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Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

Authors :
Nina Koerber
Alina Priller
Sarah Yazici
Tanja Bauer
Cho-Chin Cheng
Hrvoje Mijočević
Hannah Wintersteller
Samuel Jeske
Emanuel Vogel
Martin Feuerherd
Kathrin Tinnefeld
Christof Winter
Jürgen Ruland
Markus Gerhard
Bernhard Haller
Catharina Christa
Otto Zelger
Hedwig Roggendorf
Martin Halle
Johanna Erber
Paul Lingor
Oliver Keppler
Dietmar Zehn
Ulrike Protzer
Percy A. Knolle
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Waning immunity to SARS-CoV-2 is of concern. Here the authors follow spike- and nucleocapsid specific immunity in convalescent individuals for 9 months observing a decline in antibody levels but persisting T cell response. Vaccination approximately 11 months after infection boosts antibody and T cell immunity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.bbeaccaf4069413988e20f5fcbf34dd9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-27649-y