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MiR-218 Inhibits Invasion and Metastasis of Gastric Cancer by Targeting the Robo1 Receptor.
- Source :
- PLoS Genetics; Mar2010, Vol. 6 Issue 3, p1-11, 11p, 1 Chart, 6 Graphs
- Publication Year :
- 2010
-
Abstract
- MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased along with the expression of one of its host genes, Slit3 in metastatic GC. However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis. The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in vitro and in vivo. Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETIC research
METASTASIS
STOMACH cancer
CANCER cells
GENE expression
TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 15537390
- Volume :
- 6
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- PLoS Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 49187386
- Full Text :
- https://doi.org/10.1371/journal.pgen.1000879