Back to Search
Start Over
Dairy Consumption Lowers Systemic Inflammation and Liver Enzymes in Typically Low-Dairy Consumers with Clinical Characteristics of Metabolic Syndrome
- Source :
- Journal of the American College of Nutrition; April 2016, Vol. 35 Issue: 3 p255-261, 7p
- Publication Year :
- 2016
-
Abstract
- Objectives:A 6-week cross-over study design was used to determine the effect of increased dairy consumption in typically low-dairy consumers (n= 37) with metabolic syndrome (MetS) on systemic inflammation and hepatic enzymes.Methods:This was a randomized study in which participants consumed low-fat dairy (LFD) (10 oz 1% milk, 6 oz nonfat yogurt, 4 oz 2% cheese) or a carbohydrate-based control (CNT) (1.5 oz granola bar and 12 oz 100% juice) for 6 weeks. After a 4-week washout, they were allocated to the alternate dietary treatment. Inflammatory status was assessed by fasting plasma concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant −1 (MCP-1). In addition, gene expression of interleukin (IL)-1, IL-6, and TNF-α was evaluated in peripheral blood mononuclear cells isolated from a subset of 17 subjects (13 women, 3 men) at the end of each dietary period. Liver enzymes were also assessed to evaluate whether dairy components would affect hepatic function.Results:Participants had lower concentrations of both hepatic alanine aminotransferase (p< 0.05) and aspartate aminotransferase (p< 0.005) after the LFD period. No significant changes in any of the plasma inflammatory compounds were found when all data were analyzed together. In contrast, expression of IL-1b and IL-6 were reduced by 46% and 63%, respectively, compared to the control period. When stratified by gender, women had lower TNF-α, (p= 0.028) and MCP-1 (p= 0.001) following LFD consumption compared to CNT. In addition, hepatic steatosis index scores were significantly lower (p< 0.001) during the LFD period.Conclusions: We conclude that three dairy servings per day improved both liver function and systemic inflammation in subjects with MetS.
Details
- Language :
- English
- ISSN :
- 07315724 and 15411087
- Volume :
- 35
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of the American College of Nutrition
- Publication Type :
- Periodical
- Accession number :
- ejs38485312
- Full Text :
- https://doi.org/10.1080/07315724.2015.1022637