1,918 results on '"Vasta, S."'
Search Results
2. Changes in Cardiopulmonary Capacity Parameters after Surgery: A Pilot Study Exploring the Link between Heart Function and Knee Surgery.
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Segreti A, Fossati C, Monticelli LM, Valente D, Polito D, Guerra E, Zampoli A, Albimonti G, Zampogna B, Vasta S, Papalia R, Antonelli Incalzi R, Pigozzi F, and Grigioni F
- Abstract
Background : A knee injury in an athlete leads to periods of forced exercise interruption. Myocardial work (MW) assessed by echocardiographic and cardiopulmonary exercise testing (CPET) are two essential methods for evaluating athletes during the period following injury. However, compared to pre-surgery evaluations, the variations in cardiovascular parameters and functional capacity assessed by these methods after surgery remain unclear. Methods : We evaluated 22 non-professional athletes aged 18-52, involved in prevalently aerobic or alternate aerobic/anaerobic sports activities, who were affected by a knee pathology requiring surgical treatment. The evaluation was performed at rest using transthoracic echocardiography, including MW assessment, and during exercise using CPET. Each athlete underwent the following two evaluations: the first before surgery and the second after surgery (specifically at the end of the deconditioning period). Results : Resting heart rate (HR) increased significantly (from 63.3 ± 10.85 to 71.2 ± 12.52 beats per minute, p = 0.041), while resting diastolic and systolic blood pressure, forced vital capacity, and forced expiratory volume in the first second did not show significant changes. Regarding the echocardiographic data, global longitudinal strain decreased from -18.9 ± 1.8 to -19.3 ± 1.75; however, this reduction was not statistically significant ( p = 0.161). However, the global work efficiency (GWE) increased significantly (from 93.0% ± 2.9 to 94.8% ± 2.6, p = 0.006) and global wasted work (GWW) reduced significantly (from 141.4 ± 74.07 to 98.0 ± 50.9, p = 0.007). Additionally, the patients were able to perform maximal CPET at both pre- and post-surgery evaluations, as demonstrated by the peak respiratory exchange ratio and HR. However, the improved myocardial contractility (increased GWE and decreased GWW) observed at rest did not translate into significant changes in exercise parameters, such as peak oxygen consumption and the mean ventilation/carbon dioxide slope. Conclusions : After surgery, the athletes were more deconditioned (as indicated by a higher resting HR) but exhibited better resting myocardial contractility (increased GWE and reduced GWW). Interestingly, no significant changes in exercise capacity parameters, as evaluated by CPET, were found after surgery, suggesting that the improved myocardial contractility was offset by a greater degree of muscular deconditioning.
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- 2024
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3. How to Improve Meniscal Repair through Biological Augmentation: A Narrative Review.
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Za P, Ambrosio L, Vasta S, Russo F, Papalia GF, Vadalà G, and Papalia R
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Since the role of the menisci in knee stability, proprioception, and homeostasis has been well established, significant efforts have been made to repair meniscal tears, resulting in excellent clinical outcomes and a reduction in the progression of knee osteoarthritis (OA). However, varying failure rates have been reported, raising questions regarding the healing potential in cases of complex injuries, poorly vascularized and degenerated areas, and generally in the presence of unfavorable biological characteristics. Therefore, over the last few decades, different strategies have been described to increase the chances of meniscal healing. Biological augmentation of meniscal repair through various techniques represents a safe and effective strategy with proven clinical benefits. This approach could reduce the failure rate and expand the indications for meniscal repair. In the present study, we thoroughly reviewed the available evidence on meniscal repair surgery and summarized the main techniques that can be employed to enhance the biological healing potential of a meniscal lesion. Our aim was to provide an overview of the state of the art on meniscal repair and suggest the best techniques to reduce their failure rate.
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- 2024
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4. Thermochemical investigation on a novel sodium-metal-halide battery configuration: Experimental and FEM model results
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D’Urso, C., Briguglio, N., Bonanno, A., Ferraro, M., Antonucci, V., and Vasta, S.
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- 2019
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5. Knee osteonecrosis after SARS-CoV-2 infection: a systematic case-based review.
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Za P, Papalia GF, Russo F, Vasta S, Vadalà G, and Papalia R
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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for coronavirus disease 2019 (COVID-19). Patients with COVID-19 manifested symptoms mainly related to the respiratory system, but also the musculoskeletal system can be involved. COVID-19 has been described as a possible cause of knee osteonecrosis (ON). A systematic review was performed to investigate the hypothetical correlation between COVID-19 and knee ON., Methods: Inclusion criteria were all articles reporting cases of knee ON after a diagnosis of SARS-CoV-2 infection. Considering that COVID-19 is an emerging disease, all levels of evidence studies were included., Results: Finally, two case series and three case reports were included. We extracted data regarding demographic and clinical characteristics, details of magnetic resonance imaging (MRI), use of corticosteroids (CCS), temporal correlation between ON and COVID-19, treatment of the lesion and its outcomes. A total of seven cases of post-COVID knee ON have been described. Knee pain arose on average 11 weeks after the diagnosis of COVID-19. All patients had knee MRI showing ON. CCS were used to treat COVID-19-related symptoms in four cases. Conservative treatment was successful in five patients., Conclusions: The correlation between COVID-19 and ON remains unclear. Probably post-COVID-19 ON has a multifactorial origin in which factors related to the patient, consequences of COVID-19 and CCS therapy add up to cause a reduction of blood supply and bone vitality until ON is triggered. A greater number of patients is needed to clarify the role of COVID-19 in the etiopathogenesis of knee ON., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://aoj.amegroups.com/article/view/10.21037/aoj-23-67/coif). R.P. serves as an unpaid editorial board member of Annals of Joint from December 2022 to November 2024. The other authors have no conflicts of interest to declare., (2024 Annals of Joint. All rights reserved.)
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- 2024
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6. Assessment of cardiopulmonary capacity in deconditioned athletes because of knee injury.
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Segreti A, Fossati C, Mulè MT, Fanale V, Crispino SP, Coletti F, Parisi FR, Zampogna B, Vasta S, Mannacio E, Papalia R, Antonelli-Incalzi R, Pigozzi F, and Grigioni F
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- Humans, Adult, Male, Young Adult, Female, Middle Aged, Echocardiography, Adolescent, Cardiorespiratory Fitness physiology, Athletes, Exercise Test methods, Oxygen Consumption physiology, Knee Injuries physiopathology
- Abstract
Background: An athlete's career inevitably goes through periods of forced physical exercise interruption like a knee injury. Advanced echocardiographic methods and cardiopulmonary exercise testing (CPET) are essential in evaluating athletes in the period elapsing after the injury. However, the feasibility of a maximal pre-surgery CPET and the capacity of resting advanced echocardiographic techniques to predict cardiorespiratory capacity still need to be clarified., Methods: We evaluated 28 non-professional athletes aged 18-52, involved in prevalently aerobic or alternate aerobic/anaerobic sports activities, affected by a knee pathology with indications for surgical treatment. The evaluation was performed at rest by trans-thoracic echocardiography, including global longitudinal strain (GLS) and myocardial work (MW) assessment, and during exercise by CPET., Results: The percent-predicted peak oxygen consumption (peak VO
2 %) was 82.8±13.7%, the mean respiratory exchange ratio was 1.16±0.08, and the mean ventilation/carbon dioxide (VE /VCO2 ) slope was 24.23±3.36. Peak VO2 % negatively correlated with GLS (r=-0.518, P=0.003) and global wasted work (GWW) (r =-0.441, P=0.015) and positively correlated with global work efficiency (GWE) (r=0.455, P=0.012). Finally, we found that the VE /VCO2 slope during exercise was negatively correlated with GWE (r=-0.585, P=0.001) and positively correlated with GWW (r=0.499, P=0.005)., Conclusions: A maximal CPET can be obtained in deconditioned athletes because of a knee injury, allowing a comprehensive functional pre-surgery evaluation. In these patients, peak VO2 is reduced due to decreased physical activity after injury; however, a lower cardiopulmonary efficiency may be a concause of the injury itself. In addition, we demonstrated that the MW indexes obtained at rest could predict exercise capacity and ventilatory efficiency as evaluated by CPET.- Published
- 2024
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7. Rewiring the evolution of the human hand: How the embodiment of a virtual bionic tool improves behavior.
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Marucci M, Maddaluno O, Ryan CP, Perciballi C, Vasta S, Ciotti S, Moscatelli A, and Betti V
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Humans are the most versatile tool users among animals. Accordingly, our manual skills evolved alongside the shape of the hand. In the future, further evolution may take place: humans may merge with their tools, and technology may integrate into our biology in a way that blurs the line between the two. So, the question is whether humans can embody a bionic tool (i.e., experience it as part of their body) and thus if this would affect behavior. We investigated in virtual reality how the substitution of the hand with a virtual grafting of an end-effector, either non-naturalistic (a bionic tool) or naturalistic (a hand), impacts embodiment and behavior. Across four experiments, we show that the virtual grafting of a bionic tool elicits a sense of embodiment similar to or even stronger than its natural counterpart. In conclusion, the natural usage of bionic tools can rewire the evolution of human behavior., Competing Interests: The authors declare no competing interests., (© 2024 The Authors.)
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- 2024
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8. On the impact of different management strategies on the performance of a two-bed activated carbon/ethanol refrigerator: An experimental study
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Palomba, V., Dawoud, B., Sapienza, A., Vasta, S., and Frazzica, A.
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- 2017
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9. Dynamic Stability, Symmetry, and Smoothness of Gait in People with Neurological Health Conditions.
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Tramontano M, Orejel Bustos AS, Montemurro R, Vasta S, Marangon G, Belluscio V, Morone G, Modugno N, Buzzi MG, Formisano R, Bergamini E, and Vannozzi G
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- Humans, Male, Female, Middle Aged, Biomechanical Phenomena physiology, Aged, Walking physiology, Adult, Brain Injuries, Traumatic physiopathology, Walking Speed physiology, Gait physiology, Parkinson Disease physiopathology, Postural Balance physiology, Stroke physiopathology
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Neurological disorders such as stroke, Parkinson's disease (PD), and severe traumatic brain injury (sTBI) are leading global causes of disability and mortality. This study aimed to assess the ability to walk of patients with sTBI, stroke, and PD, identifying the differences in dynamic postural stability, symmetry, and smoothness during various dynamic motor tasks. Sixty people with neurological disorders and 20 healthy participants were recruited. Inertial measurement unit (IMU) sensors were employed to measure spatiotemporal parameters and gait quality indices during different motor tasks. The Mini-BESTest, Berg Balance Scale, and Dynamic Gait Index Scoring were also used to evaluate balance and gait. People with stroke exhibited the most compromised biomechanical patterns, with lower walking speed, increased stride duration, and decreased stride frequency. They also showed higher upper body instability and greater variability in gait stability indices, as well as less gait symmetry and smoothness. PD and sTBI patients displayed significantly different temporal parameters and differences in stability parameters only at the pelvis level and in the smoothness index during both linear and curved paths. This study provides a biomechanical characterization of dynamic stability, symmetry, and smoothness in people with stroke, sTBI, and PD using an IMU-based ecological assessment.
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- 2024
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10. An innovative technique for faecal score classification based on RGB images and artificial intelligence algorithms
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Ortenzi, L., primary, Violino, S., additional, Costa, C., additional, Figorilli, S., additional, Vasta, S., additional, Tocci, F., additional, Moscovini, L., additional, Basiricò, L., additional, Evangelista, C., additional, Pallottino, F., additional, and Bernabucci, U., additional
- Published
- 2023
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11. On the electrophysiological characterization of gait disorders in post-stroke patients
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Vasta, S, Marangon, G, Orejel Bustos, A. S., Montemurro, R, Tramontano, M, and Betti, V.
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- 2023
12. Restricted kinematic alignment is clinically non-inferior to mechanical alignment in the short and mid-term: A systematic review.
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Cortina G, Za P, Papalia GF, Gregori P, Condello V, Vasta S, Franceschetti E, Campi S, Madonna V, and Papalia R
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- Humans, Biomechanical Phenomena, Knee Joint diagnostic imaging, Knee Joint surgery, Lower Extremity, Radiography, Arthroplasty, Replacement, Knee methods, Osteoarthritis, Knee surgery, Knee Prosthesis
- Abstract
Background: In recent years, kinematic alignment (KA) is becoming a valid alternative to mechanical alignment (MA) in total knee arthroplasty (TKA). However, to avoid early failures, the restricted kinematic alignment (rKA) approach has been developed to restore native knee kinematics without reproducing extreme knee phenotype. This systematic review aims to evaluate clinical and radiological outcomes between rKA and MA for TKA., Methods: A systematic literature search was conducted following PRISMA guidelines on Pubmed, Scopus and Cochrane Library. The following search string was adopted: (((restricted kinematic) AND (mechanical)) AND (alignment)) AND (knee). We included studies that analyzed rKA versus MA in terms of clinical outcomes and complications with a minimum of 6 months of follow up. The following rKA- and MA-related data were evaluated: patient-reported outcome scores (PROMs), radiographic analysis of lower limb alignment, and complications. Criteria from the Methodological Index for Non-Randomized Studies were used to assess the methodological quality of the articles., Results: This systematic review included seven clinical studies with a total of 892 knees (471 for MA group and 421 for rKA group, respectively). Overall, post-operative PROMs were similar between rKA and MA. Moreover, rKA reached better results regarding Forgotten Joint Score and post-operative patient satisfaction. Finally, no higher complication rate was observed with the rKA approach., Conclusion: The rKA aims to restore native knee kinematics, avoiding extreme deformities. Clinical outcomes are not inferior or even better for rKA compared with MA, without increasing the risk of short-middle-term implant failure. However, there is a high heterogeneity regarding the 'restricted' protocols used., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2023
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13. Adductor longus and brevis lesion in an amateur soccer player: platelet rich plasma and multifractioned hyaluronic acid injections to enhance clinical recovery.
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Giannini S, Vasta S, Giombini A, Fossati C, Riba U, Massazza G, Papalia R, and Pigozzi F
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- Humans, Male, Young Adult, Adult, Hyaluronic Acid, Athletes, Groin injuries, Pain, Soccer physiology, Athletic Injuries therapy, Platelet-Rich Plasma
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Groin pain is a common issue in athletes, with a particularly high incidence in male soccer players. Adductor muscles are the most involved site of the groin, accounting for up to one-fourth of muscle injuries of that region. Physical therapy and rehabilitation programs for adductor-related groin pain using active exercises are effective in getting athletes back to sport. However, the return-to-play time varies according to the injury severity. Minor lesions can recover in 1-2 weeks, while severer injuries require 8-12 weeks. To enhance tendon healing and shorten the return to play time, intrandentinous injections of Platelet Rich Plasma (PRP) have been proposed. An increasing body of evidence in literature have shown efficacy of platelet rich plasma in aiding the healing process in tendinopathies. Similarly, more recent evidences have proven hyaluronic (HA) acid to have anti-inflammatory, proliferative, repairing, and analgesic effects. This case report presents the clinical application of combined PRP and a multifractioned (a mixture of different molecular weights) HA in a 24-year-old athlete suffering from a hip adductor rupture.
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- 2023
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14. Bone bruises in anterior cruciate ligament injured knee and long-term outcomes. A review of the evidence
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Papalia R, Torre G, Vasta S, Zampogna B, Pedersen DR, Denaro V, and Amendola A
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Sports medicine ,RC1200-1245 - Abstract
Rocco Papalia,1 Guglielmo Torre,1 Sebastiano Vasta,1 Biagio Zampogna,1 Douglas R Pedersen,2,3 Vincenzo Denaro,1 Annunziato Amendola3 1Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy; 2Department of Biomedical Engineering, 3Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA Background: Bone bruises are frequently associated with anterior cruciate ligament (ACL) tears as a result of trauma or direct shear stress of the bone. Purpose: To review the evidence regarding the characteristics of the bone bruise associated with ACL tears, its relevance on clinical outcomes, and its progression over time. In particular, the long-term effects of the bone bruise on the knee osteochondral architecture and joint function were evaluated. Study design: Review; level of evidence: 4. Methods: An electronic search was performed on PubMed. Combinations of keywords included: “bone bruise AND knee”; “bone bruise AND anterior cruciate ligament”; “bone bruise AND osteo-chondral defects”. Any level of evidence studies concerning bone bruises in patients with partial or complete ACL tears were retrieved. Results: A total of 25 studies were included; three of them investigated biomechanical parameters, seven were concerned with clinical outcomes, and 15 were radiological studies. Evaluation of the bone bruise is best performed using a fat-saturated T2-weighted fast spin echo exam or a short tau inversion recovery sequence where fat saturation is challenging. The location of the injury has been demonstrated to be more frequent in the lateral compartment of the joint (lateral femoral condyle and lateral tibial plateau). It is associated with ACL tears in approximately 70% of cases, often with collateral ligament or meniscal tears. Mid- and long-term outcomes demonstrated a complete healing of the marrow lesions at magnetic ρresonance imaging, but chondral defects detected with T1ρ sequences are still present 1 year after the ACL injury. Functional examination of the knee, through clinical International Knee Documentation Committee scores, did not show any correlation with the bone bruise. Conclusion: Although bone bruise presence yields to higher pain levels, no correlation with functional outcomes was reported. Most studies have a short-term follow-up (
- Published
- 2015
15. On the effective thermal conductivity of wetted zeolite under the working conditions of an adsorption chiller
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Dawoud, B., Sohel, M. Imroz, Freni, A., Vasta, S., and Restuccia, G.
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- 2011
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16. What Else Can Be Done by the Spinal Cord? A Review on the Effectiveness of Transpinal Direct Current Stimulation (tsDCS) in Stroke Recovery.
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Marangolo P, Vasta S, Manfredini A, and Caltagirone C
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- Animals, Humans, Evoked Potentials, Motor physiology, Spinal Cord physiology, Brain, Stroke therapy, Motor Cortex physiology
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Since the spinal cord has traditionally been considered a bundle of long fibers connecting the brain to all parts of the body, the study of its role has long been limited to peripheral sensory and motor control. However, in recent years, new studies have challenged this view pointing to the spinal cord's involvement not only in the acquisition and maintenance of new motor skills but also in the modulation of motor and cognitive functions dependent on cortical motor regions. Indeed, several reports to date, which have combined neurophysiological techniques with transpinal direct current stimulation (tsDCS), have shown that tsDCS is effective in promoting local and cortical neuroplasticity changes in animals and humans through the activation of ascending corticospinal pathways that modulate the sensorimotor cortical networks. The aim of this paper is first to report the most prominent tsDCS studies on neuroplasticity and its influence at the cortical level. Then, a comprehensive review of tsDCS literature on motor improvement in animals and healthy subjects and on motor and cognitive recovery in post-stroke populations is presented. We believe that these findings might have an important impact in the future making tsDCS a potential suitable adjunctive approach for post-stroke recovery.
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- 2023
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17. Meniscal extrusion: risk factors and diagnostic tools to predict early osteoarthritis.
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Papalia GF, Za P, Saccone L, Franceschetti E, Zampogna B, Vasta S, and Papalia R
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Meniscal extrusion (ME) is strongly correlated with cartilage wear and osteoarthritis (OA), be-cause of the altered kinematic and the decreased contact area between the tibia and femur. The aim of this narrative review is to analyze the process of ME, focusing on the possible causes, and to evaluate the correlation between ME and knee OA, in order to provide early diagnosis and treatments. Studies written in English that analyzed the causes of ME, provided indications re-garding diagnosis and treatment, and evaluated the relation between ME and early OA were in-cluded. Injuries, degeneration of the meniscal substance and meniscus root tears are associated with significantly increased ME. An extruded meniscus could be a manifestation of other pa-thologies such as disruption of coronary ligaments, cartilage loss, knee malalignment, ligament injuries, or OA. ME is strongly associated with osteoarthritis features, particularly with bone marrow lesion and cartilage damage. Magnetic resonance imaging represents the gold standard for the detection of ME. The severity of the medial meniscus extrusion may also affect healing af-ter repair, and meniscus extrusion is not completely reduced by meniscus posterior root tear re-pair. In this study, we proved that ME represents an important risk factor for early knee OA. We provided alternative theories of ME, such as meniscal fibers injury first and "dynamic extrusion of the menisci". The phenomenon of aging has been described as a new concept in the etiology of ME. Finally, we stated all the main techniques and characteristics of the diagnostic process, as well as the current knowledge in the therapeutic field., Competing Interests: The authors declare no conflict of interest.
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- 2023
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18. Sarcopenia and its relationship with osteoarthritis: risk factor or direct consequence?
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Papalia, R., Zampogna, B., Torre, G., Lanotte, A., Vasta, S., Albo, E., Tecame, A., and Denaro, V.
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- 2014
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19. Modelling of an adsorption system driven by engine waste heat for truck cabin A/C. Performance estimation for a standard driving cycle
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Verde, M., Cortés, L., Corberán, J.M., Sapienza, A., Vasta, S., and Restuccia, G.
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- 2010
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20. Structural properties of a new fixation strategy in double bundle ACL reconstruction: the MiniShim
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Lenschow, S., Schliemann, B., Dressler, K., Zampogna, B., Vasta, S., Raschke, M., and Zantop, T.
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- 2011
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21. An adsorptive solar ice-maker dynamic simulation for north Mediterranean climate
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Vasta, S., Maggio, G., Santori, G., Freni, A., Polonara, F., and Restuccia, G.
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- 2008
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22. Optimization of a solar-powered adsorptive ice-maker by a mathematical method
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Freni, A., Maggio, G., Vasta, S., Santori, G., Polonara, F., and Restuccia, G.
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- 2008
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23. Experimental characterization of the LiCl/vermiculite composite for sorption heat storage applications|Caractérisation expérimentale du composite LiCl/vermiculite pour les applications de stockage de chaleur par sorption
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Brancato V., Gordeeva L.G., Sapienza A., Palomba V., Vasta S., Grekova A.D., Frazzica A., and Aristov Y.I.
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dynamic ,sorption ,large temperature jump - Abstract
The present paper reports about the experimental characterization of a recently developed composite sorbent of water, LiCl/vermiculite, for thermal energy storage applications. The sorption ability as well as the thermal storage capacity (TSC) of the material itself were tested in a dedicated TG/DSC apparatus, under two relevant boundary conditions, namely, seasonal (SS) and daily (DS) storage applications. The dynamic behavior of the composite sorbent was tested by means of a G-LTJ apparatus in flat-plate adsorber configuration, under both SS and DS working conditions. Finally, preliminary tests on a lab-scale TES configuration were performed and reported. The main outcomes confirm that the composite is promising for TES applications, reaching the TSC up to 2.15 kJ/g under SS conditions. The stability of the composite was proven for 14 consecutive sorption/desorption cycles under conditions similar to those at real SS and DS cycles. The kinetic adsorption tests confirmed a slowdown of the sorption dynamics when passing from 1.7-2.0 mm to 2.36-2.80 mm of the grain size. Furthermore, the adsorption kinetic under SS mode is faster than of DS one. The preliminary testing in the lab-scale TES at SS cycle allowed getting TSC up to 1.25 kJ/g with a specific power up to 2.1 kW/kg.
- Published
- 2019
24. Automated Prototype for Bombyx mori Cocoon Sorting Attempts to Improve Silk Quality and Production Efficiency through Multi-Step Approach and Machine Learning Algorithms.
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Vasta S, Figorilli S, Ortenzi L, Violino S, Costa C, Moscovini L, Tocci F, Pallottino F, Assirelli A, Saviane A, and Cappellozza S
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- Animals, Silk, Bombyx
- Abstract
Cocoon sorting is one of the most labor-demanding activities required both at the end of the agricultural production and before the industrial reeling process to obtain an excellent silk quality. In view of the possible relaunch of European sericulture, the automatization of this production step is mandatory both to reduce silk costs and to standardize fiber quality. The described research starts from this criticality in silk production (the manual labor required to divide cocoons into different quality classes) to identify amelioration solutions. To this aim, the automation of this activity was proposed, and a first prototype was designed and built. This machinery is based on the use of three cameras and imaging algorithms identifying the shape and size of the cocoons and outside stains, a custom-made light sensor and an AI model to discard dead cocoons. The current efficiency of the machine is about 80 cocoons per minute. In general, the amelioration obtained through this research involves both the application of traditional sensors/techniques to an unusual product and the design of a dedicated sensor for the identification of dead/alive pupae inside the silk cocoons. A general picture of the overall efficiency of the new cocoon-sorting prototype is also outlined.
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- 2023
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25. An advanced solid sorption chiller using SWS-1L
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Freni, A., Russo, F., Vasta, S., Tokarev, M., Aristov, Yu.I., and Restuccia, G.
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- 2007
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26. Initial Results of Peripheral-Blood Stem-Cell Mobilization, Collection, Cryopreservation, and Engraftment After Autologous Transplantation Confirm That the Capacity-Building Approach Offers Good Chances of Success in Critical Contexts: A Kurdish-Italian Cooperative Project at the Hiwa Cancer Hospital, Sulaymaniyah
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Chra Abdullah, Dastan O. Hassan, Andrea Frigato, Annunziata Manna, Angelo Ostuni, Michele Vacca, Marco Possenti, Francesco Ipsevich, Marta Verna, Attilio Rovelli, Dlir Ali, Salah Salih, Vasta S, Angelo Palmas, Dereen Mohammed, Dosti Othman, Rebar N. Mohammed, Ignazio Majolino, Valentino Conter, Kosar Ali, Harem Karem, Maria Speranza Massei, Marcela Gabriel, Diana Noori, and Claudia Del Fante
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Plasma cell leukemia ,Cancer Research ,Pediatrics ,medicine.medical_specialty ,Mobilization ,business.industry ,Myeloid leukemia ,Retrospective cohort study ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,Transplantation ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,medicine ,Autologous transplantation ,Young adult ,business ,Multiple myeloma ,030215 immunology - Abstract
Introduction At Hiwa Cancer Hospital (Sulaymaniyah, Iraqi Kurdistan) after the center was started by a cooperative project in June 2016, autologous transplantation was developed. Patients and Methods To develop the project, the capacity-building approach was adopted, with on-site training and coaching of personnel, educational meetings, lectures, on-the-job training, and the implementation of quality management planning. Results Here, we report initial results of peripheral-blood stem-cell mobilization and collection of the first 27 patients (age 12 to 61 years; 19 males and 8 females; multiple myeloma, n = 10; plasma cell leukemia, n = 1; Hodgkin lymphoma, n = 12; non-Hodgkin lymphoma, n = 3; and acute myeloid leukemia, n = 1). Only three (11.5%) of 26 patients experienced a failure of mobilization. A median of 6.1 × 106/kg CD34-positive cells per patient were collected (range, 2.4 to 20.8), with two apheretic runs. Twenty-four patients underwent autologous transplantation. All but one transplantation engrafted fully and steadily, with 0.5 and 1.0 × 109/L polymorphonucleates on day 10.5 (range, 8 to 12) and day 11 (range, 9 to 15), respectively, and with 20 and 50 × 109/L platelets on day 13 (range, 10 to 17) and day 17 (range, 2 to 44), respectively. More than 95% of patients are projected to survive 1 year after autograft. Conclusion These data are the result of an Italian effort to establish in Iraqi Kurdistan a leading center for hemopoietic stem-cell transplantation. The capacity building approach was used, with on-site training and coaching as instruments for the development of provider ability and problem solving. With future limitations for immigration, this method will be helpful, especially in the field of high-technology medicine.
- Published
- 2017
27. TOPMACS: Thermally OPerated Mobile Air Conditioning Systems
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Magnetto, D., primary, De Boer, R., additional, and Vasta, S., additional
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- 2011
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28. Olive Fruit Selection through AI Algorithms and RGB Imaging.
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Figorilli S, Violino S, Moscovini L, Ortenzi L, Salvucci G, Vasta S, Tocci F, Costa C, Toscano P, and Pallottino F
- Abstract
(1) Background: Extra virgin olive oil production is strictly influenced by the quality of fruits. The optical selection allows for obtaining high quality oils starting from batches with different qualitative characteristics. This study aims to test a CNN algorithm in order to assess its potential for olive classification into several quality classes for industrial purposes, specifically its potential integration and sorting performance evaluation. (2) Methods: The acquired samples were all subjected to visual analysis by a trained operator for the distinction of the products in five classes related to the state of external veraison and the presence of visible defects. The olive samples were placed at a regular distance and in a fixed position on a conveyor belt that moved at a constant speed of 1 cm/s. The images of the olives were taken every 15 s with a compact industrial RGB camera mounted on the main frame in aluminum to allow overlapping of the images, and to avoid loss of information. (3) Results: The modelling approaches used, all based on AI techniques, showed excellent results for both RGB datasets. (4) Conclusions: The presented approach regarding the qualitative discrimination of olive fruits shows its potential for both sorting machine performance evaluation and for future implementation on machines used for industrial sorting processes.
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- 2022
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29. Superior EVOO Quality Production: An RGB Sorting Machine for Olive Classification.
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Violino S, Moscovini L, Costa C, Re PD, Giansante L, Toscano P, Tocci F, Vasta S, Manganiello R, Ortenzi L, and Pallottino F
- Abstract
Extra virgin olive oil (EVOO) is a commercial product of high quality, thanks to its nutritional and organoleptic characteristics. The olives ripeness and the choice of harvest time according to their color and size, strongly influences the quality of the EVOO. The physical sorting of olives with machines performing rapid and objective optical selection, impossible by hand, can improve the quality of the final product. The aim of this study concerns the classification of olives into two qualitative classes, based on the maturity stage and the presence of external defects, through an industrial RGB optical sorting prototype, evaluating its performance and comparing the results with those obtained visually by trained operators. EVOOs obtained from classified olives were characterized through chemical, physical-chemical analysis and sensory profile. For the first time, the optoelectronic technologies in an industrial system was tested on olives to produce superior quality EVOO. The selection allows late harvest, obtaining oils with good characteristics from fully ripe and unripe fruits together, separating defective olives with appropriate calibration and training. Optoelectronic selection creates the opportunity to blend the obtained oils destined to different applications according to the needs of the consumer or producer, using a vanguard technology at low cost.
- Published
- 2022
- Full Text
- View/download PDF
30. Advantages in Using Colour Calibration for Orthophoto Reconstruction.
- Author
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Tocci F, Figorilli S, Vasta S, Violino S, Pallottino F, Ortenzi L, and Costa C
- Subjects
- Agriculture, Calibration, Color, Algorithms, Photogrammetry methods
- Abstract
UAVs are sensor platforms increasingly used in precision agriculture, especially for crop and environmental monitoring using photogrammetry. In this work, light drone flights were performed on three consecutive days (with different weather conditions) on an experimental agricultural field to evaluate the photogrammetric performances due to colour calibration. Thirty random reconstructions from the three days and six different areas of the field were performed. The results showed that calibrated orthophotos appeared greener and brighter than the uncalibrated ones, better representing the actual colours of the scene. Parameter reporting errors were always lower in the calibrated reconstructions and the other quantitative parameters were always lower in the non-calibrated ones, in particular, significant differences were observed in the percentage of camera stations on the total number of images and the reprojection error. The results obtained showed that it is possible to obtain better orthophotos, by means of a calibration algorithm, to rectify the atmospheric conditions that affect the image obtained. This proposed colour calibration protocol could be useful when integrated into robotic platforms and sensors for the exploration and monitoring of different environments.
- Published
- 2022
- Full Text
- View/download PDF
31. Thermal conductivity measurement of a PCM based storage system containing carbon fibers
- Author
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Frusteri, F., Leonardi, V., Vasta, S., and Restuccia, G.
- Published
- 2005
- Full Text
- View/download PDF
32. Experimental investigation of a solid adsorption chiller based on a heat exchanger coated with hydrophobic zeolite
- Author
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Restuccia, G., Freni, A., Russo, F., and Vasta, S.
- Published
- 2005
- Full Text
- View/download PDF
33. Allogeneic peripheral blood progenitor cells for treatment of relapse after bone marrow transplantation
- Author
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Glass, B, Majolino, I, Dreger, P, Scimè, R, Santoro, A, Vasta, S, Suttorp, M, Haferlach, T, and Schmitz, N
- Published
- 1997
- Full Text
- View/download PDF
34. Il mito nel tardo neoplatonismo: a-razionalità o sovra-razionalità? Proclo e il caso del mito sconveniente
- Author
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Cardullo, R., Coniglione, F., Vasta, S., Coco, E., Militello, C., and Borbone, Giacomo
- Published
- 2019
35. Selective water sorbent for solid sorption chiller: experimental results and modelling
- Author
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Restuccia, G., Freni, A., Vasta, S., and Aristov, Yu
- Published
- 2004
- Full Text
- View/download PDF
36. Comparing hybrid hyaluronic acid with PRP in end career athletes with degenerative cartilage lesions of the knee
- Author
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Papalia R, Zampogna B, Russo F, Vasta S, Mc, Tirindelli, Nobile C, Ac, Di Martino, Gianluca Vadalà, Denaro V, Papalia, R, Zampogna, B, Russo, F, Vasta, S, Tirindelli, M C, Nobile, C, Di Martino, A, Vadalà, G, and Denaro, V
- Subjects
Cartilage ,Treatment Outcome ,Athlete ,Athletes ,Platelet-Rich Plasma ,Humans ,Hyaluronic Acid ,Osteoarthritis, Knee ,Human ,Injections, Intra-Articular - Abstract
Cartilage lesions are very common causes of chronic knee pain in athletes. Current treatment options consist in conservative strategies, such as viscosupplementation and platelet-rich plasma injections. This randomized controlled trial aims to investigate the effect of intra-articular Hybrid Hyaluronic Acid injections compared to PRP for the treatment of cartilage lesions among athletes at the end of their career. Since March 2015, 48 professional soccer players were randomized into two groups: 24 patients received 3 injections of HHA and 23 patients received 3 intra-articular injections of PRP. All patients achieved a statistically significant clinical improvement from preoperative to postoperative time in both groups. Patients in the HHA group showed a significant superiority compared to PRP group at 3 and 6 months. Intergroup differences decrease gradually until loss of significance at 12 months follow-up. Athletes with chronic degenerative cartilage lesions of the knee responded positively both to HHA and PRP until last follow up.
- Published
- 2016
37. Successful engraftment of allogeneic PBSC after conditioning with busulfan alone
- Author
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Majolino, I, Cavallaro, AM, Santoro, A, Catania, P, Cannella, S, Vasta, S, and Scime′, R
- Published
- 1997
- Full Text
- View/download PDF
38. Outcomes, Complications, and Reoperations After Meniscal Allograft Transplantation.
- Author
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Vasta S, Zampogna B, Hartog TD, El Bitar Y, Uribe-Echevarria B, and Amendola A
- Abstract
Background: Outcomes following meniscal allograft transplantation (MAT) are an evolving topic., Purpose: To review clinical outcomes in younger, previously active patients who underwent an isolated MAT or MAT plus any osteotomy. Concurrent surgeries, complications, and graft survivorship are presented., Study Design: Case series; Level of evidence, 4., Methods: Inclusion criteria included having undergone MAT with a minimum of 1 year of follow-up with at least 1 of the following patient-reported outcome (PRO) measures collected pre- and postoperatively: visual analog scale for pain, Knee injury and Osteoarthritis Outcome Score (KOOS), the Western Ontario and McMaster Universities Arthritis Index, the 36-Item Short Form Health Survey, and overall satisfaction. From patient records, we recorded descriptive data, side (medial/lateral), previous or concurrent procedures, perioperative complications, revisions, and conversion to arthroplasty. Two-factor analysis of variance (ANOVA) was used to test for differences in age and body mass index (BMI). A 2 × 2 chi-square test was used to determine if the spectrum of procedures performed on our study's patient group was representative of the entire population. PRO results were analyzed using a multivariate ANOVA., Results: From a total of 91 eligible patients, 61 (63 knees) met our inclusion criteria. Mean presurgery age was 25.5 ± 9.2 years, and mean BMI was 26.7 (range, 18.5-38.4). At follow-up (mean, 4.8 years; range, 1.0-13.6 years) overall PROs were statistically and clinically improved at final follow-up ( P ≤ .003); effect sizes were moderate and large. KOOS Pain and KOOS Activities of Daily Living showed some main or interaction effects that were trivial or small. Patient satisfaction with the treatment was ≥7 out of 10 in 85% of patients. A minimum of 1 subsequent surgery for various concerns was necessary in 23% of the 93 knees. Graft survival in the included patients was 100%., Conclusion: Complications (conditions requiring at least 1 subsequent surgery) affected about one-quarter of the patients who underwent MAT. Nevertheless, MAT seemed to provide our patients with adequate pain relief and improved function., Competing Interests: One or more of the authors has declared the following potential conflict of interest or source of funding: Y.E.B. has received education payments from Wardlow Enterprises. A.A. has received consulting fees from Arthrex, Bioventus, and Limacorporate SpA; nonconsulting fees from Arthrex; and royalties from Arthrex and has an investment interest in Anika Therapeutics. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto., (© The Author(s) 2022.)
- Published
- 2022
- Full Text
- View/download PDF
39. Design of a geothermal plant to heat a waterpark swimming pool: Case study of tramutola (Basilicata, Italy)
- Author
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DI BELLA, G, primary, SAPIENZA, A, additional, VASTA, S, additional, and LOMBARDO, G, additional
- Published
- 2018
- Full Text
- View/download PDF
40. Mobilization and collection of PBSC in healthy donors: comparison between two schemes of rhG-CSF administration
- Author
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Majolino, I., Scimé, R., Vasta, S., Cavallaro, A. M., Fiandaca, T., Indovina, A., Catania, P., and Santoro, A.
- Published
- 1996
41. Cartilage Restoration of Patellofemoral Lesions: A Systematic Review.
- Author
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Andrade R, Nunes J, Hinckel BB, Gruskay J, Vasta S, Bastos R, Oliveira JM, Reis RL, Gomoll AH, and Espregueira-Mendes J
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Transplantation, Autologous, Cartilage Diseases surgery, Cartilage, Articular surgery, Chondrocytes transplantation, Patella surgery
- Abstract
Purpose: This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery., Methods: This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed, EMBASE, and Cochrane Library databases were searched up to August 31, 2018, to identify clinical studies that assessed surgical outcomes of patellofemoral cartilage restoration surgery. The Methodological Index for Non-Randomized Studies (MINORS) was used to assess study quality., Results: Forty-two studies were included comprising 1,311 knees (mean age of 33.7 years and 56% males) and 1,309 patellofemoral defects (891 patella, 254 trochlear, 95 bipolar, and 69 multiple defects, including the patella or trochlea) at a mean follow-up of 59.2 months. Restoration techniques included autologous chondrocyte implantation (56%), particulated juvenile allograft cartilage (12%), autologous matrix-induced chondrogenesis (9%), osteochondral autologous transplantation (9%), and osteochondral allograft transplantation (7%). Significant improvement in at least one score was present in almost all studies and these surpassed the minimal clinically important difference threshold. There was a weighted 19%, 35%, and 6% rate of reported complications, reoperations, and failures, respectively. Concomitant patellofemoral surgery (51% of patients) mostly did not lead to statistically different postoperative outcomes., Conclusion: Numerous patellofemoral restoration techniques result in significant functional improvement with a low rate of failure. No definitive conclusions could be made to determine the best surgical technique since comparative studies on this topic are rare, and treatment choice should be made according to specific patient and defect characteristics., Level of Evidence: Level IV, systematic review of level II to IV studies.
- Published
- 2021
- Full Text
- View/download PDF
42. Physical Exercise and Mental Health: The Routes of a Reciprocal Relation.
- Author
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Fossati C, Torre G, Vasta S, Giombini A, Quaranta F, Papalia R, and Pigozzi F
- Subjects
- Athletes, Exercise, Humans, Quality of Life, Mental Health, Sports
- Abstract
Sport participation and exercise practice are considered to be beneficial for mental status, yielding an improved mood and better quality of life. On the other hand, good mental fitness is thought to lead to better physical status and sport performance. The key aim of this narrative review is to provide an unstructured overview on the topic with special considerations on the role of mental and physical health to summarize the evidence on their reciprocal influence. While very few papers describe the role of mental health measures in affecting physical performance, more evidence is available concerning the effect of exercise and sport in improving mental health outcomes. Furthermore, there is a consistent role of depressive and anxiety symptoms in influencing the risk of sport injury in either recreational or elite athletes. Moreover, the importance of investigating mental health issues in elite and retired athletes is highlighted. On the basis of the available literature, several biases were found to affect the provided evidence mainly because of the complexity of a proper study design in this field.
- Published
- 2021
- Full Text
- View/download PDF
43. Cogenerazione assistita da gassificazione: Analisi di un caso studio mediante simulazione dinamica
- Author
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Galvagno, A., Palomba, V., Prestipino, M., and Vasta, S.
- Subjects
TRNSYS ,gassifcazione ,cogenerazione - Abstract
I sistemi di cogenerazione alimentati da fonti rinnovabili, quali le biomasse, risultano di grande interesse per la produzione efficiente di energia in ambito industriale. Pertanto, scopo del presente lavoro è lo studio dell'integrazione, in tale contesto, di un sistema di cogenerazione alimentato da syngas prodotto tramite gassificazione di biomasse. Tale valutazione è stata sviluppata mediante la realizzazione di modelli matematici di simulazione per la modellazione di un impianto in assetto cogenerativo.
- Published
- 2017
44. La cura educativa per il reinserimento sociale di detenuti in Esecuzione Penale Esterna. Tra analisi e messa a punto del setting pedagogico
- Author
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Cerrocchi, Laura, Cavedoni, F., con contributi di Vasta, S., Pongiluppi, C., and Chitussi, B.
- Subjects
Educatore sociale ,Teorie e pratiche di cura ,Conflitto bio-psicologico e socio-culturale ,Rete-Comunità-Gruppo-Soggetto/Persona ,Pedagogia generale e sociale ,Educazione degli Adulti ,Pedagogista - Published
- 2016
45. An Open Source Low-Cost Device Coupled with an Adaptative Time-Lag Time-Series Linear Forecasting Modeling for Apple Trentino (Italy) Precision Irrigation.
- Author
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Figorilli S, Pallottino F, Colle G, Spada D, Beni C, Tocci F, Vasta S, Antonucci F, Pagano M, Fedrizzi M, and Costa C
- Abstract
Precision irrigation represents those strategies aiming to feed the plant needs following the soil's spatial and temporal characteristics. Such a differential irrigation requires a different approach and equipment with regard to conventional irrigation to reduce the environmental impact and the resources use while maximizing the production and thus profitability. This study described the development of an open source soil moisture LoRa (long-range) device and analysis of the data collected and updated directly in the field (i.e., weather station and ground sensor). The work produced adaptive supervised predictive models to optimize the management of agricultural precision irrigation practices and for an effective calibration of other agronomic interventions. These approaches are defined as adaptive because they self-learn with the acquisition of new data, updating the on-the-go model over time. The location chosen for the experimental setup is a cultivated area in the municipality of Tenna (Trentino, Alto Adige region, Italy), and the experiment was conducted on two different apple varieties during summer 2019. The adaptative partial least squares time-lag time-series modeling, in operative field conditions, was a posteriori applied in the consortium for 78 days during the dry season, producing total savings of 255 mm of irrigated water and 44,000 kW of electricity, equal to 10.82%.
- Published
- 2021
- Full Text
- View/download PDF
46. TKR after posttraumatic and primary knee osteoarthritis: a comparative study.
- Author
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Phruetthiphat OA, Zampogna B, Vasta S, Tassanawipas B, Gao Y, and Callaghan JJ
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Pain Measurement, Postoperative Complications, Retrospective Studies, Treatment Outcome, Arthroplasty, Replacement, Knee, Fractures, Bone surgery, Knee Injuries surgery, Osteoarthritis, Knee surgery
- Abstract
Background: A few literatures reported that the outcomes of total knee replacement (TKR) in posttraumatic osteoarthritis (PTOA) were lower compared to TKR in primary osteoarthritis (primary OA). The study's purpose was to compare the comorbidity and outcome of TKR among fracture PTOA, ligamentous PTOA, and primary OA. The secondary aim was to identify the effect of postoperatively lower limb mechanical axis on an 8-year survivorship after TKR between PTOA and primary OA., Methods: Seven hundred sixteen patients with primary OA, 32 patients with PTOA (knee fracture subgroup), and 104 PTOA (knee ligamentous injury subgroup) were recruited. Demography, comorbidities, Charlson Comorbidity Index (CCI), operative parameters, mechanical axis, functional outcome assessed by WOMAC, and complications were compared among the three groups., Results: PTOA group was significantly younger (p<0.0001) with a higher proportion of men (p=0.001) while the primary OA group had higher comorbidities than the PTOA group, including anticoagulant usage (p=0.0002), ASA class ≥3 (p<0.0001), number of diseases ≥ 4 (p<0.0001), and CCI (p<0.0001). Both the fracture PTOA group (p<0.0001) and ligamentous PTOA group (p = 0.009) had a significantly longer operative time than the primary OA group. The fracture PTOA group had significantly lower pain components and stiffness components than the primary OA group. There was no significant difference in the rate of an aligned group, outlier group, and an 8-year survivorship in both groups., Conclusion: The outcome following TKR in the fracture PTOA was poorer compared to primary knee OA in the midterm follow-up. However, no difference was detected between the ligamentous PTOA and primary knee OA. The mechanical axis alignment within the neutral axis did not affect the 8-year survivorship after TKR in both groups., Level of Evidence: Level III; retrospective cohort study.
- Published
- 2021
- Full Text
- View/download PDF
47. Return to Sport After Anterior Cruciate Ligament Reconstruction in a Cohort of Division I NCAA Athletes From a Single Institution.
- Author
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Zampogna B, Vasta S, Torre G, Gupta A, Hettrich CM, Bollier MJ, Wolf BR, and Amendola A
- Abstract
Background: Anterior cruciate ligament (ACL) tears are common in collegiate athletes. The rate of return to the preinjury level of sport activities after ACL reconstruction continues to evolve., Purpose/hypothesis: The purpose was to determine the return-to-sport rate after ACL reconstruction in a cohort of National Collegiate Athletic Association Division I athletes in different sports. It was hypothesized that, with intensive supervision of rehabilitation, the return-to-sport rate would be optimal., Study Design: Case series; Level of evidence, 4., Methods: We retrospectively reviewed the records of 75 collegiate athletes from a single institution who had undergone unilateral or bilateral ACL reconstruction between 2001 and 2013 and participated in an extensive supervised rehabilitation program. Prospectively collected athlete data as well as data about preinjury exposure, associated lesions, surgical technique, time lost to injury, number of games missed, time to return to full sport activity or retire, and subsequent surgical procedures were extracted from the medical and athletic trainer records., Results: The 75 patients (40 male, 35 female; mean age, 20.1 years) underwent 81 reconstruction procedures (73 primary, 8 revision). The mean follow-up was 19.3 months. The overall return-to-sport rate was 92%. After reconstruction, 9 athletes (12%) retired from collegiate sports, but 3 of them returned to sport activities after graduation. Overall, 8 athletes (11%) experienced an ACL graft retear., Conclusion: The return-to-sport rate in our National Collegiate Athletic Association Division I athletes compared favorably with that reported in other studies in the literature. The strict follow-up by the surgeon, together with the high-profile, almost daily technical and psychological support given mainly by the athletic trainers during the recovery period, may have contributed to preparing the athletes for a competitive rate of return to sport at their preinjury level., Competing Interests: One or more of the authors has declared the following potential conflict of interest or source of funding: C.M.H. has received hospitality payments from Tornier. M.J.B. has received speaking fees from Arthrex. B.R.W. has received educational support from Wardlow Enterprises and consulting fees and speaking fees from Linvatec. A.A. has received consulting fees, speaking fees, and royalties from Arthrex. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto., (© The Author(s) 2021.)
- Published
- 2021
- Full Text
- View/download PDF
48. High-dose cyclophosphamide for mobilization of circulating stem cells in chronic myeloid leukemia
- Author
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Maria Pampinella, Rosanna Scimè, Ignazio Majolino, Stefania Tringali, Vasta S, Alessandra Santoro, and Maria Assunta Marino
- Subjects
Adult ,Male ,Melphalan ,Adolescent ,Cyclophosphamide ,Neutrophils ,Clone (cell biology) ,Leukocyte Count ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,hemic and lymphatic diseases ,Humans ,Medicine ,business.industry ,Macrophages ,Hematopoietic Stem Cell Transplantation ,Myeloid leukemia ,Hematology ,General Medicine ,Hematopoietic Stem Cells ,Regimen ,medicine.anatomical_structure ,Immunology ,Blood Component Removal ,Cancer research ,Female ,Circulating Stem Cell ,Bone marrow ,Stem cell ,business ,Granulocytes ,medicine.drug - Abstract
Experimental and clinical data suggest that Ph-negative myeloid progenitor cells are present, albeit suppressed, in the bone marrow of chronic myeloid leukemia (CML) patients. These residual Ph-negative cells might, in certain circumstances, regain their proliferative advantage over the leukemic Ph-positive clone. Treating CML patients with intensive chemotherapy might allow the harvest, in the early phase of recovery, of Ph-negative stem cells to be used as graft after myeloablative regimen. In our study, 6 CML patients were admitted to a program of autograft with circulating stem cells (CSC) collected after high-dose (5 or 7 g/m2) cyclophosphamide (HD-CY) mobilization. All were autografted, using busulphan 16 mg/kg and melphalan 60 mg/m2. As graft, 4 patients received CSC only, while 2 patients were also given bone marrow, as their peripheral blood CFU-GM yield was unsatisfactory. Two previously alpha-IFN-responding patients showed a slow hematologic recovery, but achieved a marked and further reduction of their Ph-positive metaphases post-graft. Moreover, in one of them, cytogenetic analyses performed on apheresis product showed a more pronounced reduction of his Ph-positive metaphases, as compared to bone marrow samples, suggesting a potential purging effect of the mobilization procedure.
- Published
- 2009
49. High-dose cyclophosphamide, etoposide and BCNU (CVB) with autologous stem cell rescue in malignant lymphomas
- Author
-
C. Patti, A Indovina, R. Pisa, Ignazio Majolino, Vasta S, Caronia F, G. Liberti, Alessandra Santoro, Rosanna Scimè, and S. Gentile
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Time Factors ,Lymphoma ,Cyclophosphamide ,medicine.medical_treatment ,Transplantation, Autologous ,Gastroenterology ,Colony-Forming Units Assay ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Autologous transplantation ,Etoposide ,Bone Marrow Transplantation ,Neoplasm Staging ,Salvage Therapy ,Carmustine ,Chemotherapy ,business.industry ,Lymphoma, Non-Hodgkin ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Hodgkin Disease ,Transplantation ,medicine.anatomical_structure ,Female ,Bone marrow ,business ,Progressive disease ,Follow-Up Studies ,Stem Cell Transplantation ,medicine.drug - Abstract
Eighteen patients with malignant lymphoma, 10 non-Hodgkin's and 8 Hodgkin's, were treated with high-dose CVB (cyclophosphamide 4 x 1.5 g/m2, etoposide 4 x 250-400 mg/m2, carmustine 4 x 150-200 mg/m2), followed by autologous peripheral blood stem cells (PBSC, 13 patients) or bone marrow (BM, 5 patients) transplantation. At the time of autograft 6 patients were in complete remission (CR), 3 in partial remission (PR) and 5 in relapse (4 sensitive, 1 resistant), whereas 4 had progressive disease. All CR patients had poor prognostic features at presentation. PBSC were collected at the time of rapid hematologic recovery after intense chemotherapy by means of a cell separator. All patients engrafted. Median time to achieve > or = 0.5 x 10(9)/l polymorphonuclear cells (PMN) and > or = 50 x 10(9)/l platelets was 13 days for both cell types in PBSC autografted patients, versus 20 and 28 days respectively in BM autografted patients. A significant advantage of PBSC over BM was found in terms of time needed to recover either PMN > or = 0.5 and PMN > or = 1 x 10(9)/l (p = 0.01). Autograft-related toxicity consisted mainly of moderate severity interstitial pneumopathy (3 patients), and veno-occlusive disease (1 patient) that resolved completely. Of the 12 patients autografted with detectable disease, 6 (50%) obtained a CR. Seven out of 18 autografted patients (39%) had disease progression within 1 to 5 months of autograft. The projected progression-free survival is over 50% at 4 years and it was significantly longer in patients with sensitive disease than in those with resistant disease (p = 0.01). The efficacy and the low toxicity of CVB suggest that autograft with PBSC may be proposed for the primary treatment of poor prognosis malignant lymphomas.
- Published
- 2009
50. Mobilization and collection of PBSC in healthy donors: comparison between two schemes of rhG-CSF administration
- Author
-
Alessandra Santoro, A Indovina, A M Cavallaro, T Fiandaca, P Catania, Vasta S, Ignazio Majolino, and Rosanna Scimè
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,CD34 ,Urology ,Antigens, CD34 ,Blood Donors ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,Transplantation, Homologous ,Leukapheresis ,Progenitor cell ,Blood Specimen Collection ,Blood Cells ,business.industry ,Hematology ,General Medicine ,Recombinant Proteins ,Surgery ,Granulocyte colony-stimulating factor ,Transplantation ,Apheresis ,Toxicity ,Female ,Stem cell ,business ,Stem Cell Transplantation - Abstract
Procurement of a high number of progenitor cells is of primary interest in allogeneic PBSC transplantation. We have retrospectively compared toxicity, mobilization effect and progenitor cell yields of two different rhG-CSF schedules in 11 consecutive healthy individuals donating their PBSC. Five of them received rhG-CSF 16 micrograms/kg/d for 4 subsequent d in 2 divided subcutaneous injections (group A); similarly, 6 donors received rhG-CSF 10 micrograms/kg/d for 5 d (group B). The aphereses were started the last day of rhG-CSF treatment; 9 donors underwent 2 aphereses, one underwent 1 and another 3 procedures, always on subsequent days. Toxicity was mild, but moderate thrombocytopenia developed following apheretic collections, irrespective of rhG-CSF schedule. In all the donors WBC, as well as circulating CD34+ cells, CFU-GM, CFU-GEMM and BFU-E dramatically increased over the baseline values, peaking on d 5 or 6, with no statistical difference between the 2 groups for the height of the cell peaks. Also the peripheral lymphoid cell populations (CD3+, CD19+ and CD56+/CD3-) increased following the rhG-CSF administration. The number of MNC, CFU-GM, BFU-E, CFU-GEMM, as well as CD34+, CD3+, CD19+ and CD56+/CD3- cells collected by apheresis showed no statistical difference in the 2 groups. Overall, 8 of the 11 donors collected the target number of CD34+ cells > 4 x 10(6)/kg ideal recipient body weight with the first apheresis, with no difference between the 2 groups. Mobilization with rhG-CSF in healthy donors enables the collection of large number of progenitor cells with modest side effects. A schedule of 10 micrograms/kg for 5 d is as effective as 16 micrograms/kg for 4 d. A single apheresis would be enough in 80% of cases.
- Published
- 2009
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