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Sugar cross-linked gelatin for controlled release: microspheres and disks
- Source :
- Università degli studi di Ferrara-IRIS
- Publication Year :
- 1998
-
Abstract
- The aim of the present paper was to find a 'biocompatible' means to cross-link gelatin-based pharmaceutical devices. In particular, we have studied the ability of native and oxidized mono- and di-saccharides to induce the cross-linking of gelatin. To this end, gelatin discs and gelatin microspheres were produced and their dissolution kinetics at 37 degrees C were examined. In order to find evidence of sugar-mediated cross-linking, DSC and FTIR experiments were performed. The obtained results indicated that both native and oxidized sugars resulted to different extents, in the formation of a cross-linked gelatin network able to reduce the dissolution of gelatin. These results suggest that oxidized mono- and disaccharides could be an interesting method by which to cross-link gelatin thereby reducing the risk of toxic side effects arising from the use of synthetic cross-linkers.
- Subjects :
- Sucrose
Materials science
food.ingredient
Biocompatibility
Chemical Phenomena
Chemistry, Pharmaceutical
Kinetics
Biophysics
Carbohydrates
Bioengineering
Biocompatible Materials
Fructose
Gelatin
Biomaterials
Cross-linking
Disks
Drug delivery
Microspheres
food
Spectroscopy, Fourier Transform Infrared
Fourier transform infrared spectroscopy
Particle Size
Dissolution
Calorimetry, Differential Scanning
Chemistry, Physical
Biomaterial
Controlled release
Cross-Linking Reagents
Glucose
Chemical engineering
Mechanics of Materials
Delayed-Action Preparations
Ceramics and Composites
Biomedical engineering
Subjects
Details
- ISSN :
- 01429612
- Volume :
- 19
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....a84db7cda0510ee64afb1b09e1d8642f