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In vivo acute and subacute toxicities of phenolic extract from rambutan (Nephelium lappaceum) peels by oral administration

Authors :
Liping Sun
Yujing Li
Yongliang Zhuang
Wenhui Tian
Source :
Food Chemistry. 320:126618
Publication Year :
2020
Publisher :
Elsevier BV, 2020.

Abstract

Acute and subacute studies of rambutan peel phenolic (RPP) extract were conducted by oral administration on Kunming mice and Sprague-Dawley (SD) rats, respectively. Acute toxicity study (14 days) results revealed that the LD50 value of RPP extract was more than 5000 mg/kg bw in vivo. For the subacute study, four different doses were administered to SD rats by daily gavage for 28 days. Subacute toxicity study results indicated that RPP extract did not show any obvious adverse effect at doses of 312 and 625 mg/kg bw. The bw gain was significantly inhibited at 2500 mg/kg bw of RPP extract. RPP extract at doses of 1250 and 2500 mg/kg bw showed toxicities to liver, kidney, and spleen in SD rats according to the results of hematological and biochemical analyses. Furthermore, RPP extract at 2500 mg/kg bw showed toxicity on different tissues according to the results of histopathological analyses.

Details

ISSN :
03088146
Volume :
320
Database :
OpenAIRE
Journal :
Food Chemistry
Accession number :
edsair.doi.dedup.....1a6bf1bbf7eb251646927012f54aac0f
Full Text :
https://doi.org/10.1016/j.foodchem.2020.126618