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Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
- Source :
- Nutrition & Metabolism, Nutrition and Metabolism, 16(1), Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-9 (2019), Nutrition and Metabolism 16 (2019) 1
- Publication Year :
- 2019
-
Abstract
- Background Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that fiber intake also increased circulating 15:0 and 17:0, potentially resulting from fermentation by gut microbes. We examined the associations of dairy and fiber intake with circulating 15:0 and 17:0 in patients with a history of myocardial infarction (MI). Methods We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. Dietary intakes (g/d) were assessed using a 203-item food frequency questionnaire. Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). Spearman correlations (rs) were computed between intakes of total dairy, dairy fat, fiber, and circulating 15:0 and 17:0. Results Patients were on average 69 years old, 78% was male and 21% had diabetes. Total dairy intake comprised predominantly milk and yogurt (69%). Dairy fat was mainly derived from cheese (47%) and milk (15%), and fiber was mainly from grains (43%). Circulating 15:0 in PL was significantly correlated with total dairy and dairy fat intake (both rs = 0.19, p rs = 0.05, p = 0.11). Circulating 17:0 in PL was correlated both with dairy intake (rs = 0.14 for total dairy and 0.11 for dairy fat, p rs = 0.19, p rs = 0.11, p = 0.001). Circulating 15:0 was highest in those with high dairy intake irrespective of fiber intake, while circulating 17:0 was highest in those with high dairy and fiber intake. Conclusions In our cohort of post-MI patients, circulating 15:0 was associated with dairy intake but not fiber intake, whereas circulating 17:0 was associated with both dairy and fiber intake. These data suggest that cardiometabolic health benefits previously attributed to 17:0 as a biomarker of dairy intake may partly be explained by fiber intake.
- Subjects :
- Nutrition and Disease
Endocrinology, Diabetes and Metabolism
Food frequency questionnaire
Medicine (miscellaneous)
lcsh:TX341-641
Type 2 diabetes
Clinical nutrition
030204 cardiovascular system & hematology
Pentadecanoic acid
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Animal science
Diabetes mellitus
Plasma fatty acids
Voeding en Ziekte
medicine
030212 general & internal medicine
Myocardial infarction
lcsh:RC620-627
Margaric acid
VLAG
2. Zero hunger
Nutrition and Dietetics
business.industry
Research
medicine.disease
Nutritional Biology
lcsh:Nutritional diseases. Deficiency diseases
chemistry
Cohort
Heptadecanoic acid
business
lcsh:Nutrition. Foods and food supply
Biomarkers
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nutrition and Metabolism
- Accession number :
- edsair.doi.dedup.....a8af95240e6d45e777fc31536aacfbf3