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2. Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study

Author

Ferrante, Marc, D'Haens, Geert, Jairath, Vipul, Danese, Silvio, Chen, Minhu, Ghosh, Subrata, Hisamatsu, Tadakazu, Kierkus, Jaroslaw, Siegmund, Britta, Bragg, Sonja Michelle, Crandall, Wallace, Durand, Frederick, Hon, Emily, Lin, Zhantao, Lopes, Michelle Ugolini, Morris, Nathan, Protic, Marijana, Carlier, Hilde, Sands, Bruce E, Tron, Emiliano, Dorado, Fernanda Dorado, Thin, Lena, Leong, Rupert, Seltenreich, Hans, Christensen, Britt, Croft, Anthony, Ghaly, Simon, Koch, Robert, Reinisch, Walter, Heeren, Sonja, Bossuyt, Peter, Ferrante, Marc, Maximiano, Fabio Luiz, Sassaki, Ligia Yukie, Baia, Carolina, Poli, Debora, de Sousa Carlos, Alexandre, de Magalhaes Francesconi, Carlos Fernando, De Sa Rolim, Alexander, Razera, Julio, Simoes Neto, Joaquim, Rocco, Rodrigo, Stifft, Jonathas, Soldera, Jonathan, Silva, Genoile, Mendes Clemente, Cintia, Di Felice Boratto, Sandra, Teixeira de Campos, Luciana, Rodrigues Borba, Marcelo, Rosenfeld, Gregory, Ponich, Terry, Lim, Allen, Williams, Chadwick, Musgrave, Bruce, Gauthier, Stephane, Liu, Wenjia, Wang, Chengdang, Guo, Hong, Chen, Chunxiao, Chen, Yan Chen, Cao, Qian, Zhong, Jie, Xu, Min, Wang, Yufang, Zheng, Changqing, Gao, Xiang, Chen, Youxiang, Miao, Yinglei, Wang, Lin, Liu, Deliang, Wang, Bangmao, Song, Zhengji, Liu, Xiaowei, Chen, Baili, Jiang, Yi, Zhan, Qiang, Zhang, Kaiguang, Shen, Hong, Li, Zhaotao, Wang, Xiaoyan, Wang, Mei Wang, Tian, De'an, Chen, Lei, Tang, Wen, Borzan, Vladimir, Krznaric, Zeljko, Volfova, Miroslava, Pumprla, Jiri, Veberova, Lucie, Tichy, Michal, Gregar, Jan, Stepek, David, Ulbrych, Jan, Drastich, Pavel, Papik, Zdenek, Matous, Jan, Lukas, Martin, Koskova, Radka, Fallingborg, Jan, Altwegg, Romain, Fotsing, Ginette, Laharie, David, Nancey, Stephane, Peyrin, Laurent, Schreiber, Stefan, Hoffmann, Jörg, Seidler, Ursula, Fechner, Lars, Arelin, Katrin, Contzen, Christel, Trenn, Guido, Schaum, Thomas, Schoettker, Katrin, Bachmann, Oliver, Encke, Jens, Ibe, Michael, Jakobeit, Christian, Varga, Marta, Salamon, Agnes, Kafony, Andras, Horvat, Gyula, Heringh, Zsanett, Bezzegh, Katalin, Izbeki, Ferenc, Szalai, Laszlo, Schnabel, Robert, Samanta, Jayanta, Banerjee, Rupa, Subramanian, Ganesh, Mukewar, Shrikant, Bansal, Naresh Kumar, Sood, Ajit, Shankar Bagepally, Ravi, Kumar, Porika Shravan, Shrimal, Pankaj, Shah, Saumin, Pai, Nitin, Ahuja, Vineet, Melzer, Ehud, Assy, Nimer, Goldin, Eran, Shirin, Haim, Segal, Arik, Lahat, Adi, Saibeni, Simone, Luzza, Francesco, Danese, Silvio, Caprioli, Flavio, Annunziata, Maria Laura, Fantini, Massimo, Matsuda, Koichiro, Takagi, Sho, Kanmura, Shuji, Goto, Mitsuhide, Ashida, Toshifumi, Nishimata, Nobuaki, Kawakami, Kazuhiko, Ishiguro, Yoh Ishiguro, Maemoto, Atsuo Maemoto, Naito, Yuji Naito, Naoe, Hideaki, Nakase, Hiroshi, Iida, Tomohiro, Akiyama, Junichi, Yoshioka, Masao, Abe, Yasuhiko, Takeuchi, Ken, Kawai, Mikio, Hirai, Fumihito, Horiki, Noriyuki, Park, Sang Hyoung, Park, Dong II, Kang, Sang Bum, Jung, Min Kyu, Jang, Byung Ik, Lee, Yoo Jin, Shin, SungJae, Kim, Tae-oh, Kim, Hyun-Soo, Lee, Bo-In, Lee, Jonghun, Kim, Hyo Jong, Choi, Chang Hwan, Kim, Dongwoo, Eun, Chang Soo, Kang, Ben, Pokrotnieks, Juris, Kiudelis, Gediminas, Ramirez, Karina, Vega Fonseca, Jose Luis, Laheij, Robert, Kierkus, Jaroslaw, Klopocka, Maria, Wylegala, Zbigniew, Mroziak, Beata, Wojcik, Katarzyna, Korczowski, Bartosz, Gawdis, Beata, Danilkiewicz, Wit, Olszanecka, Magdalena, Krzykowska, Jolanta, Jamrozik, Zofia, Duszynska, Malgorzata, Ciesiolkiewicz, Agnieszka, Baluta, Malgorzata, Horynski, Marek, Leszczyszyn, Jaroslaw, Rozumek, Grzegorz, Firkowski, Lukasz, Konopko, Marzena, Orleanski, Jakub, Filip, Rafal, Wiechowska, Anna, Niezgoda, Krzysztof, Mateescu, Radu, Craciun, Eugeniu, Chioncel, Camelia, Musat, Marioara, Voiosu, Theodor Alexandru, Trofimov, Vasily, Shchukina, Oksana, Pershko, Anatoly, Fedorishina, Olga, Chumakova, Galina, Bakulin, Igor, Osipenko, Marina, Nikolin, Denis, Barysheva, Olga, Alexeeva, Olga, Zakharov, Konstantin, Khodareva, Irina, Tkachev, Alexander, Golovenko, Alexey, Popova, Veronika, Kashnikov, Vladimir, Vershinina, Maria, Makarchuk, Pavel, Valuyskikh, Ekaterina, Crevar, Slobodanka, Svorcan, Petar, Radakovic, Tatjana, Hlavaty, Tibor, Bunganic, Ivan, Fedurco, Miroslav, Kalisova, Iveta, Balaz, Jozef, Mihalkanin, Lubomir, Martin Arranz, Maria Dolores, De Teresa Parreno, Luis, Sans Cuffi, Miquel, Hernandez Camba, Alejandro, Brand, Stephan, Juillerat, Pascal, Seibold, Frank, Demirci, Hakan, Tezel, Ahmet, Simsek, Halis, Kiyici, Murat, Gonen, Can, Hulagu, Sadettin, Karakan, Tarkan, Cekin, Ayhan, Altintas, Engin, Guven, Kadri, Akpinar, Hale, Ozin, Yasemin, Erzin, Yusuf, Demir, Mehmet, Temel, Tuncer, Lohdanidi, Tetiana, Ivanov, Valeriy, Ivanishyn, Olha, Golovchenko, Oleksandr, Gerasymenko, Oksana, Danyliuk, Svitlana, Vyshyvanyuk, Vira, Datsenko, Olena, Stanislavchuk, Mykola, Rishko, Yaroslava, Kyrychenko, Olga, Donets, Dmytro, Shapovalova, Yana, Yurkiv, Andriy, Oliinyk, Oleksandr, Tsarynna, Nataliia, Fediv, Oleksandr, Poplyonkin, Yevgen, Kaser, Arthur, Hoque, Syed, Thomas, Hawys, Iyengar, Shalini, Newman, Frederic, Fogel, Ronald, Pedersen, Peder, Gonzales, Chad, McCord, Gregory, Galambos, Michael, Lamb, Paul, Schneider, Jeffrey, Bhandari, Bal Raj, Weiss, Michael, Thai, Christine, Shapiro, Michael, Younes, Ziad, Murali, Narayanachar, Hou, Jason, Williams, Todd, Khalid, Omer, Hsu, Connie, Bartalos, Christopher, Arimie, Calin, Mumtaz, Syed, Crespo, Israel, Marchioni Beery, Renee, Tuskey, Anne, Gaible, Ryan, Cutler, Alan, Afzali, Anita, Stuart, Kevin, Ibegbu, Eric, Irizarry-Roman, Moises, Harris, Kimberly, Agyei, Kwadwo, Jones, Frances, Sheikh, Aasim, Zakko, Liam, Cohen, Erica, Duvall, George, Al Kharrat, Houssam, Wohlman, Robert, Holderman, William, Schulman, Alan, Lidofsky, Sheldon, Wayne, Peter, Victores, Luis, Stone, Christian, Onwueme, Kenolisa, Fischer, Monika, Shahid, Shabana, Moore, Keith, Katz, Jeffry, Bullock, Jeff, and Fahed, Julien

Abstract

Mirikizumab, a humanised monoclonal antibody that inhibits IL-23p19, is effective in moderate-to-severe ulcerative colitis. We aimed to evaluate the efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease.

Published
2024
Full Text
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5. Titan Frozen Fruit Strengthens Team with the Additions of Alan Cutler as Chief Financial Officer and Tom Byrne as Executive Vice President of Commercial Development

Subjects
Frozen fruit, Fruit industry -- Officials and employees, Chief financial officers, Canned foods industry -- Officials and employees, General interest, News, opinion and commentary
Abstract

SANTA MARIA: Titan Frozen Fruit has issued the following news release: Titan Frozen Fruit ('Titan' or 'the Company'), a market-leading, value-added food ingredient manufacturer and fruit processor, announced today two [...]

Published
2023

6. Titan Frozen Fruit Strengthens Team with the Additions of Alan Cutler as Chief Financial Officer and Tom Byrne as Executive Vice President of Commercial Development

Subjects
Frozen fruit, Fruit industry -- Officials and employees, Chief financial officers, Canned foods industry -- Officials and employees, Business, News, opinion and commentary
Abstract

Longtime Industry Executives to Support Titan's Sustainable Growth and M&A Initiatives SANTA MARIA, Calif., Oct. 23, 2023 /PRNewswire/ -- Titan Frozen Fruit ('Titan' or 'the Company'), a market-leading, value-added food [...]

Published
2023

9. Cutler, Alan. The Seashell on the Mountaintop: a Story of Science, Sainthood, and Humble Genius Who Discovered a New History of the Earth

Author

Christensen, Bryce

Subjects
The Seashell on the Mountaintop: a Story of Science, Sainthood, and Humble Genius Who Discovered a New History of the Earth (Book), Books -- Book reviews, Business, Publishing industry
Abstract

May 2003. 218p. index: Dutton, $23.95 (0-525-94708-6). 550. In piquant contrast to the oft-told tale of Galileo, the acclaimed martyr of astronomy, Cutler recounts the little-known story of Nicolaus Steno, [...]

Published
2003

10. * Cutler, Alan. The Seashell on the Mountaintop: a Story of Science, Sainthood, and the Humble Genius Who Discovered a New History of the Earth

Author

Maxwell, Gloria

Subjects
The Seashell on the Mountaintop: A Story of Science, Sainthood, and the Humble Genius Who Discovered a New History of the Earth (Nonfiction work) -- Book reviews, Books -- Book reviews, Library and information science
Abstract

Dutton. May 2003. c.240p. permanent paper. index. ISBN 0-525-94708-6. $23.95. SCI At a time when science adhered to biblical parameters, the only possible explanation for seashells found inland and on [...]

Published
2003

11. Sermons in Stone.

Author

Harman, Oren

Subjects
*NONFICTION
Abstract

The article reviews the books "The Seashell on the Mountaintop: A Story of Science, Sainthood, and the Humble Genius Who Discovered a New History of the Earth," by Alan Cutler, and "The Man Who Found Time: James Hutton and the Discovery of the Earth's Antiquity," by Jack Repcheck.

Published
2007

20. What to give a First Things reader

Author

McClay, Wilfred M., Novak, David, Weigel, George, Decter, Midge, and Barr, Stephen M.

Subjects
Nicomachean Ethics (Nonfiction work) -- Aristotle -- Book reviews, The Boys of Summer (Novel) -- Kahn, Roger, The Seashell on the Mountaintop: A Story of Science, Sainthood, and the Humble Genius Who Discovered a New History of the Earth (Biography) -- Cutler, Alan, Studies in Classic American Literature (Nonfiction work) -- Lawrence, D.H., The Language of God: A Scientist Presents Evidence for Belief (Autobiography) -- Collins, Francis S., Helena (Machado de Assis) (Novel) -- Book reviews, The Civil War: A Narrative (Nonfiction work) -- Foote, Shelby -- Book reviews, The Leopard (Novel) -- di Lampedusa, Giuseppe -- Book reviews, Fides Quarens Intellectum (Nonfiction work) -- Barth, Karl, Democracy in America (Nonfiction work) -- Tocqueville, Alexis de -- Book reviews, Founding Brothers: The Revolutionary Generation (Nonfiction work) -- Ellis, Joseph J. -- Book reviews, God in Search of Man (Nonfiction work) -- Heschel, Abraham Joshua, Helena (Novel) -- Waugh, Evelyn -- Book reviews, A Distant Trumpet (Novel) -- Horgan, Paul -- Book reviews, The Fringes of Power: Downing Street Diaries (Nonfiction work) -- Colville, John, The Education of Henry Adams (Autobiography) -- Adams, Henry -- Book reviews, Personal Knowledge: Towards a Post-Critical Philosophy (Nonfiction work) -- Polanyi, Michael, Kuzari (Nonfiction work) -- Halevi, Judah, The Triumph of the Therapeutic: The Uses of Faith After Freud (Nonfiction work) -- Rieff, Philip, Crisis: The Anatomy of Two Major Foreign Policy Crises (Nonfiction work) -- Kissinger, Henry, The Foundations of Modern Science in the Middle Ages (Nonfiction work) -- Grant, Edward, The Mind Has Mountains (Essay collection) -- McHugh, Paul R., I Hear America Swinging (Nonfiction work) -- De Vries, Peter, Sayings of the Fathers (Nonfiction work) -- Hertz, Joseph, Books -- Book reviews, Philosophy and religion
Abstract

Seeking ideas for presents this year, we asked several of our well-read friends and contributors for recommendations of a few wise, or fun, or disturbing books that every FIRST THINGS [...]

Published
2008

24. Carbon dioxide complexation: infrared spectroscopy of iron and ruthenium eta-5-cyclopentadienyl carbonyl metallocarboxylates

Author

Pinkes, John R., Masi, Christopher J., Chiulli, Robert, Steffey, Bryan D., and Cutler, Alan R.

Subjects
Organometallic compounds -- Research, Complex compounds -- Research, Ruthenium -- Analysis, Cyclopentadiene -- Analysis, Chemistry
Abstract

The reaction of CpM(CO)(sub2)(super -) -Li+, -Na+, -K+ or -Mg2+ metalate with carbon dioxide at -78 degrees celsius yields iron and ruthenium eta-5-cyclapentadienyl carbonyl metallocarboxylates. FpCO(sub 2)(super -)-Mg2+, -Li+, -Na+ and -K+ are stable at room temperature. Their infrared spectra is consistent with the ionic metallocarboxylate structures that have symmetric chelation with metallic counterion. The reversible dissociation of CO2 from the metallocarboxylates converts the unbound 13CO2 to unlabelled CO2.

Published
1997

27. Hydrosilation of the manganese acetyl (CO)5MnC(O)CH3 with monohydrosilanes

Author

Gregg, Brian T. and Cutler, Alan R.

Subjects
Silane -- Analysis, Catalysis -- Research, Manganese -- Analysis, Chemistry
Abstract

The hydrosilation chemistry between the manganese acetyl (CO)5MnC(O)CH3 and 13 monohydrosilanes is described. Two noteworthy findings are the isolable alpha-siloxyethyl complexes (CO)5MnCH(OSiR3)CH3 afforded by reactions between (CO)5MnC(O)CH3 and monohydrosilanes and the fact that these reactions generate an alpha-siloxyvinyl byproduct (CO)5MnC(OSiR3)=CH2. Hydrosilation of the isolobal iron acetyl compounds Cp(CO)(L)FeC(O)CH3 yields Cp(CO)(L)FeCH(OSiR3)CH3, requiring a catalyst, while hydrosilation of the cobalt acetyl compounds (PR3)(CO)3CoC(O)CH3 generates equimolar mixtures of (CO)3(PR3)CoSiR3 plus CH3CH2OSiR3, without a catalyst.

Published
1996

28. Notes from the underground

Author

Cutler, Alan

Subjects
Signal processing -- Usage -- Research, Paleontology -- Research -- Usage, Fossils -- Research -- Usage, Science and technology, Digital signal processor, Usage, Research
Abstract

Time the destroyer is time the preserver --T. S. Eliot, 'The Dry Salvages' FOR ONE OF THE GREAT LANDMARKS OF THE history of our planet, the scrubby Wyoming hillside was [...]

Published
1995

30. Iron-tin carbon dioxide complexes (eta5-C5Me5)(CO)2Fe-CO2SnR3 (R = Me, Ph): observations pertaining to unsymmetrical metallocarboxylates and carboxylate-carbonyl 13C-label exchange

Author

Pinkes, John R. and Cutler, Alan R.

Subjects
Coordination compounds -- Research, Carbon dioxide -- Analysis, Chemistry
Abstract

Cp(CO)2Fe-SnR3 is synthesized by the treatment of R3SnCl with Cp(CO)2Fe-CO2 in THF at a temperature of -78 degrees centigrade. The synthesis is attributed to the dissociation of the metallocarboxylates to Cp(CO)2Fe-Kt. Ph3SnCl, a thermally stable iron-tin carboxylate, traps the more nucleophilic Cp(CO)2Fe-CO2-K+. Other trapping experiments yield similar but different compounds of Cp(CO)2Fe.

Published
1994

32. Diagnosing and managing H. pylori infections

Author

Cutler, Alan F.

Subjects
Helicobacter infections -- Diagnosis
Abstract

Helicobacter pylori infection has been strongly associated with gastritis, duodenal ulcers, gastric ulcers, gastric adenocarcinoma and gastric lymphoma. The diagnosis of H. pylori infection has been grouped into two major categories: noninvasive/nonendoscopic and invasive/endoscopic. The first group includes fecal antigen test, antibody detection and urea breath test, while the second group includes rapid urease tests, histology and culture., Helicobacter pylori is the most common bacterial infection found in man. The bacterium appears as a spiral or curved, motile, gram-negative rod (1.5-10 [[micro]meter] in length) that is strongly urease [...]

Published
1999

35. A felon got inculpated for looting with weapons cases and is jailed

Subjects
Robbery, Sheriffs, Business, international, Law
Abstract

A man linked to several looting cases with armaments in two counties is jailed. The Pender County Sheriffs Office informed. On Wednesday the sheriffs office had a press regarding his [...]

Published
2019

36. Testing for helicobacter pylori in clinical practice

Author

Cutler, Alan F.

Subjects
Helicobacter infections -- Diagnosis, Health, Health care industry
Abstract

It is now accepted that cure of Helicobacter pylori infection will result in healing of chronic active gastritis and will change the natural history of gastroduodenal ulcer disease. A variety of highly sensitive and specific diagnostic methods have been developed over the past few years to establish whether a patient is infected with this organism. The two major categories of diagnostic tests for H. pylori are invasive methods, which require endoscopy, and noninvasive tests in which endoscopy is not necessary. Invasive tests include rapid urease tests, histology, and culture. Noninvasive tests include various methods of antibody detection and carbon-labeled urea breath tests. This review describes the characteristics, appropriate uses, and comparative accuracy of the available diagnostic tests for detection of H. pylori. It offers suggestions on the test of choice to establish a patient's H. pylori infection status in different clinical settings.

Published
1996

43. 'We've got teeth' says new head of public sector integrity office

Subjects
Whistleblowing, Public sector, General interest, News, opinion and commentary
Abstract

Byline: CBC News The new Public Sector Integrity Commissioner of Canada defended the mandate of his office and his ability to carry it out, even as whistleblower groups say they [...]

Published
2015

44. Four-year trends in Helicbacter pylori IgG serology following successful eradication

Author

Cutler, Alan F., Prasad, Vajravel M., and Santogade, Peter

Subjects
Helicobacter infections -- Diagnosis, Immunoglobulin G, Helicobacter pylori, Health, Health care industry
Abstract

PURPOSE: Detection of anti-Helicobacter priori antibodies is accurate in the diagnosis of the infection, and there is a decline in IgG titers after successful eradication. It is not known whether these titers continue to decline during the next 3 to 4 years. PATIENTS AND METHODS: Patients had been successfully treated for H pylori with triple therapy (metronidazole, tetracycline, and bismuth subsalicylate) during 1990 and 1991. Those who had frozen serum samples available from that time were contacted to have follow-up serum collected in 1994. A simultaneous [[sup.13]C]urea breath test was done to confirm H pylori infection status. Serology was determined by quantitative enzyme-linked immunosorbent assay (ELISA) and qualitative immunoassay. RESULTS: All 29 patients who agreed to participate were free of H pylori infection. They had a mean decrease in H pylori IgG titers of 51% from baseline (P [is less than] 0.001). Titers remained stable from 1 year to a mean of 3.5 years after therapy (range 2.8 to 4.4). Of the 29 patients, 21 (72%) remained seropositive by ELISA 3.5 years after successful H priori treatment, and 18 (62%) remained positive by rapid serum immunoassay. CONCLUSION: IgG titers against H priori plateau at a 50% decrease after therapy. Helicobacterpylori serology, either quantitative or qualitative, will yield false positive results in patients who have previously been treated for H pylori and should not be used to determine infection status in this population. Am J Med. 1998;105:18-20. [C] 1998 by Excerpta Medica, Inc.

Published
1998

47. The Seashell on the Mountaintop (Book).

Author

Maxwell, Gloria

Subjects
*NONFICTION, BIOGRAPHIES
Abstract

Reviews the non-fiction book, 'The Seashell on the Mountaintop: A Story of Science, Sainthood, and the Humble Genius Who Discovered a New History of the Earth,' by Alan Cutler.

Published
2003

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