The effect of in vitro simulated gastrointestinal digestion on phenolic bioaccessibility and bioactivities of Prinsepia utilis Royle fruits

This study investigated the influence of simulated gastrointestinal digestion on phenolic bioaccessibility, antioxidant activity, and enzyme inhibition of Prinsepia utilis Royle fruits. Gastric and intestinal digestion remarkably upgraded the total phenolic and flavonoid contents, whereas the total anthocyanin content increased after gastric digestion but declined after intestinal digestion. Nineteen phenolics were characterized in P. utilis fruits among which rutin had the highest content in undigested and intestinally digested samples. Cyanidin-3-O-glucoside had the highest content in the gastrically digested sample. After digestion, fruit antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase were enhanced significantly (p