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Initial Results of Peripheral-Blood Stem-Cell Mobilization, Collection, Cryopreservation, and Engraftment After Autologous Transplantation Confirm That the Capacity-Building Approach Offers Good Chances of Success in Critical Contexts: A Kurdish-Italian Cooperative Project at the Hiwa Cancer Hospital, Sulaymaniyah

Authors :
Chra Abdullah
Dastan O. Hassan
Andrea Frigato
Annunziata Manna
Angelo Ostuni
Michele Vacca
Marco Possenti
Francesco Ipsevich
Marta Verna
Attilio Rovelli
Dlir Ali
Salah Salih
Vasta S
Angelo Palmas
Dereen Mohammed
Dosti Othman
Rebar N. Mohammed
Ignazio Majolino
Valentino Conter
Kosar Ali
Harem Karem
Maria Speranza Massei
Marcela Gabriel
Diana Noori
Claudia Del Fante
Source :
Journal of Global Oncology, Vol 4, Pp 1-8 (2017)
Publication Year :
2017
Publisher :
American Society of Clinical Oncology, 2017.

Abstract

Introduction At Hiwa Cancer Hospital (Sulaymaniyah, Iraqi Kurdistan) after the center was started by a cooperative project in June 2016, autologous transplantation was developed. Patients and Methods To develop the project, the capacity-building approach was adopted, with on-site training and coaching of personnel, educational meetings, lectures, on-the-job training, and the implementation of quality management planning. Results Here, we report initial results of peripheral-blood stem-cell mobilization and collection of the first 27 patients (age 12 to 61 years; 19 males and 8 females; multiple myeloma, n = 10; plasma cell leukemia, n = 1; Hodgkin lymphoma, n = 12; non-Hodgkin lymphoma, n = 3; and acute myeloid leukemia, n = 1). Only three (11.5%) of 26 patients experienced a failure of mobilization. A median of 6.1 × 106/kg CD34-positive cells per patient were collected (range, 2.4 to 20.8), with two apheretic runs. Twenty-four patients underwent autologous transplantation. All but one transplantation engrafted fully and steadily, with 0.5 and 1.0 × 109/L polymorphonucleates on day 10.5 (range, 8 to 12) and day 11 (range, 9 to 15), respectively, and with 20 and 50 × 109/L platelets on day 13 (range, 10 to 17) and day 17 (range, 2 to 44), respectively. More than 95% of patients are projected to survive 1 year after autograft. Conclusion These data are the result of an Italian effort to establish in Iraqi Kurdistan a leading center for hemopoietic stem-cell transplantation. The capacity building approach was used, with on-site training and coaching as instruments for the development of provider ability and problem solving. With future limitations for immigration, this method will be helpful, especially in the field of high-technology medicine.

Details

Language :
English
ISSN :
23789506
Volume :
4
Database :
OpenAIRE
Journal :
Journal of Global Oncology
Accession number :
edsair.doi.dedup.....6dc1528d03baddbead8b3c7d492e08d3