Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study

Authors :: Trajanoska, K. (Katerina)
Morris, J.A. (John A.)
Oei, L. (Ling)
Zheng, H.-F. (Hou-Feng)
Evans, D.M. (David M.)
Kiel, D.P. (Douglas P.)
Ohlsson, C. (Claes)
Richards, J.B. (Brent)
Rivadeneira Ramirez, F. (Fernando)
Trajanoska, K. (Katerina)
Morris, J.A. (John A.)
Oei, L. (Ling)
Zheng, H.-F. (Hou-Feng)
Evans, D.M. (David M.)
Kiel, D.P. (Douglas P.)
Ohlsson, C. (Claes)
Richards, J.B. (Brent)
Rivadeneira Ramirez, F. (Fernando)
Publication Year :: 2018
Abstract: Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A

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