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Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention
- Source :
- Journal of the National Cancer Institute. Dec 19, 2001, Vol. 93 Issue 24, p1872, 8 p.
- Publication Year :
- 2001
-
Abstract
- Background: Human prostate tissues are vulnerable to oxidative DNA damage. The risk of prostate cancer is lower in men reporting higher consumption of tomato products, which contain high levels of the antioxidant lycopene. We examined the effects of consumption of tomato sauce-based pasta dishes on lycopene uptake, oxidative DNA damage, and prostate-specific antigen (PSA) levels in patients already diagnosed with prostate cancer. Methods: Thirty-two patients with localized prostate adeno-carcinoma consumed tomato sauce-based pasta dishes for the 3 weeks (30 mg of lycopene per day) preceding their scheduled radical prostatectomy. Serum and prostate lycopene concentrations, serum PSA levels, and leukocyte DNA oxidative damage (ratio of 8-hydroxy-2'-deoxyguanosine [8-OHdG] to 2'-deoxyguanosine [dG]) were assessed before and after the dietary intervention. DNA oxidative damage was assessed in resected prostate tissue from study participants and from seven randomly selected prostate cancer patients. All statistical tests were two-sided. Results: After the dietary intervention, serum and prostate lycopene concentrations were statistically significantly increased, from 638 nM (95% confidence interval [CI] = 512 to 764 nM) to 1258 nM (95% CI = 1061 to 1455 nM) (P
- Subjects :
- Tomatoes -- Health aspects
Prostate cancer -- Health aspects
Health
Subjects
Details
- ISSN :
- 00278874
- Volume :
- 93
- Issue :
- 24
- Database :
- Gale General OneFile
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Periodical
- Accession number :
- edsgcl.81296672