双歧杆菌四联活菌片联合吡拉西坦对重症脑出血 患者胃肠功能及神经功能的影响.

OBJECTIVE: To explore the effects of Bifidobacterium quadruple viable tablet combined with piracetam on gastrointestinal function and neurological function in patients with severe cerebral hemorrhage. METHODS: Fifty patients with severe cerebral hemorrhage admitted into the hospital from 2021 to 2022 were extracted to be divided into the control group ( n = 24) and study group ( n = 26) via the random number table method. The control group was treated with piracetam, while the study group received Bifidobacterium quadruple viable tablet combined with piracetam. The average cerebrovascular flow rate, average cerebrovascular flow, vascular peripheral resistance and dynamic resistance level were detected. The Glasgow coma score (GCS) and activities of daily living (ADL) scores were used to assess the degree of coma and ability to perform activities of daily living. Lactobacillus, Bifidobacterium, D-lactic acid ( D-LC), diamine oxidase ( DAO), neuropeptide Y ( NPY) and ferritin level were detected. The national institutes of health neurologic deficit scale for stroke (NIHSS) was used to assess the neurologic deficits. Therapeutic effect of two groups was compared. RESULTS: After treatment, the mean cerebrovascular flow rate, mean cerebrovascular flow level, GCS, ADL scores of the study group were higher than those of the control group; the peripheral vascular resistance, dynamic resistance, D-LC, DAO, NPY, ferritin, NIHSS scores of the study group were lower than those of the control group, with statistically significant differences (P<0. 05). After treatment, the total effective rate of the study group was 92. 31% ( 24 / 26), higher than 66. 67% ( 16 / 24) of the control group, the difference was statistically significant (P<0. 05). CONCLUSIONS: Bifidobacterium quadruple viable tablet combined with piracetam can significantly restore the gastrointestinal function and neurological function of patients with severe cerebral hemorrhage, improve the cerebrovascular function, restore the balance of intestinal flora, enhance the conscious state, improve the ability of daily life, and the clinical therapeutic effect is remarkable. [ABSTRACT FROM AUTHOR]