the predictive value of Crouse Score and IMT for valve calcification in elderly patients with calcific heart valve disease. Results Crouse Score, IMT, and luminal stenosis in the observation group were significantly higher than those in control group 1 and control group 2 (P<0.05). For patients with different degrees of valve calcification in calcific heart valve disease, Crouse Score and IMT were compared as follows: Grade 1 < Grade 2 < Grade 3 (P<0.05). The correlation analysis results showed that Crouse Score and IMT were positively correlated with the degree of valve calcification in elderly patients with calcific heart valve disease (r=0.585, 0.623, P<0.05). The ROC curve demonstrated that the AUC of the joint prediction of Crouse Score and IMT for valve calcification in elderly patients with calcific heart valve disease was 0. 802 (95% CI: 0.738-0.867), significantly higher than the AUC for individual predictions, with optimal diagnostic sensitivity and specificity of 0. 887 and 0. 794, respectively (P<0.05). Conclusion Crouse Score and IMT are abnormally elevated in elderly patients with calcific heart valve disease and are positively correlated with the degree of valve calcification. Measurement of these indicators assists in the assessment of heart valve calcification levels. [ABSTRACT FROM AUTHOR]

In order to provide basis for breeding for male sterile line and maintainer line of K-type wheat and selection of hybrid combination, in this study, the genetic diversity, correlation, and cluster analysis of 7 main agronomic traits of 25 k-type wheat maintainer lines were carried out. The results showed that 7 main agronomic traits of 25 k-type wheat maintainer lines showed great variability, the variation coefficients from low to high were plant height(7.12%), 1000-grain weight(7.49%), grain number per spike(9.12%), spike length(9.61%), grain number per plant(16.69%), spike number per plant (18.37%), and grain weight per plant(20.61%). The correlation analysis showed that there were extremely significant positive correlations among the three pairs of traits, which were grain number per plant and grain weight per plant (correlation coefficient r=0.732), spike number per plant and grain number per plant(r=0.577), and grain weight per plant and spike number per plant(r=0.522), respectively. 4 significant positive correlations were found between 1000-grain weight and grain weight per plant(r=0.371), spike length and grain number per spike(r=0.278), plant height and spike length(r=0.269), spike length and grain number per plant(r=0.211). 2 significant negative correlations were found between plant height and grain number per spike(r=-0.214), grain number per spike and spike number per plant(r=-0.399). Cluster analysis showed that the genetic distance of 25 k-type wheat maintainer lines varied from 1.15 to 26.25. At the genetic distance of 12.50, the tested varieties were divided into 5 groups: there were 17 varieties in Group I, and Group I were divided into 3 sub-groups at the genetic distance of 7.50. There was one variety in Group II, ShiH09-7075, whose grain weight per plant was 8.59 g, lower than that of other groups. There was one variety in Group III, Jun 2016, whose plant height was 50.67 cm, lower than that of other groups. There were five varieties in Gropp IV, including Heng 4568, Shannong 0911, Zhoumai 16 and so on, whose spike number per plant was 9.27, more than that of other groups. There was one variety in Group V, Heng5011, whose plant height was 70.52 cm, higher than that of other groups. [ABSTRACT FROM AUTHOR]

In industrial scenarios, acoustic properties between training and test data would be changed due to the rarity and high diversity of equipment anomalies, as well as differences in machine operating conditions or ambient noise during the training and test phases. To solve these problems, an unsupervised anomalous sound detection algorithm based on joint deep learning and variable Bayesian Gaussian mixture model was proposed. The information was extracted through the joint training of two kinds of neural networks, and cluster analysis was carried out on the embedding obtained by variable Bayesian Gaussian mixture model. A new hybrid sample data enhancement method was introduced to generate samples with a combination of alternative methods to align the distribution between different domains. An improved sub-cluster AdaCos was applied to exclude potential outliers. The experimental results show that the average AUC (area under curve) of the target domain on the datasets of three industrial machine types reaches 79. 03%, and the average F1 score reaches 67. 23%. Compared with the baseline model, the average harmonic value is improved by about 20%, and it performs well in unsupervised anomalous sound detection of industrial equipment. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the effects of Bifidobacterium quadruple viable tablet combined with piracetam on gastrointestinal function and neurological function in patients with severe cerebral hemorrhage. METHODS: Fifty patients with severe cerebral hemorrhage admitted into the hospital from 2021 to 2022 were extracted to be divided into the control group ( n = 24) and study group ( n = 26) via the random number table method. The control group was treated with piracetam, while the study group received Bifidobacterium quadruple viable tablet combined with piracetam. The average cerebrovascular flow rate, average cerebrovascular flow, vascular peripheral resistance and dynamic resistance level were detected. The Glasgow coma score (GCS) and activities of daily living (ADL) scores were used to assess the degree of coma and ability to perform activities of daily living. Lactobacillus, Bifidobacterium, D-lactic acid ( D-LC), diamine oxidase ( DAO), neuropeptide Y ( NPY) and ferritin level were detected. The national institutes of health neurologic deficit scale for stroke (NIHSS) was used to assess the neurologic deficits. Therapeutic effect of two groups was compared. RESULTS: After treatment, the mean cerebrovascular flow rate, mean cerebrovascular flow level, GCS, ADL scores of the study group were higher than those of the control group; the peripheral vascular resistance, dynamic resistance, D-LC, DAO, NPY, ferritin, NIHSS scores of the study group were lower than those of the control group, with statistically significant differences (P<0. 05). After treatment, the total effective rate of the study group was 92. 31% ( 24 / 26), higher than 66. 67% ( 16 / 24) of the control group, the difference was statistically significant (P<0. 05). CONCLUSIONS: Bifidobacterium quadruple viable tablet combined with piracetam can significantly restore the gastrointestinal function and neurological function of patients with severe cerebral hemorrhage, improve the cerebrovascular function, restore the balance of intestinal flora, enhance the conscious state, improve the ability of daily life, and the clinical therapeutic effect is remarkable. [ABSTRACT FROM AUTHOR]

In order to improve the water hole blasting effect in the water rich rock area of a certain open pit mine, a study was conducted on rock debris filling materials through theoretical analysis and on site experiments. The influence of radial water uncoupling charge coefficient, filling length, and delayed detonation on the blasting effect was analyzed through numerical simulation. The results show that as the particle size of rock debris increases, the shear strength of the filling structure also increases, and the effect of filling is also enhanced; The filling effect is most significant when the ratio of <5 mm with $5 mm rock debris particles is 3 5 7 in the filling structure; When the radial water uncoupled charge coefficient Kd is 1. 33, perfect blasting effects can be achieved to save explosive costs;Delayed detonation can provide more free surfaces to reduce the fragmentation of rock masses. [ABSTRACT FROM AUTHOR]

In order to study the effect of semi-rigid base cracking on the bearing capacity response characteristics of asphalt pavement, ABAQUS software is used to establish a three-dimensional model of asphalt pavement with different types of base reflection cracks, and to study the bearing capacity response characteristics of the pavement under load, and reveal the response mechanism. The results show that the greater the length of reflective cracks, the greater the response of pavement bearing capacity. Before and after the reflection crack passes through the pavement, the bearing capacity response surges from weak to strong, and the reflection crack only affects the bearing capacity response within a certain width range. The suggestions for the treatment of reflection cracks are given, that is, according to the current scheme, attention should be paid to the distinction between reflection cracks and surface cracks to limit their development. The effect of reflection crack on the bearing capacity response is analyzed from the Angle of length, width and structure level. The simulation results are in agreement with the field measured results, which provides a reference for the study of bearing capacity response of semi-rigid asphalt pavement [ABSTRACT FROM AUTHOR]

BACKGROUND: Achilles tendon adhesion after Achilles tendon injury can lead to decreased biomechanical properties, weakened healing ability, and ultrastructural changes of Achilles tendon, which further affects patients’ daily life and work ability. Therefore, how to effectively deal with and prevent Achilles tendon adhesion has become a hot and difficult problem in clinical treatment. OBJECTIVE: To analyze the effects of biological amniotic membranes on postoperative Achilles tendon adhesion, biomechanics, and ultrastructural changes in rats with Achilles tendon rupture. METHODS: Sixty 6-week-old SD rats were selected to establish bilateral Achilles tendon rupture models and divided into two groups (n=30 per group) by the random number table method. In the model group, the severed end of the tendon was sutured directly. In the amniotic membrane group, the biological amniotic membrane was wrapped around the broken anastomosis and fixed by a suture. The adhesion, biomechanics, morphology, and structure of the Achilles tendon and the expression of p38 and ERK1/2 protein were evaluated 1, 2, and 4 weeks after surgery. RESULTS AND CONCLUSION: (1) 1 week after operation, the Achilles tendon and peritendinous tissues of the two groups were mildly edema, and the adhesion of the Achilles tendon tissues in the model group was more obvious. 2 weeks after the intervention, the Achilles tendon and peritendinous tissues of the model group still had edema, and the adhesion degree between the Achilles tendon and the surrounding tissues was heavier than that of the amniotic membrane group. 4 weeks after operation, there was no edema around the Achilles tendon in both groups, and the healing was well. The adhesion degree of the Achilles tendon in the amniotic membrane group was less than that in the model group. The maximum tension of Achilles tendons in the amniotic membrane group was higher than that in the model group at 2 and 4 weeks after operation (P < 0.001). (2) Hematoxylin-eosin staining and transmission electron microscopy revealed that 1 week after operation, the tendon structure of rats of the two groups was disordered and the collagen fibers were sparsely arranged, in which the model group demonstrated obvious inflammatory reaction and adhesion to the Achilles tendon. Two weeks after operation, the model group still demonstrated obvious inflammatory response, adhesion of Achilles tendon, and irregular ordering of collagen fibers. The amniotic membrane group exhibited an orderly arrangement of collagen fibers and expansion of the endoplasmic reticulum of fibroblasts. At 4 weeks after operation, the collagen fibers of the Achilles tendon in the model group were thickened and disordered, and the rough endoplasmic reticulum was less in the fibroblasts, while the collagen fibers in the amniotic membrane group were ordered and thin, and the fibroblasts contained a large number of rough endoplasmic reticulum. (3) Four weeks after operation, western blot assay exhibited that the expressions of p38 and ERK1/2 protein in the Achilles tendon tissue of rats in the amniotic membrane group were lower than those in the model group (P < 0.05). (4) The results confirm that the biologic amniotic membrane can promote the healing and inhibit the adhesion of Achilles tendon after the operation of the ruptured Achilles tendon, which may be associated with the regulation of the MAPK/ERK signaling pathway. [ABSTRACT FROM AUTHOR]

【Objective】Deqing County, Guangdong Province is a native habitat of Morinda officinalis How., a genuine medicinal herb in China. In the study, the genetic diversity of germplasm resources of 24 varieties of Morinda officinalis How. were analyzed.【Method】A total of 24 Morinda officinalis How. resources collected from Deqing County as research objects, and principal component analysis and molecular marker methods (SRAP and CDD) were used to analyze the genetic diversity of 24 Morinda officinalis How. materials.【Result】Phenotypic analysis showed that, in the cluster map based on principal component analysis, Guanwei Town, Gaoliang Town, Fengcun Town and Gaoliang Town were clustered in four groups. In addition,100 and 98 total bands were obtained in 18 pairs of SRAP primer combinations and 16 CDDP primers, among them, there were 50 SRAP polymorphic bands, resulting in a polymorphism ratio of 50%. The average genetic similarity coefficient (GS) was 0.87, and the GS ranged from 0.71 to 0.97. There were 80 polymorphic bands in CDDP, with a polymorphism ratio of 79.0%. The GS among germplasm resources ranged from 0.71 to 0.96, with an average (GS) of 0.86. When the coefficient was 0.82, both SRAP and CDDP molecular markers showed certain similarities among the germplasm resources of Gaoliang Town, Guanxu Town and Fengcun Town.【Conclusion】Combined with the clustering results of phenotypic and molecular marker, the genetic relationship is closest between Gaoliang Town and Guanwei Town as well as Gaoliang Town and Fengcun Town. The results of SRAP and CDDP molecular marker methods have certain differences in the genetic diversity of Morinda officinalis How., and the combined analysis can better reflect the genetic diversity of Morinda officinalis How. and the phylogenetic relationship of Morinda offi cinalis How. resources. [ABSTRACT FROM AUTHOR]

目的：通过调查上海市社区精神分裂症患者的就业情况与职业康复需求现状，为未来更好地开展职业康复工作，改 善精神分裂症患者的职业状况提供建议。 方法：采用整群随机抽样的方法，抽取了上海市2 个核心城区，4 个中心城区以及2 个郊区，8 个区的共1291 例18— 60 岁社区康复期精神分裂症患者，采用自编《康复需求调查问卷》，由调查员进行入户调查。 结果：患者发病前后无业率由22.0%增加至63.5%，差异显著（χ2=454.61，P<0.05）。982 例没有工作的患者中仅有 18.1%的患者想再就业。能通过个体劳动自食其力的患者仅占23.5%，大部分患者需要依赖家人的经济援助。有工 作的患者在健康指数（z=﹣5.281，P<0.001）和生存质量（P<0.001）上显著好于没有工作的患者。仅有10.5%的患者 表示曾参与过职业康复，20.2%的精神分裂症患者表示想参加职业康复。所需的职业康复内容调查中，社交技能训 练、职业技能训练和“庇护性”岗位工作推荐排名前三。回归分析结果表明，对没有工作的患者，其职业康复需求主 要影响因素为工作意愿程度（β=0.578，P＜0.01）；对有工作的患者，其职业康复需求主要影响因素是年龄（β=- 0.300，P＜0.01）以及健康指数（β=0.162，P＜0.01）。 结论：精神分裂症对社区患者生存状况造成了显著的影响，损害了职业能力，是造成患者失业的主要原因。就业对 于精神分裂症患者有很多益处，不仅可以降低经济负担，还可以改善健康水平和生存质量。但精神分裂症患者的就 业意愿较弱，仅少数患者曾参与过职业康复。就业意愿强烈的无业患者存在较高的职业康复意愿，已经有工作的患 者同样存在职业康复需求。未来开展职业康复工作需要注意职业技能训练与支持性就业服务并重，为患者提供多 元化的职业康复服务。 [ABSTRACT FROM AUTHOR]

[Objective] The aims of this study are to identify drought events, drought frequency and drought intensity in grassland of Xilin Gol, to understand the meteorological drought field in Xilin Gol, and then to alleviate the environmental and economic problems caused by drought in Xilin Gol. [Methods] The month-by-month observation data of nine meteorological stations in Xilin Gol region from 1969 to 2018 were selected to calculate the effective drought index (EDI) . The spatial and temporal patterns of drought in Xilin Gol over the past 60 years were analyzed by combining Mann-Kendall test, empirical orthogonal function (EOF) decomposition and quantitative drought characterization methods. [Results] The annual average EDI index of Xilin Gol region decreased at the rate of 0.029/decade, and the drought trend increased significantly, with an average of 0.5 drought events per year. The frequency of normal occurrences in Xilin Gol ranged from 67.17 to 72.65%, and the frequency of severe droughts ranged from 0.02 to 0.99%, with a large variability in the frequency of different droughts, and the southwest and central regions being the regions with higher drought intensity. Contribution of variances of the previous two major characteristic vectors of Xilin Gol reached up to 52.75% and 14.38%, respectively, and the spatial mode showed a consistent type and southeast-northwest inversion phase type. [Conclusion] EDI index considering effective precipitation has more advantages in revealing the spatiotemporal variation trend of drought in grassland, and can be used to identify the spatiotemporal variation of meteorological drought. [ABSTRACT FROM AUTHOR]

In order to study the nutritional value of different types of silage grasses, four types of grasses, oat, pea, sorghum, and alfalfa were selected for silage modulation. Conventional analysis methods were used to determine the dry matter, moisture, crude ash, crude egg white, crude fat, calcium, phosphorus, as well as the content of acidic washing fiber, neutral washing fiber, and acidic washing lignin in the seven main nutritional components of the four silage grasses, three sets of duplicate samples were taken from each group to determine the in vitro nutrient digestibility of the four silage herbages. Single factor analysis of variance and principal component analysis were used to evaluate the feeding value of the four herbages. The results showed that: ①the dry matter (DM) and calcium (Ca) components in alfalfa silage were significantly higher than those in oat silage, pea silage and sorghum silage (P<0.05). The neutral detergent fiber (NDF) of sorghum silage was significantly higher than that of pea silage (P< 0.05), and the acid detergent fiber (ADF) and acid detergent lignin (ADL) of alfalfa silage were significantly higher than those of other three silage raw materials (P<0.05). NDF12, NDF24 and NDF48 of silage sorghum were significantly higher than those of silage oat, silage arrow tongue pea and silage alfalfa (P<0.05). ② After principal component analysis, three principal components were proposed, with a cumulative variance contribution rate of 85.676%. The ranking of the nutritional value of the four silage grasses is as follows: silage alfalfa>arrow tongue pea>silage oats>silage sorghum, indicating that alfalfa has higher nutritional value and good feeding value among the four silage grasses. The use of principal component analysis to evaluate the nutritional quality of silage can provide a theoretical basis for the further rational development of different silage grasses. [ABSTRACT FROM AUTHOR]

In order to explore the activities of enzymes from plant root exudates affected rhizosphere soil enzyme activities and nutrients in karst areas, the activities of β-1,4-glucosidase( βG), β-N-acetyl-glucosaminidase(NAG), leucine aminopeptidase(LAP), and acidic phosphatase(ACP)of fine root exudates and rhizosphere soils in four vegetation restoration stages, which are shrub-grassland, shrubland, shrub-arbor forest and arbor forest, were measured. And, their relationships with soil carbon(C), nitrogen(N), phosphorus(P)contents were analyzed. The results were as follows:(1)The four enzyme activities of rhizosphere soils and root exudates were significantly higher in the late stage of vegetation restoration than in the early stage of vegetation restoration. The enzyme activities C:P to N:P ratios of root exudates in arbor forest were significantly higher than those of other three stages, while the two parameters of rhizosphere soils were opposite.(2)Correlation analysis showed that the enzyme activities of root exudates were positively correlated with the corresponding soil enzyme activity. Compared with the enzyme activities of root exudates, the correlation between soil enzyme activity and related nutrients became significantly stronger. In addition, the enzyme activities of βG, NAG and LAP in rhizosphere soils and root exudates were positively correlated with soil organic carbon(SOC)and total nitrogen(TN)in rhizosphere soil, while the enzyme activities of ACP in rhizosphere soils and root exudates were positively correlated with available phosphorus(AP)in rhizosphere soil. The above results indicate that vegetation restoration has a positive effect on increasing enzyme activities of root exudates and soils. The enzymes of root exudates are the indispensable supplement for soils, and play an important role in promoting carbon, nitrogen and phosphorus nutrient cycling. To sum up, it will be that the regulation of root exudates and its enzyme activities may provide a new perspective for vegetation restoration in karst ecosystem. [ABSTRACT FROM AUTHOR]

Objective:To investigate the effects of acute hypervolemic hemodilution (AHH) combined with control low central venous pressure (CLCVP) on inflammation,immune regulation and blood protection in patients undergoing posterior spinal operation.Methods:120 patients who were underwent posterior spinal operation in Nanjing Drum Tower Hospital from January 2020 to December2022 were selected as the research objects,patients were divided into control group,AHH group and AHH+CLCVP group according to the random number table method,with 40 cases in each group.Control group was given lactated Ringer’s solution hemodilution,AHH group was given AHH blood management,and AHH+CLCVP group was given AHH combine with CLCVP blood management.The changes of perioperative indexes,hemodynamic indexes,inflammatory factors indexes and immune function indexes were compared in three groups.Results:The intraoperative blood loss and suspended red blood cell transfusion volume in AHH+CLCVP group were lower than those in AHH group and control group (P＜0.05),the intraoperative blood loss and suspended red blood cell transfusion volume in AHH group were lower than those in control group (P＜0.05).Compared with T1time point,the heart rate (HR) in three groups increased first and then decreased at 60 min after the start of operation (T2)～the end of operation (T3)(P＜0.05),and the mean arterial pressure(MAP) decreased first and then increased (P＜0.05),the central venous pressure (CVP) in control group and AHH group increased first and then decreased at T2～T3(P＜0.05),and the CVP in AHH+CLCVP group remained stable at T0～T3(P＞0.05).HR in AHH+CLCVP group was lower than that in AHH group and control group at T2～T3(P＜0.05),MAP was higher than that in AHH group and control group (P＜0.05),CVP was lower than that in AHH group and control group (P＜0.05),HR in AHH group was lower than that in control group at T2～T3(P＜0.05),MAP was higher than that in control group (P＜0.05).Compared with T1time,the levels of serum procalcitonin (PCT),C-reactive protein (CRP) and interleukin-6 (IL-6) in three groups,peripheral blood CD8+increased first and then decreased at T2～24h after operation (T4)(P＜0.05),peripheral blood CD3+,CD4+,CD4+/CD8+decreased first and then increased at T2～T4(P＜0.05).The levels of serum PCT,CRP,IL-6 and peripheral blood CD8+in AHH+CLCVP group were lower than those in AHH group and control group at T2～T4(P＜0.05),and the levels of peripheral blood CD3+,CD4+and CD4+/CD8+were higher than those in AHH group and control group (P＜0.05),the levels of serum PCT,CRP,IL-6 and peripheral blood CD8+in AHH group were lower than those in control group at T2～T4(P＜0.05),and the levels of peripheral blood CD3+,CD4+and CD4+/CD8+were higher than those incontrol group(P＜0.05).Conclusion: AHH combined with CLCVP can stabilize hemodynamics, reduce intraoperative blood loss and blood transfusion, reduce inflammatory response and improve immune function in patients undergoing posterior spinal operation. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical application value of a predictive model for the efficacy of third-generation cephalosporin in the treatment of community-acquired spontaneous bacterial peritonitis (CASBP) . Methods This prospective study was conducted among 50 patients with liver cirrhosis and CASBP who were admitted to The Ninth Hospital of Nanchang from January 2021 to June 2022， and the patients were randomly divided into optimized treatment group and traditional treatment group， with 25 patients in each group. The patients in the optimized treatment group received ceftazidime or imipenem for initial treatment based on the above predictive model， and those in the traditional treatment group received ceftazidime for initial treatment， with the subsequent use of antibiotics adjusted based on the efficacy of initial treatment. The two groups were compared in terms of the response rate of initial treatment， cure rate on day 5， and 30-day mortality rate. The independent-samples t test or the MannWhitney U test was used for comparison of continuous data between two groups， and the chi-square test or the Fisher’s exact test was used for comparison of categorical data between two groups. Results All patients completed the study. The optimized treatment group had a significantly higher response rate of initial treatment than the traditional treatment group (88.0% vs 60.0%， χ2 =5.094，P=0.024) ， while there was no significant difference in the cure rate on day 5 between the two groups (80.0% vs 56.6%， χ2 =3.309，P=0.069) . As for the patients who received ceftazidime for initial treatment， the optimized treatment group had a significantly higher response rate of initial treatment than the traditional treatment group (88.9% vs 60.0%，χ2 =4.341，P=0.037) ， while there was no significant difference in the cure rate on day 5 between the two groups (83.3% vs 56.0%，χ2 =2.425，P=0.119) . There was no significant difference in 30-day mortality rate between the two groups (8.0% vs 20.0%，χ2 =0.664，P=0.415) . For all patients， there was a significant association between response of initial treatment and cure on day 5（odds ratio ［OR］=9.643，95% confidence interval ［CI］：2.292—40.564) and between cure on day 5 and 30-day mortality (OR=0.138，95%CI：0.023—0.813) . Conclusion This predictive model for efficacy helps clinicians to identify the patients who can benefit from third-generation cephalosporin treatment and improve the efficacy of third-generation cephalosporin in the initial empirical treatment of CASBP. [ABSTRACT FROM AUTHOR]

Objective To investigate the changes of OAT expression in bone cells in chronic renal failure (CRF) and involved mechanism, and to explore the effect of OAT expression on bone metabolism. Methods Randomly divide the rats into a control group (n=6) and a model group (n=6) .The model group established a rat chronic renal failure model using "single nephrectomy+adenine gavage" method, and the red blood cell ( RBC) and hemoglobin ( HGB) of the rat body were measured using a blood routine analyzer; Measure indicators such as creatinine (Cr), urea nitrogen (BUN), uric acid (UA), blood calcium (Ca2+), and blood phosphorus (P3+) using a fully automated biochemical analyzer; Pathological examination of rat kidneys; X-ray examination of rat tibia; Immunohistochemical examination of bone tissue OAT1 level. Results The bone density of the model group rats is lower than that of the control group; The calcium and phosphorus metabolism of rats in the model group was in metabolic disorder, and the OAT1 value of bone tissue binding was much lower than that of the control group (P= 0.001 8), which was statistically significant. (P=0.001 8) Conclusion Chronic renal failure affected the binding ability of OAT1 in bone tissue, leading to the metabolic disorder for calcium absorption and phosphorus metabolism, thus aggravating renal osteodystrophy (P<0.05). [ABSTRACT FROM AUTHOR]

The ZH, ZDR and KDP of Guangzhou S-band dual polarization radar and rainfall data of 219 automatic meteorological stations in Foshan are used to form 8 datasets. Based on the convolutional neural network CNN, a radar quantitative precipitation estimation model is established, which will be used for ground precipitation estimation. The evaluating results of 8 datasets applied to the same precipitation estimation model are compared to each other. The results show that: The increase in the number of channels(N) of the datasets is beneficial to reduce the RMSE and improve CORR of the quantitative rainfall estimation results; For the datasets Z, Z_1~3 km and Z_6 min formed by ZH, as the number of channels increases, the performance of the data sets Z, Z_1~3 km and Z_6 min are gradually improved, and the RMSE of Z_1~3 km and Z_6 min are 4.71 and 3.78, which are -1.3% and 18.7% lower than that of dataset Z; the CORR of Z_1~3 km and Z_6 min are 0.82 and 0.88, which are 2.5% and 10% higher than that of dataset Z; Among other datasets composed of KDP and ZDR, the dataset Z_ZDR_KDP has the best fitting performance. The RMSE is 3.97, which is 14.6% lower than that of dataset Z, and the CORR is 0.86, which is 7.5% higher than that of dataset Z; The statistical results of RMSE, MBR, AE and RE for seven precipitation levels of 0.6～5 mm, 5～10 mm, 10～20 mm, 20～30 mm, 30～40 mm, 40～50 mm and above 50 mm respectively, show that dataset Z_6 min has the highest rainfall accuracy. [ABSTRACT FROM AUTHOR]

Accurate, real-time, and in-situ acquisition of soil electrical conductivity can provide effective data support for the precise management of agricultural production. The current-voltage four-terminal approach as an invasive technology has considerable performance in the in-situ measurement of soil electrical conductivity on a large scale. This study aims to improve the accuracy of soil electrical conductivity measured by the traditional current-voltage four-terminal approach. A systematic analysis was made to determine the constant current source and electrode spacing in the three measurement arrays. The soil bin test was carried out to explore the influence of the main factors (soil moisture content, electrode embedded depth, soil compaction, and soil texture) on the measurement accuracy of three measurement arrays at different levels. The results showed that two measurement arrays of Wenner and Schlumberger were better applied to different soil environmental conditions. The measured values of soil electrical conductivity were further used as the inputs into the model. The regression model of soil electrical conductivity was constructed using the BP neural network. The R 2 of the model fit was 0.99762 in the training set, and the RMSE of the model between the calculated and standard value was 0.12 μS/mm in the testing set, indicating the smaller than that of individual measurement. All RMSE values were smaller than those in the individual array measurements. The measurement device of dual-array fusion soil electrical conductivity was designed using a regression model. The components of the device included the touchable LCD display, electrode sockets, switches, differential amplifier module, constant current source module, power supply, STM32 microcontroller data acquisition module, JESTON nano, and sensor. The soil electrical conductivity was then optimized using the measured values. The working stability test showed that the standard deviation of measured data was less than 0.43 μS/mm under different soil electrical conductivity gradient conditions. The comparative fieldsite performance test showed that the absolute, relative error range, and RMSE of measured soil electrical conductivity were -2.1-1.8 μS/mm, -8.0%-5.8%, 0.18 μS/mm respectively. The RMSE of 0.18 μS/mm was smaller than that of the traditional individual measurement array and the commonly used soil conductivity meters in the market. The measurement device can be expected to rapidly and accurately detect the soil's electrical conductivity, indicating better working stability and higher accuracy. The finding can provide high-precision detection and technical means for the real-time in situ collection of soil information in the field. [ABSTRACT FROM AUTHOR]