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Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study
Authors :
Ferrante, Marc D'Haens, Geert Jairath, Vipul Danese, Silvio Chen, Minhu Ghosh, Subrata Hisamatsu, Tadakazu Kierkus, Jaroslaw Siegmund, Britta Bragg, Sonja Michelle Crandall, Wallace Durand, Frederick Hon, Emily Lin, Zhantao Lopes, Michelle Ugolini Morris, Nathan Protic, Marijana Carlier, Hilde Sands, Bruce E Tron, Emiliano Dorado, Fernanda Dorado Thin, Lena Leong, Rupert Seltenreich, Hans Christensen, Britt Croft, Anthony Ghaly, Simon Koch, Robert Reinisch, Walter Heeren, Sonja Bossuyt, Peter Ferrante, Marc Maximiano, Fabio Luiz Sassaki, Ligia Yukie Baia, Carolina Poli, Debora de Sousa Carlos, Alexandre de Magalhaes Francesconi, Carlos Fernando De Sa Rolim, Alexander Razera, Julio Simoes Neto, Joaquim Rocco, Rodrigo Stifft, Jonathas Soldera, Jonathan Silva, Genoile Mendes Clemente, Cintia Di Felice Boratto, Sandra Teixeira de Campos, Luciana Rodrigues Borba, Marcelo Rosenfeld, Gregory Ponich, Terry Lim, Allen Williams, Chadwick Musgrave, Bruce Gauthier, Stephane Liu, Wenjia Wang, Chengdang Guo, Hong Chen, Chunxiao Chen, Yan Chen Cao, Qian Zhong, Jie Xu, Min Wang, Yufang Zheng, Changqing Gao, Xiang Chen, Youxiang Miao, Yinglei Wang, Lin Liu, Deliang Wang, Bangmao Song, Zhengji Liu, Xiaowei Chen, Baili Jiang, Yi Zhan, Qiang Zhang, Kaiguang Shen, Hong Li, Zhaotao Wang, Xiaoyan Wang, Mei Wang Tian, De'an Chen, Lei Tang, Wen Borzan, Vladimir Krznaric, Zeljko Volfova, Miroslava Pumprla, Jiri Veberova, Lucie Tichy, Michal Gregar, Jan Stepek, David Ulbrych, Jan Drastich, Pavel Papik, Zdenek Matous, Jan Lukas, Martin Koskova, Radka Fallingborg, Jan Altwegg, Romain Fotsing, Ginette Laharie, David Nancey, Stephane Peyrin, Laurent Schreiber, Stefan Hoffmann, Jörg Seidler, Ursula Fechner, Lars Arelin, Katrin Contzen, Christel Trenn, Guido Schaum, Thomas Schoettker, Katrin Bachmann, Oliver Encke, Jens Ibe, Michael Jakobeit, Christian Varga, Marta Salamon, Agnes Kafony, Andras Horvat, Gyula Heringh, Zsanett Bezzegh, Katalin Izbeki, Ferenc Szalai, Laszlo Schnabel, Robert Samanta, Jayanta Banerjee, Rupa Subramanian, Ganesh Mukewar, Shrikant Bansal, Naresh Kumar Sood, Ajit Shankar Bagepally, Ravi Kumar, Porika Shravan Shrimal, Pankaj Shah, Saumin Pai, Nitin Ahuja, Vineet Melzer, Ehud Assy, Nimer Goldin, Eran Shirin, Haim Segal, Arik Lahat, Adi Saibeni, Simone Luzza, Francesco Danese, Silvio Caprioli, Flavio Annunziata, Maria Laura Fantini, Massimo Matsuda, Koichiro Takagi, Sho Kanmura, Shuji Goto, Mitsuhide Ashida, Toshifumi Nishimata, Nobuaki Kawakami, Kazuhiko Ishiguro, Yoh Ishiguro Maemoto, Atsuo Maemoto Naito, Yuji Naito Naoe, Hideaki Nakase, Hiroshi Iida, Tomohiro Akiyama, Junichi Yoshioka, Masao Abe, Yasuhiko Takeuchi, Ken Kawai, Mikio Hirai, Fumihito Horiki, Noriyuki Park, Sang Hyoung Park, Dong II Kang, Sang Bum Jung, Min Kyu Jang, Byung Ik Lee, Yoo Jin Shin, SungJae Kim, Tae-oh Kim, Hyun-Soo Lee, Bo-In Lee, Jonghun Kim, Hyo Jong Choi, Chang Hwan Kim, Dongwoo Eun, Chang Soo Kang, Ben Pokrotnieks, Juris Kiudelis, Gediminas Ramirez, Karina Vega Fonseca, Jose Luis Laheij, Robert Kierkus, Jaroslaw Klopocka, Maria Wylegala, Zbigniew Mroziak, Beata Wojcik, Katarzyna Korczowski, Bartosz Gawdis, Beata Danilkiewicz, Wit Olszanecka, Magdalena Krzykowska, Jolanta Jamrozik, Zofia Duszynska, Malgorzata Ciesiolkiewicz, Agnieszka Baluta, Malgorzata Horynski, Marek Leszczyszyn, Jaroslaw Rozumek, Grzegorz Firkowski, Lukasz Konopko, Marzena Orleanski, Jakub Filip, Rafal Wiechowska, Anna Niezgoda, Krzysztof Mateescu, Radu Craciun, Eugeniu Chioncel, Camelia Musat, Marioara Voiosu, Theodor Alexandru Trofimov, Vasily Shchukina, Oksana Pershko, Anatoly Fedorishina, Olga Chumakova, Galina Bakulin, Igor Osipenko, Marina Nikolin, Denis Barysheva, Olga Alexeeva, Olga Zakharov, Konstantin Khodareva, Irina Tkachev, Alexander Golovenko, Alexey Popova, Veronika Kashnikov, Vladimir Vershinina, Maria Makarchuk, Pavel Valuyskikh, Ekaterina Crevar, Slobodanka Svorcan, Petar Radakovic, Tatjana Hlavaty, Tibor Bunganic, Ivan Fedurco, Miroslav Kalisova, Iveta Balaz, Jozef Mihalkanin, Lubomir Martin Arranz, Maria Dolores De Teresa Parreno, Luis Sans Cuffi, Miquel Hernandez Camba, Alejandro Brand, Stephan Juillerat, Pascal Seibold, Frank Demirci, Hakan Tezel, Ahmet Simsek, Halis Kiyici, Murat Gonen, Can Hulagu, Sadettin Karakan, Tarkan Cekin, Ayhan Altintas, Engin Guven, Kadri Akpinar, Hale Ozin, Yasemin Erzin, Yusuf Demir, Mehmet Temel, Tuncer Lohdanidi, Tetiana Ivanov, Valeriy Ivanishyn, Olha Golovchenko, Oleksandr Gerasymenko, Oksana Danyliuk, Svitlana Vyshyvanyuk, Vira Datsenko, Olena Stanislavchuk, Mykola Rishko, Yaroslava Kyrychenko, Olga Donets, Dmytro Shapovalova, Yana Yurkiv, Andriy Oliinyk, Oleksandr Tsarynna, Nataliia Fediv, Oleksandr Poplyonkin, Yevgen Kaser, Arthur Hoque, Syed Thomas, Hawys Iyengar, Shalini Newman, Frederic Fogel, Ronald Pedersen, Peder Gonzales, Chad McCord, Gregory Galambos, Michael Lamb, Paul Schneider, Jeffrey Bhandari, Bal Raj Weiss, Michael Thai, Christine Shapiro, Michael Younes, Ziad Murali, Narayanachar Hou, Jason Williams, Todd Khalid, Omer Hsu, Connie Bartalos, Christopher Arimie, Calin Mumtaz, Syed Crespo, Israel Marchioni Beery, Renee Tuskey, Anne Gaible, Ryan Cutler, Alan Afzali, Anita Stuart, Kevin Ibegbu, Eric Irizarry-Roman, Moises Harris, Kimberly Agyei, Kwadwo Jones, Frances Sheikh, Aasim Zakko, Liam Cohen, Erica Duvall, George Al Kharrat, Houssam Wohlman, Robert Holderman, William Schulman, Alan Lidofsky, Sheldon Wayne, Peter Victores, Luis Stone, Christian Onwueme, Kenolisa Fischer, Monika Shahid, Shabana Moore, Keith Katz, Jeffry Bullock, Jeff Fahed, Julien
Source :
The Lancet; December 2024, Vol. 404 Issue: 10470 p2423-2436, 14p
Publication Year :
2024
Abstract
Mirikizumab, a humanised monoclonal antibody that inhibits IL-23p19, is effective in moderate-to-severe ulcerative colitis. We aimed to evaluate the efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
404
Issue :
10470
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs68064808
Full Text :
https://doi.org/10.1016/S0140-6736(24)01762-8