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In vivo acute and subacute toxicities of phenolic extract from rambutan (Nephelium lappaceum) peels by oral administration
- Source :
- Food Chemistry. 320:126618
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Acute and subacute studies of rambutan peel phenolic (RPP) extract were conducted by oral administration on Kunming mice and Sprague-Dawley (SD) rats, respectively. Acute toxicity study (14 days) results revealed that the LD50 value of RPP extract was more than 5000 mg/kg bw in vivo. For the subacute study, four different doses were administered to SD rats by daily gavage for 28 days. Subacute toxicity study results indicated that RPP extract did not show any obvious adverse effect at doses of 312 and 625 mg/kg bw. The bw gain was significantly inhibited at 2500 mg/kg bw of RPP extract. RPP extract at doses of 1250 and 2500 mg/kg bw showed toxicities to liver, kidney, and spleen in SD rats according to the results of hematological and biochemical analyses. Furthermore, RPP extract at 2500 mg/kg bw showed toxicity on different tissues according to the results of histopathological analyses.
- Subjects :
- Male
Rambutan
Administration, Oral
Spleen
Pharmacology
Kidney
01 natural sciences
Analytical Chemistry
Lethal Dose 50
Rats, Sprague-Dawley
Mice
Sapindaceae
0404 agricultural biotechnology
Phenols
In vivo
Oral administration
medicine
Animals
Adverse effect
Plant Extracts
business.industry
010401 analytical chemistry
04 agricultural and veterinary sciences
General Medicine
040401 food science
Acute toxicity
Rats
0104 chemical sciences
medicine.anatomical_structure
Liver
Toxicity
Female
business
Food Science
Subjects
Details
- ISSN :
- 03088146
- Volume :
- 320
- Database :
- OpenAIRE
- Journal :
- Food Chemistry
- Accession number :
- edsair.doi.dedup.....1a6bf1bbf7eb251646927012f54aac0f
- Full Text :
- https://doi.org/10.1016/j.foodchem.2020.126618