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The activation of process-induced positive charging (PIPC) precursors after device fabrication is examined and it is shown that the loss of certain species from the gate edge through lateral diffusion is responsible for it. That studies have shown that water- and chlorine-related species have played a major role, the reactivation of the passivation precursor is examined and the results have shown that it is not thermally accelerated.

Experiments are conducted to examine the positive charge formed in silicon oxynitride (SiON) during negative bias temperature stress (NBTS). It is observed that three varying types of positive charges can be induced by NBTS, namely, as-grown hole trapping, antineutralization positive charge (ANPC), and cyclic positive charge and that the relative importance of positive charge formation depends on measurement interruption time.

Byline: M.H. Chang, Y.D. Hwang A nuclear desalination system has been developed through a thermal coupling of the MEDTVC process and SMART an integral type of advanced reactor producing rated thermal power of 330 MW. The integrated SMART desalination plant is consists of four units of the MEDTVC process to produce 40,000 m/day of potable water. The number of units varies according to water production demand. The thermal coupling between SMART and each MEDTVC unit was made using a steam transformer by considering coupling optimisation conditions. The steam transformer has a function as an intermediate loop and protects any radioactive carry-over to the desalination system. The safety analysis performed on the integrated SMART system showed no safety concerns due to the coupling of the desalination system to the nuclear system. The economic evaluation of water production cost showed that the SMART nuclear desalination system can produce potable water comparable to or more economically than the other options with respect to water production costs.

We previously demonstrated in house sparrows substantial absorption in vivo of L-glucose, the stereoisomer of D-glucose that does not interact with the intestine's D-glucose transporter. The mechanism, as first proposed by Pappenheimer and coworkers in 1987, might be solvent drag through paracellular spaces, activated by Na+-coupled nutrient transport. This hypothesis predicts that absorption of L-glucose might be highest when it is administered orally in the presence of D-glucose and/or amino acids. We tested this in two experiments with house sparrows (Passer domesticus) using pharmacokinetic methods to measure absorption. In Exp. 1, fractional absorption of L-glucose (administered by oral garage and measured by enzymatic method in plasma) in fed sparrows was higher (0.46 +-0.02, n = 7) than in sparrows fasted 12. h (0.40 +- 0.01, n = 6) (simple t-test T = -2.27, P = 0.044, DF= 11).The greater absorption was apparently not due simply to longer retention time of digesta, because no significant difference was found for retention times. In Exp. 2, fractional absorption of radiolabeled L-glucose was significantly higher when administered to fasted birds in solution with 200 mM D-glucose (+ 80 mM NaCl) than when administered with 200 mM mannitol (+ 80 mM NaCl) (respectively, 0.79 + 0.04 vs. 0.66 + 0.03; T= -2.47, P=0.035, DF= 9). In the former group, the absorption rate of L-glucose, determined by pharmacokinetic methods, was 67% faster (P = 0.032). Our results are consistent with the solvent-drag hypothesis, and indicate that small, hydrophilic compounds are absorbed faster and to a greater extent when there are nutrients (e.g., sugar, amino acids) in the gut. Supported by FONCYT (01-03101) to ECV, and NSF IBN-9723793 toWHK.

The stability of viscous flow between concentric rotating cylinders with an axial flow due to an axial pressure gradient is considered. The governing equations with respect to three-dimensional disturbances are derived and solved by a direct numerical procedure. Results are given for the case of small-gap approximation. Three typical cases &b.mu; = -1, 0 and 0.5 are studied, where &b.mu; represents the fatio of angular velocity of the outer cylinder to that of the inner cylinder. The value of the axial Reynolds number R is up to 100. It is found that the critical disturbance is a non-axisymmetric mode when the value of R is sufficiently large, and the transition of the onset mode with R is demonstrated in detail. Results for the critical Taylor number, wave number, vortex incline angle, and relative wave velocity are also determined. The present stability analysis is found to be in agreement with previous experimental studies and particularly reveals the stability characteristics with the variation of &b.mu;. [ABSTRACT FROM AUTHOR]

Chicken yolk immunoglobulin (IgY), an immunologically active component, is used as an alternative to antibiotics for the treatment of enteritis. In this study, IgY was embedded in a W/O/W emulsion to overcome the digestive barrier and to investigate the protective effect of IgY against LPS-induced enteritis in mice. Four different hydrophilic emulsifiers (T80, PC, SC, and WPI) were selected to prepare separate W/O/W emulsions for encapsulating IgY. The results showed that the IgY-embedded double emulsion in the WPI group was the most effective. IgY embedded in the W/O/W emulsion could reduce the damage of LPS to the mouse intestine and prevent LPS-induced intestinal mucosal damage in mice. It increased the number of cup cells, promoted the expression of Muc2, and increased the mRNA expression levels of KLF3, TFF3, Itln1, and Ang4 (p < 0.05). It also enhanced the antioxidant capacity of the colon tissue, reduced the level of inflammatory factors in the colon tissue, and protected the integrity of the colon tissue. Stable embedding of IgY could be achieved using the W/O/W emulsion. In addition, the IgY-embedded W/O/W emulsion can be used as a dietary supplement to protect against LPS-induced enteritis in mice. [ABSTRACT FROM AUTHOR]

Simple Summary: The global economic cost of managing invasive species exceeded $423 billion annually in 2019 and has increased at least fourfold every decade since 1970. In South Korea, the annual damage caused by invasive species is estimated to be between $93 million and $51.68 million. South Korea is vulnerable to invasive species and the cost of invasive species is estimated to be the highest among other countries, indicating the need for policy measures and responses. Most of the invasive reptiles in South Korea are introduced and released by humans. The hybridization of the Chinese striped-necked turtle Mauremys sinensis and Reeves' turtle M. reevesii identified in the current study is also suspected to have been introduced from captivity into the wild, raising alarm bells. This suggests that the introduction of hybrids into the wild could pose a serious problem for biodiversity, especially for the M. reevesii, as it could undermine the genetic diversity of the population. Public awareness and education are needed to preserve South Korea's biodiversity, and efforts must be made to reduce the number of exotic reptiles introduced into the wild. The Chinese striped-necked turtle Mauremys sinensis, introduced into South Korea presumably in 2012, is considered an invasive alien species owing to its devastating impact, including hybridization with the native protected species Reeves' turtle M. reevesii. Recently, the presence of M. sinensis has been confirmed throughout the country, and several sympatric areas with M. reevesii have been reported. Thus, field surveys were conducted at 47 sites across M. sinensis and M. reevesii habitats in South Korea to determine the extent of hybridization. Five sympatric sites were confirmed, and hybrid individuals were identified at four sites. Genetic analyses (COI and R35) of two individuals from Jeju Island confirmed maternal M. reevesii and paternal M. sinensis lineages. Hybridization presumably does not occur under natural conditions, and the hybrids likely originated from captive breeding. This study identifies for the first time the habitats of M. sinensis and its hybrids in the wild of South Korea. The management measures proposed in the current study could be of value for the conservation of the native species; however, our study did not include reproductive monitoring, and there is a need for such surveys as well as for systematic management of non-native turtles introduced into South Korea. [ABSTRACT FROM AUTHOR]

This study employs the two-dimensional Legendre polynomial fitting (2-D LPF) method to fit M2 tidal harmonic constants from satellite altimetry data within the region of 53°E–131°E, 34°S–6°N, extracting internal tide signals acting on the sea surface. The M2 tidal harmonic constants are derived from the sea surface height (SSH) data of the TOPEX/Poseidon (T/P), Jason-1, Jason-2, and Jason-3 satellites via t-tide analysis. We validate the 2-D LPF method against the 300 km moving average (300 km smooth) method and the one-dimensional Legendre polynomial fitting (1-D LPF) method. Through cross-validation across 42 orbits, the optimal polynomial orders are determined to be seven for 1-D LPF, and eight and seven for the longitudinal and latitudinal directions in 2-D LPF, respectively. The 2-D LPF method demonstrated superior spatial continuity and smoothness of internal tide signals. Further single-orbit correlation analysis confirmed generally higher correlation with topographic and density perturbations (correlation coefficients: 0.502, 0.620, 0.245; 0.420, 0.273, −0.101), underscoring its accuracy. Overall, the 2-D LPF method can use all regional data points, overcoming the limitations of single-orbit approaches and proving its effectiveness in extracting internal tide signals acting on the sea surface. [ABSTRACT FROM AUTHOR]

In this study, the Regional Ocean Modeling System (ROMS) is employed to construct a three-dimensional barotropic ocean model with a monodirectional upper boundary and homogeneous and steady wind covering the entire computation area. Eight perturbation experiments are designed to determine the vertical grid distribution difference with high resolution at the surface and bottom. Two types are considered in the model, including removing the Coriolis force (type 1) and employing a different Coriolis force (type 2). According to the experiments, the velocity of the current in type 1 yields uncertainty, and wind energy could penetrate the upper ocean and reach the abyss. The surface velocity in type 2 is fundamentally compatible with the empirical relationship constructed by Ekman, and the curved lines of the vertical distribution of horizontal currents nearly match. For type 1, the velocity is very strong from the sea surface to the bottom. When comparing type 1 and type 2 cases, the Coriolis force obstructs the wind energy transfer into the deep ocean. In addition, the European Centre for Medium-Range Weather Forecasts (ECMWF)'s global surface wind distribution indicates that the realistic ocean upper wind boundary is similar to the numerical experiment in the Pacific and Atlantic oceans, where the wind direction is along the latitude line at the equator. In order to make the experimental situation as close as possible to the real ocean, validation experiments are conducted in this study to consider the uncertainty in the current profile at the equator. The simulation results of type 1 differ significantly from the data obtained from the real ocean. This uncertainty may transfer the signal to higher latitudes, causing incorrect simulation results, especially in the critical region. Overall, this research not only makes discoveries in physical ocean theory but also guides predictive and forecasting techniques for ocean modeling. [ABSTRACT FROM AUTHOR]

Chopper and capacitively coupled techniques are employed in instrumentation amplifiers to create capacitively coupled chopper instrumentation amplifiers (CCIAs) that obtain a high noise power efficiency. However, the CCIA has some disadvantages due to the chopper technique, namely chopper ripple and a low input impedance. The amplifier can easily saturate due to the chopper ripple of the CCIA, especially in extremely low noise problems. Therefore, ripple attenuation is required when designing CCIAs. To record biomedical information, a CCIA with a low power consumption and a low noise, low output ripple, and high input impedance (Zin) is presented in this paper. By introducing a ripple attenuation loop (RAL) including the chopping offset amplifier and a low pass filter, the chopping ripple can be reduced to 0.36 mV. To increase the Zin of the CCIA up to 1.8 GΩ, an impedance boost loop (IBL) is added. By using 180 nm CMOS technology, the 0.123 mm2 CCIA consumes 1.87 µW at a supply voltage of 1 V. According to the simulation results using Cadance, the proposed CCIA architecture achieves a noise floor of 136 nV/√Hz, an input-referred noise (IRN) of 2.16 µVrms, a closed-loop gain of 40 dB, a power supply rejection ratio (PSRR) of 108.6 dB, and a common-mode rejection ratio (CMRR) of 118.7 dB. The proposed CCIA is a helpful method for monitoring neural potentials. [ABSTRACT FROM AUTHOR]

Galectins have the potential to interact with transmembrane glycoproteins to modulate their functions. Since galectin-1 interacts with PDGF-Rβ, we analyzed the effect of galectin-1 on PDGF-BB-mediated AKT signaling in primary human retinal pigment epithelial (RPE) cells and galectin-1-deficient immortalized human RPE cells (LGALS1−/−/ARPE-19) following incubation with PDGF-BB and galectin-1. Expression and localization of galectin-1, PDGF-Rβ and pAKT were investigated using western blot analysis and immunohistochemical staining. Cell proliferation of RPE cells was analyzed using BrdU ELISA. Following treatment of human RPE cells with human recombinant (hr)-galectin-1 and PDGF-BB, an intense clustering of PDGF-Rβ and colocalization with galectin-1 were detected. By Western blot analysis and immunocytochemistry of human RPE cells, an enhanced PDGF-BB-mediated expression of pAKT was observed, which was substantially reduced by additional incubation with hr-galectin-1. Vice versa, in LGALS1−/−/ARPE-19 cells, the PDGF-BB-induced pAKT signal was enhanced compared to wild-type cells. Furthermore, a decreased expression of PDGF-Rβ in human RPE cells was observed after treatment with PDGF-BB and hr-galectin-1, while in untreated LGALS1−/−/ARPE-19 cells, its constitutive expression was increased. In addition, after treatment of RPE cells with hr-galectin-1, the PDGF-BB-induced proliferation was markedly reduced. In summary, galectin-1 has the distinct potential to reduce PDGF-mediated pAKT signaling and proliferation in human RPE cells—an effect that is most likely facilitated via a decreased expression of PDGF-Rβ. [ABSTRACT FROM AUTHOR]

Taiwan Bank (TB) is located in the southern Taiwan Strait (TS). The uplifted continental slope and bottom currents in this area result in the formation of upwelling areas, which serve as crucial fishing grounds. Climate-induced fluctuations in fish populations occur in the TS. However, how predation and competition affect the interspecies relationships in the TB ecosystem warrants clarification. In this study, we collected high-grid-resolution data on fishery activity (2013–2019) and constructed ecosystem models using Ecopath with Ecosim (EwE). Three mass-balanced models for determining the influence of El Niño–Southern Oscillation (ENSO) events on the TB ecosystem were constructed using EwE. A range of groups, including representative pelagic, benthic, and reef species, were collected for analyzing the relationship between migratory and sedentary species in terms of ecosystem structure variation due to climate change. The results demonstrated that the total system throughput (TST) was 10,556–11,122 t km−2 year−1, with an average transfer efficiency of 12.26%. According to the keystoneness index, calculated through mixed trophic impact analysis, Polydactylus sextarius and Scomber japonicus were the key species with top–down control and relatively high impact on the ecosystem in normal years. The keystone species also shifted to the predator fish Thunnus albacares and Katsuwonus pelamis during El Niño and La Niña events, respectively. Moreover, total biomass, TST, consumption, and respiration were noted to increase during ENSO events. However, during La Niña events, the diversity and connectance indexes were relatively low but pelagic species' biomass was relatively high, whereas the biomass of most benthic and reef species was relatively high during El Niño events. [ABSTRACT FROM AUTHOR]

Pediatric chronic intestinal failure (PIF) is a rare and heterogeneous condition characterized by the inability of the patient's intestine to adequately absorb the required fluids and/or nutrients for growth and homeostasis. As a result, patients will become dependent on home parenteral nutrition (HPN). A MEDLINE search was performed in May 2024 with keywords "intestinal failure", "parenteral nutrition" and "pediatric". Different underlying conditions which may result in PIF include short bowel syndrome, intestinal neuromuscular motility disorders and congenital enteropathies. Most common complications associated with HPN are catheter-related bloodstream infections, catheter-related thrombosis, intestinal failure-associated liver disease, small intestinal bacterial overgrowth, metabolic bone disease and renal impairment. Treatment for children with PIF has markedly improved with a great reduction in morbidity and mortality. Centralization of care in specialist centers and international collaboration between centers is paramount to further improve care for this vulnerable patient group. A recently promising medical therapy has become available for children with short bowel syndrome which includes glucagon-like peptide 2, a naturally occurring hormone which is known to delay gastric emptying and induce epithelial proliferation. Despite advances in curative and supportive treatment, further research is necessary to improve nutritional, pharmacological and surgical care and prevention of complications associated with parenteral nutrition use. [ABSTRACT FROM AUTHOR]

Simple Summary: In this retrospective study, three dogs and three cats were selected from the database of the Chonnam National University Teaching Hospital from February 2017 to June 2019. The inclusion criteria for the selection of patients were as follows: (1) clinical data including age, sex, breed, clinical signs, histology, fine-needle aspiration, or fluid centesis were available and (2) intraluminal CEUS was performed; CEUS findings helped confirm the diagnosis. Each patient underwent physical examination, blood tests, radiography, and conventional ultrasonography. Intraluminal CEUS was performed using contrast agents, including SonoVue, agitated saline, saline, or a combination for GI hydrosonography in two patients and sono-cystourethrography in four patients. GI hydrosonography could assess the anatomic relationship between the mass and gastric lumen after administration of a mixture of 0.1 mL SonoVue and 30 mL/kg water in case 1 and could dilate the colonic lumen to detect the thickened wall using saline infusion in case 2. Upon sono-cystourethrography, communication between the urinary tract and prostatic cyst was clearly visualized in case 3, and narrowing of the urethral lumen secondary to prostatomegaly could be ruled out in case 4 with pyogranulomatous prostitis using agitated saline. The saline or agitated saline is appropriate for filling the lumen and improving the acoustic window for GI hydrosonography. Intraluminal CEUS examinations helped to assess the patency of the lumen, evaluate the extent of luminal dilation, rule out luminal narrowing, determine the presence of a mass within the lumen, and identify rupture sites. Administering intraluminal fluid can improve the acoustic window for the visualization of the lumen and wall layers in the cavitary organs. Microbubbles in ultrasound contrast agents can also be used for intracavitary applications to enhance visualization of the lesion in human patients. However, there was no literature extending the clinical application of intraluminal contrast-enhanced ultrasonography (CEUS) to patients with naturally occurring diseases in veterinary medicine. This case series aims to describe the detailed application and diagnostic value of intraluminal CEUS in six clinical cases with naturally occurring gastrointestinal (GI) and urinary tract diseases. [ABSTRACT FROM AUTHOR]