Search

Background: The prevalence of obstructive sleep apnea (OSA) in older people (aged over 65 years) is high. However, OSA in older populations has not received sufficient attention. This study examined the clinical phenotypic characteristics of older patients with newly diagnosed OSA. Methods: A total of 110 older patients (≥ 65 years) and 220 younger patients (< 65 years), matched by gender, body mass index (BMI), and apnea–hypopnea index (AHI), were enrolled in this retrospective study. Clinical manifestations, comorbidities, and polysomnographic results were compared between the two groups, and correlations between age ≥ 65 years and OSA comorbidities were explored. Results: Nocturia was more common in older patients with OSA, as with lower sleep efficiency, longer wake after sleep onset, increased stage N1 sleep, and decreased stage N3 sleep and average SpO2. The proportions of older OSA patients who had comorbid hypertension, coronary artery disease (CAD), chronic obstructive pulmonary disease, and ischemic stroke were significantly higher than those of younger patients. The incidence of tonsillar enlargement and pharyngeal narrowing was lower in older patients. Age ≥ 65 years was an independent risk factor for patients with OSA to have hypertension (OR: 1.89, 95% CI: 1.11–3.21), CAD (OR: 4.83, 95% CI: 2.29–10.21), and ischemic stroke (OR: 2.92, 95% CI: 1.02 to 8.38). Conclusions: The presence of OSA in older adults was associated with significant abnormalities of sleep architecture, aggravated nocturnal hypoxia and increased risks of hypertension, CAD, and stroke, which can be distinguished as a unique clinical phenotype. [ABSTRACT FROM AUTHOR]

A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines (PC-3, LNCaP, and DU145) were evaluated by a CCK-8 assay. Compounds 9 and 15 exhibited strong cytotoxic activities against LNCaP cells (IC50 < 5 μM), and compound 8 (IC50 = 8.25 μM) possessed the most potent activity against DU145 cells. However, these compounds also exhibited cytotoxicity towards human epithelial prostate normal cells RWPE-1. The structure-activity relationship (SAR) of these arylpiperazine derivatives was also discussed based on the obtained experimental data. [ABSTRACT FROM AUTHOR]

With the availability of multi-sensor, multi-temporal, multi-resolution and multi-spectral images from operational Earth observation satellites, remote sensing image fusion has become a valuable tool. The goal of remote sensing image fusion is to integrate complementary information from multi-source data such that the new images are more suitable for human visual perception and computer-processing tasks such as segmentation, feature extraction, and object recognition. In this paper, a pixel-level remote sensing image fusion method is proposed, which is based on combining the principal component analysis (PCA) and the curvelet transformation (CT). First, the multi-spectral image with low-spatial-resolution is transformed by PCA and principal components are obtained. Second, the panchromatic image with high-spatial-resolution and the principal components of the multi-spectral image are respectively merged with the curvelet transform. Finally, the fused image is obtained by inverse CT and inverse PCA. The experiments using Landsat-8 OLI multi-spectral and panchromatic image show that, compared with the traditional methods such as the WT-based method, the IHS-based method, the HPF-based method, the BT-based method, the PCA-based method and the CT-based method, the results of the proposed method preserve the spatial details while preserving more spectral information of the original image. [ABSTRACT FROM AUTHOR]

Most aquatic vegetation restorations involve the transplantation of submerged macrophytes. Sediment type and the clonal size are of great significance as they determine the fate of submerged macrophytes. In order to ensure successful restoration, a simulation experiment was conducted using aquarium mesocosms to investigate the response of stolon propagation capacity, the morphological features and productivity of Vallisneria natans for four types of sediment (lake mud [L], lake mud + sand [L + S, 50:50, v/v mixture], sand [S], clay [C]), and three types of clonal sizes. Results showed that sediment types significantly affected V. natans biomass accumulation, stolon propagation ability, ramet morphological characteristics, and productivity, where the asexual reproduction ability and productivity ranked as L > L + S > S > C in four sediment types. Total biomass, maximum net production, number of ramets, root diameter, number of stolons, and stolon propagation rate were all highest in L. In L and L + S, the plant chlorophyll content was higher than in S and C. The root diameter and the ratio of aboveground/underground biomass in S were the smallest among the four sediments. Moreover, when more V. natans seedlings were linked, more ramets and biomass were produced. The stolon propagation rate was ranked as the stolon with single seedling greater than the stolon with two‐linked seedlings greater than the stolon with three‐linked seedlings in L and L + S. The concentration of total nitrogen, total phosphorus, and NO3−‐N in water was remarkably reduced in four aquariums. Findings provide a scientific basis for restoring submerged macrophytes in different sediment settings. [ABSTRACT FROM AUTHOR]

In recent years, public health officials and scholars have voiced their concerns about comparatively low condom use in China, citing high rates of abortion and the growing HIV/AIDS crisis. By examining condom use through the lenses of gender and the history of medicine, this article traces heterosexual condom consumption in China from the early twentieth century to the present and situates contemporary attitudes toward condoms within long-term contraceptive patterns. Rather than simply taking for granted the role that men play in family planning decisions, this research takes men and masculinity as a central focus. An eye to the past reveals numerous historical obstacles to condom use, as well as an enduring aversion to condoms grounded in fears of reduced male sexual pleasure, and the gendered assumption that birth control is the sole responsibility of women. Analyzing evolving perceptions of condoms sheds light on constructions of sexuality, gender relations, and the roles of the state, society, and the individual in contraceptive decision-making in China. [ABSTRACT FROM AUTHOR]

MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased along with the expression of one of its host genes, Slit3 in metastatic GC. However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis. The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in vitro and in vivo. Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis. [ABSTRACT FROM AUTHOR]