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Today, business organizations, seek to build creative capabilities by adopting advanced management concepts and methods such as employee voice to enable them facing potential challenges. This research investigates the impact of employee's voice on creative performance in a number of industrial companies in Baghdad City. The research's problem is started by the issues with weakness in corporate consciousness and the knowledge of employee voice that restrict firms from developing and innovating, and ignoring those voices except concerning the interest of companies. The main question of the research's problem is (What is the level of impact for employee voice on creative performance?). For the importance of the industrial sector in Iraq, the three companies which are Baghdad Soft Drinks Company, Electronic Industries Company, and the Iraqi Company for Carton Industry have been selected as a research domain. The research sample consists of 168 employees who work at these companies. Regarding to the statistical aspect, this research used the confirmative analysis coefficient, Cronbach's alpha coefficient, the weighted arithmetic, the standard deviation, the mean, the coefficient of relative difference, and relative weight (relative importance). The questionnaire was used as a main instrument for collecting data. Hypotheses were tested through statistical programs (AMOS.V.25, SPSS.V). One of the most important findings is the significant positive impact of employee voice on creative performance. [ABSTRACT FROM AUTHOR]

Background: The recovery from cardiac surgery involves resolving inflammation and remodeling with significant connective tissue turnover. Dynamics of smoldering inflammation and injury (white blood cells, platelets, CRP, IL-8, IL-6), vascular inflammation (IL-15, VEGF, RANTES), connective tissue remodeling (tenascin, MMP-9), cardiac injury and remodeling (YKL-40), and vascular remodeling (epiregulin, MCP-1, VEGF) were assessed up to 3 months after cardiac surgery. We hypothesize that at 3 months, studied markers will return to pre-surgical levels., Methods: Patients (n = 139) scheduled for non-emergent heart surgery were included, except for patients with pre-existing immunological aberrancies. Blood was collected before surgery(t baseline ), 24 h later(t 24h ) after the first sample, 7 days(t 7d ), and 3 months(t 3m ) after t baseline . Serum markers were measured via multiplex or ELISA. Electronic medical records (EMR) were used to extract demographical, pre-existing conditions and clinical data. Disposition (discharge home, discharge to facility, death, re-admission) was determined at 28 days and 3 months from admission., Results: Not all inflammatory markers returned to baseline (CRP↑↑, leukocytosis, thrombocytosis, IL-8↓, IL-6↓). Tenascin and YKL-40 levels remained elevated even at t 3m . YKL-40 serum levels were significantly elevated at t 24h and t 7d while normalized at t 3m . VEGF returned to the baseline, yet MCP-1 remained elevated at 3 months. CCL28 increased at 3 months, while RANTES and IL-15 declined at the same time. Disposition at discharge was determined by serum MMP-9, while YKL-40 correlated with duration of surgery and APACHE II 24h ., Conclusions: The data demonstrated an ongoing extracellular matrix turnover at 3 months, while acute inflammation and vascular remodeling resolved only partially., (© 2022. The Author(s).)

BACKGROUND Cardiac surgery triggers acute changes in serum leptin and fibroblast growth factor 21 (FGF-21). Considering their pleiotropic role in inflammation and abnormal glucose metabolism, perseverance of their abnormal serum level can have a long-term impact on recovery and end-organ failures. Long-term dynamics after cardiac surgery are unknown. MATERIAL AND METHODS Serum was collected from 123 patients before cardiac surgery (tbaseline) and 24 h (t24h), 7 days (t7d), and 3 months (t3m) later. Also, interleukin 6 (IL-6) and C-reactive protein (CRP) assessed nonspecific inflammatory responses. Neurodegeneration was gauged with serum amyloid ß1-40 and ß1-42. Demographic and clinical information, including disposition at 28 days and t3m from admission, were collected. RESULTS Serum leptin increased at t24h (leptinbaseline=613+747.9 vs leptin24h=768±718.1; P=0.0083) and decreased at t7d (leptin7d=499.5±540.2; P=0.043). FGF-21 levels increased at t24h and t7d. Cytokines normalized by t3m. Presurgical leptin levels were higher in Asians and were the primary determinant of postoperative leptin changes. Leptin levels were most elevated in patients undergoing aortic valve and arch surgery; the perioperative increase was significant only in patients with mitral valve surgery. Leptin and FGF-21 did not correlate with markers of general inflammation (CRP, IL-6), which partially resolved after t3m. Amyloid ß1-42 at t3m correlated with leptin peak at t24h. Low prehospital FGF-21 level correlated with the incidence of perioperative stroke; postoperative FGF-21 correlated with discharge to facility vs home. CONCLUSIONS Leptin and FGF-21 evolve independently from the inflammatory response in the aftermath of cardiac surgery and correlate with cardiac remodeling and neurodegeneration markers.

Although several therapeutics are used to treat coronavirus disease 2019 (COVID-19) patients, there is still no definitive metabolic marker to evaluate disease severity and recovery or a quantitative test to end quarantine. Because severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects human cells via the angiotensin-converting-enzyme 2 (ACE2) receptor and COVID-19 is associated with renin-angiotensin system dysregulation, we evaluated soluble ACE2 (sACE2) activity in the plasma/saliva of 80 hospitalized COVID-19 patients and 27 non-COVID-19 volunteers, and levels of ACE2/Ang (1-7) in plasma or membrane (mACE2) in lung autopsy samples. sACE2 activity was markedly reduced (p < 0.0001) in COVID-19 plasma (n = 59) compared with controls (n = 27). Nadir sACE2 activity in early hospitalization was restored during disease recovery, irrespective of patient age, demographic variations, or comorbidity; in convalescent plasma-administered patients (n = 45), restoration was statistically higher than matched controls (n = 22, p = 0.0021). ACE2 activity was also substantially reduced in the saliva of COVID-19 patients compared with controls (p = 0.0065). There is a strong inverse correlation between sACE2 concentration and sACE2 activity and Ang (1-7) levels in participant plasmas. However, there were no difference in membrane ACE2 levels in lungs of autopsy tissues of COVID-19 (n = 800) versus other conditions (n = 300). These clinical observations suggest sACE2 activity as a potential biomarker and therapeutic target for COVID-19., Competing Interests: Authors declare no competing interests., (© 2022 The Authors.)

Background: Despite clinical relevance of immunological activation due to histone leakage into the serum following cardiac surgery, long-term data describing their longitudinal dynamic are lacking. Therefore, this study examines the serum levels of histone 3 (tH3) and its modifications (H3K4me3 and H3K27ac) alongside immune system activation during the acute and convalescence phases of cardiac surgery., Methods: Blood samples from fifty-nine individuals were collected before non-emergent cardiac surgery (t pre-op ) and 24 h (t 24hr ), seven days (t 7d ), and three months (t 3m ) post-procedure to examine serum levels of tH3, H3K4me3, and H3K27ac. Serum heat shock protein-60 (HSP-60) was a surrogate of the cellular damage marker. Serum C-reactive protein (CRP) and interleukin 6 (IL-6) assessed smoldering inflammation. TNFα and IL-6 production by whole blood in response to lipopolysaccharide (LPS) evaluated immunological activation. Electronic medical records provided demographic, peri-operative, and clinical information. Paired longitudinal analyses were employed with data expressed as mean and standard deviation (X ± SD) or median and interquartile range (Me[IQ25; 75%]., Results: Compared to pre-operative levels (tH3 Pre-op  = 1.6[0.33;2.4]), post-operative serum tH3 significantly (p > 0.0001) increased after heart surgery (tH3 24hr  = 2.2[0.3;28]), remained elevated at 7 days (tH3 7d  = 2.4[0.37;5.3]), and at 3 months (tH3 3m  = 2.0[0.31;2.9]). Serum H3K27ac was elevated at 24 h (H3K27ac 24hr  = 0.66 ± 0.51; p = 0.025) and seven days (H3K27ac 7d  = 0.94 ± 0.95; p = 0.032) as compared to baseline hours (H3K27ac Pre-op  = 0.55 ± 0.54). Serum H3K4me3 was significantly diminished at three months (H3K4me3 Pre-op  = 0.94 ± 0.54 vs. H3K27ac 3m  = 0.59 ± 0.89; p = 0.008). tH3 correlated significantly with the duration of anesthesia (r 2  = 0.38). In contrast, HSP-60 normalized seven days after surgery. Peri-operative intake of acetaminophen, but no acetylsalicylic acid (ASA), acid, ketorolac or steroids, resulted in the significant depression of serum H3K4me3 at 24 h (H3K4me3 acetom-  = 1.26[0.71; 3.21] vs H3K4me3 acetom+  = 0.54[0.07;1.01]; W[50] = 2.26; p = 0.021). CRP, but not IL-6, remained elevated at 3 months compared to pre-surgical levels and correlated with tH3 24hrs (r 2  = 0.43), tH3 7d (r 2  = 0.71; p < 0.05), H3K4me3 7d (r 2  = 0.53), and H3K27ac 7d (r 2  = 0.49). Production of TNFα by whole blood in response to LPS was associated with serum tH3 24hrs (r 2  = 0.67). Diminished H3K4me3 24hrs, H3K27ac 24hrs , and H3K27ac 3m , accompanied the emergence of liver failure., Conclusions: We demonstrated a prolonged elevation in serum histone 3 three months after cardiac surgery. Furthermore, histone 3 modifications had a discrete time evolution indicating differential immune activation., (© 2022. The Author(s).)

Incorporating the advanced practice provider (APP) in the delivery of tele critical care medicine (teleCCM) addresses the critical care provider shortage. However, the current literature lacks details of potential workflows, deployment difficulties and implementation outcomes while suggesting that expanding teleCCM service may be difficult. Here, we demonstrate the implementation of a telemedicine APP (eAPP) pilot service within an existing teleCCM program with the objective of determining the feasibility and ease of deployment. The goal is to augment an existing tele-ICU system with a balanced APP service to assess the feasibility and potential impact on the ICU performance in several hospitals affiliated within a large academic center. A REDCap survey was used to assess eAPP workflows, expediency of interventions, duration of tasks, and types of assignments within different service locations. Between 02/01/2021 and 08/31/2021, 204 interventions (across 133 12-h shift) were recorded by eAPP (n routine  = 109 (53.4%); n urgent  = 82 (40.2%); n emergent  = 13 (6.4%). The average task duration was 10.9 ± 6.22 min, but there was a significant difference based on the expediency of the task (F [2; 202] = 3.89; p < 0.022) and type of tasks (F [7; 220] = 6.69; p < 0.001). Furthermore, the eAPP task type and expediency varied depending upon the unit engaged and timeframe since implementation. The eAPP interventions were effectively communicated with bedside staff with only 0.5% of suggestions rejected. Only in 2% cases did the eAPP report distress. In summary, the eAPP can be rapidly deployed in existing teleCCM settings, providing adaptable and valuable care that addresses the specific needs of different ICUs while simultaneously enhancing the delivery of ICU care. Further studies are needed to quantify the input more robustly., (© 2022. The Author(s).)

Identification of novel immune biomarkers to gauge the underlying pathology and severity of COVID-19 has been difficult due to the lack of longitudinal studies. Here, we analyzed serum collected upon COVID-19 admission (t1), 48 hours (t2), and seven days later (t3) using Olink proteomics and correlated to clinical, demographics, and therapeutic data. Older age positively correlated with decorin, pleiotrophin, and TNFRS21 but inversely correlated with chemokine (both C-C and C-X-C type) ligands, monocyte attractant proteins (MCP) and TNFRS14. The burden of pre-existing conditions was positively correlated with MCP-4, CAIX, TWEAK, TNFRS12A, and PD-L2 levels. Individuals with COVID-19 demonstrated increased expression of several chemokines, most notably from the C-C and C-X-C family, as well as MCP-1 and MCP-3 early in the course of the disease. Similarly, deceased individuals had elevated MCP-1 and MCP-3 as well as Gal-9 serum levels. LAMP3, GZMB, and LAG3 at admission correlated with mortality. Only CX3CL13 and MCP-4 correlated positively with APACHE score and length of stay, while decorin, MUC-16 and TNFRSF21 with being admitted to the ICU. We also identified several organ-failure-specific immunological markers, including those for respiratory (IL-18, IL-15, Gal-9) or kidney failure (CD28, VEGF). Treatment with hydroxychloroquine, remdesivir, convalescent plasma, and steroids had a very limited effect on the serum variation of biomarkers. Our study identified several potential targets related to COVID-19 heterogeneity (MCP-1, MCP-3, MCP-4, TNFR superfamily members, and programmed death-ligand), suggesting a potential role of these molecules in the pathology of COVID-19., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Laudanski, Jihane, Antalosky, Ghani, Phan, Hernandez, Okeke, Wu, Rader and Susztak.)

In this paper, we study the dynamics of the CoVid-19 outbreak in Semarang, Indonesia, using a fractional CoVid-19 model. We first determine the effects of the isolation rate e and infection rate ẞ on the reрго- duction number Ro and infected number V. We find that Ro is directly proportional to ẞ and inversely proportional to e. For V, the effect of physical distancing is not as significant as changing e. As e increases, V decreases, the number of susceptible individuals increases, the number of quarantined individuals decreases sharply, and the number of recovered individuals decreases. Moreover, the effect of vaccination is also considered. The combination of physical distancing, isolation, and vaccination has a significant impact on reducing the number of infected individuals. Analysis of dynamical systems allows us to understand the characteristics of our model, such as its boundedness and non-negativity, the existence of equilibrium points, the existence and uniqueness of solutions, and the local and global stability. To val- idate our fractional CoVid-19 model, we introduce the fractional extended Kalman filter (FracEKF) as a prediction method and compare the results against reported CoVid-19 data. FracEKF is a modified version of the basic extended Kalman filter with a time-fractional memory effect. The prediction results illustrate the accuracy of this model in terms of the root mean square error (RMSE), normalized root mean square еггог (NRMSE), and mean absolute percentage error (MAPE) for each fractional-order. Varying e repro- duces the trends observed in the reported data for the number of infected individuals, i.e., when e increases, the infected number decreases. Moreover, a higher fractional-order results in higher model accuracy. Furthermore, higher values of the process noise Q give smaller errors, whereas higher values of the observation noise Ry produce higher errors. Q, and the fractional-order are inversely proportional to RMSE, NRMSE, and MAPE, whereas Ry is directly proportional to RMSE, NRMSE, and MAPE. [ABSTRACT FROM AUTHOR]

This paper addresses the problem of controlling quarter-vehicle semi-active suspension systems. Presently, the suspension system involves a magnetorheological (MR) damper featuring hysteretic behavior captured through the Bouc-Wen model. The control objective is to regulate well the chassis vertical position despite the road irregularities. The difficulty of the control problem lies in the nonlinearity of the system model, the uncertainty of some parameters and the inaccessibility to measurements of the hysteresis internal state variable. The control design is petformed using Lyapunov control design tools; it includes an observer providing online estimates of the hysteresis internal state and an adaptive state-feedback regulator. The adaptive controller, obtained by combining the state observer and the state-feedback regulator, is formally shown to meet the desired control objectives. This theoretical result is confirmed by several simulations. The latter illustrate the performances of the present adaptive controller and compare them with those of earlier control approaches and those of the passive suspension. [ABSTRACT FROM AUTHOR]

To enhance control effectiveness and mitigate system oscillations in backstepping sliding mode control, a robust backstepping sliding mode control strategy based on a hysteretic quantizer is proposed for application in magnetorheological (MR) semi-active suspension (SAS) systems. To accurately predict the output current for precise control, a fuzzy neural network (FNN) is used to construct an inverse model for magnetorheological damper (MRD), input the current into the Dahl model and output the actual damping force. Based on the MRD inverse model, the robust term is introduced in the backstepping sliding mode control, and a hysteretic quantizer is used to quantify the controller input signals, avoiding the occurrence of oscillations and forming a complete closed-loop feedback control. Simulation results demonstrate that the FNN inverse model can accurately predict the control current. Compared to backstepping control and passive suspension, the robust backstepping sliding mode control strategy based on a hysteretic quantizer (RBSMC-HQ) reduces the root mean square (RMS) values of vehicle body acceleration by 37.59% and 44.82% respectively under A-Class road conditions, and by 41.93% and 44.84% respectively under B-Class road conditions. This control strategy effectively enhances the ride comfort and handling stability. [ABSTRACT FROM AUTHOR]

Background/Objectives: For several decades, protein drugs (biologics) made in cell cultures have been delivered as sterile injections, decreasing their affordability and patient preference. Angiotensin Converting Enzyme 2 (ACE2) gum is the first engineered human blood protein expressed in plant cells approved by the FDA without the need for purification and is a cold-chain and noninvasive drug delivery. This biologic is currently being evaluated in human clinical studies to debulk SARS-CoV-2 in the oral cavity to reduce coronavirus infection/transmission (NCT 0543318). Methods: Chemistry, manufacturing, and control (CMC) studies for the ACE2/Ang(1–7) drug substances (DSs) and ACE2 gum drug product (DP) were conducted following USP guidelines. GLP-compliant toxicology studies were conducted on Sprague Dawley rats (n = 120; 15/sex/group) in four groups—placebo, low (1.6/1.0 mg), medium (3.2/2.0 mg), and high (8.3/5.0 mg) doses IP/kg/day. Oral gavage was performed twice daily for 14 days (the dosing phase) followed by the recovery phase (35 days). Plasma samples (n = 216) were analyzed for the product Ang(1–7) by ELISA. Results: The ACE2 protein was stable in the gum for at least up to 78 weeks. The toxicology study revealed the dose-related drug delivery to the plasma and increases in the AUC (56.6%) and Cmax (52.9%) after 28 high-dose gavages (95% C.I.), although this quantitation excludes exogenously delivered membrane-associated ACE2/Ang(1–7). Vital biomarkers and organs were not adversely affected despite the 10-fold higher absorption in the tissues, demonstrating the safety for the first in-human clinical trials of ACE2/Ang(1–7). The NOAEL observed in the rats was 2.5–7.5-fold higher than that of the anticipated efficacious therapeutic dose in humans for the treatment of cardiopulmonary disorders, and it was 314-fold higher than the NOAEL for topical delivery via chewing gum. Conclusions: This report lays the foundation for the regulatory process approval for noninvasive and affordable human biologic drugs bioencapsulated in plant cells. [ABSTRACT FROM AUTHOR]

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

For a two-block splitting iterative scheme to solve the complex linear equations system resulting from the complex Helmholtz equation, the iterative form using descent vector and residual vector is formulated. We propose splitting iterative schemes by considering the perpendicular property of consecutive residual vector. The two-block splitting iterative schemes are proven to have absolute convergence, and the residual is minimized at each iteration step. Single and double parameters in the two-block splitting iterative schemes are derived explicitly utilizing the orthogonality condition or the minimality conditions. Some simulations of complex Helmholtz equations are performed to exhibit the performance of the proposed two-block iterative schemes endowed with optimal values of parameters. The primary novelty and major contribution of this paper lies in using the orthogonality condition of residual vectors to optimize the iterative process. The proposed method might fill a gap in the current literature, where existing iterative methods either lack explicit parameter optimization or struggle with high wave numbers and large damping constants in the complex Helmholtz equation. The two-block splitting iterative scheme provides an efficient and convergent solution, even in challenging cases. [ABSTRACT FROM AUTHOR]

The optimization of maintenance intervals is crucial for enhancing efficiency, sustainability, and cost-effectiveness in transport operations. This paper presents a method for optimizing maintenance intervals for vehicles in various modes of transport, focusing on minimizing downtime due to repairs and maintenance. By integrating advanced technologies like artificial intelligence (AI) and the Internet of Things (IoT), maintenance intervals are dynamically adjusted using real-time data, resulting in better resource utilization and reduced operational costs. The key findings of this research indicate significant reductions in downtime and maintenance costs, leading to improved efficiency and sustainability across transport modes. Although the case study is based on railway vehicles, the approach is applicable to road, maritime, and air transport as well. By leveraging optimization algorithms, such as machine learning, this solution predicts optimal maintenance timing, thereby reducing resource consumption and improving operational efficiency. The case study on pantograph maintenance demonstrates significant financial savings and reduced waste. This research highlights the benefits of maintenance optimization for sustainability and efficiency across the entire transport sector. [ABSTRACT FROM AUTHOR]

Interest in single-atom catalysts (SACs) has surged due to their potential to mitigate greenhouse N2O gas from the environment. In this study, we explore the potential of N2O reduction using porous 3D phosphorus graphdiyne decorated with an Al atom (3D-Al/PGDYN) through density functional theory. Results confirm the energetic stability of Al decorations on 3D-PGDYN and indicate that the Al atom plays an active role in catalysis. The N2O molecule undergoes spontaneous dissociation on the surface of the 3D-Al/PGDYN, initiating from the O-end, with a dissociation energy of −2.93 eV. In parallel, N2O dissociation through the N-end involves chemisorption onto the 3D-Al/PGDYN surface, with an adsorption energy (Ead) of −1.74 eV. The negative Ead values (−2.47 and −2.64 eV) indicate that CO and O2 species chemisorb onto the 3D-Al/PGDYN surface, but these energies are lower than that of N2O, suggesting that CO and O2 molecules do not hinder the N2O reduction process. Furthermore, the reaction CO + O* → CO2, which is vital for catalyst regeneration, proceeds swiftly on the 3D-Al/PGDYN catalyst with a low energy barrier of 0.11 eV, highlighting the catalyst's exceptional reactivity. This work holds significance in the design of catalysts and could be instrumental in developing new and efficient solutions for effectively removing harmful N2O from the environment. [ABSTRACT FROM AUTHOR]

Background/Objectives: Taste dysfunction is a frequent symptom of acute coronavirus disease (COVID)-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). While the majority of those affected reported recovery over time, emerging data suggest that 20–25% of individuals experience persistent taste dysfunction, constituting a common symptom of long COVID. Gustation is mediated by continuously renewing taste bud cells. A balance between the counteracting processes of cell generation and cell death maintains the homeostatic turnover. Sonic hedgehog (SHH) is a morphogenic protein that promotes taste cell proliferation and differentiation. Enzymatic proteins such as gustin modulate the environment around the taste receptors and influence taste perception. Hence, we hypothesized that increased taste cell turnover and reduced taste-related salivary proteins contribute to the taste dysfunction in long COVID. Methods: Unstimulated whole saliva (UWS) was collected from individuals with long COVID experiencing taste dysfunction after obtaining informed consent. The normal control included archived saliva samples catalogued prior to 2019. Taste perception was objectively determined by the waterless empirical taste test. The SHH, gustin, and inflammatory cytokines in UWS were determined with ELISA. The expressions of epithelial and taste-cell-specific markers in cellular saliva were assessed by immunoflurorescence. Results: Impaired bitter taste was the most common dysfunction in the long-COVID cohort. Salivary gustin was significantly lower in those with long COVID and correlated with lower bitter taste score. Cellular saliva showed keratin-10- and small-proline-rich protein-positive epithelial cells as well as SHH-, occluding- and KCNQ1-positive taste cells. Conclusions: Salivary gustin could be a marker for impaired bitter taste in long COVID. [ABSTRACT FROM AUTHOR]

In the medical image analysis field, brain tumors (BTs) classification is a complicated process. For effortlessly detecting the tumor devoid of any surgical interference, the radiologists are aided with automated along with computerized technology. Currently, in the field of medical image processing along with analysis, admirable progress has been made by deep learning (DL) methodologies. In medical fields, for resolving several issues, huge attention was paid to DL techniques. For automation of several performed by radiologists like (1) lesion detection, (2) segmentation, (3) classification, (4) monitoring, along with (5) also prediction of treatment response that is not achievable without software, DL might be wielded. Nevertheless, classifying BTs by utilizing magnetic resonance imaging (MRI) has various complications like the difficulty of brain structure along with the intertwining of tissues in it; additionally, the brain's higher density nature also makes the BT Classification (BTC) process quite complex. Therefore, by utilizing novel systems, MRI-centric Automatic segmentation together with classifications of BT and swelling have been proposed to overcome the aforementioned issues. The proposed methodology underwent various operations to detect BTs effectively. Initially, by utilizing the Range-centric Otsu's Thresholding (ROT) algorithm, the skull stripping (SS) is conducted. After that, by performing contrast enhancement (CE) along with noise removal, the skull-stripped images are pre-processed. Next, by employing the Rectilinear Watershed Segmentation (RWS) algorithm, the tumor or swelling areas are segmented. Afterward, to obtain the precise tumor or swelling region, the morphological operations are executed on the segmented areas; subsequently, the desired along with relevant features are extracted. Lastly, the features being extracted are inputted to the classifier termed Uniform Convolution neural network (UCNN). The tumor tissues along with the swelling tissues are classified precisely in the classification phase. Here, the openly accessible BT Image Segmentation Benchmark (BRATS) datasets are utilized. Then, the outcomes obtained are analogized with prevailing methodologies. The experiential outcomes displayed that the BTC is performed by the proposed model with a higher accuracy rate; thus, outshined the other prevailing models. [ABSTRACT FROM AUTHOR]

Increased plasma creatine concentrations are associated with the risk of type 2 diabetes, but whether this alteration is associated with or causal for impairments in metabolism remains unexplored. Because skeletal muscle is the main disposal site of both creatine and glucose, we investigated the role of intramuscular creatine metabolism in the pathophysiology of insulin resistance in type 2 diabetes. In men with type 2 diabetes, plasma creatine concentrations were increased, and intramuscular phosphocreatine content was reduced. These alterations were coupled to reduced expression of sarcomeric mitochondrial creatine kinase 2 (CKMT2). In C57BL/6 mice fed a high-fat diet, neither supplementation with creatine for 2 weeks nor treatment with the creatine analog β-GPA for 1 week induced changes in glucose tolerance, suggesting that increased circulating creatine was associated with insulin resistance rather than causing it. In C2C12 myotubes, silencing Ckmt2 using small interfering RNA reduced mitochondrial respiration, membrane potential, and glucose oxidation. Electroporation-mediated overexpression of Ckmt2 in skeletal muscle of high-fat diet–fed male mice increased mitochondrial respiration, independent of creatine availability. Given that overexpression of Ckmt2 improved mitochondrial function, we explored whether exercise regulates CKMT2 expression. Analysis of public data revealed that CKMT2 content was up-regulated by exercise training in both humans and mice. We reveal a previously underappreciated role of CKMT2 in mitochondrial homeostasis beyond its function for creatine phosphorylation, independent of insulin action. Collectively, our data provide functional evidence for how CKMT2 mediates mitochondrial dysfunction associated with type 2 diabetes. Editor's summary: Increased plasma creatine is associated with type 2 diabetes, but causation has not been established. Rizo-Roca et al. show that men with type 2 diabetes had increased plasma creatine and decreased muscle phosphocreatine, which was associated with poor glucose handling. In myotubes in vitro, silencing the mitochondria-associated sarcomeric mitochondrial creatine kinase 2 (Ckmt2) gene resulted in impaired mitochondrial functions. In mice fed a high-fat diet, creatine supplementation had no effect on glucose handling, but overexpression of Ckmt2 in muscle improved mitochondrial functions. Data from humans and mice showed that exercise increased CKMT2 and metrics of mitochondrial functions. These results suggest that creatine changes are a consequence rather than a cause of insulin resistance in type 2 diabetes. —Brandon Berry [ABSTRACT FROM AUTHOR]

Objectives: This study was performed to identify predictive markers of worse outcomes in patients with severe COVID-19 in an intensive care unit. Methods: Sixty patients with severe COVID-19, hospitalized in the Intensive Care Unit (ICU) between March and July 2021, were stratified into two groups according to the outcome survivors and non-survivors. After admission to the ICU, blood samples were collected directly for biomarker analysis. Routine hematological and biochemical biomarkers, as well as serum levels of cytokines, chemokines, and immunoglobulins, were investigated. Results: Lymphopenia, neutrophilia, and thrombocytopenia were more pronounced in non-surviving patients, while the levels of CRP, AST, creatinine, ferritin, AST, troponin I, urea, magnesium, and potassium were higher in the non-surviving group than the survival group. In addition, serum levels of IL-10, CCL2, CXCL9, and CXCL10 were significantly increased in patients who did not survive. These changes in the biomarkers evaluated were associated with increased mortality in patients with severe COVID-19. Conclusion: The present study confirmed and expanded the validity of laboratory biomarkers as indicators of mortality in severe COVID-19. [ABSTRACT FROM AUTHOR]

The pantograph–catenary system (PCS) is essential for trains to obtain electrical energy. As the train's operating speed increases, the vibration between the pantograph and the catenary intensifies, reducing the quality of the current collection. Active control may significantly reduce the vibration of the PCS, effectively lower the cost of line retrofitting, and enhance the quality of the current collection. This article proposes an improved deep deterministic policy gradient (IDDPG) for the pantograph active control problem, which delays updating the Actor and Target–Actor networks and adopts a reconstructed experience replay mechanism. The deep reinforcement learning (DRL) environment module was first established by creating a PCS coupling model. On this basis, the controller's DRL module is precisely designed using the IDDPG strategy. Ultimately, the control strategy is integrated with the PCS for training, and the controller's performance is validated on the PCS. Simulation experiments show that the improved strategy significantly reduces the training time, enhances the steady-state performance of the agent during later training stages, and effectively reduces the standard deviation of the pantograph–catenary contact force (PCCF) by an average of over 51.44%, effectively improving the quality of current collection. [ABSTRACT FROM AUTHOR]

Transport networks, such as vasculature or river networks, provide key functions in organisms and the environment. They usually contain loops whose significance for the stability and robustness of the network is well documented. However, the dynamics of their formation is usually not considered. Such structures often grow in response to the gradient of an external field. During evolution, extending branches compete for the available flux of the field, which leads to effective repulsion between them and screening of the shorter ones. Yet, in remarkably diverse processes, from unstable fluid flows to the canal system of jellyfish, loops suddenly form near the breakthrough when the longest branch reaches the boundary of the system. We provide a physical explanation for this universal behavior. Using a 1D model, we explain that the appearance of effective attractive forces results from the field drop inside the leading finger as it approaches the outlet. Furthermore, we numerically study the interactions between two fingers, including screening in the system and its disappearance near the breakthrough. Finally, we perform simulations of the temporal evolution of the fingers to show how revival and attraction to the longest finger leads to dynamic loop formation. We compare the simulations to the experiments and find that the dynamics of the shorter finger are well reproduced. Our results demonstrate that reconnection is a prevalent phenomenon in systems driven by diffusive fluxes, occurring both when the ratio of the mobility inside the growing structure to the mobility outside is low and near the breakthrough. [ABSTRACT FROM AUTHOR]

Cationic lipids are crucial in medical and biotechnological applications including cellular transfection and gene delivery. Ionizable cationic lipids are critical components of the mRNA‐based COVID vaccines while permanently charged cationic lipids have shown promise in cancer treatment. Despite significant research progress over the past few decades in designing improved, biocompatible cationic lipids, their transfection efficiency remains lower than that of viral vectors. Cationic lipids with additional functionalities like fusogenicity, stimuli‐responsiveness, targeting capabilities, and therapeutic activity have been engineered to improve their performance. This review highlights the importance of molecular hybridization toward the design of biocompatible cationic lipids having fusogenic, stimuli‐responsive, targeting, or therapeutic properties. This review mainly focuses on cationic lipids, having a permanent positive charge in the headgroup region, as these are typically employed to both increase cellular interactions and for improved loading, particularly for anionic nucleic acid‐based therapeutics and vaccines. Structure–activity relationships between the lipid chemical structure (headgroup, spacer, hydrocarbon chain) and, to a lesser extent, the self‐assembled nanostructure and the intrinsic biological activity of the multi‐functional cationic lipids are described. Finally, the challenges involved in developing smart lipids without affecting their inherent capacity to self‐assemble into structured nano‐carriers are discussed. [ABSTRACT FROM AUTHOR]

DESERT date or Balanites aegyptiaca (L.) Del is one of the most prevalent, wild plant species in the arid regions of Africa and the Middle East. The desert date tolerates a broad range of soil types and can be found in a variety of habitat types. It has a wide ecological distribution but is mainly found on level alluvial sites with deep sandy loam and free access to water. B.egyptiaca is used in African and Indian traditional medicine. Many underutilized tree species are good sources of food, fodder and possible therapeutic agents. B. aegyptiaca tree is considered drought tolerant and a potential source of many secondary metabolites. This study investigated the adaptive and physiological response to severe aridity and drought stress on the growth of B. aegyptiaca in El-Kharga Oasis, which is the driest region in the Western Desert. Clay soil was found to be dominant in the mechanical soil analysis. Weakly to moderately calcareous soil carbonate was found, and the estimated pH values of the soil solution appeared to be slightly alkaline and exhibited a comparatively high electric conductivity. Total free amino acid concentration was greater than that of soluble protein and sugar. Results indicated that B. aegyptiaca is a drought-tolerant plant in severely arid areas that are subject to drought stress. [ABSTRACT FROM AUTHOR]

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Semi-active primary suspensions are an effective means of improving ride quality in high-speed railway vehicles in relation to the mitigation of car-body bending vibration. In this paper, prototype magnetorheological (MR) dampers are tested and the results are used to define a mathematical model of the dampers. Then, three control schemes for semi-active primary suspensions are proposed: Skyhook, LQG and Mix-1-Sensor, and their performance is assessed by means of Hardware-In-the-Loop (HIL) tests considering a simple quarter-vehicle model which is run on a real-time board and set in interaction with one physical MR damper. The results show that all three considered control strategies lead to a reduction of car-body vibration by around 30% and a very good agreement is found between HIL tests and numerical simulations in which the physical damper is replaced by the mathematical damper model. The damper model is finally interfaced with a flexible multi-body model of the complete vehicle to provide further assessment of semi-active control. The results of the latter simulations show that the semi-active suspension could provide an improvement of the $ {N_{mvz}} $ N mvz ride quality index in the order of 40–45% with respect to the passive vehicle for all three control schemes. [ABSTRACT FROM AUTHOR]

Numerous nations have prioritised the inclusion of citizens with disabilities, such as hearing loss, in all aspects of social life. Sign language is used by this population, yet they still have trouble communicating with others. Many sign language apps are being created to help bridge the communication gap as a result of technology advances enabled by the widespread use of smartphones. These apps are widely used because they are accessible and inexpensive. The services and capabilities they offer and the quality of their content, however, differ greatly. Evaluation of the quality of the content provided by these applications is necessary if they are to have any kind of real effect. A thorough evaluation like this will inspire developers to work hard on new apps, which will lead to improved software development and experience overall. This research used a systematic literature review (SLR) method, which is recognised in gaining a broad understanding of the study whilst offering additional information for future investigations. SLR was adopted in this research for smartphone-based sign language apps to understand the area and main discussion aspects utilised in the assessment. These studies were reviewed on the basis of related work analysis, main issues, discussions and methodological aspects. Results revealed that the evaluation of sign language mobile apps is scarce. Thus, we proposed a future direction for the quality assessment of these apps. The findings will benefit normal-hearing and hearing-impaired users and open up a new area where researchers and developers could work together on sign language mobile apps. The results will help hearing and non-hearing users and will pave the way for future collaboration between academicians and app developers in the field of sign language technology. [ABSTRACT FROM AUTHOR]