Back to Search
Start Over
Iron physiological requirements in Chinese adults assessed by the stable isotope labeling technique
- Source :
- Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-8 (2018), Nutrition & Metabolism, Nutrition & metabolism, 15:29
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Iron is a kind of essential trace mineral in the human body, while the studies on its physiological requirement are very limited recently, especially in China. And most studies were performed with the radioisotope tracer technique, which was harmful to health. This study aimed to first get the value of iron physiological requirements in Chinese adults assessed by the stable isotope labeling technique. Methods Forty-four eligible young Chinese healthy adults were randomly recruited from the Bethune Military Medical College (Shijiazhuang, Hebei, China) between January 2010 and March 2011, and 19 subjects were included in the final data analysis. After adaptive diets and observation, subjects received 58Fe intravenously. The baseline venous blood sample and general information were collected on day 0. Venous blood samples were also collected on day 14, 30, 60, 100, 120, 150, 240, 330, 425, 515, 605, 767, 1155, respectively. The blood samples were acid digested by a Microwave Digestion System and then analyzed by the MC-ICP-MS and Atomic Absorption Spectroscopy to get the abundance of Fe isotopes and the total iron concentration respectively. The circulation rate (the proportion of blood iron to whole body iron) could be calculated by the intake amount, background content and the peak isotope content. When the abundance changed stably, the iron physiological requirement could be calculated by the iron loss in a period of time. Results The abundance of 58Fe reached its peak on day 14, and changed stably from day 425. The average circulation rate was 84%, with no significance difference between the 2 genders. The mean iron requirement in females was 1101.68 μg/d, and the mean requirement adjusted by body weight was 20.69 μg/kg.d. For males, the mean iron requirement was 959.9 μg/d, and the requirement adjusted by body weight was 14.04 μg/kg.d. Conclusion Our study has obtained the data about the iron physiological requirements of Chinese adults using stable isotope labeling technique, which could provide the basis for adjusting iron DRIs of Chinese people in the future. Trial registration The trial was registered at the Chinese Clinical Trial Registry (No: ChiCTR-TRC-09000581).
- Subjects :
- 0301 basic medicine
Trace mineral
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
lcsh:TX341-641
Clinical nutrition
Blood iron
03 medical and health sciences
Animal science
Medicine
lcsh:RC620-627
030109 nutrition & dietetics
Nutrition and Dietetics
Isotope
business.industry
Research
Venous blood sample
Chinese adults
Iron physiological requirements
Venous blood
lcsh:Nutritional diseases. Deficiency diseases
030104 developmental biology
Stable Isotope Labeling
Stable isotope labeling technique
business
lcsh:Nutrition. Foods and food supply
Subjects
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nutrition & Metabolism
- Accession number :
- edsair.doi.dedup.....ff6a71b05ead39ae095f7d7c1ce56f85