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Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort
- Source :
- Vermeulen, E, Zamora-Ros, R, Duell, E J, Luján-Barroso, L, Boeing, H, Aleksandrova, K, Bueno-de-Mesquita, H B, Scalbert, A, Romieu, I, Fedirko, V, Touillaud, M, Fagherazzi, G, Perquier, F, Molina-Montes, E, Chirlaque, M-D, Vicente Argüelles, M, Amiano, P, Barricarte, A, Pala, V, Mattiello, A, Saieva, C, Tumino, R, Ricceri, F, Trichopoulou, A, Vasilopoulou, E, Ziara, G, Crowe, F L, Khaw, K-T, Wareham, N J, Lukanova, A, Grote, V A, Tjønneland, A, Halkjær, J, Bredsdorff, L, Overvad, K, Siersema, P D, Peeters, P H M, May, A M, Weiderpass, E, Skeie, G, Hjartåker, A, Landberg, R, Johansson, I, Sonestedt, E, Ericson, U, Riboli, E & González, C A 2013, ' Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort ', American Journal of Epidemiology, vol. 178, no. 4, pp. 570-81 . https://doi.org/10.1093/aje/kwt026
- Publication Year :
- 2016
-
Abstract
- We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log(2))=0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multi-variable models (HR (log(2))=0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log(2)) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers.
- Subjects :
- Adult
Male
medicine.medical_specialty
Esophageal Neoplasms
Epidemiology
Flavonoid
Adenocarcinoma
Gastroenterology
Diet Surveys
Risk Assessment
Flavonols
Internal medicine
Medicine
Humans
Multicenter Studies as Topic
Prospective Studies
Registries
Aged
Proportional Hazards Models
chemistry.chemical_classification
Flavonoids
business.industry
Hazard ratio
Smoking
Esophageal cancer
Middle Aged
medicine.disease
Confidence interval
European Prospective Investigation into Cancer and Nutrition
Surgery
Diet
Europe
chemistry
Cohort
Carcinoma, Squamous Cell
Female
business
Biomedical sciences
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Vermeulen, E, Zamora-Ros, R, Duell, E J, Luján-Barroso, L, Boeing, H, Aleksandrova, K, Bueno-de-Mesquita, H B, Scalbert, A, Romieu, I, Fedirko, V, Touillaud, M, Fagherazzi, G, Perquier, F, Molina-Montes, E, Chirlaque, M-D, Vicente Argüelles, M, Amiano, P, Barricarte, A, Pala, V, Mattiello, A, Saieva, C, Tumino, R, Ricceri, F, Trichopoulou, A, Vasilopoulou, E, Ziara, G, Crowe, F L, Khaw, K-T, Wareham, N J, Lukanova, A, Grote, V A, Tjønneland, A, Halkjær, J, Bredsdorff, L, Overvad, K, Siersema, P D, Peeters, P H M, May, A M, Weiderpass, E, Skeie, G, Hjartåker, A, Landberg, R, Johansson, I, Sonestedt, E, Ericson, U, Riboli, E & González, C A 2013, ' Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort ', American Journal of Epidemiology, vol. 178, no. 4, pp. 570-81 . https://doi.org/10.1093/aje/kwt026
- Accession number :
- edsair.doi.dedup.....ae861dda1df11d97f0d46e8e2461e6a1